Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 64, Issue 4, Pages 801-805Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.5b05461
Keywords
apoptosis; A2780 ovarian carcinoma cells; caspase; MAPK p38; polyphenols; raspberry; sanguiin H-6; truncated BID
Funding
- Korea Institute of Science and Technology Institutional Program [2Z04371]
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea [HI15C0089]
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The effects of a red raspberry component, sanguiin H-6 (SH-6), on the induction of apoptosis and the related signaling pathways in A2780 human ovarian carcinoma cells were investigated. SH-6 caused an antiproliferative effect and a severe morphological change resembling that of apoptotic cell death but no effect on the cancer cell cycle arrest: In addition, SH-6 induced an early apoptotic effect and activation of caspases as well as the deavage of PARP, which is a hallmark of apoptosis. The early apoptotic percentages of A2780 cells exposed to 20 and 40 mu M SH-6 were 35.39 and 41.76, respectively. Also, SH-6 caused the activation of mitogen-activated protein, kinases (MAPKs), especially p38, and the increase of truncated p15/BID. These results in the present study suggest that the apoptosis of A2780 human ovarian carcinoma cells by SH-6 is mediated by the MAPK p38 and a caspase-8-dependent BID cleavage pathway.
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