Antimicrobial Peptides and Cationic Nanoparticles: A Broad-Spectrum Weapon to Fight Multi-Drug Resistance Not Only in Bacteria

Successful Dendrimer and Liposome-Based Strategies to Solubilize an Antiproliferative Pyrazole Otherwise Not Clinically Applicable

(2022) Silvana Alfei et al.   Nanomaterials

Designing bioresponsive nanomaterials for intracellular self-assembly

(2022) Sarah Chagri et al.   Nature Reviews Chemistry

Recommendations to Synthetize Old and New β-Lactamases Inhibitors: A Review to Encourage Further Production

(2022) Silvana Alfei et al.   Pharmaceuticals

Antimicrobial Effect of a Novel Chitosan Derivative and Its Synergistic Effect with Antibiotics

(2021) Zhangyong Si et al.   ACS Applied Materials & Interfaces

Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation

(2021) Yunjiang Jiang et al.   ADVANCED DRUG DELIVERY REVIEWS

Broad-Spectrum Bactericidal Activity of a Synthetic Random Copolymer Based on 2-Methoxy-6-(4-Vinylbenzyloxy)-Benzylammonium Hydrochloride

(2021) Anna Maria Schito et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synthesis, Characterization, and Bactericidal Activity of a 4-Ammoniumbuthylstyrene-Based Random Copolymer

(2021) Silvana Alfei et al.   Polymers

Synthesis of Polystyrene-Based Cationic Nanomaterials with Pro-Oxidant Cytotoxic Activity on Etoposide-Resistant Neuroblastoma Cells

(2021) Silvana Alfei et al.   Nanomaterials

PKCα Inhibition as a Strategy to Sensitize Neuroblastoma Stem Cells to Etoposide by Stimulating Ferroptosis

(2021) Lorenzo Monteleone et al.   Antioxidants

Bactericidal Activity of a Self-Biodegradable Lysine-Containing Dendrimer against Clinical Isolates of Acinetobacter Genus

(2021) Silvana Alfei et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Considerable Improvement of Ursolic Acid Water Solubility by Its Encapsulation in Dendrimer Nanoparticles: Design, Synthesis and Physicochemical Characterization

(2021) Silvana Alfei et al.   Nanomaterials

Membrane-disruptive peptides/peptidomimetics-based therapeutics: Promising systems to combat bacteria and cancer in the drug-resistant era

(2021) Liming Lin et al.   Acta Pharmaceutica Sinica B

Bactericidal Activity of Non-Cytotoxic Cationic Nanoparticles against Clinically and Environmentally Relevant Pseudomonas spp. Isolates

(2021) Anna Maria Schito et al.   Pharmaceutics

Preparation and Physicochemical Characterization of Water-Soluble Pyrazole-Based Nanoparticles by Dendrimer Encapsulation of an Insoluble Bioactive Pyrazole Derivative

(2021) Silvana Alfei et al.   Nanomaterials

Efficacy of Ursolic Acid-Enriched Water-Soluble and Not Cytotoxic Nanoparticles against Enterococci

(2021) Anna Maria Schito et al.   Pharmaceutics

Pyrazole-Based Water-Soluble Dendrimer Nanoparticles as a Potential New Agent against Staphylococci

(2021) Silvana Alfei et al.   Biomedicines

Facial Amphiphilicity-Induced Polymer Nanostructures for Antimicrobial Applications

(2020) Md Anisur Rahman et al.   ACS Applied Materials & Interfaces

Potent Antibiotics Active against Multidrug-Resistant Gram-Negative Bacteria

(2020) Yasunari Otsuka   CHEMICAL & PHARMACEUTICAL BULLETIN

Titanium Incorporation into Zr‐Porphyrinic Metal–Organic Frameworks with Enhanced Antibacterial Activity against Multidrug‐Resistant Pathogens

(2020) Mian Chen et al.   Small

Research Progress Evaluating the Function and Mechanism of Anti-Tumor Peptides

(2020) Xinxing Pan et al.   Cancer Management and Research

Structural Superiority of Guanidinium-Rich, Four-Armed Copolypeptides: Role of Multiple Peptide–Membrane Interactions in Enhancing Bacterial Membrane Perturbation and Permeability

(2020) Jing Wang et al.   ACS Applied Materials & Interfaces

Size and Charge Adaptive Clustered Nanoparticles Targeting the Biofilm Microenvironment for Chronic Lung Infection Management

(2020) Yifan Gao et al.   ACS Nano

Resistance of Gram-Negative Bacteria to Current Antibacterial Agents and Approaches to Resolve It

(2020) Zeinab Breijyeh et al.   MOLECULES

Positively Charged Polymers as Promising Devices against Multidrug Resistant Gram-Negative Bacteria: A Review

(2020) Silvana Alfei et al.   Polymers

Nanomedicines for the Delivery of Antimicrobial Peptides (AMPs)

(2020) Maria C. Teixeira et al.   Nanomaterials

Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides

(2020) Ines Greco et al.   Scientific Reports

Antibacterial Activity of Non-Cytotoxic, Amino Acid-Modified Polycationic Dendrimers against Pseudomonas aeruginosa and Other Non-Fermenting Gram-Negative Bacteria

(2020) Anna Maria Schito et al.   Polymers

Synthetic macromolecules as therapeutics that overcome resistance in cancer and microbial infection

(2020) Jason Tan et al.   BIOMATERIALS

From Nanobiotechnology, Positively Charged Biomimetic Dendrimers as Novel Antibacterial Agents: A Review

(2020) Silvana Alfei et al.   Nanomaterials

Anticancer polymers designed for killing dormant prostate cancer cells

(2019) Haruko Takahashi et al.   Scientific Reports

Hyaluronic acid-modified cationic nanoparticles overcome enzyme CYP1B1-mediated breast cancer multidrug resistance

(2019) Jun Zhang et al.   Nanomedicine

Inhibition of fatty acid synthesis arrests colorectal neoplasm growth and metastasis: Anti-cancer therapeutical effects of natural cyclopeptide RA-XII

(2019) Yurong Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Copy number variation of PR-39 cathelicidin, and identification of PR-35, a natural variant of PR-39 with reduced mammalian cytotoxicity

(2019) Hyoim Jeon et al.   GENE

Antibiotic Adjuvants: Make Antibiotics Great Again!

(2019) Hana Douafer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Emulsion Techniques for the Production of Pharmacological Nanoparticles

(2019) Ratchapol Jenjob et al.   MACROMOLECULAR BIOSCIENCE

Antimicrobial Potential of Benzimidazole Derived Molecules

(2019) Yogita Bansal et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Natural products against cancer: Review on phytochemicals from marine sources in preventing cancer

(2019) Adil Farooq Wali et al.   SAUDI PHARMACEUTICAL JOURNAL

Specific and Selective Bacteriophages in the Fight against Multidrug-resistant Acinetobacter baumannii

(2019) Natalia Bagińska et al.   VIROLOGICA SINICA

MYC Expression and Metabolic Redox Changes in Cancer Cells: A Synergy Able to Induce Chemoresistance

(2019) Barbara Marengo et al.   Oxidative Medicine and Cellular Longevity

Renaissance of Vancomycin: Approaches for Breaking Antibiotic-Resistance in Multidrug-Resistant Bacteria

(2019) Eric Mühlberg et al.   CANADIAN JOURNAL OF MICROBIOLOGY

From Worms to Drug Candidate: The Story of Odilorhabdins, a New Class of Antimicrobial Agents

(2019) Emilie Racine et al.   Frontiers in Microbiology

Nanoscale Melittin@Zeolitic Imidazolate Frameworks for Enhanced Anticancer Activity and Mechanism Analysis

(2018) Yawei Li et al.   ACS Applied Materials & Interfaces

Inhibitors of Selected Bacterial Metalloenzymes

(2018) Raivis Zalubovskis et al.   CURRENT MEDICINAL CHEMISTRY

Loading of polymyxin B onto anionic mesoporous silica nanoparticles retains antibacterial activity and enhances biocompatibility

(2018) Zahra Gounani et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Recent insights into structure-function relationships of antimicrobial peptides

(2018) Tamer A.E. Ahmed et al.   JOURNAL OF FOOD BIOCHEMISTRY

Nano-Strategies to Fight Multidrug Resistant Bacteria—“A Battle of the Titans”

(2018) Pedro V. Baptista et al.   Frontiers in Microbiology

Etoposide-resistance in a neuroblastoma model cell line is associated with 13q14.3 mono-allelic deletion and miRNA-15a/16-1 down-regulation

(2018) Barbara Marengo et al.   Scientific Reports

Self-Assembled Nanomedicines for Anticancer and Antibacterial Applications

(2018) Lingyun Zhou et al.   Advanced Healthcare Materials

Antibacterial and Antibiofilm Activity and Mode of Action of Magainin 2 against Drug-Resistant Acinetobacter baumannii

(2018) Min Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The disparate effects of bacteriophages on antibiotic-resistant bacteria

(2018) Clara Torres-Barceló   Emerging Microbes & Infections

N-myristoylation of Antimicrobial Peptide CM4 Enhances Its Anticancer Activity by Interacting With Cell Membrane and Targeting Mitochondria in Breast Cancer Cells

(2018) Caiyun Li et al.   Frontiers in Pharmacology

Understanding the extracellular matrix in acute myeloid leukemia

(2017) Valerio Izzi et al.   HAEMATOLOGICA

New drug candidates for liposomal delivery identified by computer modeling of liposomes' remote loading and leakage

(2017) Ahuva Cern et al.   JOURNAL OF CONTROLLED RELEASE

Tumor accumulation of liposomal doxorubicin in three murine models: Optimizing delivery efficiency

(2017) Charlene M. Dawidczyk et al.   Nanomedicine-Nanotechnology Biology and Medicine

Nanoparticles as Efflux Pump and Biofilm Inhibitor to Rejuvenate Bactericidal Effect of Conventional Antibiotics

(2017) Divya Gupta et al.   Nanoscale Research Letters

Antimicrobial peptides with selective antitumor mechanisms: prospect for anticancer applications

(2017) Berthony Deslouches et al.   Oncotarget

pH-sensitive polymeric micelles for the Co-delivery of proapoptotic peptide and anticancer drug for synergistic cancer therapy

(2017) Anbu Mozhi et al.   RSC Advances

Understanding the extracellular matrix in acute myeloid leukemia

(2017) Valerio Izzi et al.   HAEMATOLOGICA

Nanoparticles as Efflux Pump and Biofilm Inhibitor to Rejuvenate Bactericidal Effect of Conventional Antibiotics

(2017) Divya Gupta et al.   Nanoscale Research Letters

Nanotechnology-based combination therapy for overcoming multidrug-resistant cancer

(2017) Meng Zhang et al.   Cancer Biology & Medicine

Metal-based antimicrobial strategies

(2017) Raymond J. Turner   Microbial Biotechnology

Two cyclic hexapeptides from Penicillium sp. FN070315 with antiangiogenic activities

(2017) Jun-Pil Jang et al.   PLoS One

Cell surface binding, uptaking and anticancer activity of L-K6, a lysine/leucine-rich peptide, on human breast cancer MCF-7 cells

(2017) Che Wang et al.   Scientific Reports

The effects of LPS on the activity of Trp-containing antimicrobial peptides against Gram-negative bacteria and endotoxin neutralization

(2016) Dejing Shang et al.   Acta Biomaterialia

Molecular mechanisms of membrane targeting antibiotics

(2016) Richard M. Epand et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Antitumor effects of cecropin B-LHRH’ on drug-resistant ovarian and endometrial cancer cells

(2016) Xiaoyong Li et al.   BMC CANCER

Antimicrobial Peptides and Innate Lung Defenses

(2016) Pieter S. Hiemstra et al.   CHEST

Effect of ligand density and PEG modification on octreotide-targeted liposome via somatostatin receptor in vitro and in vivo

(2016) Huipeng Li et al.   DRUG DELIVERY

Methionine enkephalin, its role in immunoregulation and cancer therapy

(2016) Dingliang Zhao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Antimicrobial Peptides: Mechanisms of Action and Resistance

(2016) B. Bechinger et al.   JOURNAL OF DENTAL RESEARCH

Redox Homeostasis and Cellular Antioxidant Systems: Crucial Players in Cancer Growth and Therapy

(2016) Barbara Marengo et al.   Oxidative Medicine and Cellular Longevity

Antibiotic Adjuvants: Rescuing Antibiotics from Resistance

(2016) Gerard D. Wright   TRENDS IN MICROBIOLOGY

Archetypal tryptophan-rich antimicrobial peptides: properties and applications

(2016) Nadin Shagaghi et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

The oncolytic peptide LTX-315 triggers immunogenic cell death

(2016) H Zhou et al.   Cell Death & Disease

Bovine lactoferricin P13 triggers ROS-mediated caspase-dependent apoptosis in SMMC7721 cells

(2016) Lixiang Meng et al.   Oncology Letters

Glutathione-mediated antioxidant response and aerobic metabolism: two crucial factors involved in determining the multi-drug resistance of high-risk neuroblastoma

(2016) Renata Colla et al.   Oncotarget

Combating multidrug-resistant Gram-negative bacteria with structurally nanoengineered antimicrobial peptide polymers

(2016) Shu J. Lam et al.   Nature Microbiology

Cyclic depsipeptides as potential cancer therapeutics

(2015) Jirouta Kitagaki et al.   ANTI-CANCER DRUGS

Phospholipid-driven differences determine the action of the synthetic antimicrobial peptide OP-145 on Gram-positive bacterial and mammalian membrane model systems

(2015) Nermina Malanovic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Apoptotic human neutrophil peptide-1 anti-tumor activity revealed by cellular biomechanics

(2015) Diana Gaspar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Methionine Enkephalin (MENK) Inhibits tumor growth through regulating CD4+Foxp3+ Regulatory T cells (Tregs) in mice

(2015) Xuan Li et al.   CANCER BIOLOGY & THERAPY

Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp

(2015) Khalid O Alfarouk et al.   Cancer Cell International

Membrane interaction of antimicrobial peptides using E. coli lipid extract as model bacterial cell membranes and SFG spectroscopy

(2015) Lauren Soblosky et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Mammalian Antimicrobial Peptides: Promising Therapeutic Targets Against Infection and Chronic Inflammation

(2015) Pujarini Dutta et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Reviving old antibiotics

(2015) Ursula Theuretzbacher et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Melanoma cell surface-expressed phosphatidylserine as a therapeutic target for cationic anticancer peptide, temporin-1CEa

(2015) Che Wang et al.   JOURNAL OF DRUG TARGETING

Horizontal gene transfer: building the web of life

(2015) Shannon M. Soucy et al.   NATURE REVIEWS GENETICS

Efficacy of the antimicrobial peptide TP4 against Helicobacter pylori infection: in vitro membrane perturbation via micellization and in vivo suppression of host immune responses in a mouse model

(2015) Jayaram Lakshmaiah Narayana et al.   Oncotarget

TAT Modification of Alpha-Helical Anticancer Peptides to Improve Specificity and Efficacy

(2015) Xueyu Hao et al.   PLoS One

Complete regression and systemic protective immune responses obtained in B16 melanomas after treatment with LTX-315

(2014) Ketil André Camilio et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Bovine Lactoferrin Induces Cell Cycle Arrest and Inhibits Mtor Signaling in Breast Cancer Cells

(2014) Yunlei Zhang et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Antimicrobial and Immunomodulatory Activities of PR-39 Derived Peptides

(2014) Edwin J. A. Veldhuizen et al.   PLoS One

A novel cyclic pentapeptide, H-10, inhibits B16 cancer cell growth and induces cell apoptosis

(2014) GENG ZHANG et al.   Oncology Letters

Cationic Polymer Nanoparticles and Nanogels: From Synthesis to Biotechnological Applications

(2013) Jose Ramos et al.   CHEMICAL REVIEWS

Generation of a hematologic malignancy-selective membranolytic peptide from the antimicrobial core (RRWQWR) of bovine lactoferricin

(2013) Ashley L. Hilchie et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

The effect of alloferon on the enhancement of NK cell cytotoxicity against cancer via the up-regulation of perforin/granzyme B secretion

(2013) Seyeon Bae et al.   IMMUNOBIOLOGY

Antimicrobial peptide LL-37 attenuates LTA induced inflammatory effect in macrophages

(2013) Yang Ruan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Antimicrobial activity of metals: mechanisms, molecular targets and applications

(2013) Joseph A. Lemire et al.   NATURE REVIEWS MICROBIOLOGY

Ribosome-targeting antibiotics and mechanisms of bacterial resistance

(2013) Daniel N. Wilson   NATURE REVIEWS MICROBIOLOGY

Role of Glutathione in Cancer Progression and Chemoresistance

(2013) Nicola Traverso et al.   Oxidative Medicine and Cellular Longevity

Marine natural products: Bryostatins in preclinical and clinical studies

(2013) Peter Kollár et al.   PHARMACEUTICAL BIOLOGY

FK-16 Derived from the Anticancer Peptide LL-37 Induces Caspase-Independent Apoptosis and Autophagic Cell Death in Colon Cancer Cells

(2013) Shun X. Ren et al.   PLoS One

From antimicrobial to anticancer peptides. A review

(2013) Diana Gaspar et al.   Frontiers in Microbiology

Cationic Peptidopolysaccharides Show Excellent Broad-Spectrum Antimicrobial Activities and High Selectivity

(2012) Peng Li et al.   ADVANCED MATERIALS

Inhibitory effect of novel somatostatin peptide analogues on human cancer cell growth based on the selective inhibition of DNA polymerase β

(2012) Isoko Kuriyama et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Designed synthetic analogs of the α-helical peptide temporin-La with improved antitumor efficacies via charge modification and incorporation of the integrin αvβ3 homing domain

(2012) Yuwen Diao et al.   JOURNAL OF PEPTIDE SCIENCE

DCAP: A Broad-Spectrum Antibiotic That Targets the Cytoplasmic Membrane of Bacteria

(2012) Ye-Jin Eun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Surfactant-Assisted Synthesis and Characterization of Stable Silver Bromide Nanoparticles in Aqueous Media

(2012) Moumita Chakraborty et al.   LANGMUIR

Novel cationic antimicrobial peptide GW-H1 induced caspase-dependent apoptosis of hepatocellular carcinoma cell lines

(2012) Yi-Lin Sophia Chen et al.   PEPTIDES

Prokaryotic selectivity and LPS-neutralizing activity of short antimicrobial peptides designed from the human antimicrobial peptide LL-37

(2012) Yong Hai Nan et al.   PEPTIDES

Overview on the recent study of antimicrobial peptides: Origins, functions, relative mechanisms and application

(2012) Yanmei Li et al.   PEPTIDES

Antimicrobial polymers as synthetic mimics of host-defense peptides

(2012) Kenichi Kuroda et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

The Oligo-Acyl Lysyl Antimicrobial Peptide C12K-2β12Exhibits a Dual Mechanism of Action and Demonstrates StrongIn VivoEfficacy against Helicobacter pylori

(2011) Morris O. Makobongo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A novel transferrin receptor-targeted hybrid peptide disintegrates cancer cell membrane to induce rapid killing of cancer cells

(2011) Megumi Kawamoto et al.   BMC CANCER

Microparticles and their emerging role in cancer multidrug resistance

(2011) J. Gong et al.   CANCER TREATMENT REVIEWS

Will new generations of modified antimicrobial peptides improve their potential as pharmaceuticals?

(2011) Nicole K. Brogden et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Pardaxin-induced apoptosis enhances antitumor activity in HeLa cells

(2011) Jung-Chieh Hsu et al.   PEPTIDES

Cationic Amphiphiles, a New Generation of Antimicrobials Inspired by the Natural Antimicrobial Peptide Scaffold

(2010) B. Findlay et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structural determinants of antimicrobial activity in polymers which mimic host defense peptides

(2010) Edmund F. Palermo et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Pentastatin-1, a collagen IV derived 20-mer peptide, suppresses tumor growth in a small cell lung cancer xenograft model

(2010) Jacob E Koskimaki et al.   BMC CANCER

Cationic nanoparticles for cancer therapy

(2010) Erem Bilensoy   Expert Opinion on Drug Delivery

In vivo efficacy of the antimicrobial peptide ranalexin in combination with the endopeptidase lysostaphin against wound and systemic meticillin-resistant Staphylococcus aureus (MRSA) infections

(2010) Andrew P. Desbois et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Antimicrobial cyclic decapeptides with anticancer activity

(2010) Lidia Feliu et al.   PEPTIDES

The clinical consequences of antimicrobial resistance

(2009) Louis B Rice   CURRENT OPINION IN MICROBIOLOGY

Targeting Phosphatidylserine in Anti-Cancer Therapy

(2009) Heidi Kenis et al.   CURRENT PHARMACEUTICAL DESIGN

Intracellular Receptor for Human Host Defense Peptide LL-37 in Monocytes

(2009) N. Mookherjee et al.   JOURNAL OF IMMUNOLOGY

Antimicrobial peptides: linking partition, activity and high membrane-bound concentrations

(2009) Manuel N. Melo et al.   NATURE REVIEWS MICROBIOLOGY

A novel peptide from human apolipoprotein(a) inhibits angiogenesis and tumor growth by targeting c-Src phosphorylation in VEGF-induced human umbilical endothelial cells

(2008) Zheng-Fang Yi et al.   INTERNATIONAL JOURNAL OF CANCER

Melittin, a Major Component of Bee Venom, Sensitizes Human Hepatocellular Carcinoma Cells to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-induced Apoptosis by Activating CaMKII-TAK1-JNK/p38 and Inhibiting IκBα Kinase-NFκB

(2008) Chen Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of NF-κB by alloferon through down-regulation of antioxidant proteins and IκBα

(2008) Myung-Jeom Ryu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY