Article
Medicine, General & Internal
Rihwa Choi, Wonseo Park, Gayoung Chun, Sang Gon Lee, Eun Hee Lee
Summary: Diminished ovarian reserve can be assessed using serum AMH and FSH tests. This study evaluated the prevalence of diminished ovarian reserve in a large population of reproductive-aged women in Korea using different cutoffs of AMH and FSH levels. The prevalence increased with age and was comparable to that in the USA. The study provides important knowledge for infertility support programs and the field of maternal aging.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Cong Zhang, Shi Song, Ming Yang, Liying Yan, Jie Qiao
Summary: Declining ovarian reserve, rather than age, is the main predictor for adverse assisted reproductive treatment outcomes in older women. Our study revealed that changes in oxygen metabolism in cumulus cells may interfere with their function of supporting oocytes. Assessing ovarian reserve status in elderly women at an early stage is crucial for guiding assisted reproductive treatments.
Article
Obstetrics & Gynecology
Margaret M. Hopeman, Katherine E. Cameron, Maureen Prewitt, Kurt Barnhart, Jill P. Ginsberg, Mary D. Sammel, Clarisa R. Gracia
Summary: This study developed a clinical predictive tool that accurately predicts the likelihood of diminished ovarian reserve in young cancer patients after chemotherapy using a multivariable logistic regression model. The tool provides useful information based on age, cancer type, exposure to an alkylating agent, and baseline AMH levels.
FERTILITY AND STERILITY
(2021)
Article
Obstetrics & Gynecology
Luxin Liu, Bing Cai, Xiubing Zhang, Jifan Tan, Jia Huang, Canquan Zhou
Summary: This study compared the gene expression profiles of cumulus granulosa cells in patients with diminished ovarian reserve and those with normal ovarian reserves. It identified IL1RL1, IL33, SFRP4, and S1PR1 as potential genes involved in the pathogenesis of diminished ovarian reserve.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Obstetrics & Gynecology
Xinmei Lu, Xiaolong Lv, Xi Dong, Yulin Li, Bongkoch Turathum, Suying Liu, Xuemei Wang, Huijuan Shi, Yubing Liu
Summary: This study reveals that the gene expression of cumulus cells (CCs) differs between young women with diminished ovarian reserve (DOR) and those of similar age with normal ovarian reserve (NOR). The de novo serine synthesis pathway (SSP) is found to be increased in the CCs of young women with DOR. This finding is significant for understanding the cause and mechanisms of ovarian hypofunction in young women.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
A. K. Knight, H. S. Hipp, S. Abhari, S. A. Gerkowicz, Q. S. Katler, L. J. McKenzie, W. Shang, A. K. Smith, J. B. Spencer
Summary: This study demonstrates that reproductive aging in granulosa cells is associated with markers of ovarian reserve, including levels of anti-Mullerian hormone, antral follicle count, oocyte yield and maturity, and the number of successfully fertilized embryos. These findings have potential clinical relevance in evaluating oocyte quantity and quality.
HUMAN REPRODUCTION
(2022)
Article
Genetics & Heredity
Blair R. McCallie, Mary Haywood, Michelle M. Denomme, Rachel Makloski, Jason C. Parks, Darren K. Griffin, William B. Schoolcraft, Mandy G. Katz-Jaffe
Summary: The study identified significant DNA variants associated with diminished ovarian reserve (DOR) in young women, particularly impacting the Glucocorticoid receptor signaling pathway. Further analysis revealed a cut-off at 31 years for distinguishing young DOR patients. Embryonic global methylome sequencing showed minimal methylation alterations in the DOR group, while RNA sequencing indicated no significant transcription changes between DOR blastocysts and controls.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Review
Geriatrics & Gerontology
Natalia Llarena, Christopher Hine
Summary: As delayed childbearing becomes more prevalent worldwide, understanding the biological basis and implications of age-related infertility has become increasingly important. Women aged 35 and older face significantly higher incidences of infertility, aneuploidy, and birth defects due to age-related declines in ovarian reserve and oocyte quality. Various pathways related to aging and nutrient-sensing in the mammalian ovary regulate primordial follicle maintenance and follicular growth, ultimately impacting reproductive longevity.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Obstetrics & Gynecology
Marcelle I. Cedars
Summary: This month's Views and Reviews focuses on individuals with low ovarian reserve and limited response to stimulation, providing insights into patient characterization and alternative management strategies.
FERTILITY AND STERILITY
(2022)
Article
Medicine, General & Internal
Lisa Boucret, Lea Tramon, Jeremie Riou, Veronique Ferre-L'Hotellier, Pierre-Emmanuel Bouet, Pascale May-Panloup
Summary: There is controversy regarding whether women with Diminished Ovarian Reserve (DOR) experience only a decrease in ovarian reserve or if oocyte and embryo quality are also impaired. This retrospective study found no significant association between DOR and morphokinetic parameters. Additionally, there was a slower embryo development in older women, although this difference was not statistically significant in multivariate analysis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Genetics & Heredity
Sibel Bulgurcuoglu Kuran, Ayse Altun, Burcin Karamustafaoglu Balci, Ilknur Keskin, Meryem Hocaoglu
Summary: This study investigated the expressions of caspase-3, cytochrome c, and Hsp70 in granulosa cells from women with normal ovarian reserve (NOR) and diminished ovarian reserve (DOR) undergoing intracytoplasmic sperm injection (ICSI). The results showed that COC score of 0 was associated with increased expression levels of apoptotic proteins and decreased expression levels of anti-apoptotic protein, as well as poor ICSI clinical outcomes in women with and without DOR.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Oncology
Luyan Shen, Li Zhou, Meihui Xia, Nan Lin, Jiaoyan Ma, Delu Dong, Liankun Sun
Summary: The study highlights the important role of mitochondria in ovarian cancer cells, particularly in cisplatin resistance. By regulating mitochondrial biogenesis and oxidative phosphorylation, cellular energy metabolism and apoptosis evasion can be influenced.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Geriatrics & Gerontology
Marcelo Borges Cavalcante, Olga Goiana Martins Sampaio, Fernanda Eunice Araujo Camara, Augusto Schneider, Bianca Machado de avila, Juliane Prosczek, Michal M. Masternak, Adriana Rolim Campos
Summary: Ovarian reserve refers to the total number of immature follicles in the ovaries. It decreases progressively from birth to menopause, with genetics being the main determinant. However, factors such as physical activity, diet, and lifestyle can also impact the age of menopause.
Article
Biochemistry & Molecular Biology
James T. Hagen, McLane M. Montgomery, Ericka M. Biagioni, Polina Krassovskaia, Filip Jevtovic, Daniel Shookster, Uma Sharma, Kang Tung, Nickolas T. Broskey, Linda May, Hu Huang, Jeffrey J. Brault, P. Darrell Neufer, Myles C. Cabot, Kelsey H. Fisher-Wellman
Summary: Chemoresistance is a complex process, and one common mechanism is the active efflux of chemotherapeutic drugs. This study investigates the role of ABC transporter protein ABCB1 in mitochondrial remodeling and mitochondrial respiratory kinetics in chemoresistant cells. The findings suggest that ABCB1 activity contributes to enhanced oxidative phosphorylation and mitochondrial content, and increased oxidative phosphorylation power output is associated with reduced tumorigenicity in the absence of chemotherapeutic stress.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2022)
Review
Genetics & Heredity
Zexu Jiao, Orhan Bukulmez
Summary: Diminished ovarian reserve (DOR) negatively affects patient outcomes in assisted reproductive technology treatment, prompting the need for alternative approaches to restore fertility. Various techniques such as mitochondrial transfer and activation of primordial follicles have been explored to improve oocyte quality and quantity in DOR patients.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Developmental Biology
Shun Zhang, Fenghua Lu, Qingyou Liu, Yubing Liu, Xiaomei Guan, Yingming Wei, Shijian Tan, Deshun Shi
REPRODUCTION FERTILITY AND DEVELOPMENT
(2016)
Article
Virology
Yuqi Huo, Wenhui Wang, Tong Ling, Xin Wan, Li Ding, Shuo Shen, Jinling Huo, Shanfeng Zhang, Mingchen Wang, Yumei Wang, Yubing Liu
Article
Cell & Tissue Engineering
Jeong-Yeh Yang, Jennifer L. Mumaw, Yubing Liu, Steve L. Stice, Franklin D. West
CELL TRANSPLANTATION
(2013)
Article
Cell & Tissue Engineering
Yubing Liu, Jeong Yeh Yang, Yangqing Lu, Ping Yu, C. Robert Dove, Jessica M. Hutcheson, Jennifer L. Mumaw, Steven L. Stice, Franklin D. West
CELLULAR REPROGRAMMING
(2013)
Article
Cell & Tissue Engineering
Ping Yu, Yangqing Lu, Brian J. Jordan, Yubing Liu, Jeong-Yeh Yang, Jessica M. Hutcheson, Christina L. Ethridge, Jennifer L. Mumaw, Holly A. Kinder, Robert B. Beckstead, Steven L. Stice, Franklin D. West
CELLULAR REPROGRAMMING
(2014)
Article
Engineering, Biomedical
Xinmei Lu, Yubing Liu, Xiang Cao, Su-Ying Liu, Xi Dong
LASERS IN MEDICAL SCIENCE
(2019)
Meeting Abstract
Obstetrics & Gynecology
Yubing Liu, Xinmei Lu, Xiaocan Lei, Richeng Chian
FERTILITY AND STERILITY
(2019)
Article
Obstetrics & Gynecology
Er-Meng Gao, Bongkoch Turathum, Ling Wang, Di Zhang, Yu-Bing Liu, Rong-Xin Tang, Ri-Cheng Chian
Summary: This study evaluated the differences in metabolites between cumulus cells (CCs) and mural granulosa cells (MGCs) from human preovulatory follicles. The metabolomics analysis revealed significantly different metabolites related to cholesterol transport, estradiol production, and antiapoptosis between CCs and MGCs. These differences may play a role in regulating oocyte maturation.
REPRODUCTIVE SCIENCES
(2022)
Letter
Biochemistry & Molecular Biology
Yubing Liu, Xinmei Lu, Min Ye, Ling Wang, Rongxin Tang, Zhiyong Yang, Bongkoch Turathum, Chenchen Liu, Yujing Xue, Menghua Wu, Yannan Yang, Ermeng Gao, Di Zhang, Feng Yang, Keh-Kooi Kee, Xingxu Huang, Guanglei Li, Ri-Cheng Chian
JOURNAL OF GENETICS AND GENOMICS
(2022)
Article
Endocrinology & Metabolism
Bongkoch Turathum, Er-Meng Gao, Khwanthana Grataitong, Yu-Bing Liu, Ling Wang, Xue Dai, Ri-Cheng Chian
Summary: We evaluated the metabolic profiles of cumulus cells and mural granulosa cells derived from women with endometriosis, and found differences in sphingolipid metabolites between the two cell types. These differences may be involved in the regulation of oocyte quality.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Genetics & Heredity
Bongkoch Turathum, Er-Meng Gao, Feng Yang, Yu-Bing Liu, Zhi-Yong Yang, Chen-Chen Liu, Yun-Jing Xue, Meng-Hua Wu, Ling Wang, Khwanthana Grataitong, Ri-Cheng Chian
Summary: Polycystic ovary syndrome (PCOS) is a complex endocrine disorder associated with metabolic abnormalities and female infertility. This study used a metabolomics approach to investigate changes in cumulus cells (CCs) and oocyte quality in women with PCOS. The results showed that women with PCOS had increased levels of pyroglutamic acid, glutamate, and phenylalanine, as well as decreased levels of Cys-Gly and N-acetyl-l-methionine in CCs. Gene expressions of OPLAH and GSS, involved in pyroglutamic acid and glutathione synthesis, respectively, were altered in women with PCOS. Furthermore, the expression of nuclear factor erythroid 2-related factor 2, related to oxidative stress resistance, was increased in women with PCOS. These findings suggest that the levels of pyroglutamic acid and reduced glutathione synthesis in CCs may be related to oocyte quality in women with PCOS.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Obstetrics & Gynecology
Yan-Nan Yang, Ling Wang, Yu-Bing Liu, Yun-Jing Xue, Chen-Chen Liu, Fei Shi, Xue Dai, Ri-Cheng Chian
Summary: The purpose of this study was to evaluate the sperm motility and DNA integrity at different temperatures to analyze whether the sperms are suitable for insemination of in vitro matured oocytes by intra-cytoplasmic sperm injection (ICSI) following density gradient centrifugation (DGC) and swim-up (SU) procedures. The combination of DGC and SU procedures significantly improved the sperm motility and DNA fragmentation index (DFI). Sperm samples incubated at 25 degrees C were found to be the most suitable for ICSI.
REPRODUCTIVE AND DEVELOPMENTAL MEDICINE
(2022)
Article
Andrology
Xin-Mei Lu, Yu-Bing Liu, Dou-Dou Zhang, Xiang Cao, Tian-Cheng Zhang, Miao Liu, Hui-Juan Shi, Xi Dong, Su-Ying Liu
Summary: This retrospective cohort study aimed to analyze the reproductive outcomes of couples undergoing in vitro fertilization (IVF) cycles and assess the influence of advanced paternal age. The study found that advanced paternal age did not significantly affect fertilization and high-quality embryo rates, but had a negative impact on pregnancy and implantation rates, especially in men over 40 years old. Additionally, the study found a significant increase in miscarriage rate in the 35-39-year-old age group. Therefore, paternal age is an important factor that influences the success rate of assisted reproductive technology.
ASIAN JOURNAL OF ANDROLOGY
(2023)
Article
Obstetrics & Gynecology
Xinmei Lu, Xiaolong Lv, Xi Dong, Yulin Li, Bongkoch Turathum, Suying Liu, Xuemei Wang, Huijuan Shi, Yubing Liu
Summary: This study reveals that the gene expression of cumulus cells (CCs) differs between young women with diminished ovarian reserve (DOR) and those of similar age with normal ovarian reserve (NOR). The de novo serine synthesis pathway (SSP) is found to be increased in the CCs of young women with DOR. This finding is significant for understanding the cause and mechanisms of ovarian hypofunction in young women.
HUMAN REPRODUCTION
(2023)