Article
Cell Biology
Pravat Kumar Parida, Mauricio Marquez-Palencia, Vidhya Nair, Akash K. Kaushik, Kangsan Kim, Jessica Sudderth, Eduardo Quesada-Diaz, Ambar Cajigas, Vamsidhara Vemireddy, Paula Gonzalez-Ericsson, Melinda E. Sanders, Bret C. Mobley, Kenneth Huffman, Sunati Sahoo, Prasanna Alluri, Cheryl Lewis, Yan Peng, Robert M. Bachoo, Carlos L. Arteaga, Ariella B. Hanker, Ralph J. DeBerardinis, Srinivas Malladi
Summary: Metabolic diversity and plasticity within brain-tropic cells play a crucial role in determining the metastatic fitness of HER2+ breast cancer patients. Lactate secretion by aggressive metastatic cells or lactate supplementation inhibits innate immunosurveillance and promotes overt metastasis. Inhibiting lactate metabolism can impede brain metastasis, but some brain metastatic cells adapt and survive through specific metabolic pathways. xCT, an amino acid transporter, is significantly upregulated in brain metastatic cells compared to primary tumors, and targeting xCT can attenuate residual disease and recurrence.
Review
Chemistry, Medicinal
Jun-Kyu Byun
Summary: Tumor development is affected by circulating metabolites, with elevated levels of lactic acid and low levels of glucose and glutamine. Lactic acid, a major circulating carbon metabolite produced by tumors, regulates energy metabolism and cancer cell signaling pathways. Recent studies have identified the pro-tumorigenic action of lactic acid and propose targeting its metabolism as a therapeutic strategy for anti-cancer therapy.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Zi-Xian Liao, Ivan M. Kempson, Chia-Chen Hsieh, S-Ja Tseng, Pan-Chyr Yang
Summary: The presence of lactate and its relationship with drug resistance and genetic mutations in NSCLC highlights the potential for improving therapeutic outcomes by enzymatically lowering lactate levels. Targeting lactate may promote an oncolytic immune microenvironment within the tumor, offering a promising approach for enhancing NSCLC treatment efficacy.
DRUG DISCOVERY TODAY
(2021)
Review
Medicine, Research & Experimental
John M. Macharia, Zsolt Kaposztas, Timea Varjas, Ferenc Budan, Afshin Zand, Imre Bodnar, Raposa L. Bence
Summary: Although the pathophysiology of colorectal cancer (CRC) is complex and not well understood, interactions between risk factors play a crucial role in the development and progression of the disease. The use of lactic acid bacteria (LAB) prebiotics and probiotics to modulate the tumor microenvironment (TME) has become increasingly popular in CRC management. This study aims to investigate the negative effects of LAB-derived lactic acid in the colonic mucosa in colorectal cancer management. More research is needed to ensure that LAB and their lactic acid by-products do not have unintended adverse effects in CRC management.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Y. -S. Wang, L. Niu, W. -X. Shi, X. -Y. Li, L. Shen
Summary: This study reviewed the association between the Naples prognostic score (NPS) and lung cancer prognosis. The results showed that a high NPS score is associated with worse overall survival (OS) and disease-free survival (DFS). Although all the studies were conducted in China, further research from non-Chinese populations is needed to supplement the results.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Oncology
Wen Huang, Ping Liu, Min Zong, Qian-Qian Chen, Hong Zhou, Hui Kong, Wei-Ping Xie
Summary: LDH and Fbg were identified as independent risk factors in predicting progression-free survival (PFS) and overall survival (OS) in SCLC patients receiving first-line chemotherapy and radiotherapy. Combining serum LDH and Fbg levels could potentially improve the prediction efficacy for chemotherapy response and prognosis in SCLC patients.
CANCER MANAGEMENT AND RESEARCH
(2021)
Review
Oncology
Petr Shegay, Anastasia A. Zabolotneva, Olga P. Shatova, Aleksandr Shestopalov, Andrei D. Kaprin
Summary: Lactic acid, once considered a toxic byproduct of metabolism, has been found to have various functions in living organisms. It acts as a signaling molecule and regulates metabolic processes, cell differentiation, and inflammatory response. Lactate also plays a role in providing stemness and promoting unlimited cell growth, which is utilized by malignant tumors. This review aims to summarize the functions of lactate in cell metabolism and its involvement in carcinogenesis, considering the evolutionary significance of the Warburg effect.
Article
Biochemistry & Molecular Biology
Yingsheng Wen, Guangran Guo, Longjun Yang, Lianjuan Chen, Dechang Zhao, Xiaotian He, Rusi Zhang, Zirui Huang, Gongming Wang, Lanjun Zhang
Summary: This study identified a potentially effective model for estimating overall survival in lung cancer patients by analyzing the tumor microenvironment (TME) components. A gene panel consisting of seven TME-related genes was proposed as a candidate signature set. The study also revealed that patients at high-risk had less immune cells infiltration and more fibroblasts in their tumor tissues, leading to a worse immunotherapy response.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Oncology
Jinjin Chen, Xiaoyue Zou
Summary: This study assessed the link between lactate dehydrogenase (LDH) levels and the overall survival (OS) and disease-free survival (DFS) in patients with gastric cancer (GC). The results showed that elevated LDH levels may correlate with worse OS and DFS in GC patients, but the association is not significant. The association between LDH and OS was more prominent in Caucasian cohorts compared to Asian cohorts.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Haocheng Wang, Dongfeng Shan, Ya Dong, Xue Yang, Linwei Zhang, Zhuang Yu
Summary: The study investigated the impact of serum Cys C, UA, and LDH concentrations on the prognosis of patients with small-cell lung cancer (SCLC) before initial treatment. Elevated levels of Cys C, UA, and LDH prior to chemotherapy were associated with shorter progression-free survival and overall survival times in SCLC patients. LDH concentration may serve as an independent prognostic factor for both progression-free and overall survival in SCLC patients.
Article
Biochemistry & Molecular Biology
Nan Wang, Xin Jiang, Shuo Zhang, Angqi Zhu, Yafei Yuan, Hanwen Xu, Jianlin Lei, Chuangye Yan
Summary: The study presents cryo-EM structures of human MCT1 bound to lactate or inhibitors, shedding light on its substrate binding and transport mechanism, as well as providing a framework for structure-guided drug discovery targeting MCTs.
Article
Oncology
Zixin Guo, Liwen Hu, Qingwen Wang, Yujin Wang, Xiao-Ping Liu, Chen Chen, Sheng Li, Weidong Hu
Summary: This study explores lactate-related genes (LRGs) in lung adenocarcinoma (LUAD) using multiple methods. Lactate subtypes are found to be independent prognostic biomarkers and closely related to the tumor microenvironment (TME). Comprehensive evaluation of lactate subtypes helps understand TME infiltration characteristics and guide immunotherapy strategies.
Article
Immunology
Fangchao Zhao, Zengying Wang, Zhirong Li, Shiquan Liu, Shujun Li
Summary: Lactic acid metabolism-related genes (LRGs) play a significant role in lung adenocarcinoma (LUAD), with the identification of distinct molecular subtypes and the development of a prognostic signature. Patients with low LRG_score demonstrate better prognosis, higher immune score, lower somatic mutation rate, and increased responsiveness to anti-PD-1/PD-L1 medications. The stability and reliability of LRG_score were validated in cell lines, clinical tissue samples, and HPA databases, indicating its potential to improve prognostic information and guide drug treatment strategies for LUAD patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Biao Zhang, Jiaao Sun, Hewen Guan, Hui Guo, Bingqian Huang, Xu Chen, Feng Chen, Qihang Yuan
Summary: This study investigated the role of neutrophils in the carcinogenesis and development of pancreatic cancer and successfully developed a survival prediction model based on neutrophil marker genes. By analyzing single-cell RNA sequencing data and tissue transcriptome data, the study provided insights into the prognosis and immune microenvironment of pancreatic cancer.
Review
Pharmacology & Pharmacy
Naihui Sun, Xing Zhao
Summary: Metabolic reprogramming is crucial for tumor cells to adapt to nutrient-deprived environment and promote malignant behaviors. Fatty acid-binding protein 4 (FABP4), upregulated in various malignant solid tumors, is not only involved in activating oncogenic signaling pathways but also in rewiring the metabolic phenotypes of tumor cells to meet their high energy demand.
FRONTIERS IN PHARMACOLOGY
(2022)
Meeting Abstract
Oncology
Christopher T. Su, Emily Nizialek, Jacob E. Berchuck, Panagiotis J. Vlachostergios, Ryan Ashkar, Alexandra Sokolova, Pedro C. Barata, Rahul Raj Aggarwal, Heather McClure, Nellie Nafissi, Alan Haruo Bryce, A. Oliver Sartor, Heather H. Cheng, Nabil Adra, Cora N. Sternberg, Mary-Ellen Taplin, Marcin Cieslik, Emmanuel S. Antonarakis, Ajjai Shivaram Alva
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Meeting Abstract
Oncology
Jones T. Nauseef, Yajas Shah, Alon Shaiber, Joel Rosiene, David Wilkes, Michael Sigouros, Jyothi Manohar, Panagiotis J. Vlachostergios, Brian D. Robinson, Olivier Elemento, David M. Nanus, Juan Miguel Mosquera, Marcin Imielinski
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Panagiotis J. Vlachostergios, Muhammad J. Niaz, Charlene Thomas, Paul J. Christos, Joseph R. Osborne, Daniel J. A. Margolis, Francesca Khani, Neil H. Bander, Douglas S. Scherr, Scott T. Tagawa
Summary: PSMA-PET imaging shows higher detection rate and accuracy compared to mpMRI in localized prostate cancer, with potential implications for management and treatment strategies.
Article
Genetics & Heredity
Panagiotis J. Vlachostergios, Athanasios Karathanasis, Vassilios Tzortzis
Summary: FAP expression may serve as a valuable NE marker indicating a worse prognosis in patients with metastatic castration-resistant prostate cancer (CRPC).
Article
Urology & Nephrology
Iraklis C. Mitsogiannis, Maria Mitsogianni, Vissarion Bakalis, Anna Tzortzi de Paz, Panagiotis J. Vlachostergios, Vassilios Tzortzis
Summary: This survey study examined how urologists from the Hellenic Urological Association (HUA) perceive and utilize health-related quality of life (HRQoL) assessment in their daily practice. Most urologists considered HRQoL assessment important and valuable, but only a small percentage incorporated HRQoL questionnaires into their daily practice. Experienced physicians were less likely to utilize HRQoL, while urologists in-training were mainly concerned about limited time for HRQoL assessment.
RESEARCH AND REPORTS IN UROLOGY
(2022)
Review
Oncology
Iraklis C. Mitsogiannis, Maria Mitsogianni, Maria Papathanassiou, Maria Anagnostou, Ioannis Tamposis, Lampros Mitrakas, Maria Samara, Vassilios Tzortzis, Panagiotis J. Vlachostergios
Summary: This review discusses currently available therapeutic options in patients who have progressive RCC after prior treatment with double immune check-point inhibitors or ICI-TKI combinations.
JOURNAL OF KIDNEY CANCER AND VHL
(2022)
Article
Endocrinology & Metabolism
Christopher T. Su, Emily Nizialek, Jacob E. Berchuck, Panagiotis J. Vlachostergios, Ryan Ashkar, Alexandra Sokolova, Pedro C. Barata, Rahul R. Aggarwal, Rana R. McKay, Neeraj Agarwal, Heather M. McClure, Nellie Nafissi, Alan H. Bryce, Oliver Sartor, Nicolas Sayegh, Heather H. Cheng, Nabil Adra, Cora N. Sternberg, Mary-Ellen Taplin, Marcin Cieslik, Ajjai S. Alva, Emmanuel S. Antonarakis
Summary: PARP inhibitors (PARPi) are standard treatment for mCRPC patients with specific mutations, but response may differ in patients with ATM and BRCA2 mutations. We investigated differences in response to taxanes, which may inform treatment sequencing decisions.
Review
Medicine, General & Internal
Asimina Valsamaki, Maria Xanthoudaki, Katerina G. Oikonomou, Panagiotis J. Vlachostergios, Antonios Papadogoulas, Periklis Katsiafylloudis, Ioanna Voulgaridi, Apostolia-Lemonia Skoura, Apostolos Komnos, Panagiotis Papamichalis
Summary: COVID-19, caused by SARS-CoV-2, emerged in Wuhan, China in December 2019 and quickly spread worldwide, leading to the declaration of a global pandemic by the World Health Organization in March 2020. In addition to respiratory symptoms, the virus also significantly affects various organs, with an estimated 14.8%-53.0% of severe cases experiencing liver injury. Elevated levels of liver enzymes and bilirubin, as well as decreased levels of albumin and prealbumin, are the main laboratory findings. Patients with underlying liver disease are particularly prone to severe liver injury. This literature review provides insights into the pathophysiological mechanisms, drug interactions, early diagnostic tests, and the impact of COVID-19 on healthcare systems and liver transplant programs.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Oncology
Konstantinos Dimitropoulos, Louis L. Pisters, Christos N. Papandreou, Danai Daliani, Anastasios Karatzas, Argiro Petsiti, Vassilios Tassoudis, Eleni Arnaoutoglou, Panagiotis J. Vlachostergios, Vassilios Tzortzis
Summary: This study aimed to investigate whether the implementation of Enhanced Recovery After Surgery (ERAS) protocol in post-chemotherapy retroperitoneal lymph node dissection (PC-RPLND) patients could help reduce postoperative pain and opioid use. The results showed that implementing the ERAS protocol improved pain management, optimized patient recovery, and prevented over-prescription of opioid analgesics.
CURRENT CANCER DRUG TARGETS
(2023)
Review
Oncology
Konstantinos Evmorfopoulos, Panagiotis J. Vlachostergios, Petros Sountoulides, Vassilios Tzortzis
Summary: This review discusses the advances in understanding the biology of testicular germ cell tumors (TGCT) and the discovery of biomarkers for diagnosis and treatment evaluation. Serum biomarkers play a significant role in TGCT diagnosis and treatment response evaluation, while molecular biomarkers potentially have important implications for future disease diagnosis, treatment selection, and prognosis assessment.
CURRENT CANCER DRUG TARGETS
(2023)
Review
Biochemistry & Molecular Biology
Konstantinos Evmorfopoulos, Lampros Mitrakas, Athanasios Karathanasis, Ioannis Zachos, Vassilios Tzortzis, Panagiotis J. Vlachostergios
Summary: Upper tract urothelial carcinoma (UTUC) is a rare malignancy involving the renal pelvis, calyces, or ureters. Therapeutic management is challenging and platinum-based chemotherapy has been the standard treatment. Recent advances in the genetic and immune aspects of UTUC have led to the development of precision-based therapeutic approaches, such as immune checkpoint inhibitors and FGFR-targeting agents, improving prognosis for patients.
Article
Oncology
Konstantinos Evmorfopoulos, Georgios Chasiotis, Alexandros Barbatis, Ioannis Zachos, George Kouvelos, Metaxia Bareka, Panagiotis J. Vlachostergios, Eleni Arnaoutoglou, Vassilios Tzortzis, Miltiadis Matsagkas
Summary: Testicular germ cell tumors (TGCTs) are a major cause of cancer-related death in males aged 20 to 40. Combination therapy involving cisplatin-based chemotherapy and surgical excision can effectively treat advanced stages of the disease. In some cases, vascular procedures may be necessary during retroperitoneal lymph node dissection (RPLND) to ensure complete removal of residual masses. This study highlights a successful case of post-chemotherapy RPLND with additional replacement of the infrarenal inferior vena cava (IVC) and abdominal aorta using synthetic grafts.
Article
Biochemistry & Molecular Biology
Maria Samara, Panagiotis J. Vlachostergios, Eleni Thodou, Ioannis Zachos, Lampros Mitrakas, Konstantinos Evmorfopoulos, Vassilios Tzortzis, Antonis Giakountis
Summary: This study designed a computational approach to identify a miRNA signature as a non-invasive method for early diagnosis and prognosis of bladder cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Panagiotis J. Vlachostergios, Ioannis A. Tamposis, Maria Anagnostou, Maria Papathanassiou, Lampros Mitrakas, Ioannis Zachos, Eleni Thodou, Maria Samara, Vassilios Tzortzis
Summary: This study investigated the clinical and molecular characteristics of HIF-2-altered urothelial carcinoma (UC). The results showed that UC with HIF-2 alterations is associated with higher tumor stage, grade, and lymph node metastasis, as well as shorter progression-free and overall survival. These tumors also exhibit a distinct genomic and immunogenomic profile enriched in genes promoting angiogenesis and immune evasion.
Article
Oncology
Neil J. Shah, Vaibhav G. Patel, Xiaobo Zhong, Luis Pina, Jessica E. Hawley, Emily Lin, Benjamin A. Gartrell, Victor Adorno Febles, David R. Wise, Qian Qin, George Mellgard, Himanshu Joshi, Jones T. Nauseef, David A. Green, Panagiotis J. Vlachostergios, Daniel H. Kwon, Franklin Huang, Bobby Liaw, Scott Tagawa, Philip Kantoff, Michael J. Morris, William K. Oh
Summary: In patients with prostate cancer, androgen deprivation therapy (ADT) does not affect severe COVID-19 outcomes. Age 70 years and older is significantly associated with a higher risk of developing severe COVID-19 disease.
JNCI CANCER SPECTRUM
(2022)