Article
Polymer Science
Karina L. Bierbrauer, Laura R. Comini, Victoria Leonhard, Micaela A. Escobar Manzanelli, Gabriela Castelli, Silvia Farfan, Roxana Alasino, Dante M. Beltramo
Summary: Diabetes mellitus (DM) is a prevalent disease with acute and chronic conditions that significantly increases the risk of ophthalmic complications. Alpha-lipoic acid (LA), a natural antioxidant, shows potential for prevention and treatment of these complications. However, its low solubility in water limits its application, necessitating formulation systems. This study developed an erodible insert based on Eudragit E100 (E PO) and LA, which demonstrated promising properties for ocular disease treatment, including improved corneal permeation and retention.
Article
Pharmacology & Pharmacy
Khaled M. Hosny, Waleed Y. Rizg, Hala M. Alkhalidi, Walaa A. Abualsunun, Rana B. Bakhaidar, Alshaimaa M. Almehmady, Adel F. Alghaith, Sultan Alshehri, Amani M. El Sisi
Summary: The study successfully optimized an NT-loaded cubosome formulation and converted it into an in situ gel system, which effectively enhanced the ocular permeation and antifungal activity of natamycin, reduced ocular irritation, and prolonged retention time within the eye.
Article
Nanoscience & Nanotechnology
Alanood S. Almurshedi, Hessah A. Aljunaidel, Bushra Alquadeib, Basmah N. Aldosari, Iman M. Alfaqiah, Salma S. Almarshidy, Eram K. D. Eltahir, Amany Z. Mohamoud
Summary: This study developed optimized inhalable nanostructured lipid carriers (NLCs) for CIP to enhance deposition and accumulation in deeper parts of the lungs for treatment of noncystic fibrosis bronchiectasis (NCFB). The results showed that CIP-NLCs were in the nanometric size range, had efficient CIP encapsulation, and NCMPs prepared by spray-drying with different ratios of chitosan exhibited different properties.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Polymer Science
Nebojsa Pavlovic, Isidora Anastasija Bogicevic, Dragana Zaklan, Maja Danic, Svetlana Golocorbin-Kon, Hani Al-Salami, Momir Mikov
Summary: The effects of different gelling agents and bile acid concentrations on the release rate and permeation of clindamycin hydrochloride were investigated. The results showed that sodium carmellose hydrogels had higher release rates and permeation, and bile acids significantly enhanced the permeation.
Article
Materials Science, Biomaterials
Lingwen Gu, Cui Li, Jing Lin, Qian Wang, Min Yin, Lina Zhang, Na Li, Hao Lin, Zhihu You, Siyu Wang, Daohao Li, Guiqiu Zhao
Summary: This study innovatively explores the application of mesoporous carbon as a carrier in the treatment of fungal keratitis. Mesoporous carbon exhibits better drug release and therapeutic effects compared to microporous carbon. In vivo experiments demonstrate the excellent therapeutic effects of mesoporous carbon loaded with natamycin and silver nanoparticles.
BIOMATERIALS ADVANCES
(2022)
Proceedings Paper
Acoustics
Claire Allison, Blake Cellum, Bianca Karpinecz, Fadi Nasrallah, Vesna Zderic
Summary: The study demonstrates that ultrasound can safely and effectively increase transcorneal drug delivery of natamycin. However, it may cause damage to corneal epithelium, requiring further research into the long-term effects on human ocular tissues.
INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS 2021)
(2021)
Article
Pharmacology & Pharmacy
Sadaf Faiz, Shumaila Arshad, Yousaf Kamal, Sadia Imran, Mulazim Hussain Asim, Arshad Mahmood, Sana Inam, Hafiz Muhammad Irfan, Humayun Riaz
Summary: Pioglitazone-loaded nanostructured lipid carriers (PZ-loaded NLCs) were developed to improve the oral bioavailability of pioglitazone. The PZ-loaded NLCs exhibited small particle size, negative zeta potential, and high drug entrapment efficiency and loading capacity. In vitro and in vivo studies confirmed the enhanced bioavailability of pioglitazone when formulated as PZ-loaded NLCs.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Giulia Vanti, Lucrezia Muti, Mario D'Ambrosio, Lucia Grifoni, Maria Camilla Bergonzi, Cristina Luceri, Anna Rita Bilia
Summary: A novel formulation based on NLCs was developed to enhance the solubility and intestinal absorption of khellin. The K-NLCs were characterized physically and chemically, showing good stability in simulated gastric and intestinal fluids, and enhanced permeability across Caco-2 cells. This versatile formulation has the potential to improve the bioavailability and therapeutic effects of khellin.
Review
Pharmacology & Pharmacy
Manisha Pandey, Hira Choudhury, Azila Abdul-Aziz, Subrat Kumar Bhattamisra, Bapi Gorain, Jocelyn Sziou Ting Su, Choo Leey Tan, Woon Yee Chin, Khar Yee Yip
Summary: Eyes are vulnerable to various ailments, with corneal infection by herpes simplex viruses being a prevalent yet serious cause of blindness globally. Novel drug delivery systems, including nanocarriers, prodrugs, and peptides, play a vital role in improving therapeutic efficacy and patient convenience in the treatment of ocular herpes infections.
Article
Biochemistry & Molecular Biology
Anna Czajkowska-Kosnik, Emilia Szymanska, Katarzyna Winnicka
Summary: In this study, nanostructured lipid carrier (NLC) gels containing etodolac (ETD) were developed for topical drug delivery. The gels exhibited favorable drug release and permeation properties, as well as stability, as confirmed by tests on pH, viscosity, rheological, mechanical, and bioadhesive properties.
Article
Polymer Science
Mohammed Ghazwani, Umme Hani, Mohammed H. Alqarni, Aftab Alam
Summary: This study aimed to improve the efficiency of beta-caryophyllene administration by developing a nanostructured lipid carrier for topical use in skin disorders. The newly created formulation showed promising results in terms of its particle size, entrapment efficiency, and zeta potential. In vitro release investigation demonstrated controlled release of beta-caryophyllene for 24 hours. Ex vivo experiments showed an increased skin retention capacity compared to traditional gel formulations. Overall, nanostructured lipid carriers loaded with beta-caryophyllene have the potential to enhance topical administration in skin disorders.
Article
Chemistry, Medicinal
Ahmed Adel Ali Youssef, Chuntian Cai, Narendar Dudhipala, Soumyajit Majumdar
Summary: Bacterial keratitis is a serious ocular infection, and using CIP-loaded nanoemulsion (CIP-NE) can enhance drug penetration into the cornea, improve treatment outcomes, and exhibit better release and permeation performance than commercial ophthalmic solutions.
Article
Engineering, Biomedical
Liyuan Gu, Wenjuan Wang, Bi Wu, Suping Ji, Qiang Xia
Summary: The aim of this study was to evaluate the astaxanthin-loaded nanostructured lipid carriers (ASX-NLC) for local application of astaxanthin. The effects of microencapsulation on the properties of ASX-NLC were studied using dynamic light scattering (DLS) and X-ray diffraction (XRD). The ASX-NLC showed a mean size of 108.43 +/- 0.26 nm and a high encapsulation efficiency of 95.69 +/- 0.13%. It exhibited good light stability and temperature stability, indicating its feasibility. The ASX-NLC could effectively release astaxanthin and increase astaxanthin retention in the skin.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2023)
Article
Pharmacology & Pharmacy
Kawthar K. Abla, Soumaya M. Hijazi, Mohammed M. Mehanna
Summary: In this study, a safe and effective in-situ ocular limonene-based nanostructured lipid carriers (NLCs) gel was developed to enhance the solubility and efficacy of azithromycin (AZ) against ocular biofilm infections caused by methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA). The NLCs, prepared using limonene, Gelucire, Labrasol, and Labrafil, showed nanometric size, narrow size distribution, and spherical shape, with improved MRSA biofilm eradicating efficacy compared to free AZ. The NLCs-based in-situ gel exhibited enhanced trans-corneal permeability and a safe ocular profile, making it a promising vehicle against resistant bacterial strains.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Chukwuebuka Emmanuel Umeyor, Ifunanya Okoye, Emmanuel Uronnachi, Tochukwu Okeke, Franklin Kenechukwu, Anthony Attama
Summary: The study evaluated the potential of miconazole (MNZ) as an alternative antimalarial agent by embedding MNZ in nanostructured lipid carriers (NLC). The MNZ-loaded NLC showed a controlled release effect with high encapsulation efficiency and demonstrated good in vitro and in vivo antimalarial activities. Stability testing indicated that MNZ could be repurposed as an effective alternative for the treatment of malaria.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)