In situ polydopamine functionalized poly-L-lactic acid nanofibers with near-infrared-triggered antibacterial and reactive oxygen species scavenging capability

The development of a new multi-functional poly(L)-lactide (PLLA) nanofibrous scaffold with excellent antibacterial and reactive oxygen species (ROS) scavenging capability is quite important in tissue engineering. In this study, polydopamine (PDA)/PLLA nanofibers were prepared by combining electrospinning and post in-situ polymerization. The post in-situ polymerization of PDA on the PLLA nanofiber enable PDA uniformly distribute on PLLA nanofiber surface. PDA/PLLA nanofibrous composites also achieved stronger mechanical strength, hydrophilicity, good oxidation resistance and enhanced near-infrared photothermal effect. The near-infrared photothermal effect from PDA made the PDA/PLLA a good antibacterial material. The in vitro ROS scavenging ability of the PDA made PDA/PLLA be beneficial to damaged tissue repair. These results indicate that PDA/PLLA nanofibrous scaffold can be used as a tissue engineering scaffold material with versatile biomedical applications.

Automated summary

The development of a new multi-functional poly(L)-lactide (PLLA) nanofibrous scaffold with excellent antibacterial and reactive oxygen species (ROS) scavenging capability is crucial in tissue engineering. In this study, polydopamine (PDA)/PLLA nanofibers were successfully prepared using electrospinning and post in-situ polymerization techniques. The PDA/PLLA composite demonstrated enhanced mechanical strength, hydrophilicity, oxidation resistance, and near-infrared photothermal effect, making it a promising antibacterial material for tissue engineering applications. The in vitro ROS scavenging ability of PDA also suggests its potential for damaged tissue repair. These findings highlight the versatility and biomedical applications of the PDA/PLLA nanofibrous scaffold.