Acoustic ejection mass spectrometry: fundamentals and applications in high-throughput drug discovery

Ultra-High-Throughput Ambient MS: Direct Analysis at 22 Samples per Second by Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry

(2022) Andrew J. Radosevich et al.   ANALYTICAL CHEMISTRY

A Perspective on the Analytical Challenges Encountered in High-Throughput Experimentation

(2021) Rachel Grainger et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

High-Throughput Mass Spectrometry for Hit Identification: Current Landscape and Future Perspectives

(2021) David G. McLaren et al.   SLAS Discovery

High-Throughput Label-Free Biochemical Assays Using Infrared Matrix-Assisted Desorption Electrospray Ionization Mass Spectrometry

(2021) Fan Pu et al.   ANALYTICAL CHEMISTRY

Direct Analysis from Phase-Separated Liquid Samples using ADE-OPI-MS: Applicability to High-Throughput Screening for Inhibitors of Diacylglycerol Acyltransferase 2

(2021) Xiujuan Wen et al.   ANALYTICAL CHEMISTRY

Fluid Dynamics of the Open Port Interface for High-Speed Nanoliter Volume Sampling Mass Spectrometry

(2021) Chang Liu et al.   ANALYTICAL CHEMISTRY

Acoustic Ejection Mass Spectrometry for High-Throughput Analysis

(2021) Hui Zhang et al.   ANALYTICAL CHEMISTRY

Maintaining a High-Quality Screening Collection: The GSK Experience

(2021) Ruben Gomez-Sanchez et al.   SLAS Discovery

Acoustic Ejection Mass Spectrometry: A Fully Automatable Technology for High-Throughput Screening in Drug Discovery

(2021) Roman P. Simon et al.   SLAS Discovery

High-Throughput Analysis from Complex Matrices: Acoustic Ejection Mass Spectrometry from Phase-Separated Fluid Samples

(2021) Yuzhu Guo et al.   Metabolites

Mass spectrometry based approaches and strategies in bioanalysis for qualitative and quantitative analysis of pharmaceutically relevant molecules

(2021) Frank Klont et al.   Drug Discovery Today: Technologies

Advancing Liquid Atmospheric Pressure Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Toward Ultrahigh-Throughput Analysis

(2020) Henriette Krenkel et al.   ANALYTICAL CHEMISTRY

Ultra-High-Throughput Acoustic Droplet Ejection-Open Port Interface-Mass Spectrometry for Parallel Medicinal Chemistry

(2020) Kenneth J. DiRico et al.   ACS Medicinal Chemistry Letters

Current status and future directions of high-throughput ADME screening in drug discovery

(2020) Wilson Z. Shou   Journal of Pharmaceutical Analysis

Coupling droplet microfluidics with mass spectrometry for ultra-high-throughput analysis of complex mixtures up to and above 30Hz.

(2020) Emily E. Kempa et al.   ANALYTICAL CHEMISTRY

Ultrahigh-Throughput ESI-MS: Sampling pushed to six Samples per Second by Acoustic Ejection Mass Spectrometry

(2020) Tim Häbe et al.   ANALYTICAL CHEMISTRY

High Throughput Label‐Free Enzymatic Assays using Desorption Electrospray Ionization Mass Spectrometry

(2020) R Graham Cooks et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Acoustic Droplet Ejection and Open Port Interface for Rapid Analysis of Metabolic Stability Assays

(2020) Tom Hollenbeck et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Application of 3D printed tools for customized open port probe-electrospray mass spectrometry

(2020) Piotr Sosnowski et al.   TALANTA

Operational Modes and Speed Considerations of an Acoustic Droplet Dispenser for Mass Spectrometry

(2020) Chang Liu et al.   ANALYTICAL CHEMISTRY

Ultrahigh-Throughput and Chromatography-Free Bioanalysis of Polar Analytes with Acoustic Ejection Mass Spectrometry

(2020) Andrew Wagner et al.   ANALYTICAL CHEMISTRY

Acoustic Mist Ionization-Mass Spectrometry: A Comparison to Conventional High-Throughput Screening and Compound Profiling Platforms

(2020) Arseniy M. Belov et al.   ANALYTICAL CHEMISTRY

Emerging Chromatography-Free High-Throughput Mass Spectrometry Technologies for Generating Hits and Leads

(2020) Fan Pu et al.   ACS Medicinal Chemistry Letters

Acoustic Ejection/Full-Scan Mass Spectrometry Analysis for High-Throughput Compound Quality Control

(2020) Jun Zhang et al.   SLAS Technology

Direct Coupling of Dispersive Extractions with Magnetic Particles to Mass Spectrometry via Microfluidic Open Interface

(2019) Marcos Tascon et al.   ANALYTICAL CHEMISTRY

Acoustic Mist Ionization Platform for Direct and Contactless Ultrahigh-Throughput Mass Spectrometry Analysis of Liquid Samples

(2019) Ian Sinclair et al.   ANALYTICAL CHEMISTRY

RapidFire BLAZE-Mode Is Boosting ESI-MS Toward High-Throughput-Screening

(2019) Tom Bretschneider et al.   SLAS Technology

High-Throughput Nanoelectrospray Ionization-Mass Spectrometry Analysis of Microfluidic Droplet Samples

(2019) Daniel J. Steyer et al.   ANALYTICAL CHEMISTRY

Rapid MALDI-TOF Molecular Imaging: Instrument Enhancements & Their Practical Consequences

(2019) Marvin Vestal et al.   JOURNAL OF MASS SPECTROMETRY

High-throughput mapping of CoA metabolites by SAMDI-MS to optimize the cell-free biosynthesis of HMG-CoA

(2019) Patrick T. O’Kane et al.   Science Advances

Absolute quantitative imaging of sphingolipids in brain tissue by exhaustive liquid microjunction surface sampling–liquid chromatography–mass spectrometry

(2019) Qian Wu et al.   JOURNAL OF CHROMATOGRAPHY A

High-Throughput Bioassays using “Dip-and-Go” Multiplexed Electrospray Mass Spectrometry

(2019) Zhenwei Wei et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development of a Microfluidic Open Interface with Flow Isolated Desorption Volume for the Direct Coupling of SPME Devices to Mass Spectrometry

(2018) Marcos Tascon et al.   ANALYTICAL CHEMISTRY

Solvent effects on differentiation of mouse brain tissue using laser microdissection ‘cut and drop’ sampling with direct mass spectral analysis

(2018) John F. Cahill et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Automated MALDI Target Preparation Concept: Providing Ultra-High-Throughput Mass Spectrometry–Based Screening for Drug Discovery

(2018) Martin Winter et al.   SLAS Technology

Gas-Phase Stability of Negatively Charged Organophosphate Metabolites Produced by Electrospray Ionization and Matrix-Assisted Laser Desorption/Ionization

(2017) Daiki Asakawa et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Use of an Open Port Sampling Interface Coupled to Electrospray Ionization for the On-Line Analysis of Organic Aerosol Particles

(2017) Kenneth D. Swanson et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Rapid sample classification using an open port sampling interface coupled with liquid introduction atmospheric pressure ionization mass spectrometry

(2017) Gary J. Van Berkel et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Development of a high-performance, enterprise-level, multimode LC–MS/MS autosampler for drug discovery

(2017) Brendon Kapinos et al.   Bioanalysis

Immediate drop on demand technology (I-DOT) coupled with mass spectrometry via an open port sampling interface

(2017) Gary J Van Berkel et al.   Bioanalysis

Online, Absolute Quantitation of Propranolol from Spatially Distinct 20- and 40-μm Dissections of Brain, Liver, and Kidney Thin Tissue Sections by Laser Microdissection–Liquid Vortex Capture–Mass Spectrometry

(2016) John F. Cahill et al.   ANALYTICAL CHEMISTRY

Laser dissection sampling modes for direct mass spectral analysis

(2016) John F. Cahill et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Characterization and Application of a Hybrid Optical Microscopy/Laser Ablation Liquid Vortex Capture/Electrospray Ionization System for Mass Spectrometry Imaging with Sub-micrometer Spatial Resolution

(2015) John F. Cahill et al.   ANALYTICAL CHEMISTRY

Mass spectrometry imaging of levofloxacin distribution in TB-infected pulmonary lesions by MALDI-MSI and continuous liquid microjunction surface sampling

(2015) Brendan Prideaux et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Differential mobility spectrometry/mass spectrometry history, theory, design optimization, simulations, and applications

(2015) Bradley B. Schneider et al.   MASS SPECTROMETRY REVIEWS

An open port sampling interface for liquid introduction atmospheric pressure ionization mass spectrometry

(2015) Gary J. Van Berkel et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Transmission geometry laser ablation into a non-contact liquid vortex capture probe for mass spectrometry imaging

(2014) Olga S. Ovchinnikova et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

A high-speed liquid chromatography/tandem mass spectrometry platform using multiplexed multiple-injection chromatography controlled by single software and its application in discovery ADME screening

(2013) Jun Zhang et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

LC-ESI-MS/MS Analysis of Testosterone at Sub-Picogram Levels Using a Novel Derivatization Reagent

(2012) Michal Star-Weinstock et al.   ANALYTICAL CHEMISTRY

Targeted Data Extraction of the MS/MS Spectra Generated by Data-independent Acquisition: A New Concept for Consistent and Accurate Proteome Analysis

(2012) Ludovic C. Gillet et al.   MOLECULAR & CELLULAR PROTEOMICS

Development of a high-speed, multiplexed sample-delivery instrument for LC–MS/MS bioanalysis

(2012) John Janiszewski et al.   Bioanalysis

An integrated platform for fully automated high-throughput LC–MS/MS analysis of in vitro metabolic stability assay samples

(2010) Andreas H. Luippold et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Bioanalysis without Sample Cleanup or Chromatography: The Evaluation and Initial Implementation of Direct Analysis in Real Time Ionization Mass Spectrometry for the Quantification of Drugs in Biological Matrixes

(2008) Shaoxia Yu et al.   ANALYTICAL CHEMISTRY

Liquid microjunction surface sampling probe electrospray mass spectrometry for detection of drugs and metabolites in thin tissue sections

(2007) Gary J. Van Berkel et al.   JOURNAL OF MASS SPECTROMETRY