Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 64, Issue 48, Pages 9180-9188Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.6b04147
Keywords
(-)-epigallocatechin gallate (EGCG); niosomes; digestive stability; cellular antioxidant activity (CAA)
Funding
- National Natural Science Foundation of China [31401533, 31571891]
- National Thirteenth-Five Year Research Program of China [2016YFD0400801]
- Fundamental Research Funds for the Central Universities [JUSRP11422, JUSRP51507]
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In order to improve the chemical stability and antioxidant activity of (-)-epigallocatechin gallate (EGCG) in the gastrointestinal tract, niosomes composed of Tween-60 and cholesterol were developed to encapsulate EGCG in this investigation. EGCG loaded niosomes with encapsulation efficiency around 76% exhibited a small Z-average diameter about 60 nm. Compared to free EGCG, the EGCG remaining in dialysis tubes was significantly improved for niosomes at pH 2 and 7.4. Meanwhile, the residual EGCG for niosomes increased from 3% to 49% after 2 h incubation in simulated intestinal fluid (SIF). Pancreatin was found to impact the stability of niosomes in SIF mainly. Furthermore, the results from ferric reducing antioxidant power and cellular antioxidant activity tests indicated that EGCG loaded niosomes exhibited stronger antioxidant ability than free EGCG during intestinal digestion. Thus, we can infer that niosomal encapsulation might be a promising approach to improve the oral bioavailability of EGCG in the body.
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