Article
Chemistry, Analytical
Tianyu Wang, Jianxing Feng, Hao Sun, Yanmin Liang, Ting Du, Jie Dan, Jianlong Wang, Wentao Zhang
Summary: CuBi bimetallic aerogels with different atomic ratios were synthesized and studied for their peroxidase (POD)-like activity. They were found to be a cheap alternative to equivalent noble metal materials for biosensor applications. A colorimetric method for the total antioxidant capacity (TAC) using ascorbic acid (AA) as a representative antioxidant model was developed.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Multidisciplinary
Kaiwei Wan, Bing Jiang, Ting Tan, Hui Wang, Minmin Liang
Summary: Fe3O4 nanoparticles exhibit peroxidase-like catalytic activity primarily due to complexed hydroxyl radicals and high-valent Fe(sic)O species under acid conditions. The enzyme-like activity of Fe3O4 NPs can be rationally regulated by modulating the size, surface structure, and valence of active metal atoms according to this newly proposed nanozyme catalytic mechanism.
Article
Polymer Science
Xiuqing Hou, Ruoxue Wang, Huijuan Zhang, Meng Zhang, Xiongwei Qu, Xiuli Hu
Summary: Developing sensitive and accurate sensing strategies for detecting H2O2 and glucose in biological systems is crucial. Biocompatible iron-coordinated L-lysine-based hydrogen peroxide (H2O2)-mimetic enzymes (Lys-Fe-NPs) were prepared by precipitation polymerization in aqueous solution. These enzymes showed great potential for colorimetric detection of H2O2 and glucose, with linear ranges and detection limits suitable for biorelevant assays.
Article
Chemistry, Multidisciplinary
Mohamad Zandieh, Juewen Liu
Summary: Nanozyme refers to various catalysts, including immobilized inorganic metal complexes, immobilized enzymes, and inorganic nanoparticles. This article provides a detailed history of nanozymes and categorizes them into two types. The definition of nanozymes is evolving and can cover most claimed nanozymes based on the same substrates and products as enzymes, although with different mechanisms. A broader definition can inspire application-based research using nanomaterials for analytical, environmental, and biomedical purposes. Understanding the catalytic mechanism of nanozymes is crucial for further engineering of active sites, and the future perspective of the nanozyme field is discussed.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Physical
Shan Wang, Zunfu Hu, Qiulian Wei, Huimin Zhang, Weina Tang, Yunqiang Sun, Haiqiang Duan, Zhichao Dai, Qingyun Liu, Xiuwen Zheng
Summary: In this study, atomically dispersed diatomic active sites nanozymes with enhanced peroxidase-like activity were successfully prepared, and the synergistic effect between Fe-Pt heteronuclear diatomic active sites was confirmed. The nanozymes showed a wide detection range and low detection limit for dopamine and hydrogen peroxide, and could be used for in-situ detection of intracellular hydrogen peroxide.
Article
Chemistry, Inorganic & Nuclear
Yangyang Chang, Qiaoshu Chen, Biwu Liu, Zijie Zhang, Meng Liu, Juewen Liu
Summary: Nanoparticles are discharged into aquatic environments, impacting health. Their behavior and toxicity are influenced by the composition of the aqueous system. Nanomaterials with enzyme-like activities, such as CeO2 and Fe3O4 nanoparticles, have significant catalytic activities influenced by adsorption of small molecules and polymers. Inorganic arsenic species play important roles in environmental and catalytic research, affecting the activity of nanomaterials and vice versa.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Engineering, Environmental
Yong Wang, Yue Ding, Yiyun Tan, Xiaohui Liu, Lixian Fu, Weixia Qing
Summary: Metal-based nanozymes, such as Ag-Fe3O4, are attractive alternatives to natural enzymes due to their stability and low cost. This study successfully constructed Ag-Fe3O4 nanozymes with high peroxidase-like activity and specificity, which showed improved performance compared to single Fe3O4 nanozymes. Furthermore, these nanozymes were used for sulfur ion detection and catalytic degradation of toxic dyes with high efficiency and reusability.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Chemistry, Analytical
Chenyu Zhou, Junyang Chen, Guannan Wang, Xingguang Su
Summary: Iron-cobalt oxide nanosheets (FeCo-ONSs) were found to have intrinsic peroxidase-like activity. The addition of heparin significantly enhanced the peroxidase-like activity of FeCo-ONSs towards 3,3,5,5-tetramethylbenzidine (TMB). However, the activity promotion was suppressed when protamine bound with heparin. The addition of trypsin hydrolyzed protamine and restored the catalytic activity enhancement effect of FeCo-ONSs. Based on these findings, a sensitive colorimetric platform for trypsin activity determination was developed.
Article
Chemistry, Physical
Jinghan Wang, Shanqing Gao, Xiao Wang, Haozhen Zhang, Xitong Ren, Juewen Liu, Feng Bai
Summary: Functional nanoparticles used as peroxidase-like catalysts have shown great potential in cancer therapy, particularly through their shape-dependent catalytic activities and accumulation at tumor sites. The manganese phthalocyanine nanocrystals synthesized in this study demonstrated high catalytic efficiency under acidic tumor-like microenvironments, leading to excellent anti-tumor effects with minimal damage to normal tissues, which highlights their promising application as nanozymes for catalytic tumor therapy.
Review
Chemistry, Multidisciplinary
Mohamad Zandieh, Juewen Liu
Summary: The article discusses the issue of calculating catalytic turnover rates of nanozymes, emphasizing that only surface atoms should be considered as active sites. Different types of nanozymes exhibit varying catalytic activity characteristics, which may be influenced by the adsorption of reaction products.
Article
Chemistry, Multidisciplinary
Yuhui Wang, Jiechen Yao, Zhanglei Cao, Pan Fu, Chen Deng, Shifeng Yan, Shuai Shi, Jianping Zheng
Summary: This study presents a new strategy for the design of antimicrobial nano-agents using Cu-doped CDs. The Cu-CDs showed superior antimicrobial activity by triggering oxidative stress and membrane disruption.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Chong-Bo Ma, Yaping Xu, Lixin Wu, Quan Wang, Jia-Jia Zheng, Guoxi Ren, Xiaoyu Wang, Xingfa Gao, Ming Zhou, Ming Wang, Hui Wei
Summary: This study presents a facile synthetic strategy for a dual single-atom nanozyme composed of zinc (Zn) and molybdenum (Mo). The nanozyme utilizes polyoxometalates and supramolecular coordination complexes as metal-atom precursors, and an amphiphilic aerogel as the supporting substrate. The dual single-atoms of Zn and Mo exhibit a synergistic effect and peroxidase-like activity. The nanozyme shows outstanding stability and is capable of detecting various analytes in different samples.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Materials Science, Multidisciplinary
Zehong Xiao, Kui Qu, Fan Ye, Jiangxin Zheng, Yimeng Wang, Hao Wang, Qingchi Xu, Jun Xu
Summary: In this study, single-atom Fe nanozymes supported on B-doped graphite carbon nitride (B-g-C3N4) were successfully synthesized and exhibited peroxidaselike activity in the presence of H2O2. The obtained catalyst also showed potential as a 3-minute colorimetric sensor for sulfide anion detection.
SCIENCE CHINA-MATERIALS
(2023)
Article
Chemistry, Analytical
Xiaoyi Xie, Xiaofang Chen, Yaohui Wang, Maosen Zhang, Yuxiu Fan, Xiupei Yang
Summary: This study developed a colorimetric sensor based on two-dimensional carbon nitride (CN)-supported Cu single-atom nanozymes (Cu/CN) for the quantitative analysis of tannic acid (TA). Cu/CN, synthesized by supramolecular preorganization and calcination, exhibited peroxidase-mimicking activity and excellent catalytic performance due to its ultrathin nanosheet structure and high density of Cu active sites (up to 14.3 wt%). The sensor demonstrated fast and sensitive quantification of TA in the range of 0.09-3.2 μM with a low detection limit of 30 nM. Furthermore, it was successfully applied to analyze TA in different varieties of tea samples. This work is of great importance for the design of nanozymes with high active site density and the analysis of TA in real environments.
Article
Chemistry, Analytical
Yanrong Miao, Mingyuan Xia, Chenyu Tao, Jiqing Zhang, Pengjuan Ni, Yuanyuan Jiang, Yizhong Lu
Summary: A colorimetric assay based on iron-doped carbon nitride and smartphone platform is developed for convenient detection of total antioxidant capacity (TAC). The peroxidase-like activity of carbon nitride is enhanced by introducing Fe atoms, and the assay is successfully applied to TAC detection of fruit juices and commercial beverages.
Review
Nanoscience & Nanotechnology
Anamika Kumari, Vibha Vyas, Santosh Kumar
Summary: This article is a review of the synthesis, characterization methods and applications of gold nanoparticles (Au-NPs) in fiber optic sensors. It analyzes the reported research work to understand the trends and gaps in developing plasmonic optical fiber sensors.
Article
Engineering, Electrical & Electronic
Azhar Shadab, Md Tauseef Iqbal Ansari, Sanjeev Kumar Raghuwanshi, Santosh Kumar
Summary: This experimental work demonstrates the use of reduced graphene oxide (rGO) coated on etched fiber Bragg grating (eFBG)-based sensors for smoke detection in coal mines. Lab experiments were conducted using combustible coal samples from different regions of coal mines in India. The results showed higher interaction between rGO and coal samples with higher carbon content. The sensor successfully detected smoke particles inside the smoke chamber, with a percent enhancement in the Bragg wavelength shifts of up to 34.74%.
IEEE SENSORS JOURNAL
(2023)
Article
Engineering, Electrical & Electronic
Pintu Gorai, Santosh Kumar, Carlos Marques, Prabhat K. Singh, Rajan Jha
Summary: Interferometry integrated with molecularly imprinting polymer (MIP) is an advanced futuristic approach for developing ultrasensitive and selective remote detection technology. By combining a concatenated microfiber interferometer and an artificial molecular receptor-based imprinting technique, a label-free, hypersensitive, online, and selective biodetection method has been developed. The imprinted polymer functionalized optical sensor exhibits high sensitivity and selectivity, paving a new path for selective biosensing, water quality monitoring, and environmental research applications.
IEEE SENSORS JOURNAL
(2023)
Review
Engineering, Electrical & Electronic
Shelma Cheeran Sajan, Anamika Singh, Prabhat Kumar Sharma, Santosh Kumar
Summary: Biosensors have revolutionized the detection of environmental risks and diagnosis of diseases. Optical biosensors, particularly integrated with silicon photonics technology, provide real-time monitoring, faster response, improved accuracy, and increased sensitivity for detecting cancer cells. This article explores the application of silicon photonics in cancer cell detection and compares different designs for biosensors.
IEEE SENSORS JOURNAL
(2023)
Review
Chemistry, Analytical
Baljinder Kaur, Santosh Kumar, Brajesh Kumar Kaushik
Summary: This review presents the progress made in the development of novel wearable optical sensors for vital health monitoring systems, including the details of different substrates, sensing platforms, and biofluids used for the detection of target molecules. Wearable technologies could increase the quality of health monitoring systems at a nominal cost and enable continuous and early disease diagnosis.
Review
Chemistry, Analytical
Santosh Kumar, Zhi Wang, Wen Zhang, Xuecheng Liu, Muyang Li, Guoru Li, Bingyuan Zhang, Ragini Singh
Summary: This article discusses optically active nanomaterials and their optical biosensing applications. Nanomaterials, including carbon-based, inorganic-based, organic-based, and composite-based nanomaterials, enhance sensitivity and biocompatibility in biosensing. These nanomaterials are extensively used in fiber optic biosensing to improve response time, detection limit, and specificity. The article provides valuable contemporary research and applications for researchers in nanomaterial-based optical sensing, along with outlining difficulties and future prospects in the field.
Article
Optics
Ipshitha Charles, Sandip Swarnakar, Geetha Rani Nalubolu, Venkatrao Palacharla, Santosh Kumar
Summary: This study proposes, designs, and simulates a unique plasmonic Y-shaped MIM waveguide based 2 x 1 multiplexer (MUX) structure utilizing opti-FDTD software. Two plasmonic Y-shaped waveguides are positioned facing one another inside a minimum wafer size of 6 μm x 3.5 μm in the 2 x 1 MUX configurations that is being described. The design parameters are adjusted until the plasmonic multiplexer performs as required under optimal conditions. Extinction ratio and insertion loss are two performance metrics calculated for performance analysis of the design, indicating the potential to be applied in plasmonic integrated circuits.
Article
Materials Science, Multidisciplinary
Mayank Srivastava, Bramha P. Pandey, Neha Mishra, Dharmendra Kumar, Vinay K. Tomar, Santosh Kumar
Summary: This paper investigates the electronic and optical properties of pristine and p-type doped WSSe monolayers through first-principles calculation. The results indicate that doping of p-type materials induces magnetic attributes and enhances light-absorbing capacity. The study concludes that boron-doped WSSe is more suitable for designing optoelectronic devices.
NANOMATERIALS AND ENERGY
(2023)
Article
Physics, Applied
Guoru Li, Ragini Singh, Jiajun Guo, Bingyuan Zhang, Santosh Kumar
Summary: We fabricated Nb2CTx-enhanced localized surface plasmon resonance (LSPR) sensors using double S-tapered fiber sensors functionalized with gold nanoparticles/graphene oxide/tyrosinase and gold nanoparticles/Nb2CTx/tyrosinase. The Nb2CTx-enhanced LSPR sensor showed superior performance due to the presence of surface functional groups and large specific surface area of Nb2CTx. Our work provides a research platform for improving the sensitivity of LSPR sensors.
APPLIED PHYSICS LETTERS
(2023)
Review
Engineering, Electrical & Electronic
Vivek Kumar Gupta, Kuldeep Choudhary, Santosh Kumar
Summary: This article summarizes the wide use of two-dimensional materials-based plasmonic sensors in various sensing applications, particularly in biosensors. These sensors offer label-free detection, cost-effectiveness, and real-time monitoring. The review also compares the sensitivity, detection range, and detection limit of these sensors based on different materials such as graphene, antimonene, phosphorene, blue phosphorous, molybdenum sulfide, molybdenum selenide, and tungsten selenide. These parameters play a crucial role in determining the accuracy and applicability of the sensors in health monitoring systems for desired results.
IEEE SENSORS JOURNAL
(2023)
Article
Computer Science, Hardware & Architecture
Mourina Ghosh, Pulak Mondal, Shekhar S. Borah, Santosh Kumar
Summary: This article proposes a resistorless electronically tunable grounded and floating memristor emulator based on current-mode building blocks. The proposed emulator shows robustness and maintains performance under non-ideal conditions such as temperature fluctuations and process corner variations. Layout and simulation using CADENCE environment validate the accuracy and stability of the emulator. The pinched hysteresis loop can reach up to 5 MHz, and the emulator maintains good performance in terms of speed and operating range. Binary frequency shift keying (BFSK) experiments have been conducted to validate its functionality in applications such as communication systems, analog computation, and neuromorphic and biological systems.
IEEE TRANSACTIONS ON COMPUTER-AIDED DESIGN OF INTEGRATED CIRCUITS AND SYSTEMS
(2023)
Article
Biochemical Research Methods
Yu Wang, Ragini Singh, Muyang Li, Rui Min, Qiang Wu, Brajesh Kumar Kaushik, Rajan Jha, Bingyuan Zhang, Santosh Kumar
Summary: The article presents the development of a hetro-core optical fiber sensor using localized surface plasmon resonance (LSPR) to detect cardiac troponin I (cTnI) solution. The sensor structure consists of a single-mode fiber - multimode fiber - single-mode fiber (SMS) structure, immobilized with gold and cerium oxide nanoparticles. The sensor has a linear range of 0-1000 ng/mL cTnI, a sensitivity of 3 pm/(ng/mL), and a detection limit of 108.15 ng/mL. It will be used in real-time to detect acute myocardial infarction (AMI).
IEEE TRANSACTIONS ON NANOBIOSCIENCE
(2023)
Article
Biophysics
Ragini Singh, Zhi Wang, Carlos Marques, Rui Min, Bingyuan Zhang, Santosh Kumar
Summary: A multi-layer material fiber structure biosensor has been developed to quantitatively determine the concentration of alanine aminotransferase (ALT) biomolecules ranging from 0 to 1000 IU/L. The sensor has the advantages of high sensitivity, good stability, fast detection, no electromagnetic interference, low cost, real-time monitoring, and biocompatibility.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Computer Science, Information Systems
Manoj Kumar, Syed Sadique Anwer Askari, Purnendu Shekhar Pandey, Yadvendra Singh, Rajesh Singh, Sanjeev Kumar Raghuwanshi, Gyanendra Kumar Singh, Santosh Kumar
Summary: An experimental investigation was conducted on Tin Oxide (SnO) film to analyze the impact of varying the oxygen ratio on its optical and electrical properties. Changes in the oxygen composition led to variations in the film's extinction coefficient and band gap. Additionally, density functional theory (DFT) was employed to study the film's optical properties, yielding similar trends to the experimental results. These findings demonstrate the potential use of SnO film as an absorber layer in opto-electronic sensor devices, particularly solar cells, and highlight the ability to tune its optoelectronic properties through adjustments in the oxygen mole fraction ratio. The study also obtained important electrical parameters such as Hall mobility, carrier concentration, and resistivity for SnO films with different Sn and O ratios, paving the way for a wide range of opto-electronic devices.
Article
Optics
Ragini Singh, Wen Zhang, Xuecheng Liu, Bingyuan Zhang, Santosh Kumar
Summary: In this study, a highly sensitive and selective method for detecting tyramine using localized surface plasmon resonance (LSPR) optical fiber-based sensor is proposed. The sensor is functionalized with MXene and gold nanoparticles to increase the surface area for enzyme immobilization and enhance the sensor performance. The results demonstrate that the developed sensor efficiently detects tyramine with high specificity due to the presence of the tyrosinase enzyme. Further studies reveal the stability, repeatability, and reusability of the proposed biosensor, with a detection limit of 6.96 μM and a sensitivity of 0.0385 nm/μM. Therefore, the optical fiber-based sensor has significant potential for detecting the presence of tyramine in various agricultural and food samples.
OPTICS AND LASER TECHNOLOGY
(2024)
