Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 64, Issue 13, Pages 2682-2689Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.6b00290
Keywords
isoorientin; hyperglycemia; liver damage; oxidative stress; lipid metabolism; hepatic inflammation
Funding
- Young Scientists Fund of the National Natural Science Foundation of China [31501584]
- Fundamental Research Funds for the Central Universities of Shaanxi Normal University, China [GK201503071]
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Isoorientin (ISO), a natural flavonoid, has been found to have multiple biological properties. In the present study, obese mice with high-fructose (HF)-induced liver injury were used to investigate the hepatoprotective effects of ISO. The results showed that ISO significantly reduced the serum lipid parameters in mice fed 20% HF water. Meanwhile, ISO appeared to alleviate HF-induced lipid metabolic disorders by increasing the serum levels of apo-A1 and decreasing the serum apoB levels, apoB/apo-A1 ratio, and FAS activity in the liver. ISO also remarkably ameliorated HF-induced hepatic oxidative injury and inflammation by decreasing ALT, AST, and ALP levels; enhancing antioxidant enzyme activities; and inhibiting inflammatory cytokine (TNF-alpha, IL-1, IL-6) release. Histopathology of liver stained by H&E and Oil Red 0 showed the liver steatosis and oxidative injury after HF treatment and the protective effect of ISO. Furthermore, aortic pathology observation found that ISO had a protective effect on the vascular endothelium. This is the first report that ISO efficiently inhibited HF-induced hyperlipidemia and liver injury by ameliorating lipid metabolism, enhancing the antioxidant defensedefense system, and regulating the secretion of inflammatory cytokines.
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