Gasdermin E is required for induction of pyroptosis and severe disease during enterovirus 71 infection

Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin-E-dependent pyroptosis in barrier epithelial cells

(2021) Megan H. Orzalli et al.   IMMUNITY

EV71 infection induces cell apoptosis through ROS generation and SIRT1 activation

(2020) Hongyan Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Characteristics of enterovirus 71-induced cell death and genome scanning to identify viral genes involved in virus-induced cell apoptosis

(2019) Jinjin Bai et al.   VIRUS RESEARCH

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

(2019) Corey Rogers et al.   Nature Communications

Enterovirus 71 induces apoptosis by directly modulating the conformational activation of pro-apoptotic protein Bax

(2017) Xiaodong Han et al.   JOURNAL OF GENERAL VIROLOGY

Enterovirus 71 Inhibits Pyroptosis through Cleavage of Gasdermin D

(2017) Xiaobo Lei et al.   JOURNAL OF VIROLOGY

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

The Golgi protein ACBD3 facilitates Enterovirus 71 replication by interacting with 3A

(2017) Xiaobo Lei et al.   Scientific Reports

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

(2016) Xin Chen et al.   CELL RESEARCH

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

(2016) Lorenzo Sborgi et al.   EMBO JOURNAL

Enterovirus 71 2B Induces Cell Apoptosis by Directly Inducing the Conformational Activation of the Proapoptotic Protein Bax

(2016) Haolong Cong et al.   JOURNAL OF VIROLOGY

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

(2016) Robin A. Aglietti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Intrinsic apoptosis and proinflammatory cytokines regulated in human astrocytes infected with enterovirus 71

(2015) Chunyang Wang et al.   JOURNAL OF GENERAL VIROLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Reciprocal Regulation between Enterovirus 71 and the NLRP3 Inflammasome

(2015) Hongbin Wang et al.   Cell Reports

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Hand, foot, and mouth disease in China, 2008–12: an epidemiological study

(2014) Weijia Xing et al.   LANCET INFECTIOUS DISEASES

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

Rupintrivir is a promising candidate for treating severe cases of enterovirus-71 infection: Evaluation of antiviral efficacy in a murine infection model

(2013) Xiaonan Zhang et al.   ANTIVIRAL RESEARCH

Differential apoptosis gene expressions of rhabdomyosarcoma cells in response to enterovirus 71 infection

(2012) Weifeng Shi et al.   BMC INFECTIOUS DISEASES

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

The 3C Protein of Enterovirus 71 Inhibits Retinoid Acid-Inducible Gene I-Mediated Interferon Regulatory Factor 3 Activation and Type I Interferon Responses

(2010) X. Lei et al.   JOURNAL OF VIROLOGY

Virology, epidemiology, pathogenesis, and control of enterovirus 71

(2010) Tom Solomon et al.   LANCET INFECTIOUS DISEASES

Clinical features, diagnosis, and management of enterovirus 71

(2010) Mong How Ooi et al.   LANCET NEUROLOGY

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

(2010) Edward A Miao et al.   NATURE IMMUNOLOGY