Article
Plant Sciences
Ahmad Abdollahi, Nader Farsad-Akhtar, Elham Mohajel Kazemi, Maryam Kolahi
Summary: Hypericum perforatum, commonly known as St. John's wort, is a leafy herb with various secondary metabolites that can be used for medicinal purposes. The effects of heavy metals and elicitors on the morphometric and biochemical properties of St. John's wort were studied using the Taguchi statistical method. The results showed that cadmium chloride and lead nitrate had negative effects, while salicylic acid compensated for these effects.
PHYSIOLOGY AND MOLECULAR BIOLOGY OF PLANTS
(2023)
Review
Pharmacology & Pharmacy
Gita Kholghi, Shirin Arjmandi-Rad, Mohammad-Reza Zarrindast, Salar Vaseghi
Summary: St. John's wort is a herbaceous plant with therapeutic effects on psychiatric and mood disorders. Its active components, hyperforin and hypericin, play a major role in these effects. Changes in neurotransmitter levels in depression are complex and St. John's wort has inconsistent effects on neurotransmitter levels. Glutamate and acetylcholine may be important neurotransmitters to study in future works, and the dualistic modulation on cholinergic signaling induced by St. John's wort is an interesting topic for future studies.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Meshari A. Alzahrani, Salman Bin Ofisan, Nasser I. Alshumaymiri, Muath Alghuwainem, Muath Altamimi, Ali Y. Alali, Muhammad Rabie, Ahmed K. Aboskena, Khalid Almaymuni, Raed Almannie, Saleh Binsaleh
Summary: This review assessed the effects of St. John's wort on male sexual and reproductive health. The studies found that St. John's wort may cause sexual dysfunction and reproductive toxicity, with potential adverse events. However, the safety and efficacy of St. John's wort in the treatment of human sexual and reproductive health remain unclear.
Review
Biochemistry & Molecular Biology
Alessandro Allegra, Alessandro Tonacci, Elvira Ventura Spagnolo, Caterina Musolino, Sebastiano Gangemi
Summary: Hypericum, widely used as a therapeutic cure for depression, skin wounds, and respiratory and inflammatory disorders, also demonstrates various biological actions such as anti-infective, anti-oxidant, and spasmolytic abilities. Recent studies have shown its potential in the treatment of pathological conditions like trigeminal neuralgia and cancer. In hematologic malignancies, Hypericum induces apoptosis in myeloid and lymphoid cells, and targets mediators of cell migration and angiogenesis. Furthermore, it downregulates proteins involved in leukemia cell resistance to chemotherapeutic agents, making it a potential candidate for tumor photodynamic therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Hematology
Zelal Adibelli, Ilayda Karacay, Murat Demir, Cevdet Duran
Summary: A patient developed acute kidney injury after ingesting Hypericum perforatum tea for sleep disorder remedy, leading to acute kidney failure and requiring hemodialysis. The patient recovered after 1 week and was discharged with normal kidney function, marking the first reported case of acute kidney failure caused by ingestion of Hypericum perforatum.
BLOOD PURIFICATION
(2022)
Article
Chemistry, Medicinal
Xuebing Zhao, Yi Guo, Qianqian Xu, Zhengyi Shi, Ming Xiang, Hua Li, Yanyan Wang, Changxing Qi, Yonghui Zhang
Summary: A pair of new terpenoid-based bicyclic dihydmpyran enantiomers, Hyperpyran A (1a/1b), were isolated from the aerial parts of Hypericum perforatum, and compound 1a exhibited a moderate promotion of glucose uptake activity in hepatocytes.
Article
Chemistry, Medicinal
Xuebing Zhao, Yi Guo, Qianqian Xu, Zhengyi Shi, Ming Xiang, Hua Li, Yanyan Wang, Changxing Qi, Yonghui Zhang
Summary: This study isolated a pair of new terpenoid-based bicyclic dihydmpyran enantiomers, (+/-)-Hyperpyran A, from Hypericum perforatum, with a proposed biosynthetic pathway and one of the compounds showing moderate promotion of glucose uptake activity in hepatocytes.
Article
Chemistry, Analytical
Lisa Wang, Afoke Ibi, Chuck Chang, Julia Solnier
Summary: St. John's Wort is a popular herb used to treat mood disorders and its potency can be determined using various analytical methods, with high performance liquid chromatography (HPLC) being the most widely used. This paper presents a modified HPLC method for determining the hypericin content in St. John's Wort products, which provides better resolution, shorter run time, and increased sustainability compared to the current method in the United States Pharmacopeia (USP). The proposed method, developed using ultra-high performance liquid chromatography (UHPLC), is more accurate and reliable for determining hypericin content in St. John's Wort.
Article
Medicine, General & Internal
Hantai Kim, Jungho Ha, Hun Yi Park, Yun-Hoon Choung, Jeong Hun Jang
Summary: This study investigated whether the co-administration of St. John's wort and Ginkgo biloba extracts can suppress tinnitus. The results showed that the combination did not improve the symptoms of subjective tinnitus compared to using Ginkgo biloba extract alone.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Hendrik Bussmann, Hanns Haberlein, Georg Boonen, Juergen Drewe, Veronika Butterweck, Sebastian Franken
Summary: This study found that the St. John's wort extract Ze 117 has an effect on the lateral mobility of SNAP-tagged beta 1-adrenergic receptors in the plasma membrane of C6 cells. Treatment with Ze 117 decreased the mobility of the receptors and increased receptor confinement. These findings suggest that Ze 117 may have therapeutic potential for depression.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Toxicology
Yiming Jiang, Yanying Zhou, Shaofei Song, Shicheng Fan, Yue Gao, Yuan Li, Min Huang, Huichang Bi
Summary: This study found that prolonged use of St. John's wort worsened acetaminophen-induced liver injury by promoting glutathione depletion and increasing the formation of acetaminophen metabolites. Additionally, St. John's wort increased the activity and expression levels of certain liver enzymes and activated signaling pathways associated with liver injury. These results suggest caution in the clinical use of St. John's wort and acetaminophen.
TOXICOLOGICAL SCIENCES
(2022)
Article
Chemistry, Physical
Meenakshi Dudi, Komal Sharma, Satish Kumar Pandey, S. K. Mehta
Summary: St. John's wort extract, a plant flowering species, has various biological activities such as antidepressant, anticancer, wound healing, antibiotic, antiviral, antioxidant, anxiolytic, and anti-inflammatory properties. A study has been conducted to improve the aqueous solubility and biological efficacy of the extract by preparing an inclusion complex with beta-cyclodextrin. The complex showed enhanced antioxidant activity, improved safety profile, and moderate antimicrobial activity.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Reproductive Biology
Wiebke Schafer, Nadine Wentzell, Tania Schink, Ulrike Haug
Summary: This study investigated the utilization of St. John's wort during pregnancy and found that babies exposed to St. John's wort during the first trimester had a slightly higher risk of major malformations compared to exposure in other trimesters.
REPRODUCTIVE TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Irene Scholz, Evangelia Liakoni, Felix Hammann, Katharina Elisabeth Grafinger, Urs Duthaler, Michael Nagler, Stephan Kraehenbuhl, Manuel Haschke
Summary: The study found that Hypericum perforatum extract induced CYP3A4 and P-gp activity, resulting in a decrease in rivaroxaban exposure and proportional decrease in pharmacodynamic effect. However, there were no clinically significant differences in peak concentration, time to peak concentration, and plasma elimination half-life of rivaroxaban.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Huayong Lou, Fengwei Ma, Ping Yi, Zhanxing Hu, Wei Gu, Liejun Huang, Wenwen He, Chunmao Yuan, Xiaojiang Hao
Summary: This study discovered bioactive polycyclic polyprenylated acylphloroglucinols (PPAPs) from St. John's wort, which showed significant neuroprotective effects against corticosterone-induced injury. A new PPAP with a unique core structure was identified, along with several known PPAPs, highlighting their potential value for the treatment of depression.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Agricultural Engineering
Jingmo Zhou, Shubin Wu, Ying Liu
Summary: Expenditure isolation of lignin and the understanding of its structural variations during different isolation processes are crucial for the high-value utilization of lignin. This study proposed a green deep eutectic solvent (DES) consisting of choline chloride, ethylene glycol, and 4-chlorobenzene sulfonic acid for rapid lignin separation from poplar. The structural variations of DES lignin and its relationship with alkali pre-extraction of hemicellulose were investigated. The results showed that alkali pretreatment enhanced the DES separation of lignin and promoted the cleavage of specific linkages, resulting in reduced molecular weight and thermal stability of isolated DES lignin. Moreover, DES lignin obtained from integrated utilization displayed higher purity and S/G ratio compared to lignin obtained from direct DES treatment.
INDUSTRIAL CROPS AND PRODUCTS
(2024)
Article
Agricultural Engineering
Yuping Li, Ziyan Xie, Yun Huang, Jiangyi Zeng, Chao Yang, Ling Yuan, Ying Wang, Yongqing Li
Summary: In this study, the characteristic flavonoids (CFs) of three licorice species were identified through integrated metabolic and transcriptomic analysis. The key regulators of CF biosynthesis were also identified. These findings provide valuable information for understanding the biosynthesis of CFs and future breeding of Glycyrrhiza varieties.
INDUSTRIAL CROPS AND PRODUCTS
(2024)
Article
Agricultural Engineering
Xianjie Pan, Zhaoyi Luo, Fanqi Liu, Quanqian Yi, Yanning Zeng
Summary: This study presents a novel strategy for fabricating fully bio-based epoxy vitrimers using peach gum and itaconic acid, which exhibit superior mechanical properties and thermostability. The materials were characterized and the self-healing and recycling capabilities were evaluated. The results demonstrate the potential of using these materials for sustainable industrial applications.
INDUSTRIAL CROPS AND PRODUCTS
(2024)
Article
Agricultural Engineering
Mohsen Sabzi-Nojadeh, Mohammad Pouresmaeil, Mina Amani, Mehdi Younessi-Hamzekhanlu, Filippo Maggi
Summary: This study shows that inoculating Summer savory plants with endophytic fungus Trichoderma harzianum can improve plant growth and increase salt tolerance. The fungus enhances growth, restores chlorophyll and antioxidant levels, reduces harmful substances, and increases proline and soluble sugar levels, thereby increasing crop productivity in saline conditions.
INDUSTRIAL CROPS AND PRODUCTS
(2024)
Article
Agricultural Engineering
Yu Liu, Lei Li, Aichen Zhao, Xiuming Song, Lulu Wei, Mengdi Fang, Chuchu Zheng, Xiaodong Zhu
Summary: This study investigates the impact of peppermint essential oil microcapsules on the unpleasant odor emissions from wax oil coated wood products. The results show that microcapsules can improve the time and stability of odor release.
INDUSTRIAL CROPS AND PRODUCTS
(2024)
Article
Agricultural Engineering
Mesut Budak, Mirac Kilic, Hikmet Guenal, Ismail Velik, Mesut Sirri
Summary: This study assessed land suitability for rapeseed production using topography, climate, and soil data by analytical hierarchy process (AHP) and the Mamdani Fuzzy Inference System (MFIS). The study area covered land in the Diyarbakir province of southeastern Turkiye. The results indicated the proportions of different land suitability classes and showed the compatibility of AHP and MFIS methods in assessing suitability.
INDUSTRIAL CROPS AND PRODUCTS
(2024)
Article
Agricultural Engineering
Rui Tian, Yue Liu, Chao Wang, Weikun Jiang, Srinivas Janaswamy, Guihua Yang, Xingxiang Ji, Gaojin Lyu
Summary: In this study, hollow and solid lignin nanoparticles were synthesized through self-assembly and their application in PVA nanocomposite films was investigated. The results showed that the presence of hollow lignin nanoparticles in the films resulted in a room-like network structure, while the solid lignin nanoparticles induced different structural changes. The inclusion of LNPs improved the mechanical properties of the films, and both types of LNPs exhibited good hydrophobicity.
INDUSTRIAL CROPS AND PRODUCTS
(2024)
Article
Agricultural Engineering
Marcos Vinicius Silva de Andrade, Simone Ribeiro Lucho, Renato Delmondez de Castro, Paulo Roberto Ribeiro
Summary: Stevia rebaudiana Bertoni, commonly known as stevia, is a widely cultivated shrub with highly sweetening metabolites. It has gained significant interest in the food and beverage industries due to its extremely sweet taste and various health benefits. Researchers are currently focused on studying biotechnological strategies to enhance the biosynthesis of stevia plant metabolites for improved cultivation and production.
INDUSTRIAL CROPS AND PRODUCTS
(2024)
Article
Agricultural Engineering
Eleonora Cintura, Paulina Faria, Luisa Molari, Luca Barbaresi, Dario D'Orazio, Lina Nunes
Summary: This study investigated the properties of Arundo donax as a building material and found that it has strong adaptability, high hygroscopicity, and unique sound absorption behavior. The mechanical tests also demonstrated the applicability of the Arundo donax-based composite. This opens up new possibilities for the further application of Arundo donax-based materials.
INDUSTRIAL CROPS AND PRODUCTS
(2024)
Article
Agricultural Engineering
Stiina Kotiranta, Juha-Matti Pihlava, Titta Kotilainen, Pauliina Palonen
Summary: The effect of light spectra, particularly far-red and short wavelength radiation, on the growth and secondary metabolites of cannabis is significant. Altering the R:FR ratio can increase the concentration and yield of secondary metabolites, while short wavelength radiation does not significantly affect plant morphology and secondary metabolite concentrations.
INDUSTRIAL CROPS AND PRODUCTS
(2024)
Article
Agricultural Engineering
Xuze Liu, Fangmin Liang, Jinyuan Cheng, Xuelian Zhou, Jia Wang, Guigan Fang, Kuizhong Shen, Xianzhi Meng, Chen Huang, Arthur J. Ragauskas
Summary: A novel Na2S-facilitated DES pretreatment method was proposed to fractionate moso bamboo, which achieved high lignin removal and preserved most cellulose and hemicellulose with excellent enzymatic digestibility.
INDUSTRIAL CROPS AND PRODUCTS
(2024)
Article
Agricultural Engineering
Zechun Ren, Xinyuan Zhou, Kejiao Ding, Tong Ji, Hao Sun, Xiang Chi, Yunzhao Wei, Min Xu
Summary: This study prepared a thermal/magnetic/light-triggered multi-stimuli responsive shape memory polymer composite with excellent properties by adding magnetic nanoparticles into a polyurethane composite. The composite showed high shape recovery rate, fast response behavior, and suitability for 3D printing. Controllable external stimuli allowed for dynamic, remote, and precise control of 4D transformations. This work is significant for the design of smart materials and devices.
INDUSTRIAL CROPS AND PRODUCTS
(2024)
Article
Agricultural Engineering
Yurany Camacho Ardila, Jaiver Efren Jaimes Figueroa, Maria Regina Wolf Maciel
Summary: The higher heating value (HHV) and elemental composition are important properties of biomass, and their prediction using proximate and ultimate analysis is accurate.
INDUSTRIAL CROPS AND PRODUCTS
(2024)
Article
Agricultural Engineering
Xiaohan Chen, Xianke Wang, Lili Shang, Xinxin Ma, Changhua Fang, Benhua Fei, Huanrong Liu, Shuqin Zhang
Summary: This study focuses on the comprehensive characterization of the three-dimensional (3D) structure of bamboo parenchyma and the evaluation of its tensile and compressive properties, as well as the analysis of its failure mechanisms. The study found that the measured tensile strength and elastic modulus of the parenchyma tissue are 48.81 MPa and 706.48 MPa, respectively. Compression failure modes in parenchyma tissue encompass compression bending and cell fracture, shear failure of the middle lamella, and detachment and debonding of the cell wall.
INDUSTRIAL CROPS AND PRODUCTS
(2024)
Article
Agricultural Engineering
Tianfeng Liu, Yuxin Liu, Yunlin Fu, Mengji Qiao, Penglian Wei, Zhigao Liu, Yingjian Li
Summary: This study explored the formation mechanism of agarwood induced by fungus and its potential application in high-quality and high-yielding agarwood production. The results showed that the transition layer played a critical role in the continuous accumulation of agarwood, and the parenchyma cells of the xylem rays and interxylary phloem were the main action site of fungus. The accumulation and distribution of chemical composition in different layers were also investigated. The study identified the drivers of specific compounds and provided a theoretical foundation for future agarwood production.
INDUSTRIAL CROPS AND PRODUCTS
(2024)