Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/ijms23052449
Keywords
autonomic nervous system; sympathetic system; parasympathetic system; inflammatory reflex; innate immunity; adaptive immunity; systemic autoimmune diseases; inflammation; gut microbiota
Funding
- Italian Ministry of Health [RC-2021-305.01]
Ask authors/readers for more resources
The autonomic nervous system and the immune system are closely related, regulating immune response and inflammation. Imbalance can lead to chronic conditions, such as systemic autoimmune diseases. Vagal stimulation techniques offer a potential solution to improve symptoms and reduce ANS dysfunction in chronic diseases.
The autonomic nervous system (ANS) and the immune system are deeply interrelated. The ANS regulates both innate and adaptive immunity through the sympathetic and parasympathetic branches, and an imbalance in this system can determine an altered inflammatory response as typically observed in chronic conditions such as systemic autoimmune diseases. Rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis all show a dysfunction of the ANS that is mutually related to the increase in inflammation and cardiovascular risk. Moreover, an interaction between ANS and the gut microbiota has direct effects on inflammation homeostasis. Recently vagal stimulation techniques have emerged as an unprecedented possibility to reduce ANS dysfunction, especially in chronic diseases characterized by pain and a decreased quality of life as well as in chronic inflammation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available