Article
Pathology
Ankur Pandita, Matias Ekstrand, Sara Bjursten, Zhiyuan Zhao, Per Fogelstrand, Kristell Le Gal, Lars Ny, Martin O. Bergo, Joakim Karlsson, Jonas A. Nilsson, Levent M. Akyurek, Malin C. Levin, Jan Boren, Andrew J. Ewald, Keith E. Mostov, Max Levin
Summary: Intussusceptive angiogenesis, characterized by intravascular pillars, may play a role in the growth of human melanoma metastases. Inhibition of matrix metalloproteinase 9 (MMP9) could potentially block pillar formation and serve as a promising anti-angiogenic drug target for metastatic melanoma.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Oncology
Jun Wang, Yiye Tao, Queqiao Bian
Summary: This study identified 1172 DEmRNAs and 26 DEmiRNAs, revealing that cytokine-cytokine receptor interaction and chemokine signaling pathway are key pathways in CM metastasis. miR-29c-3p, miR-100-5p, miR-150-5p, and miR-150-3p were not only diagnostic biomarkers but also related to survival time, showing potential clinical applications.
EXPERT REVIEW OF ANTICANCER THERAPY
(2021)
Article
Genetics & Heredity
Guoliang Jia, Zheyu Song, Zhonghang Xu, Youmao Tao, Yuanyu Wu, Xiaoyu Wan
Summary: Bioinformatics analysis identified feature DEGs like CALML5 that are associated with the prognosis of metastatic CM, with better survival prognosis in the nonmetastatic group in both the TCGA training and validation datasets. CALML5 and other DEGs were found to be involved in 9 KEGG signaling pathways, with CALML5 being a key DEG in the melanogenesis pathway.
BMC MEDICAL GENOMICS
(2021)
Article
Biotechnology & Applied Microbiology
Wenpin Qin, Zibin Zhang, Jianfei Yan, Xiaoxiao Han, Li-Na Niu, Kai Jiao
Summary: This study demonstrated, for the first time, the intimate interactions among innervation, angiogenesis, and inflammation in the condylar cartilage of temporomandibular joint osteoarthritis (TMJ-OA).
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Cell Biology
Zhiwen Luo, Xiao Chen, Yefan Zhang, Zhen Huang, Hong Zhao, Jianjun Zhao, Zhiyu Li, Jianguo Zhou, Jianmei Liu, Jianqiang Cai, Xinyu Bi
Summary: The study aimed to predict the recurrence of metastatic colorectal cancer (mCRC) and guide adjuvant therapy through gene models. The development of MEM and IPM models based on RNA gene expression analysis revealed that downregulation of the immune response increased the risk of recurrence, with IPM-high patients showing insensitivity to immuno-/chemotherapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Simon Mylius Rasmussen, Thomas Nielsen, Sofie Hody, Henrik Hager, Lars Peter Schousboe
Summary: This study introduces a video processing algorithm designed to identify cancer suspicious skin areas, based on remote photoplethysmography signal differences between squamous cell carcinoma and healthy skin. The research shows significant temporal signal changes in cancer areas versus healthy areas, providing valuable insights for further investigation on detailed disease boundary recognition.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Huxia Wang, Yanan Tang, Xiaomin Yang, Weiyi Wang, Pihua Han, Jing Zhao, Sai He, Peijun Liu
Summary: This study revealed that the angiogenesis-related gene MEOX2 can be used as a novel biomarker for breast cancer diagnosis and clinical therapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Yong Liu, Jiayi Sun, Dongran Han, Shengnan Cui, Xiaoning Yan
Summary: By analyzing gene expression data and performing functional annotation, we identified seven targets associated with cutaneous melanoma (CM) and found that furazolidone could potentially be used for CM treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Oncology
Domenico Ribatti
Summary: The chick embryo chorioallantoic membrane (CAM) is commonly used in vivo experimental model for studying the angiogenic and metastatic capabilities of malignant cell lines or tumor tissues. Due to the natural immunodeficiency of chick embryos, CAM can support the engraftment of tumor cells and faithfully recapitulate most characteristics of the carcinogenic process, including growth, invasion, angiogenesis, and colonization. This review focuses on recent literature data regarding the use of CAM in investigating the metastatic process.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Genetics & Heredity
Cong Fu, Kun Yang, Yuqing Zou, Ran Huo
Summary: This study performed a miRNA microarray analysis in infantile hemangiomas (IH) and identified 68 differentially expressed miRNAs. Furthermore, miRNA-gene networks and protein-protein interactions were constructed. Pathway analysis revealed the involvement of these differentially expressed miRNAs and genes in various tumor-related processes and pathways.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Weiyuan Li, Ji-Ao Ma, Xun Sheng, Chunjie Xiao
Summary: This study identified the upregulation of certain CXC chemokines in ovarian cancer samples and their correlation with immune cell infiltration. Experimental evidence showed that CXCL10 could enhance T cell killing effect, inhibit angiogenesis, and affect the progression of ovarian cancer.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hongfei Ci, Xufeng Wang, Keyu Shen, Wei Du, Jiaming Zhou, Yan Fu, Qiongzhu Dong, Huliang Jia
Summary: This study identified key genes associated with angiogenesis in hepatocellular carcinoma (HCC) and explored therapeutic targets to improve patient prognosis. A risk score model based on 14 angiogenesis-related genes was developed and shown to predict overall survival in HCC patients. The study also predicted that the anti-angiogenic drug Crizotinib may be more effective in high-risk patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Gastroenterology & Hepatology
Yan-Dong Miao, Xiao-Long Tang, Jiang-Tao Wang, Deng-Hai Mi
Summary: The expression of ANGPTs, VEGFs, and PGF is significantly higher in tumor tissues and plays a role in multiple signaling pathways. High expression of ANGPT2, PGF, VEGFA, and VEGFD is associated with decreased overall survival and shorter disease-free survival in HCC patients.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Cell Biology
Zili Zhen, Zhemin Shen, Yanmei Hu, Peilong Sun
Summary: A novel signature consisting of 7 angiogenesis-related genes was established to predict the prognosis of HCC patients. Patients in the high-risk group had a poor prognosis, and the risk score was an independent predictor for overall survival. Functional enrichment analysis showed that these genes were enriched in pathways related to cell proliferation and mitosis, with significant differences in immune cell infiltration between the two risk groups.
Article
Chemistry, Multidisciplinary
Xiaodong Xie, Shu Lian, Yu Zhou, Bifei Li, Yusheng Lu, Iwin Yeung, Lee Jia
Summary: This study demonstrates that drug-loaded extracellular vesicles derived from breast cancer plasma can inhibit breast cancer metastasis to the lungs, while the CD47 protein helps extend their circulation time in blood, and their tissue distribution ratio mirrors that of companion extracellular vesicles.
JOURNAL OF CONTROLLED RELEASE
(2021)
Editorial Material
Oncology
James W. Jakub, Michael Lowe, J. Harrison Howard, Jeffrey M. Farma, Amod Sarnaik, Todd Tuttle, Heather B. Neuman, Charlotte E. Ariyan, Abhineet Uppal, Steve Trocha, Georgia M. Beasley, Nabil Wasif, Karl Y. Bilimoria, Alan A. Thomay, Jacob B. Allred, Lucia Chen, Alicia M. Terando, Jeffrey D. Wayne, John F. Thompson, Alistair J. Cochran, Myunlg-Shin Sim, David E. Elashoff, Keith A. Delman, Mark B. Faries
ANNALS OF SURGICAL ONCOLOGY
(2022)
Editorial Material
Oncology
James W. Jakub, Mark B. Faries
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
James W. Jakub, Michael Lowe, J. Harrison Howard, Jeffrey M. Farma, Amod Sarnaik, Todd Tuttle, Heather B. Neuman, Charlotte E. Ariyan, Abhineet Uppal, Steve Trocha, Georgia M. Beasley, Nabil Wasif, Karl Y. Bilimoria, Alan A. Thomay, Jacob B. Allred, Lucia Chen, Alicia M. Terando, Jeffrey D. Wayne, John F. Thompson, Alistair J. Cochran, Myung-Shin Sim, David E. Elashoff, Keith A. Delman, Mark B. Faries
Summary: This study retrospectively analyzed the oncologic outcomes of minimally invasive inguinal lymphadenectomy (MILND) in patients with melanoma. The results showed that MILND is safe and has favorable oncologic outcomes compared to traditional open inguinal lymphadenectomy (OILND).
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Thomas Robbins, Tanya L. Hoskin, Courtney N. Day, Mary M. Mrdutt, Tina J. Hieken, James W. Jakub, Katrina Glazebrook, Judy C. Boughey, Amy C. Degnim
Summary: Patients with suspicious lymph nodes on ultrasound and negative fine needle aspiration (FNA) as well as patients with negative axillary ultrasound have a similarly low chance of positive nodes. Routine targeted excision of FNA-negative clipped nodes is not warranted.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Samuel E. Broida, Xiao T. Chen, Christian L. Baum, Jerry D. Brewer, Matthew S. Block, James W. Jakub, Barbara A. Pockaj, Robert L. Foote, Svetomir N. Markovic, Tina J. Hieken, Matthew T. Houdek
Summary: Merkel cell carcinoma is a rare and aggressive cutaneous malignancy that can develop in lymph nodes or parotid gland. Patients with MCC of unknown primary have a high risk of recurrence and mortality, and the optimal treatment is still unclear.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Diane M. Durgan, Gabriel De la Cruz Ku, Mathew Thomas, Barbara A. Pockaj, Sarah A. McLaughlin, William J. Casey, Aparna Vijayasekaran, Dennis Wigle, John C. Cheville, Jennifer Tonneson, Tanya L. Hoskin, James W. Jakub
Summary: This retrospective study examined the outcomes of full-thickness chest wall resection (FTCWR) in breast cancer patients between 2000 and 2020. The results showed that FTCWR was associated with low morbidity, recurrence rates, and good overall survival.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Letter
Dermatology
Anagha Bangalore Kumar, Margot S. Peters, James W. Jakub, William Harmsen, Christian L. Baum
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Surgery
James W. Jakub, Wenexia Zhang, Malvika Solanki, Jennifer Yonkus, Judy C. Boughey, Scott Harmsen, Karthik Giridhar
Summary: This study retrospectively examined the effectiveness of neoadjuvant therapy for breast cancer. The results showed that the potential for achieving a complete pathological response in HER2-negative cases is low with either neoadjuvant chemotherapy or neoadjuvant endocrine therapy. Most patients' nodal status and tumor size remained unchanged after neoadjuvant therapy, and there is a potential for the pathological stage to be higher at surgery than the clinical stage prior to neoadjuvant therapy.
Article
Oncology
Alexandra M. Adams, Elizabeth L. Carpenter, Guy T. Clifton, Timothy J. Vreeland, Robert C. Chick, Anne E. O'Shea, Patrick M. McCarthy, Phillip M. Kemp Bohan, Annelies T. Hickerson, Franklin A. Valdera, Ankur Tiwari, Diane F. Hale, John R. Hyngstrom, Adam C. Berger, James W. Jakub, Jeffrey J. Sussman, Montaser F. Shaheen, Xianzhong Yu, Thomas E. Wagner, Mark B. Faries, George E. Peoples
Summary: This study examined the efficacy of the TLPLDC vaccine in patients with melanoma and found that patients who did not receive pretreatment with G-CSF had improved overall survival and disease-free survival. Direct collection of dendritic cells without G-CSF resulted in higher expression of genes associated with dendritic cell maturation, potentially improving clinical efficacy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Oncology
Amanda L. Nash, Samantha M. Thomas, Suniti N. Nimbkar, Tina J. Hieken, Kandice K. Ludwig, Lisa K. Jacobs, Megan E. Miller, Kristalyn K. Gallagher, Jasmine Wong, Heather B. Neuman, Jennifer Tseng, Taryn E. Hassinger, Tari A. King, E. Shelley Hwang, James W. Jakub, Laura H. Rosenberger
Summary: This study explores racial-ethnic differences in a large US cohort of women with phyllodes tumors (PT) and finds that age, tumor size, and subtype have small differences. However, there are no differences in recurrence-free survival according to race-ethnicity.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Amy C. Degnim, Brittany L. Siontis, Safia K. Ahmed, Tanya L. Hoskin, Tina J. Hieken, James W. Jakub, Christian L. Baum, Courtney Day, Sarah E. Schrup, Lauren Smith, Jodi M. Carter, Tiffany M. Sae Kho, Katrina N. Glazebrook, Aparna Vijayasekaran, Scott H. Okuno, Ivy A. Petersen
Summary: This study evaluated the impact of trimodality treatment compared to monotherapy or dual therapy for radiation-associated angiosarcoma of the breast (RAASB) after prior breast cancer treatment. The study found that trimodality therapy demonstrated a higher rate of pathological complete response and improved 5-year recurrence-free survival, but had more surgical complications and toxic effects.
CLINICAL CANCER RESEARCH
(2023)
Editorial Material
Oncology
Molly M. Benolken, Sarah McLaughlin, Mara Piltin, Mary Mrdutt, Zhuo Li, James W. Jakub
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Molly M. Benolken, Sarah McLaughlin, Mara Piltin, Mary Mrdutt, Zhuo Li, James W. Jakub
Summary: This study aimed to determine the frequency of metastatic involvement of an axillary reverse mapping (ARM) lymph node (LN) among patients undergoing axillary lymph node dissection (ALND). Among the 139 patients enrolled, 20% of the patients had a positive ARM LN.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Haeyoung Kim, Tina J. Hieken, Feven Abraha, James W. Jakub, Kimberly S. Corbin, Keith M. Furutani, Judy C. Boughey, Bradley J. Stish, Christopher L. Deufel, Amy C. Degnim, Dean A. Shumway, Safia K. Ahmed, Mara A. Piltin, Nicole P. Sandhu, Amy L. Conners, Kathryn J. Ruddy, Robert W. Mutter, Sean S. Park
Summary: This study evaluated the long-term outcome of accelerated partial breast irradiation using intraoperatively placed applicator-based brachytherapy in early-stage breast cancer. The results showed that patients treated with this method had a low rate of breast tumor recurrence, and it was correlated with menopausal status, BMI, and adherence to endocrine therapy.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)