Article
Biophysics
Hongmei Liu, Shichen Deng, Lu Han, Yan Ren, Jian Gu, Lili He, Tianqing Liu, Zhi-xiang Yuan
Summary: Mesenchymal stem cells (MSCs) have the potential to differentiate into multiple cell types and possess anti-tumor features. Exosomes derived from MSCs play a crucial role in therapy, but challenges like low yield and isolation hinder their clinical applications. Research on exosome-mimics has gained attention as a way to overcome these limitations.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Pharmacology & Pharmacy
Hee Byung Koh, Hyo Jeong Kim, Shin-Wook Kang, Tae-Hyun Yoo
Summary: Exosome-based drug delivery is a promising field that could revolutionize therapeutic interventions. These small extracellular vesicles have unique properties and can transport bioactive molecules. Despite challenges such as limited isolation methods and low cargo loading efficiency, exosomes have the potential to improve personalized medicine and precision therapy.
Review
Medicine, Research & Experimental
Lianlian Fan, Anhui Wei, Zihui Gao, Xupeng Mu
Summary: Nanodrug delivery systems face challenges of weak drug targeting, immune system clearance, and low biocompatibility. Cell membrane, especially Mesenchymal stem cell (MSC) membrane, can be used as a drug coating material to overcome these limitations. MSC membrane-coated nanoparticles have potential applications in tumor treatment, inflammatory disease, tissue regeneration, and other fields. This review summarizes recent progress in the use of MSC membrane-coated nanoparticles for therapy and drug delivery, aiming to provide guidance for future design and clinical application of membrane carriers.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Multidisciplinary
Wanrong Meng, Linlin Wang, Xueyu Du, Mingzhe Xie, Fan Yang, Fei Li, Zhanxuan E. Wu, Jianguo Gan, Hongxuan Wei, Chang Cao, Shun Lu, Bangrong Cao, Longjiang Li, Ling Li, Guiquan Zhu
Summary: Extracellular vesicles (EVs) are potential therapeutic carriers, but they have limited targeting ability. To address this issue, researchers genetically engineered natural free streptavidin (SA) on the cellular surface of bone marrow mesenchymal stem cells (BMSCs) to obtain BMSC-derived EVs (BMSC-EVs) with enhanced targetability. The study demonstrated that these BMSC-EVs could be modified with different molecules to achieve specific delivery of drugs to different types of tumors, making them a versatile platform for targeted drug delivery.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Oncology
Zhijie Weng, Bowen Zhang, Chenzhou Wu, Fanyuan Yu, Bo Han, Bo Li, Longjiang Li
Summary: Extracellular vesicles (EVs) are essential regulators of intercellular communication enclosing various biomolecules, and MSC-derived EVs have shown potential applications in cancer treatment. However, challenges remain in translating MSC-derived EVs from bench to bedside.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Review
Cell Biology
Huizhi Chen, Liyan Wang, Xinling Zeng, Herbert Schwarz, Himansu Sekhar Nanda, Xinsheng Peng, Yubin Zhou
Summary: Exosomes are cell-secreted nanoparticles that can serve as carriers for targeted drug/gene delivery, but the current challenge lies in the insufficient targeting ability and efficacy. Various approaches have been applied to engineer exosomes for higher selectivity and effectiveness.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Yuxi Yang, Yiqiu Peng, Yingying Li, Tingjuan Shi, Yingyi Luan, Chenghong Yin
Summary: Mesenchymal stem cells (MSCs) are pluripotent stem cells that can differentiate into various cell types. Stem cell derivatives, particularly exosomes, released from MSCs have shown great potential in treating degenerative diseases, cancer, and inflammatory diseases. Exosomes derived from MSCs can suppress inflammatory response, inhibit apoptosis, and promote tissue repair. They have become a promising option for cell-free therapy due to their safety and easy preservation and transportation through intercellular communication.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Zhimin Yang, Yanyu Li, Zihua Wang
Summary: Exosomes are important communication carriers between cells and can be used for disease diagnosis and treatment. MSCs-Exo, as a natural drug delivery carrier, has therapeutic effects and is increasingly used in the treatment of cardiovascular diseases and neurodegenerative diseases.
Article
Nanoscience & Nanotechnology
Jing Zhang, Haijing Song, Yanan Dong, Ganghui Li, Jun Li, Qizhe Cai, Shoujun Yuan, Yi Wang, Haifeng Song
Summary: This study explores surface engineering approaches to reduce non-specific adhesion and improve enrichment of extracellular vesicles (EVs) in target tissues. The engineered EVs system carrying a tumor-specific nanobody and interleukin-12 demonstrated therapeutic potential in hepatocellular carcinoma models.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Oncology
Debora Ferreira, Joao Nuno Moreira, Ligia R. Rodrigues
Summary: In recent years, drug nano-delivery platforms have been developed to improve the effectiveness of cancer treatment. However, their translation to clinical use has been hindered by unwanted side effects and toxicity. Therefore, there is a need for drug delivery vehicles capable of overcoming cellular barriers and delivering therapeutic payloads to tumor cells. Exosomes, small extracellular vesicles released by cells, have been explored as a promising delivery vehicle due to their natural role in cell communication and biocompatibility. This review discusses exosome biogenesis, contents, isolation methods, and their natural functions, as well as different approaches for encapsulating therapeutic payloads. The use of molecules to improve pharmacokinetics, tumor homing-ligands, and stimuli-responsive elements to enhance cell specificity are also discussed. Finally, the current status of clinical-grade exosome-based therapies is outlined.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Pharmacology & Pharmacy
Lidija Filipovic, Milica Kojadinovic, Milica Popovic
Summary: This article provides an overview of exosome biogenesis, biological role, and purification methods, with a focus on specific applications of exosomes and exosome-mimetics as drug delivery systems in pharmaceutical drug development. The challenges in translating exosome-based drug carriers to clinical use are also discussed.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jonathan O. Martinez, Michael Evangelopoulos, Ava A. Brozovich, Guillermo Bauza, Roberto Molinaro, Claudia Corbo, Xuewu Liu, Francesca Taraballi, Ennio Tasciotti
Summary: The study introduces a versatile multicomponent delivery platform that combines MSC tropism with MSV-mediated payload delivery, demonstrating increased drug release and reduced inflammation, resulting in improved outcomes in experimental models.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Jinkui Wang, Mujie Li, Liming Jin, Peng Guo, Zhaoxia Zhang, Chenghao Zhanghuang, Xiaojun Tan, Tao Mi, Jiayan Liu, Xin Wu, Guanghui Wei, Dawei He
Summary: Osteosarcoma is a bone tumor with a high incidence in children and adolescents. The low production of exosomes hinders its development as a drug carrier, but exosome mimetics (EMs) have been developed as an alternative with good drug delivery performance. In this study, EMs were used to encapsulate doxorubicin (EM-Dox) for the treatment of osteosarcoma, and it showed significantly stronger tumor inhibition activity and fewer side effects compared to free doxorubicin. This novel biological nanomedicine system provides a promising opportunity for the development of precision medicine for osteosarcoma.
Review
Medicine, Research & Experimental
Jianghong Huang, Qisong Liu, Jiang Xia, Xi Chen, Jianyi Xiong, Lei Yang, Yujie Liang
Summary: This article comprehensively reviews the homing effect of stem cells in joints and highlights progress towards the targeted modification of MSCs.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Jenifer Garcia-Fernandez, Maria de la Fuente Freire
Summary: This article introduces the characteristics of exosomes and their application in the field of biomedical research. However, there are still limitations in manufacturing processes, quality control, and clinical studies. In recent years, exosome-like systems based on surface engineering and nanoscale platforms have been developed to overcome these limitations. By combining the latest knowledge of exosome research with promising developments in nanotechnology, innovative targeted anti-cancer therapies can be developed. This article provides a critical overview of the design and testing of innovative exosome-like systems and discusses the most promising modalities that can be translated into the clinic, as well as future perspectives and challenges in this field.