Journal
JOURNAL OF ANTIBIOTICS
Volume 75, Issue 4, Pages 199-206Publisher
SPRINGERNATURE
DOI: 10.1038/s41429-022-00512-y
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Funding
- Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)) from the Japan Agency for Medical Research & Development (AMED) [JP19am0101096]
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In this study, four new tricyclic macrolides, named shikinefragalides A (1), B (2), C (3) and D (4), were isolated from a static culture material of Stachybotryaceae sp. FKI-9632 using physicochemical screening. Their structures were determined as new analogs of colletofragarones through MS and NMR analyses. Compounds 1 and 2 exhibited weak antimalarial activity and cytotoxicity.
Four new tricyclic macrolides, named shikinefragalides A (1), B (2), C (3) and D (4), were isolated by physicochemical (PC) screening from a static culture material of Stachybotryaceae sp. FKI-9632. Their structures were elucidated as new analogs of colletofragarones by MS and NMR analyses. Compounds 1 and 2 showed weak antimalarial activity and cytotoxicity.
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