Review
Polymer Science
Gustavo A. Rico-Llanos, Sara Borrego-Gonzalez, Miguelangel Moncayo-Donoso, Jose Becerra, Rick Visser
Summary: Collagen type I is widely used in bone tissue engineering due to its excellent biocompatibility and osteoconductivity, but it also has drawbacks such as high biodegradability and low mechanical strength. Recent efforts have been focused on designing and producing collagen implants to enhance bone regeneration.
Article
Chemistry, Applied
Kai Zhu, Zhenxiao Zheng, Zhiyuan Dai
Summary: In this study, a novel method based on peptidomics and bioinformatic was used to identify and characterize antifreeze peptides (AFPs) from shrimp byproducts autolysate (SBPA). The results showed that the synthesized AFP-1 and AFP-2 exhibited significant cryoprotection in shrimp muscle and the protection effect was enhanced with higher concentration. The mechanisms of antifreeze peptides might be related to their ability to bind with ice and inhibit ice crystal growth. This study provides new insights into the identification and characterization of AFPs.
Article
Biochemistry & Molecular Biology
Ntlama Lesotho, Thabo Peme, Maya Makatini
Summary: The synthesis of wound-healing collagen mimetic peptides (CMPs) containing the integrin binding motif GFOGER is reported. Peptides also include lipophilic moieties for improved membrane permeability and different collagen-inducing tripeptides. The synthesized peptides were successfully characterized and purified, and their desired helical structure was confirmed to promote integrin binding.
JOURNAL OF PEPTIDE SCIENCE
(2023)
Article
Nutrition & Dietetics
Changwei Cao, Zhichao Xiao, Huiquan Tong, Yuntao Liu, Yinglong Wu, Changrong Ge
Summary: The study found that orally administered chicken bone collagen peptides have significant effects in alleviating skin aging by improving the composition and structure of aging skin, enhancing skin antioxidant levels, and inhibiting inflammation. The mechanism of action involves reducing skin oxidation, activating the TGF-beta/Smad signaling pathway for collagen synthesis, inhibiting collagen degradation, and suppressing skin inflammation. It was also discovered that lysosomes activation may play an important role in the anti-aging effects of orally administered collagen peptides.
Article
Chemistry, Applied
Julio Alfonso Gonzalez-Noriega, Martin Valenzuela-Melendres, Adrian Hernandez-Mendoza, Humberto Astiazaran-Garcia, Miguel Angel Mazorra-Manzano, Etna Aida Pena-Ramos
Summary: The objective of this study was to obtain hydrolysates and peptide fractions from pork and chicken skin collagen extracts and assess their potential as pancreatic lipase inhibitors. The results showed that these hydrolysates and peptide fractions exhibited strong inhibitory activity against lipase under appropriate conditions.
Article
Nutrition & Dietetics
Hongru Zhang, Liwei Qi, Qingshan Shen, Ruiqi Wang, Yujie Guo, Chunhui Zhang, Aurore Richel
Summary: This study investigates the therapeutic effects of bioactive compounds from chicken cartilage food supplements on osteoarthritis. The results show that oral chondroitin sulfate can improve athletic ability and reduce inflammatory cytokine levels in rats with osteoarthritis, indicating its potential as a treatment option.
FRONTIERS IN NUTRITION
(2022)
Article
Agriculture, Multidisciplinary
Madison Fomich, Vermont P. Dia, Uvinduni I. Premadasa, Benjamin Doughty, Hari B. Krishnan, Tong Wang
Summary: The study investigated the ice recrystallization inhibition (IRI) activity of soy protein isolate (SPI) hydrolysates and determined that the F1 fraction (4-14 kDa) had the highest IRI activity. Vibrationalsum frequency generation (VSFG) analysis indicated that the molecular interactions at the water/air interface were linked to IRI activity.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Tatsuhiko Goto, Saki Shimamoto, Masahiro Takaya, Shun Sato, Kanna Takahashi, Kenji Nishimura, Yasuko Morii, Kyoko Kunishige, Akira Ohtsuka, Daichi Ijiri
Summary: The study showed significant breed effects on egg quality and amino acid traits, with significant heterosis effect. Positive correlations were found within each trait category, while weak correlations were observed among different trait categories.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Applied
Yadong Zhao, Kunyu Lu, Xinyue Piao, Yan Song, Libin Wang, Rusen Zhou, Pingping Gao, Heng Yen Khong
Summary: This study evaluated the effect of adding collagen on the gel properties of surimi and observed the influence of collagen type for the first time. Compared to type II, collagen type I has higher water solubility and more charged amino acids, which allows it to better intertwine with surimi myofibrillar proteins, resulting in higher exposure of protein functional domains, more conformational changes of myosin, and stronger formation of chemical forces among proteins. These improvements accelerate the gelation rate, leading to a well-stabilized surimi gel. Surimi gels containing collagen I have more compact structures with uniformly distributed smaller pores compared to those containing collagen II, resulting in higher water holding capacity and better texture. The fortification performance of collagen I in surimi gel and the elucidated interaction mechanism between collagen and myofibrillar protein will guide the further use of collagen as an effective additive in the food industry.
Article
Nutrition & Dietetics
Tengfei Liu, Lifang Zou, Xiaowen Ji, Guiran Xiao
Summary: This study prepared low molecular weight chicken skin collagen peptides (CCP) and novel CCP-chelated zinc (CCP-Zn) to improve the utilization value of chicken by-products. The bioavailability of CCP-Zn was found to be higher than ZnSO4 and it effectively suppressed tumor growth, invasion, and migration in a Drosophila malignant tumor model. Mechanistic studies revealed that CCP-Zn inhibits tumor progression by reducing autophagy in tumor cells and the microenvironment.
FRONTIERS IN NUTRITION
(2022)
Article
Chemistry, Medicinal
Krishna K. Sharma, Ravikant Ravi, Indresh Kumar Maurya, Akshay Kapadia, Shabana Khan, Vinod Kumar, Kulbhushan Tikoo, Rahul Jain
Summary: A new structural class of ultrashort peptide-based antifungal, His(2-aryl)-Trp-Arg, was reported in this study. Structural changes on the His-Trp-Arg scaffold showed the impact of charge and lipophilic character on biological activity. Peptide 14f exhibited potent anticryptococcal activity and showed no cytotoxic effects, acting through nuclear fragmentation, membrane permeabilization, and pore formations in microbial cells.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Oncology
Run Shi, Zhe Zhang, Ankai Zhu, Xingxing Xiong, Jie Zhang, Jiang Xu, Man-Sun Sy, Chaoyang Li
Summary: Collagen, the most abundant protein in animals, plays a crucial role in tumor development. Specifically, type I collagen, which is upregulated during tumorigenesis, promotes tumor cell proliferation, epithelial-mesenchymal transition, metastasis, and affects the efficacy of tumor therapies. However, the roles of type I collagen in tumor biology are complex and depend on the tumor type. This review discusses the expression and regulation of type I collagen synthesis, its role in cancer progression, and recent approaches targeting type I collagen for cancer treatment.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Polymer Science
Nils Wilharm, Tony Fischer, Alexander Hayn, Stefan G. Mayr
Summary: Biopolymer blends, such as collagen elastin hybrid gels, are advantageous materials with novel properties. In this study, the interaction between collagen and elastin fibers during polymerization was investigated, and it was found that elastin fibers bind in a lateral manner to collagen fibers.
Article
Fisheries
Rodrigo Guabiraba, Damaris Ribeiro Rodrigues, Paul T. Manna, Melanie Chollot, Vincent Saint-Martin, Sascha Trapp, Marisa Oliveira, Clare E. Bryant, Brian J. Ferguson
Summary: The innate immune response relies on the ability of host cells to detect and respond to microbial nucleic acids. Toll-like receptors (TLRs) play a crucial role in this process by distinguishing self from non-self. This study focused on TLR21, an avian TLR that recognizes bacterial DNA motifs. The findings suggest that avian TLR21 shares similar activation mechanisms to mammalian TLR9, highlighting the conservation of nucleic acid sensing mechanisms across species.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Chemistry, Applied
Yuan Yuan, Madison Fomich, Vermont P. Dia, Tong Wang
Summary: The aim of this research was to enhance the ice recrystallization inhibition (IRI) activity of zein and gelatin hydrolysates (ZH and GH) by succinylation modification. Modified hydrolysates (SA modified ZH and OSA modified GH) decreased the average Feret's diameter of ice crystal from 50.2 μm to 28.8 μm and 29.5 μm, respectively. Succinylated samples also exhibited altered surface hydrophobicity, potentially contributing to their enhanced IRI activity. This study demonstrates that succinylation of food-derived protein hydrolysates can improve their IRI activity.