Orphan G-Protein Coupled Receptor GPRC5B Is Critical for Lymphatic Development

Advances in understanding and examining lymphatic function: relevance for understanding autoimmunity

(2021) William Ambler et al.   CURRENT OPINION IN RHEUMATOLOGY

Orphan G-Protein-Coupled Receptor GPRC5B Controls Smooth Muscle Contractility and Differentiation by Inhibiting Prostacyclin Receptor Signaling

(2020) Jorge Carvalho et al.   CIRCULATION

Roles of GPRC5 family proteins: focusing on GPRC5B and lipid-mediated signalling

(2020) Yoshio Hirabayashi et al.   JOURNAL OF BIOCHEMISTRY

Use of genetic variation to separate the effects of early and later life adiposity on disease risk: mendelian randomisation study

(2020) Tom G Richardson et al.   BMJ-British Medical Journal

The Lymphatic Vasculature in the 21st Century: Novel Functional Roles in Homeostasis and Disease

(2020) Guillermo Oliver et al.   CELL

Biological functions of lymphatic vessels

(2020) Tatiana V. Petrova et al.   SCIENCE

S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress–dependent VEGF-C signaling

(2020) Xin Geng et al.   JCI Insight

The orphan receptor GPRC5B modulates inflammatory and fibrotic pathways in cardiac fibroblasts and mice hearts

(2019) Friedrich Alexander von Samson-Himmelstjerna et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lysolipid receptor cross-talk regulates lymphatic endothelial junctions in lymph nodes

(2019) Yu Hisano et al.   JOURNAL OF EXPERIMENTAL MEDICINE

GPRC5b Modulates Inflammatory Response in Glomerular Diseases via NF-κB Pathway

(2019) Sonia Zambrano et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Identifying Signalling Pathways Regulated by GPRC5B in β-Cells by CRISPR-Cas9-Mediated Genome Editing

(2018) Patricio Atanes et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The evolving role of lymphatics in cancer metastasis

(2018) Rae H Farnsworth et al.   CURRENT OPINION IN IMMUNOLOGY

Unexplored therapeutic opportunities in the human genome

(2018) Tudor I. Oprea et al.   NATURE REVIEWS DRUG DISCOVERY

Loss of GPRC5B impairs synapse formation of Purkinje cells with cerebellar nuclear neurons and disrupts cerebellar synaptic plasticity and motor learning

(2018) Takamitsu Sano et al.   NEUROSCIENCE RESEARCH

Meta-analysis of genome-wide association studies for body fat distribution in 694,649 individuals of European ancestry

(2018) Sara L Pulit et al.   HUMAN MOLECULAR GENETICS

hCALCRL mutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia

(2018) Duncan I. Mackie et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Trends in GPCR drug discovery: new agents, targets and indications

(2017) Alexander S. Hauser et al.   NATURE REVIEWS DRUG DISCOVERY

Cardiac lymphatics are heterogeneous in origin and respond to injury

(2015) Linda Klotz et al.   NATURE

Decoy Receptor CXCR7 Modulates Adrenomedullin-Mediated Cardiac and Lymphatic Vascular Development

(2014) Klara R. Klein et al.   DEVELOPMENTAL CELL

Lymphangiogenic factors, mechanisms, and applications

(2014) Wei Zheng et al.   JOURNAL OF CLINICAL INVESTIGATION

The G protein-coupled receptor GPRC5B contributes to neurogenesis in the developing mouse neocortex

(2013) N. Kurabayashi et al.   DEVELOPMENT

The Orphan Adhesion G Protein-coupled Receptor GPR97 Regulates Migration of Lymphatic Endothelial Cells via the Small GTPases RhoA and Cdc42

(2013) Nadejda Valtcheva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GPRC5B Activates Obesity-Associated Inflammatory Signaling in Adipocytes

(2012) Y.-J. Kim et al.   Science Signaling

Comparative characterization of GPRC5B and GPRC5C LacZ knockin mice; behavioral abnormalities in GPRC5B-deficient mice

(2011) Takamitsu Sano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The lymphatic vasculature in disease

(2011) Kari Alitalo   NATURE MEDICINE

A Computational Tool for Quantitative Analysis of Vascular Networks

(2011) Enrique Zudaire et al.   PLoS One

Current concepts and future directions in the diagnosis and management of lymphatic vascular disease

(2010) Stanley G Rockson   VASCULAR MEDICINE

G Protein–Coupled Receptors as Potential Drug Targets for Lymphangiogenesis and Lymphatic Vascular Diseases

(2009) William P. Dunworth et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The Clinical Spectrum of Lymphatic Disease

(2008) Kavita Radhakrishnan et al.   Annals of the New York Academy of Sciences

Foxn4 directly regulates tbx2b expression and atrioventricular canal formation

(2008) N. C. Chi et al.   GENES & DEVELOPMENT

Adrenomedullin signaling is necessary for murine lymphatic vascular development

(2007) Kimberly L. Fritz-Six et al.   JOURNAL OF CLINICAL INVESTIGATION