Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 64, Issue 9, Pages 1945-1949Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.6b00176
Keywords
Phellinus rhabarbarinus; lanostane triterpenoid; NO production inhibition; cytotoxicity
Funding
- National Key Technology Support Program, China [2013BAI11B02]
- National Natural Science Foundation of China [81373289]
- West Light Foundation of The Chinese Academy of Sciences [2013312D11016]
- Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, CAS [AB2015001]
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Phellinus rhabarbarinus soaked in wine has folk usages by local residents of Ailao mountain of Yunnan province, China, which were to daub the wound to prevent infection and to drink to enhance immunity and treat other diseases such as cough, gastritis, and cancer. Systemic investigation on the chemical constituents of fruiting bodies of P. rhabarbarinus resulted in the isolation of 11 lanostane triterpenoids (1-10) including three new ones, namely, phellibarins A-C (1-3), together with five ergosterols (11-15). This is the first time reporting secondary metabolites of P. rhabarbarinus. Compounds 2, 3, 7, and 8 showed inhibitory activities against nitric oxide (NO) production in LPS-activated RAW264.7 macrophages, whereas compounds 2-4, 6, 7, and 10 exhibited cytotoxicities against human cancer cell lines. The results of this assessment suggested that the lanostane triterpenoids in fruiting bodies of P. rhabarbarinus played key roles in its folk usages.
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