Article
Immunology
Lindsay R. Grant, Aster Meche, Leah McGrath, Amanda Miles, Tamuno Alfred, Qi Yan, Erica Chilson
Summary: In this study, the risk of pneumococcal disease among adults in the United States between 2016 and 2019 was quantified using retrospective cohort study design and administrative health claims data. The results showed that older age and certain medical conditions, particularly immunocompromising conditions, increased the risk of pneumococcal disease.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Immunology
Kaile Chen, Xiyan Zhang, Yunzhen Tao, Yunzhong Wang, Jian Xue, Changpeng Liu, Shuang Feng, Yongdong Yan, Qinghui Chen, Jianmei Tian, Genming Zhao, Xuejun Shao, Tao Zhang
Summary: This study described the hospitalization of 105 children <5 years of age for IPD in a hospital in Suzhou, China, from 2010 to 2017, and calculated the incidence rate of IPD in Suzhou. Eight different capsular serotypes of pneumococcus were identified in the study.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Alexis Rybak, Corinne Levy, Francois Angoulvant, Anne Auvrignon, Piotr Gembara, Kostas Danis, Sophie Vaux, Daniel Levy-Bruhl, Sylvie van der Werf, Stephane Bechet, Stephane Bonacorsi, Zein Assad, Andrea Lazzati, Morgane Michel, Florentia Kaguelidou, Albert Faye, Robert Cohen, Emmanuelle Varon, Naim Ouldali
Summary: This study examined the impact of nonpharmaceutical interventions implemented during the COVID-19 pandemic on the incidence of invasive pneumococcal disease (IPD) in France. The results showed that the decrease in IPD incidence was associated with decreased viral infection cases, rather than changes in pneumococcal carriage rate.
Article
Microbiology
Brita Askeland Winje, Didrik Frimann Vestrheim, Richard Aubrey White, Anneke Steens
Summary: The study indicates that the elderly and adults with medical risk conditions are still at high risk of invasive pneumococcal disease, highlighting the importance of age- and risk-group-based prevention strategies.
Article
Multidisciplinary Sciences
Ryan Robinson, Christopher A. Myerscough, Nengjie He, Helen Hill, Wendi Shepherd, Patricia Gonzalez-Dias, Konstantinos Liatsikos, Samuel Latham, Fred Fyles, Klara Doherty, Phoebe Hazenberg, Fathimath Shiham, Daniella Mclenghan, Hugh Adler, Vicki Randles, Seher Zaidi, Angela Hyder-Wright, Elena Mitsi, Hassan Burhan, Ben B. Morton, Jamie M. Rylance, Maia M. Lesosky, Stephen Gordon, Andrea Collins, Daniela Ferreira
Summary: Experimental Human Pneumococcal Challenge (EHPC) is a safe procedure for studying vaccine research, with no serious adverse events related to pneumococcal inoculation. Colonised individuals were more likely to experience safety events, but most symptoms were mild and could be managed conservatively. Outpatient human pneumococcal challenge can be conducted safely with appropriate safety monitoring procedures in place.
Review
Immunology
Ayumi Morimura, Shigeto Hamaguchi, Yukihiro Akeda, Kazunori Tomono
Summary: Research on Streptococcus pneumoniae has shown that it is a commensal in the human upper respiratory tract as well as a pathogen causing various diseases. The lack of tractable animal models has hindered the full understanding of its transmission mechanism, but recent studies and novel animal models have helped shed light on this aspect.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Infectious Diseases
Clara Ines Agudelo, Carlos Castaneda-Orjuela, Maria Cristina de Cunto Brandileone, Gabriela Echaniz-Aviles, Samanta Cristine Grassi Almeida, Maria Noemi Carnalla-Barajas, Mabel Regueira, Sofia Fossati, Pedro Alarcon, Pamela Araya, Carolina Duarte, Jacqueline Sanchez, Mirna Novas, Gilda Torano-Peraza, Misladys Rodriguez-Ortega, Gustavo Chamorro-Cortesi, Anibal Kawabata, Gabriela Garcia-Gabarrot, Teresa Camou, Enza Spadola, Daisy Payares, Ana Lucia Andrade, Jose Luis Di Fabio, Elizabeth Castaneda
Summary: A multicentre, retrospective observational study in eight Latin American and Caribbean countries assessed the direct effect of pneumococcal conjugate vaccines (PCVs) on the distribution of pneumococcal serotypes causing invasive pneumococcal disease in children younger than 5 years. The study found a significant decrease in the percentage of vaccine serotypes in PCV countries after PCV introduction.
LANCET INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Angharad E. Green, Deborah Howarth, Chrispin Chaguza, Haley Echlin, R. Fredi Langendonk, Connor Munro, Thomas E. Barton, Jay C. D. Hinton, Stephen D. Bentley, Jason W. Rosch, Daniel R. Neill
Summary: The study investigated the adaptation and evolution of pneumococcus in different transmission environments. Through serial passage experiments in mouse models, pneumococci passaged in the lungs became more effective colonizers of the respiratory tract, displaying potential parallel evolution. Mutations in specific genes were identified in nasopharynx-passaged pneumococci, highlighting the impact of within-host environmental conditions on bacterial evolution.
MOLECULAR BIOLOGY AND EVOLUTION
(2021)
Review
Immunology
Catherine S. Palmer, Jacqueline M. Kimmey
Summary: This article summarizes the pathways of neutrophil migration from the bloodstream to the lungs during pneumococcal infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Kristina L. Bajema, Ryan Gierke, Monica M. Farley, William Schaffner, Ann Thomas, Arthur L. Reingold, Lee H. Harrison, Ruth Lynfield, Kari E. Burzlaff, Susan Petit, Meghan Barnes, Salina Torres, Paula M. Snippes Vagnone, Bernard Beall, Tamara Pilishvili
Summary: The incidence of antibiotic-nonsusceptible invasive pneumococcal disease (NS-IPD) has decreased in the United States after the introduction of 7- and 13-valent pneumococcal conjugate vaccines (PCVs). However, there has been an increase in nonvaccine type NS-IPD, particularly among older adults. The use of higher valency PCVs containing the common nonsusceptible serotypes could help further reduce NS-IPD.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Biology
Philip H. C. Kremer, Bart Ferwerda, Hester J. Bootsma, Nienke Y. Rots, Alienke J. Wijmenga-Monsuur, Elisabeth A. M. Sanders, Krzysztof Trzcinski, Anne L. Wyllie, Paul Turner, Arie van der Ende, Matthijs C. Brouwer, Stephen D. Bentley, Diederik van de Beek, John A. Lees
Summary: This study identified genetic variations in pneumococcal carriage that differ between infants and adults. Serotypes and genetic background were found to explain a proportion of the heritability in carriage. The findings support the proposal for adaptive vaccination strategies targeting dominant circulating serotypes and tailored to the composition of the pathogen populations.
Article
Immunology
Xueqing Wu, Shanshan Zhao, Yan Jiang, Xi Xiang, Lihong Ge, Qiong Chen, Yanfei Wang, Jorge E. Vidal, Yunsong Yu
Summary: This study evaluated the impact of interrupted PCV availability on pneumococcal pneumonia and genetic variation of Streptococcus pneumoniae. The findings showed that interrupted PCV availability affected the prevalence of pneumococcal disease and pneumococcal genome variation.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Infectious Diseases
Leigh M. Howard, Xiang Huang, Wencong Chen, Yuhan Liu, Kathryn M. Edwards, Marie R. Griffin, Yuwei Zhu, Jorge E. Vidal, Keith P. Klugman, Ana I. Gil, Nicole R. Soper, Isaac P. Thomsen, Katherine Gould, Jason Hinds, Claudio F. Lanata, Carlos G. Grijalva
Summary: We investigated the association between nasopharyngeal pneumococcal co-colonization and pneumococcal density in young Peruvian children. Pneumococcal co-colonization was common but not associated with increased pneumococcal density.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Sana S. Ahmed, Fernanda C. Lessa, Hilma Coradin, Jacqueline Sanchez, Maria da G. Carvalho, Elizabeth Soda, Chabela Pena, Josefina Fernandez, Doraliza Cedano, Cynthia G. Whitney, Jesus Feris-Iglesias
Summary: The introduction of PCV13 had an impact on the serotypes causing pneumococcal pneumonia with pleural effusion, with no significant difference in the prevalence of pneumococcus before and after PCV13 introduction, but changes in the proportion of cases caused by different serotypes. The PCV13 uptake rate decreased in 2015 compared to 2014, highlighting the need for higher vaccination coverage.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Food Science & Technology
Jasmin Bazant, Benjamin Ott, Martina Hudel, Torsten Hain, Rudolf Lucas, Mobarak Abu Mraheil
Summary: H2O2 negatively affects the activity and release of PLY. Decreased H2O2 production leads to a decline in PLY release, possibly due to the upregulation of certain genes.
Article
Emergency Medicine
Yusuke Katayama, Tetsuhisa Kitamura, Kosuke Kiyohara, Kenichiro Ishida, Tomoya Hirose, Shunichiro Nakao, Jotaro Tachino, Tasuku Matsuyama, Takeyuki Kiguchi, Yutaka Umemura, Tomohiro Noda, Yuko Nakagawa, Takeshi Shimazu
Summary: Fluid administration by ELST to traffic accident patients was not associated with hospital mortality, but showed better outcomes in terms of CPAOA.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Article
Substance Abuse
Kosuke Kiyohara, Takahiro Tabuchi
Summary: This study examined the use of heated tobacco products (HTPs) in locations where smoking was not allowed in Japan and found that a considerable number of people used HTPs in these smoke-free locations. The study also identified that individuals who believed HTP use was not forbidden in smoke-free locations were more likely to use HTPs in such places.
Article
Cardiac & Cardiovascular Systems
Tasuku Matsuyama, Sho Komukai, Junichi Izawa, Koichiro Gibo, Masashi Okubo, Kosuke Kiyohara, Takeyuki Kiguchi, Taku Iwami, Bon Ohta, Tetsuhisa Kitamura
Summary: Using a population-based registry with time-dependent propensity score-sequential matching analysis, prehospital epinephrine administration in adult OHCA patients with refractory shockable rhythm was positively associated with 1-month survival and prehospital ROSC.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2022)
Article
Emergency Medicine
Yutaka Umemura, Yusuke Katayama, Tetsuhisa Kitamura, Kosuke Kiyohara, Tomoya Hirose, Takeyuki Kiguchi, Jotaro Tachino, Shunichiro Nakao, Yuko Nakagawa, Takeshi Shimazu
Summary: The study revealed that male patients had a relatively higher risk of death in the older adult subset, but there were no significant mortality differences between sexes in the other two age groups. Further analysis indicated that the predicted survival probability decreased more sharply with age for male patients compared to female patients.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Article
Oncology
Kentaro Yamato, Ai Ikeda, Motoki Endo, Ronald Filomeno, Kosuke Kiyohara, Ken Inada, Katsuji Nishimura, Takeshi Tanigawa
Summary: This study found that patients with pancreatic cancer, leukemia, and oropharyngeal cancer have a higher risk of developing delirium compared to gastric cancer.
Article
Medicine, General & Internal
Sanae Hosomi, Tetsuhisa Kitamura, Tomotaka Sobue, Ling Zha, Kosuke Kiyohara, Tasuku Matsuyama, Jun Oda
Summary: This study analyzed the effects of timing of epinephrine administration on survival rates in patients with out-of-hospital cardiac arrest following traffic collisions. The results showed that delayed epinephrine administration was associated with decreased one-month survival rates. Only a few patients showed favorable neurological outcomes after receiving early epinephrine administration.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Yusuke Katayama, Kenta Tanaka, Kenichiro Ishida, Tomoya Hirose, Jotaro Tachino, Shunichiro Nakao, Yutaka Umemura, Kosuke Kiyohara, Masahiro Ojima, Takeyuki Kiguchi, Tetsuhisa Kitamura, Jun Oda
Summary: This study revealed several factors associated with blunt traumatic diaphragmatic rupture, including disturbance of consciousness, FAST positive, front seat passenger, and compression injury by heavy object.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Kenichiro Ishida, Yusuke Katayama, Tetsuhisa Kitamura, Tomoya Hirose, Masahiro Ojima, Shunichiro Nakao, Jotaro Tachino, Yutaka Umemura, Takeyuki Kiguchi, Tasuku Matsuyama, Tomohiro Noda, Kosuke Kiyohara, Jun Oda, Mitsuo Ohnishi
Summary: The lack of established diagnostic criteria makes diagnosing blunt cardiac injury difficult. We investigated the factors associated with blunt cardiac injury using the Japan Trauma Data Bank (JTDB) in a multicenter observational study. Hypotension on hospital arrival, thoracic aortic injury, pulmonary contusion, rib fracture, sternal fracture, and hemothorax/pneumothorax were positively associated with blunt cardiac injury.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Tomoya Hirose, Tetsuhisa Kitamura, Yusuke Katayama, Kenta Tanaka, Jotaro Tachino, Shunichiro Nakao, Kenichiro Ishida, Masahiro Ojima, Takeyuki Kiguchi, Yutaka Umemura, Kosuke Kiyohara, Jun Oda
Summary: This study analyzed a large number of cases from the Japanese Trauma Data Bank to reveal the incidence and characteristics of cranial nerve injuries. Facial nerve injury was the most common, occurring mostly in males aged 30-50, and often associated with skull base fractures.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Naoaki Nishimura, Haruhisa Fukuda
Summary: This study suggests that S. pneumoniae infection increases the risk of subsequent stroke and atrial fibrillation (AF), indicating that pneumococcal infections have short-term effects on patients' health and increase their susceptibility to serious cardiovascular events in the midterm to long term.
Article
Health Care Sciences & Services
Yusuke Katayama, Kosuke Kiyohara, Tomoya Hirose, Kenichiro Ishida, Jotaro Tachino, Shunichiro Nakao, Tomohiro Noda, Masahiro Ojima, Takeyuki Kiguchi, Tasuku Matsuyama, Tetsuhisa Kitamura
Summary: This study aimed to assess the relationship between mobile app use frequency among children and seasonal influenza. The results showed a positive association between the number of app uses and the number of influenza patients, particularly during the influenza epidemic season.
JMIR FORMATIVE RESEARCH
(2022)
Article
Medicine, General & Internal
Sanae Hosomi, Ling Zha, Kosuke Kiyohara, Tetsuhisa Kitamura, Taro Irisawa, Hiroshi Ogura, Jun Oda
Summary: During the COVID-19 pandemic, the survival rate of patients with out-of-hospital cardiac arrests in Japan decreased significantly, particularly for those caused by cardiac origin, asphyxia, or external causes.
ACUTE MEDICINE & SURGERY
(2022)
Article
Critical Care Medicine
Tasuku Matsuyama, Bon Ohta, Kosuke Kiyohara, Tetsuhisa Kitamura
Summary: This study aimed to assess the association between cardiopulmonary resuscitation (CPR)duration and outcomes after out-of-hospital cardiac arrest (OHCA). The results demonstrated that the probability of favorable neurological outcomes decreased with CPR duration. The impact of CPR duration may be influenced by each patient's clinical features.