Review
Respiratory System
Cassandra Spector, Camden M. De Sanctis, Reynold A. Panettieri Jr, Cynthia J. Koziol-White
Summary: Rhinovirus infections can lead to airway remodeling, which is characterized by irreversible airway obstruction and diminished responsiveness to bronchodilators. Structural cells of the airways, including epithelial cells, smooth muscles, fibroblasts, myofibroblasts, and lung vascular endothelial cells, play a role in this process by producing various mediators and components that contribute to airway remodeling. Rhinovirus exposure can induce airway hyperresponsiveness and remodeling phenotypes such as mucus hypersecretion, epithelial-mesenchymal transition, and fibroblast-myofibroblast transdifferentiation. Different cellular responses to rhinovirus infection can lead to persistent airway remodeling in asthmatic individuals, including exaggerated type 2 inflammation, increased extracellular matrix deposition, and enhanced production of pro-angiogenic mediators.
RESPIRATORY RESEARCH
(2023)
Article
Physiology
Amanda L. Tatler, Christopher J. Philp, Michael R. Hill, Sam Cox, Andrew M. Bullock, Anthony Habgood, Alison John, Robert Middlewick, Katherine E. Stephenson, Amanda T. Goodwin, Charlotte K. Billington, Reuben D. O. ' Dea, Simon R. Johnson, Bindi S. Brook
Summary: Airway remodeling in chronic asthma involves increased ASM and ECM. A new method reveals that ASM and ECM changes are more pronounced in small and large airways compared to intermediate airways. Changes in ASM resolve over 7 days, while ECM and epithelial changes persist. The method highlights important spatial differences in remodeling and could set new analysis standards for murine asthma models.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Review
Biology
Harshita Shailesh, Ibrahim A. Janahi
Summary: Obesity is a significant risk factor for asthma and has a detrimental effect on the severity of the disease. It impairs lung airway function and leads to increased inflammation and severe remodeling of the bronchus. This review discusses the current research on the role of obesity in modulating airway cell functions and explores different therapeutic approaches for treating obese asthmatic individuals.
Review
Allergy
Salman Siddiqui, Claus Bachert, Leif Bjermer, Kathleen M. Buchheit, Mario Castro, Yimin Qin, Hitasha Rupani, Hironori Sagara, Peter Howarth, Camille Taille
Summary: This review provides an overview of tissue remodeling in both health and airway disease, with a focus on eosinophilic asthma and chronic rhinosinusitis with nasal polyps. It discusses the role of eosinophils in these processes and the implications for therapeutic interventions.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Airidas Rimkunas, Andrius Januskevicius, Egle Vasyle, Jolita Palacionyte, Ieva Janulaityte, Skaidrius Miliauskas, Kestutis Malakauskas
Summary: Airway remodeling in asthma is characterized by increased airway smooth muscle mass and disturbed extracellular matrix homeostasis. This study investigated the impact of blood inflammatory-like eosinophils and lung resident-like eosinophils on airway smooth muscle cells in asthma, finding that these eosinophil subtypes promote migration and ECM-related proliferation of airway smooth muscle cells, potentially contributing to airway remodeling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Ieva Janulaityte, Andrius Januskevicius, Virginija Kalinauskaite-Zukauske, Jolita Palacionyte, Kestutis Malakauskas
Summary: The study showed that asthmatic eosinophils can significantly increase contractility and migration of ASMC and PF, as well as upregulate the expression of contractile apparatus proteins in these cells. Eosinophils from asthma patients have a greater effect on ASMC and PF compared to healthy subjects' eosinophils.
Article
Biochemistry & Molecular Biology
Miguel Angel Hernandez-Lara, Santosh K. Yadav, Sushrut D. Shah, Mariko Okumura, Yuichi Yokoyama, Raymond B. Penn, Taku Kambayashi, Deepak A. Deshpande
Summary: Airway remodeling in asthma involves the hyperproliferation of airway smooth muscle (ASM) cells. The inhibition of diacylglycerol kinase (DGK) reduces the conversion of diacylglycerol (DAG) into phosphatidic acid (PA) and inhibits ASM cell proliferation. These findings suggest that DGK may serve as a potential drug target for mitigating airway remodeling in asthma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Mengyuan Zhang, Jiangtao Lin, Jingyuan Zhang, Ruiheng Zhao, Jingxuan Wan, Ying Nong
Summary: This study investigated the molecular mechanism of artesunate (ART) in treating asthma. The results showed that ART can attenuate inflammation, mucus secretion, and collagen fibers deposition in asthma. Further analysis revealed that ART exerts its protective function by downregulating phosphorylated p38 MAPK and suggests that FIZZ1 may be a potential target for asthma airway remodeling.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yan Ren, Xiuhua Zhong, Hongyu Wang, Zhongqi Chen, Yanan Liu, Xiaoning Zeng, Yuan Ma
Summary: Chloroquine, an agonist of bitter taste receptors, improves airway function in asthmatic patients by controlling the phenotype shift of airway smooth muscle (ASM) cells through the inhibition of oxidative stress and ROS-AKT signal.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Anthony Tam, Emmanuel Twumasi Osei, Chung Y. Cheung, Michael Hughes, Chen X. Yang, Kelly M. McNagny, Delbert R. Dorscheid, Gurpreet K. Singhera, Teal S. Hallstrand, Stephanie Warner, James C. Hogg, Tillie L. Hackett, Chinten J. Lim, Don D. Sin
Summary: This study found that the Hedgehog signaling pathway is involved in the process of airway remodeling in asthma, which is partially mediated via the PTCH1-SMO-GLI axis. This provides hope for finding new targets for treating airway tissue remodeling in patients with allergic airways disease.
Article
Oncology
Qin Yang, Qing Miao, Hui Chen, Duo Li, Yongfeng Luo, Joanne Chiu, Hong-Jun Wang, Michael Chuvanjyan, Michael S. Parmacek, Wei Shi
Summary: Abnormal growth of airway smooth muscle cells is a key feature in asthmatic airway remodeling. The role of Myocd, a transcriptional coactivator, in this process has been investigated in a mouse model of chronic asthma. Deletion of Myocd mitigated airway smooth muscle cell hypertrophy and hyperplasia, reduced inflammation and collagen deposition, and attenuated abnormal mucin production. Myocd could be a potential therapeutic target for treating severe and persistent asthma.
JOURNAL OF PATHOLOGY
(2023)
Review
Nutrition & Dietetics
Laila Salameh, Walid Mahmood, Rifat Hamoudi, Khulood Almazrouei, Mahesh Lochanan, Suheyl Seyhoglu, Bassam Mahboub
Summary: Asthma, a common chronic respiratory disease affecting millions of people worldwide, is being increasingly linked to vitamin D deficiency. This systematic review evaluated the effects of vitamin D supplementation on airway remodeling in asthmatic patients. After a thorough search of several databases, 9 experimental studies were included, suggesting that vitamin D inhibits airway smooth muscle cell contraction and remodeling, reduces inflammation, regulates collagen synthesis in the airways, and modulates the action of bronchial fibroblasts. However, the role of TGF-beta 1 in impairing vitamin D-induced airway epithelial host defense mechanisms needs further investigation.
Article
Immunology
Dong Zhang, Xin-rui Qiao, Wen-Jing Cui, Jin-tao Zhang, Yun Pan, Xiao-fei Liu, Liang Dong
Summary: SDC-1 plays a crucial role in airway remodeling in chronic asthma by modulating the TGF beta 1/Smad3 pathway, affecting collagen I expression in airway epithelial cells and fibroblasts.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Veterinary Sciences
Giulia D'Annunzio, Francesca Gobbo, Giancarlo Avallone, Barbara Bacci, Silvia Sabattini, Giuseppe Sarli
Summary: This study describes the spontaneous pulmonary changes in cats resembling airway remodeling seen in humans, including ASMCs hyperplasia, airway fibrosis, and vascular remodeling. The findings suggest that cats could be a potential animal model for studying nonspecific airway remodeling in humans.
TOPICS IN COMPANION ANIMAL MEDICINE
(2022)
Article
Cell Biology
Te Jiang, Di Zhao, Zhiyuan Zheng, Zhankui Li
Summary: Sigma-1R plays a significant role in airway inflammation and remodeling, and its activation can alleviate inflammation and remodeling by regulating pAMPK and inhibiting CXCR4 expression. Furthermore, Sigma-1R agonist RPE-084 can suppress inflammatory cytokines, improve cell proliferation, migration, and epithelial-mesenchymal transition (EMT) process.
Article
Physiology
Andrius Januskevicius, Reinoud Gosens, Raimundas Sakalauskas, Simona Vaitkiene, Ieva Janulaityte, Andrew J. Halayko, Deimante Hoppenot, Kestutis Malakauskas
FRONTIERS IN PHYSIOLOGY
(2017)
Article
Immunology
Edita Gasiuniene, Ieva Janulaityte, Zivile Zemeckiene, Diana Barkauskiene, Brigita Sitkauskiene
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2019)
Article
Medicine, General & Internal
Andrius Januskevicius, Ieva Janulaityte, Virginija Kalinauskaite-Zukauske, Reinoud Gosens, Kestutis Malakauskas
JOURNAL OF CLINICAL MEDICINE
(2019)
Article
Respiratory System
Virginija Kalinauskait-Zukauske, Andrius Januskevicius, Ieva Janulaityte, Skaidrius Miliauskas, Kestutis Malakauskas
CANADIAN RESPIRATORY JOURNAL
(2019)
Article
Biochemistry & Molecular Biology
Ieva Janulaityte, Andrius Januskevicius, Virginija Kalinauskaite-Zukauske, Ieva Bajoriuniene, Kestutis Malakauskas
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Cell Biology
Andrius Januskevicius, Egle Jurkeviciute, Ieva Janulaityte, Virginija Kalinauskaite-Zukauske, Skaidrius Miliauskas, Kestutis Malakauskas
Article
Cell Biology
Ieva Janulaityte, Andrius Januskevicius, Virginija Kalinauskaite-Zukauske, Jolita Palacionyte, Kestutis Malakauskas
Summary: The study showed that asthmatic eosinophils can significantly increase contractility and migration of ASMC and PF, as well as upregulate the expression of contractile apparatus proteins in these cells. Eosinophils from asthma patients have a greater effect on ASMC and PF compared to healthy subjects' eosinophils.
Article
Cell Biology
Jolita Palacionyte, Andrius Januskevicius, Egle Vasyle, Airidas Rimkunas, Ieva Bajoriuniene, Skaidrius Miliauskas, Kestutis Malakauskas
Summary: This study investigated the proliferative properties of different subtypes of eosinophils in asthma patients, and found that IL-5 and GM-CSF enhance the proliferation of iEOS-like and rEOS-like eosinophils on airway smooth muscle cells. The gene expression of IL-3 and IL-5 receptors is higher in rEOS-like cells compared to iEOS-like cells.
Article
Biochemistry & Molecular Biology
Airidas Rimkunas, Andrius Januskevicius, Egle Vasyle, Jolita Palacionyte, Ieva Janulaityte, Skaidrius Miliauskas, Kestutis Malakauskas
Summary: Airway remodeling in asthma is characterized by increased airway smooth muscle mass and disturbed extracellular matrix homeostasis. This study investigated the impact of blood inflammatory-like eosinophils and lung resident-like eosinophils on airway smooth muscle cells in asthma, finding that these eosinophil subtypes promote migration and ECM-related proliferation of airway smooth muscle cells, potentially contributing to airway remodeling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)