Recent research advances in polysaccharides from Undaria pinnatifida: Isolation, structures, bioactivities, and applications

The water-soluble non-starch polysaccharides from natural resources against excessive oxidative stress: A potential health-promoting effect and its mechanisms

(2021) Xianxiang Chen et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Progress of Plant Medicine Derived Extracts and Alkaloids on Modulating Viral Infections and Inflammation

(2021) Huihui Ti et al.   Drug Design Development and Therapy

Optimizing treatment of renal cell carcinoma with VEGFR-TKIs: a comparison of clinical pharmacology and drug-drug interactions of anti-angiogenic drugs

(2020) Stefano Fogli et al.   CANCER TREATMENT REVIEWS

Characterization of Undaria pinnatifida Root Enzymatic Extracts Using Crude Enzyme from Shewanella oneidensis PKA 1008 and Its Anti-Inflammatory Effect

(2020) Xiaotong Xu et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Micro RNA Expression after Ingestion of Fucoidan; A Clinical Study

(2020) Nuri Gueven et al.   Marine Drugs

Resistance Mechanisms to Anti-angiogenic Therapies in Cancer

(2020) Yolla Haibe et al.   Frontiers in Oncology

Comparison of physicochemical properties and antidiabetic effects of polysaccharides extracted from three seaweed species

(2020) Rui-Bo Jia et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Undaria pinnatifida Fucoidan-Rich Extract Recovers Immunity of Immunosuppressed Mice

(2020) Hwan Hee Lee et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Protective Effects of Fucoidan Isolated from Celluclast-Assisted Extract of Undaria pinnatifida Sporophylls against AAPH-Induced Oxidative Stress In Vitro and In Vivo Zebrafish Model

(2020) Jae-Young Oh et al.   MOLECULES

Sulfated modification, characterization and monosaccharide composition analysis of Undaria pinnatifida polysaccharides and anti‑tumor activity

(2020) Fu‑Ling Wang et al.   Experimental and Therapeutic Medicine

Electrospun Nano-Fibers for Biomedical and Tissue Engineering Applications: A Comprehensive Review

(2020) Shokoh Parham et al.   Materials

Fucoidan Supplementation Restores Fecal Lysozyme Concentrations in High-Performance Athletes: A Pilot Study

(2020) Amanda J. Cox et al.   Marine Drugs

The Role of Fucoidans Isolated from the Sporophylls of Undaria pinnatifida against Particulate-Matter-Induced Allergic Airway Inflammation: Evidence of the Attenuation of Oxidative Stress and Inflammatory Responses

(2020) Kalahe Hewage Iresha Nadeeka Madushani Herath et al.   MOLECULES

Structural Dependence of Sulfated Polysaccharide for Diabetes Management: Fucoidan From Undaria pinnatifida Inhibiting α-Glucosidase More Strongly Than α-Amylase and Amyloglucosidase

(2020) Hui Si Audrey Koh et al.   Frontiers in Pharmacology

Sulfated polysaccharides from Undaria pinnatifida improved high fat diet-induced metabolic syndrome, gut microbiota dysbiosis and inflammation in BALB/c mice

(2020) Pingrui Jiang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Characterization and hypoglycemic effects of sulfated polysaccharides derived from brown seaweed Undaria pinnatifida

(2020) Qi-Wu Zhong et al.   FOOD CHEMISTRY

Undaria pinnatifida fucoidan nanoparticles loaded with quinacrine attenuate growth and metastasis of pancreatic cancer

(2020) Samar M. Etman et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

The Effect of Fucoidan, a Potential New, Natural, Anti-Neoplastic Agent on Uterine Sarcomas and Carcinosarcoma Cell Lines: ENITEC Collaborative Study

(2019) Marcin Bobiński et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Pathway Analysis of Fucoidan Activity Using a Yeast Gene Deletion Library Screen

(2019) Monika Corban et al.   Marine Drugs

Antimicrobial biopolymer formation from sodium alginate and algae extract using aminoglycosides

(2019) Lokender Kumar et al.   PLoS One

Fucoidan from Undaria pinnatifida has anti-diabetic effects by stimulation of glucose uptake and reduction of basal lipolysis in 3 T3-L1 adipocytes

(2019) Sung-Yi Sim et al.   NUTRITION RESEARCH

Biocatalysis of Fucodian in Undaria pinnatifida Sporophyll Using Bifidobacterium longum RD47 for Production of Prebiotic Fucosylated Oligosaccharide

(2019) Jeong Lee et al.   Marine Drugs

Chemistry and immunostimulatory activity of a polysaccharide from Undaria pinnatifida

(2019) Yongyi Yu et al.   FOOD AND CHEMICAL TOXICOLOGY

Structure characterization and antioxidant activity of fucoidan isolated from Undaria pinnatifida grown in New Zealand

(2019) Hui Si Audrey Koh et al.   CARBOHYDRATE POLYMERS

Characterization and Immunomodulatory Effects of High Molecular Weight Fucoidan Fraction from the Sporophyll of Undaria pinnatifida in Cyclophosphamide-Induced Immunosuppressed Mice

(2019) Hee Joon Yoo et al.   Marine Drugs

Sulfated polysaccharide from Undaria pinnatifida stabilizes the atherosclerotic plaque via enhancing the dominance of the stabilizing components

(2019) Zhuoyue Song et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Fucoidan from Undaria pinnatifida Ameliorates Epidermal Barrier Disruption via Keratinocyte Differentiation and CaSR Level Regulation

(2019) Yu Chen et al.   Marine Drugs

Novel fucoidan based bioactive targeted nanoparticles from Undaria Pinnatifida for treatment of pancreatic cancer

(2019) Samar M. Etman et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Inhibitory effects of edible seaweeds, polyphenolics and alginates on the activities of porcine pancreatic α-amylase

(2018) Nazikussabah Zaharudin et al.   FOOD CHEMISTRY

Layer-by-layer buildup of polysaccharide-containing films: Physico-chemical properties and mesenchymal stem cells adhesion

(2018) Viktoryia I. Kulikouskaya et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Immune activation of RAW264.7 macrophages by low molecular weight fucoidan extracted from New Zealand Undaria pinnatifida

(2018) Bi Decheng et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Low Molecular Weight Mannogalactofucans Derived from Undaria pinnatifida Induce Apoptotic Death of Human Prostate Cancer Cells In Vitro and In Vivo

(2018) Jisun Lee et al.   MARINE BIOTECHNOLOGY

Fucoidan Extracted from Undaria pinnatifida: Source for Nutraceuticals/Functional Foods

(2018) Yu Zhao et al.   Marine Drugs

Effect of polysaccharide from Undaria pinnatifida on proliferation, migration and apoptosis of breast cancer cell MCF7

(2018) Jun Wu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Potential Usefulness of a Wakame/Carob Functional Snack for the Treatment of Several Aspects of Metabolic Syndrome: From In Vitro to In Vivo Studies

(2018) Cristina Martínez-Villaluenga et al.   Marine Drugs

Investigation of Different Molecular Weight Fucoidan Fractions Derived from New Zealand Undaria pinnatifida in Combination with GroA Therapy in Prostate Cancer Cell Lines

(2018) Xu Yang et al.   Marine Drugs

Fucoidan Extracted from the New Zealand Undaria pinnatifida—Physicochemical Comparison against Five Other Fucoidans: Unique Low Molecular Weight Fraction Bioactivity in Breast Cancer Cell Lines

(2018) Jun Lu et al.   Marine Drugs

Comparative study on neuroprotective activities of fucoidans from Fucus vesiculosus and Undaria pinnatifida

(2018) Mousa Alghazwi et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Evaluation Fucoidan Extracts From Undaria pinnatifida and Fucus vesiculosus in Combination With Anticancer Drugs in Human Cancer Orthotopic Mouse Models

(2017) Maryam Burney et al.   INTEGRATIVE CANCER THERAPIES

In vitro and in vivo evaluation of anti-arthritic, antioxidant efficacy of fucoidan from Undaria pinnatifida (Harvey) Suringar

(2017) Abdul-Rehman Phull et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Promoting Wound Healing Using Low Molecular Weight Fucoidan in a Full-Thickness Dermal Excision Rat Model

(2017) Jun-Hyeong Park et al.   Marine Drugs

Effect of Content of Sulfate Groups in Seaweed Polysaccharides on Antioxidant Activity and Repair Effect of Subcellular Organelles in Injured HK-2 Cells

(2017) Xiao-Tao Ma et al.   Oxidative Medicine and Cellular Longevity

The natural compound fucoidan from New Zealand Undaria pinnatifida synergizes with the ERBB inhibitor lapatinib enhancing melanoma growth inhibition

(2017) Varsha Thakur et al.   Oncotarget

Stimulatory effect of an algal fucoidan on the release of vascular endothelial tissue-type plasminogen activator as a mechanism of fucoidan-mediated thrombolysis

(2016) Soon-Ki Min et al.   BLOOD COAGULATION & FIBRINOLYSIS

Adherence to Diet and Physical Activity Cancer Prevention Guidelines and Cancer Outcomes: A Systematic Review

(2016) L. N. Kohler et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis

(2016) Jay S. Skyler et al.   DIABETES

The Effect of Undaria pinnatifida Fucoidan on the Pharmacokinetics of Letrozole and Tamoxifen in Patients With Breast Cancer

(2016) Shreya Tocaciu et al.   INTEGRATIVE CANCER THERAPIES

Separation, characterization and anticancer activities of a sulfated polysaccharide from Undaria pinnatifida

(2016) Yun Han et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Effects of the Polysaccharide from the Sporophyll of Brown AlgaUndaria Pinnatifidaon Serum Lipid Profile and Fat Tissue Accumulation in Rats Fed a High-Fat Diet

(2016) Byoung-Mok Kim et al.   JOURNAL OF FOOD SCIENCE

Biomimetic Extracellular Environment Based on Natural Origin Polyelectrolyte Multilayers

(2016) Joana M. Silva et al.   Small

Repair Effect of Seaweed Polysaccharides with Different Contents of Sulfate Group and Molecular Weights on Damaged HK-2 Cells

(2016) Poonam Bhadja et al.   Polymers

Protective Effects of Mekabu Aqueous Solution Fermented by Lactobacillus plantarum Sanriku-SU7 on Human Enterocyte-Like HT-29-luc Cells and DSS-Induced Murine IBD Model

(2016) Maki Nemoto et al.   Probiotics and Antimicrobial Proteins

Using satellite-derived sea surface temperature to predict the potential global range and phenology of the invasive kelp Undaria pinnatifida

(2015) Kate James et al.   BIOLOGICAL INVASIONS

Structural characterization and antioxidant activity of a heteropolysaccharide from Ganoderma capense

(2015) Pan Yi et al.   CARBOHYDRATE POLYMERS

Fucoidans Disrupt Adherence ofHelicobacter pylorito AGS CellsIn Vitro

(2015) Eng-Guan Chua et al.   Evidence-based Complementary and Alternative Medicine

Anti-HSV1 activity of brown algal polysaccharides and possible relevance to the treatment of Alzheimer's disease

(2015) Matthew Wozniak et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Sulfated polysaccharides from Cyclocarya paliurus reduce H 2 O 2 -induced oxidative stress in RAW264.7 cells

(2015) Zhi-Jun Wang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Fucoidan delays apoptosis and induces pro-inflammatory cytokine production in human neutrophils

(2015) Jun-O Jin et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Fucoidan Suppresses Hypoxia-Induced Lymphangiogenesis and Lymphatic Metastasis in Mouse Hepatocarcinoma

(2015) Hongming Teng et al.   Marine Drugs

Fucoidan from Macrocystis pyrifera Has Powerful Immune-Modulatory Effects Compared to Three Other Fucoidans

(2015) Wei Zhang et al.   Marine Drugs

Suppressive Effect of Dietary Fucoidan on Proinflammatory Immune Response and MMP-1 Expression in UVB-Irradiated Mouse Skin

(2015) Hiroko Maruyama et al.   PLANTA MEDICA

Tuning polyelectrolyte multilayer structure by exploiting natural variation in fucoidan chemistry

(2015) Tracey T. M. Ho et al.   Soft Matter

Hyaluronan, Inflammation, and Breast Cancer Progression

(2015) Kathryn L. Schwertfeger et al.   Frontiers in Immunology

The enhancing effect of fucoidan derived fromUndaria pinnatifidaon immunoglobulin production by mouse spleen lymphocytes

(2014) Mika Takai et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Mekabu fucoidan: Structural complexity and defensive effects against avian influenza A viruses

(2014) Andriy Synytsya et al.   CARBOHYDRATE POLYMERS

The invasive kelp Undaria pinnatifida (Laminariales, Ochrophyta) along the north coast of Portugal: Distribution model versus field observations

(2014) P. Veiga et al.   MARINE POLLUTION BULLETIN

Fucoidan from New Zealand Undaria pinnatifida: Monthly variations and determination of antioxidant activities

(2013) W. Mak et al.   CARBOHYDRATE POLYMERS

The fucoidans from brown algae of Far-Eastern seas: Anti-tumor activity and structure–function relationship

(2013) Olesya S. Vishchuk et al.   FOOD CHEMISTRY

Fucoidan Derived from Undaria pinnatifida Induces Apoptosis in Human Hepatocellular Carcinoma SMMC-7721 Cells via the ROS-Mediated Mitochondrial Pathway

(2013) Lili Yang et al.   Marine Drugs

The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells

(2013) Hye-Jin Boo et al.   Marine Drugs

Anti-influenza A virus characteristics of a fucoidan from sporophyll of Undaria pinnatifida in mice with normal and compromised immunity

(2013) Kyoko Hayashi et al.   MICROBES AND INFECTION

Algal fucoidan, unlike heparin, has thrombolytic activity in a murine arterial thrombosis model

(2012) Soon-Ki Min et al.   BLOOD COAGULATION & FIBRINOLYSIS

Fabrication of electrospun biocomposites comprising polycaprolactone/fucoidan for tissue regeneration

(2012) Ji Seok Lee et al.   CARBOHYDRATE POLYMERS

Fucoidan regulate blood glucose homeostasis in C57BL/KSJ m+/+db and C57BL/KSJ db/db mice

(2012) Kui-Jin Kim et al.   FITOTERAPIA

Low molecular weight fucoidan from the sporophyll of Undaria pinnatifida suppresses inflammation by promoting the inhibition of mitogen-activated protein kinases and oxidative stress in RAW264.7 cells

(2012) Kui-Jin Kim et al.   FITOTERAPIA

Low molecular weight fucoidan ameliorating the chronic cisplatin-induced delayed gastrointestinal motility in rats

(2012) Moon Yong Song et al.   FOOD AND CHEMICAL TOXICOLOGY

Fucoidan extract derived from Undaria pinnatifida inhibits angiogenesis by human umbilical vein endothelial cells

(2012) Fang Liu et al.   PHYTOMEDICINE

Topical Application of Fucoidan Improves Atopic Dermatitis Symptoms in NC/Nga Mice

(2012) Jae-Ho Yang   PHYTOTHERAPY RESEARCH

Isolation and characterization of Microbulbifer species 6532A degrading seaweed thalli to single cell detritus particles

(2011) Masayuki Wakabayashi et al.   BIODEGRADATION

Sulfated polysaccharides from brown seaweeds Saccharina japonica and Undaria pinnatifida: isolation, structural characteristics, and antitumor activity

(2011) Olesya S. Vishchuk et al.   CARBOHYDRATE RESEARCH

An Antithrombotic Fucoidan, Unlike Heparin, Does Not Prolong Bleeding Time in a Murine Arterial Thrombosis Model: A Comparative Study of Undaria pinnatifida sporophylls and Fucus vesiculosus

(2011) Soon-Ki Min et al.   PHYTOTHERAPY RESEARCH

Fucoidan from Undaria pinnatifida Induces Apoptosis in A549 Human Lung Carcinoma Cells

(2011) Hye-Jin Boo et al.   PHYTOTHERAPY RESEARCH

Anticoagulating activities of low-molecular weight fuco-oligosaccharides prepared by enzymatic digestion of fucoidan from the sporophyll of Korean Undaria pinnatifida

(2010) Woo Jung Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Genotoxicity studies on fucoidan from Sporophyll of Undaria pinnatifida

(2010) Kui-Jin Kim et al.   FOOD AND CHEMICAL TOXICOLOGY

Relationship between Oversulfation and Conformation of Low and High Molecular Weight Fucoidans and Evaluation of Their in Vitro Anticancer Activity

(2010) Myoung Lae Cho et al.   MOLECULES

The differential effect of high and low molecular weight fucoidans on the severity of collagen-induced arthritis in mice

(2010) Seung-Beom Park et al.   PHYTOTHERAPY RESEARCH

Multiple Functionalities of Polyelectrolyte Multilayer Films: New Biomedical Applications

(2009) Thomas Boudou et al.   ADVANCED MATERIALS

Virucidal activity of polysaccharide extracts from four algal species against herpes simplex virus

(2009) Emma A. Harden et al.   ANTIVIRAL RESEARCH

Quantification and Localization of Fucoidan inLaminaria japonicaUsing a Novel Antibody

(2009) Masashi MIZUNO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Antioxidant activity of sulfated polysaccharide fractions extracted from Undaria pinnitafida in vitro

(2009) Tingting Hu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

A 4-week repeated oral dose toxicity study of fucoidan from the Sporophyll of Undaria pinnatifida in Sprague–Dawley rats

(2009) Kui-Jin Kim et al.   TOXICOLOGY

The effects of fucoidan extracts on CCl4-induced liver injury

(2008) Kum Suk Kang et al.   ARCHIVES OF PHARMACAL RESEARCH

Characterization of meFucoidan as a Selective Inhibitor for Secretory Phospholipase A2-IIA and the Phosphorylation of meFucoidan-Binding Proteins by A-Kinase in Vitro

(2008) Hiroko Maruyama et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Selenium nanoparticles fabricated in Undaria pinnatifida polysaccharide solutions induce mitochondria-mediated apoptosis in A375 human melanoma cells

(2008) Tianfeng Chen et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Focus on antivirally active sulfated polysaccharides: From structure–activity analysis to clinical evaluation

(2008) Tuhin Ghosh et al.   GLYCOBIOLOGY

Effects of molecular weight and hydrolysis conditions on anticancer activity of fucoidans from sporophyll of Undaria pinnatifida

(2008) Chen Yang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Elastin peptide receptor-directed monocyte chemotactic polysaccharides derived from seaweed sporophyll and from infectious fungus

(2008) Ying Li et al.   MICROBIAL PATHOGENESIS

Fucoidan: Structure and Bioactivity

(2008) Bo Li et al.   MOLECULES

Growth-inhibitory effect of a fucoidan from brown seaweed Undaria pinnatifida on Plasmodium parasites

(2008) Jun-Hu Chen et al.   PARASITOLOGY RESEARCH

Defensive effects of a fucoidan from brown alga Undaria pinnatifida against herpes simplex virus infection

(2007) Kyoko Hayashi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY