Journal
HUMAN MUTATION
Volume 43, Issue 11, Pages 1519-1530Publisher
WILEY
DOI: 10.1002/humu.24381
Keywords
cancer; molecular diagnostic testing; whole-genome sequencing
Categories
Ask authors/readers for more resources
Characterizing the genomic landscape of cancers has revolutionized the understanding of cancer biology and led to therapeutic advances and improved patient outcomes. However, the application of next-generation sequencing in the clinical laboratory has been limited until recent technological innovations and reductions in sequencing costs made tumor whole-genome sequencing as a practical clinical assay.
Characterizing the genomic landscape of cancers is a routine part of clinical care that began with the discovery of the Philadelphia chromosome and has since coevolved with genomic technologies. Genomic analysis of tumors at the nucleotide level using DNA sequencing has revolutionized the understanding of cancer biology and identified new molecular drivers of disease that have led to therapeutic advances and improved patient outcomes. However, the application of next-generation sequencing in the clinical laboratory has generally been limited until very recently to targeted analysis of selected genes. Recent technological innovations and reductions in sequencing costs are now able to deliver the long-promised goal of tumor whole-genome sequencing as a practical clinical assay.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available