Imp2 regulates GBM progression by activating IGF2/PI3K/Akt pathway

Multiple lesions in receptor tyrosine kinase pathway determine glioblastoma response to pan-ERBB inhibitor PF-00299804 and PI3K/mTOR dual inhibitor PF-05212384

(2014) Yanni Zhu et al.   CANCER BIOLOGY & THERAPY

A complex mechanism for HDGF-mediated cell growth, migration, invasion, and TMZ chemosensitivity in glioma

(2014) Ye Song et al.   JOURNAL OF NEURO-ONCOLOGY

IGF2 mRNA binding protein p62/IMP2-2 in hepatocellular carcinoma: antiapoptotic action is independent of IGF2/PI3K signaling

(2012) Sonja M. Kessler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells

(2012) M. Janiszewska et al.   GENES & DEVELOPMENT

Current clinical development of PI3K pathway inhibitors in glioblastoma

(2012) P. Y. Wen et al.   NEURO-ONCOLOGY

mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry

(2011) N. Dai et al.   GENES & DEVELOPMENT

Insulin Growth Factor-2 Binding Protein 3 (IGF2BP3) Is a Glioblastoma-specific Marker That Activates Phosphatidylinositol 3-Kinase/Mitogen-activated Protein Kinase (PI3K/MAPK) Pathways by Modulating IGF-2

(2011) Ramaswamy Suvasini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of PI3K/mTOR pathways in glioblastoma and implications for combination therapy with temozolomide

(2011) G. Prasad et al.   NEURO-ONCOLOGY

E-cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via β-catenin-Egr1-mediated PTEN expression

(2011) M-T Lau et al.   ONCOGENE

A Dual PI3K/mTOR Inhibitor, PI-103, Cooperates with Stem Cell-Delivered TRAIL in Experimental Glioma Models

(2010) T. Bagci-Onder et al.   CANCER RESEARCH

Role of the RNA-Binding Protein IMP-2 in Muscle Cell Motility

(2010) S. Boudoukha et al.   MOLECULAR AND CELLULAR BIOLOGY

Ack1 Mediated AKT/PKB Tyrosine 176 Phosphorylation Regulates Its Activation

(2010) Kiran Mahajan et al.   PLoS One

IGF2 mRNA-binding protein 2: biological function and putative role in type 2 diabetes

(2009) Jan Christiansen et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

E-cadherin directly contributes to PI3K/AKT activation by engaging the PI3K-p85 regulatory subunit to adherens junctions of ovarian carcinoma cells

(2009) G De Santis et al.   ONCOGENE

Insulin-Like Growth Factor Binding Protein-2 Is a Novel Therapeutic Target Associated with Breast Cancer

(2008) A. I. So et al.   CLINICAL CANCER RESEARCH

Molecular evolution of the cadherin superfamily

(2008) Paco Hulpiau et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Malignant Gliomas in Adults

(2008) Patrick Y. Wen et al.   NEW ENGLAND JOURNAL OF MEDICINE