Article
Clinical Neurology
Eric E. Abrahamson, Julia K. Kofler, Carl R. Becker, Julie C. Price, Kathy L. Newell, Bernardino Ghetti, Jill R. Murrell, Catriona A. McLean, Oscar L. Lopez, Chester A. Mathis, William E. Klunk, Victor L. Villemagne, Milos D. Ikonomovic
Summary: In a post-mortem study, it has been found that the amyloid PET radioligand Pittsburgh compound B (PiB) interacts poorly with cotton wool plaques, which are common in familial Alzheimer's disease but rare in sporadic Alzheimer's disease. This limited interaction may lead to an underestimation of total amyloid burden in patients with familial Alzheimer's disease.
Article
Neurosciences
Xi Chen, Kaitlin E. Cassady, Jenna N. Adams, Theresa M. Harrison, Suzanne L. Baker, William J. Jagust
Summary: Studies suggest that tau deposition begins in the anterolateral entorhinal cortex during normal aging and is facilitated by the presence of beta-amyloid, potentially marking the onset of Alzheimer's disease. Higher tau deposition in the anterior-temporal memory network is associated with faster memory decline, especially in individuals with beta-amyloid. When all three tau measures are considered, only tau in the anterior-temporal region significantly predicts memory decline.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Wha Jin Lee, Hanna Cho, Min Seok Baek, Han-Kyeol Kim, Jae Hoon Lee, Young Hoon Ryu, Chul Hyoung Lyoo, Joon-Kyung Seong
Summary: This study describes the differences in tau-spreading processes in early- and late-onset Alzheimer's disease spectrum. The results suggest that the tau propagation pathways are distinct between individuals with early and late onset of symptoms, with specific hub regions playing a dominant role in tau spreading.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Medicine, General & Internal
Nicholas J. Ashton, Andrea L. Benedet, Tharick A. Pascoal, Thomas K. Karikari, Juan Lantero-Rodriguez, Wagner S. Brum, Sulantha Mathotaarachchi, Joseph Therriault, Melissa Savard, Mira Chamoun, Erik Stoops, Cindy Francois, Eugeen Vanmechelen, Serge Gauthier, Eduardo R. Zimmer, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto
Summary: CSF p-tau epitopes increase early in the development of AD pathology and are a primary candidate for detecting incipient Aβ pathology.
Article
Clinical Neurology
Hana Florian, Deli Wang, Steven E. Arnold, Merce Boada, Qi Guo, Ziyi Jin, Hui Zheng, Nahome Fisseha, Hari Varun Kalluri, Beatrice Rendenbach-Mueller, Kumar Budur, Michael Gold, Thomas Aware Investigators, Lealani Acosta, Thomas Ala, Sanka Amadoru, Jeffrey Apter, Steven Arnold, Merce Boada-Rovira, Anne Boerjesson-Hanson, Wendy Bond, Michael Borrie, Gabriella Bottini, Bruce Brew, Mark Brody, James Burke, Jeffrey Burns, Annalisa Chiari, Roger Clarnette, Sharon Cohen, Martin Farlow, Simon Fishman, Norman Foster, Kristian Frederiksen, Giovanni Frisoni, Nigel Gilchrist, Darren Gitelman, Ira Goodman, Marc Gordon, Neill Graff-Radford, Merja Hallikainen, Adrian Ivanoiu, Gregory Jicha, Michael Jonsson, Diana Kerwin, Dineke Koek, James Lah, Ayesha Lall, Elly Lee, Gabriel Leger, Peter Ljubenkov, Camillo Marra, Pablo Martinez-Lage, Joseph Masdeu, Scott McGinnis, Patrizia Mecocci, Philip Morris, Marshall Nash, Allison Perrin, Aimee Pierce, Robert Riesenberg, Juha Rinne, Raquel Sanchez Del Valle, Elio Scarpini, Paul Schulz, Ronald Schwartz, Amanda Smith, Bryan Spann, Sylvie Van Snick, Rik Vandenberghe, Cherian Verghese, Alberto Villarejo, Chuang-Kuo Wu
Summary: Tau accumulation in patients with Alzheimer's disease is closely related to cognitive decline. This study evaluated tilavonemab, an anti-tau monoclonal antibody, in treating patients with early Alzheimer's disease. The results showed that tilavonemab did not demonstrate efficacy in treating early Alzheimer's disease.
Article
Clinical Neurology
Gregory Klein, P. Delmar, G. A. Kerchner, C. Hofmann, D. Abi-Saab, A. Davis, N. Voyle, M. Baudler, P. Fontoura, R. Doody
Summary: The study demonstrates that prolonged treatment with high-dose gantenerumab can reduce amyloid plaque levels below the positivity threshold in patients with early to moderate Alzheimer's disease, showing continued reduction in amyloid plaque removal over time. Ongoing Phase III trials will evaluate the potential clinical benefits of gantenerumab-induced amyloid lowering in early-stage Alzheimer's disease patients.
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Olin Janssen, Willemijn J. Jansen, Stephanie J. B. Vos, Merce Boada, Lucilla Parnetti, Tomasz Gabryelewicz, Tormod Fladby, Jose Luis Molinuevo, Sylvia Villeneuve, Jakub Hort, Stephane Epelbaum, Alberto Lleo, Sebastiaan Engelborghs, Wiesje M. van der Flier, Susan Landau, Julius Popp, Anders Wallin, Philip Scheltens, Marcel Olde Rikkert, Peter J. Snyder, Chris Rowe, Gael Chetelat, Agustin Ruiz, Marta Marquie, Elena Chipi, Steffen Wolfsgruber, Michael Heneka, Henning Boecker, Oliver Peters, Jonas Jarholm, Lorena Rami, Adria Tort-Merino, Alexa Pichet Binette, Judes Poirier, Pedro Rosa-Neto, Jiri Cerman, Bruno Dubois, Marc Teichmann, Daniel Alcolea, Juan Fortea, M. Belen Sanchez-Saudinos, Jarith Ebenau, Cornelia Pocnet, Marie Eckerstrom, Louisa Thompson, Victor Villemagne, Rachel Buckley, Samantha Burnham, Marion Delarue, Yvonne Freund-Levi, Asa K. Wallin, Inez Ramakers, Magda Tsolaki, Hilkka Soininen, Harald Hampel, Luiza Spiru, Betty Tijms, Rik Ossenkoppele, Frans R. J. Verhey, Frank Jessen, Pieter Jelle Visser
Summary: In addition to age, setting, and APOE ε4 carriership, specific characteristics of subjective cognitive decline may aid in identifying individuals with amyloid positivity.
ALZHEIMERS & DEMENTIA
(2022)
Article
Clinical Neurology
Stephen Zicha, Randall J. Bateman, Leslie M. Shaw, Henrik Zetterberg, Anthony W. Bannon, Wesley A. Horton, Mike Baratta, Hartmuth C. Kolb, Iwona Dobler, Yulia Mordashova, Ziad S. Saad, David L. Raunig, Emmanouil (Manos) Spanakis, Yan Li, Suzanne E. Schindler, Kyle Ferber, Carrie E. Rubel, Robert L. Martone, Christopher J. Weber, Rebecca M. Edelmayer, Emily A. Meyers, James G. Bollinger, Erin G. Rosenbaugh, William Z. Potter
Summary: This study evaluated the performance of six plasma A beta assays in predicting amyloid positivity compared to age and APOE genotype. The results showed that three of the assays significantly improved the prediction accuracy, and plasma A beta 42/40 predicted amyloid PET status better than A beta 42 or A beta 40 alone.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Se Jong Oh, Namhun Lee, Kyung Rok Nam, Kyung Jun Kang, Sang Jin Han, Kyo Chul Lee, Yong Jin Lee, Jae Yong Choi
Summary: This study aimed to investigate the impact of amyloid pathology on the functional aspects of neurotransmitter systems in Alzheimer's disease. The results revealed increased amyloid pathology in the AD group, as well as decreased glutamatergic and GABAergic systems and a reduction in the dopaminergic system. These findings suggest a connection between dysfunction of neurotransmitter systems and AD pathology.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Clinical Neurology
Lyduine E. Collij, Gill Farrar, David Vallez Garcia, Ilona Bader, Mahnaz Shekari, Luigi Lorenzini, Hugh Pemberton, Daniele Altomare, Sandra Pla, Mery Loor, Pawel Markiewicz, Maqsood Yaqub, Christopher Buckley, Giovanni B. Frisoni, Agneta Nordberg, Pierre Payoux, Andrew Stephens, Rossella Gismondi, Pieter Jelle Visser, Lisa Ford, Mark Schmidt, Cindy Birck, Jean Georges, Anja Mett, Zuzana Walker, Merce Boada, Alexander Drzezga, Rik Vandenberghe, Bernard Hanseeuw, Frank Jessen, Michael Scholl, Craig Ritchie, Isadora Lopes Alves, Juan Domingo Gispert, Frederik Barkhof, AMYPAD Consortium
Summary: Amyloid Imaging to Prevent Alzheimer's Disease (AMYPAD) consortium aims to provide evidence on the clinical utility and cost-effectiveness of Positron Emission Tomography (PET) imaging in AD diagnosis and support clinical trial design. AMYPAD has contributed significantly to understanding of amyloid deposition in the brain and improving measurement methodology. Future steps include integrating and curating available clinical data for wider scientific access.
FRONTIERS IN NEUROLOGY
(2023)
Article
Medicine, General & Internal
Cecile Tissot, Joseph Therriault, Peter Kunach, Andrea L. Benedet, Tharick A. Pascoal, Nicholas J. Ashton, Thomas K. Karikari, Stijn Servaes, Firoza Z. Lussier, Mira Chamoun, Dana L. Tudorascu, Jenna Stevenson, Nesrine Rahmouni, Nina Margherita Poltronetti, Vanessa Pallen, Gleb Bezgin, Min Su Kang, Sulantha S. Mathotaarachchi, Yi-Ting Wang, Jaime Fernandez Arias, Pamela Cristina Lukasewicz Ferreira, Joao Pedro Ferrari-Souza, Eugeen Vanmechelen, Kaj Blennow, Henrik Zetterberg, Serge Gauthier, Pedro Rosa-Neto
Summary: This study investigated the agreement between [F-18]MK6240 tau-PET, plasma pTau181, and pTau231 in Alzheimer's disease. The findings suggest that these biomarkers reflect different stages of tau progression and can be useful in diagnosing and evaluating the disease stage.
Article
Computer Science, Information Systems
Bo-Hye Choi, Donghwi Hwang, Seung-Kwan Kang, Kyeong-Yun Kim, Hongyoon Choi, Seongho Seo, Jae-Sung Lee
Summary: The lack of physically measured attenuation maps (mu-maps) in brain-dedicated stand-alone PET scanners is a challenge, but the study successfully developed a transmission-less attenuation correction method for A beta brain PET imaging using a deep learning approach. Among the three U-net models tested, the 3D U-net model showed the best performance in reducing noise and artifacts, significantly improving the accuracy of mu-map generation compared to traditional MLAA method.
Article
Clinical Neurology
Hang-Rai Kim, Sang-Hyuk Jung, Jaeho Kim, Hyemin Jang, Sung Hoon Kang, Song Hwangbo, Jun Pyo Kim, So Yeon Kim, Beomsu Kim, Soyeon Kim, Jee Hyang Jeong, Soo Jin Yoon, Kyung Won Park, Eun-Joo Kim, Bora Yoon, Jae-Won Jang, Jin Yong Hong, Seong Hye Choi, Young Noh, Ko Woon Kim, Si Eun Kim, Jin San Lee, Na-Yeon Jung, Juyoun Lee, Byeong C. Kim, Sang Joon Son, Chang Hyung Hong, Duk L. Na, Sang Won Seo, Hong-Hee Won, Hee Jin Kim
Summary: This study identified novel genetic variants associated with a decreased risk of A beta positivity in the Korean population, providing a potential therapeutic target for AD and emphasizing the importance of genetic studies in diverse populations.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Clinical Neurology
Taewon Kim, Dahyun Yi, Min Soo Byun, Hyejin Ahn, Joon Hyung Jung, Nayeong Kong, Min Jung Kim, Gijung Jung, Jun-Young Lee, Yun-Sang Lee, Yu Kyeong Kim, Dong Young Lee
Summary: This study found a synergistic interaction between high current blood pressure and beta-amyloid and tau deposition in late-life, but no association with a history of hypertension. This suggests that strict blood pressure control is important for the prevention of Alzheimer's disease in cognitively normal older adults with hypertension.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
MiaoMiao Xu, Jun Guo, JiaCheng Gu, LinLin Zhang, ZiHao Liu, Lin Ding, HongLiang Fu, YuFei Ma, Sheng Liang, Hui Wang
Summary: A new Aβ tracer [F-18]DRKXH1 was synthesized and evaluated for its performance in diagnosing AD using various methods. The tracer showed promising results in detecting Aβ plaques in the brains of AD transgenic mice and AD patients, suggesting its potential for in vivo detection of the human brain.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Geriatrics & Gerontology
Galit Weinstein, Miri Lutski, Uri Goldbourt, David Tanne
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2018)
Article
Geriatrics & Gerontology
Galit Weinstein, Roni Elran Barak, Michal Schnaider Beeri, Ramit Ravona-Springer
AGING & MENTAL HEALTH
(2019)
Article
Multidisciplinary Sciences
Galit Weinstein, Kendra L. Davis-Plourde, Sarah Conner, Jayandra J. Himali, Alexa S. Beiser, Anne Lee, Andreea M. Rawlings, Sanaz Sedaghat, Jie Ding, Erin Moshier, Cornelia M. van Duijn, Michal S. Beeri, Elizabeth Selvin, M. Arfan Ikram, Lenore J. Launer, Mary N. Haan, Sudha Seshadri
Article
Gastroenterology & Hepatology
Galit Weinstein, Kendra Davis-Plourde, Jayandra J. Himali, Shira Zelber-Sagi, Alexa S. Beiser, Sudha Seshadri
LIVER INTERNATIONAL
(2019)
Article
Endocrinology & Metabolism
Miri Lutski, Galit Weinstein, David Tanne, Uri Goldbourt
Article
Endocrinology & Metabolism
Galit Weinstein, Miri Lutski, Uri Goldbourt, David Tanne
Letter
Gastroenterology & Hepatology
Galit Weinstein, Kendra L. Davis-Plourde, Alexa S. Beiser, Sudha Seshadri
LIVER INTERNATIONAL
(2020)
Article
Neurosciences
Miri Lutski, Galit Weinstein, Shelly Ben-Zvi, Uri Goldbourt, David Tanne
Summary: This study highlights the possible role of adherence to Mediterranean diet in cognitive function of patients with cardiovascular disease, and may provide a basis for future interventions to reduce their risk for cognitive decline.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Psychiatry
Galit Weinstein, Miri Lutski, Lital Keinan-Boker, Uri Goldbourt, David Tanne
Summary: Exposure to Holocaust conditions may be associated with poorer cognitive function and greater cognitive decline in elderly male adults with coronary heart disease.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Clinical Neurology
Galit Weinstein, Kendra Davis-Plourde, Alexa S. Beiser, Sudha Seshadri
Summary: The study found that high resting heart rate and heart rate variability can influence the risk of stroke and dementia, especially in older adults and men.
Article
Geriatrics & Gerontology
Galit Weinstein, Shiraz Vered, Dana Ivancovsky-Wajcman, Ramit Ravona-Springer, Anthony Heymann, Shira Zelber-Sagi, Danit Rivka Shahar, Michal Schnaider Beeri
Summary: This study suggests that a high intake of ultra-processed meat and oils/spreads may be associated with accelerated cognitive decline in older individuals with T2D.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Clinical Neurology
Shuo Li, Galit Weinstein, Habil Zare, Alexander Teumer, Uwe Voelker, Nele Friedrich, Maria J. Knol, Claudia L. Satizabal, Vladislav A. Petyuk, Hieab H. H. Adams, Lenore J. Launer, David A. Bennett, Philip L. De Jager, Hans J. Grabe, M. Arfan Ikram, Vilmundur Gudnason, Qiong Yang, Sudha Seshadri
BRAIN COMMUNICATIONS
(2020)