Article
Psychiatry
Chih-Ken Chen, Shu-Yu Yang, Seon-Cheol Park, Ok-Jin Jang, Xiaomin Zhu, Yu-Tao Xiang, Wen-Chen Ouyang, Afzal Javed, M. Nasar Sayeed Khan, Sandeep Grover, Ajit Avasthi, Roy Abraham Kallivayalil, Kok Yoon Chee, Norliza Chemi, Takahiro A. Kato, Kohei Hayakawa, Pornjira Pariwatcharakul, Margarita Maramis, Lakmi Seneviratne, Kang Sim, Wai Kwong Tang, Tin Oo, Norman Sartorius, Chay-Hoon Tan, Mian-Yoon Chong, Yong Chon Park, Naotaka Shinfuku, Shih-Ku Lin
Summary: This study investigated the distribution of mood stabilizer prescriptions for different psychiatric diagnoses in 10 Asian countries and found that mood stabilizers are commonly prescribed for conditions other than bipolar disorder, with schizophrenia and other non-mood psychotic disorders being the most common diagnosis. Valproic acid was the most frequently used medication.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Clinical Neurology
Jonne Lintunen, Markku Lahteenvuo, Antti Tanskanen, Jari Tiihonen, Heidi Taipale
Summary: This study investigated the prevalence of primary non-adherence to medication and its associated factors in patients with bipolar disorder in Finland. The majority of patients did not adhere to their prescribed medications, with factors such as young age, recent diagnosis of bipolar disorder, multiple hospitalizations, and use of benzodiazepines or antidepressants being associated with an increased risk of non-adherence.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Sandeep Grover, Ajit Avasthi, Rahul Chakravarty, Amitava Dan, Kaustav Chakraborty, Rajarshi Neogi, Avinash Desouza, Omkar Nayak, Samir Kumar Praharaj, Vikas Menon, Raman Deep, Manish Bathla, Alka A. Subramanyam, Naresh Nebhinani, Prosenjit Ghosh, Bhavesh Lakdawala, Ranjan Bhattacharya, AbMajid Gania
Summary: The study evaluated the prescription pattern of patients with BD in clinical remission, with almost all participants receiving medications. There was variation in prescription patterns across different centres, including monotherapy, polypharmacy, and use of preferred mood stabilizers, antipsychotics, and antidepressants.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Psychiatry
R. Ogulcan Ciray, Eren Halac, Serkan Turan, Mustafa Tuncturk, Mutlu Ozbek, Cagatay Ermis
Summary: Analysis of the FAERS database revealed that SSRI drugs are associated with a higher risk of inducing mania in patients with bipolar disorder, with fluvoxamine showing the largest effect size. Significant effects were found for Ki values of H1 and M1 receptors, while receptor occupancy did not appear to have an effect. Further pharmacological data and clinical assessments are needed to validate these findings.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Review
Neurosciences
Janusz K. Rybakowski
Summary: The narrative review focuses on mood stabilizers. It provides the author's definition of mood-stabilizing drugs and describes the two generations of drugs that meet this definition. The article presents the clinical experiences with first and second-generation mood stabilizers and discusses their use in preventing recurrences of bipolar mood disorder.
Article
Pharmacology & Pharmacy
Marcin Siwek, Aleksandra Gorostowicz, Magdalena Bosak, Dominika Dudek
Summary: Epilepsy and depression often coexist, and there is a bidirectional relationship between the two disorders. However, current evidence on the effectiveness of antidepressant therapy in patients with epilepsy and comorbid depression is limited. Vortioxetine, a multimodal antidepressant, shows promise as a treatment option for depressed patients with cognitive dysfunctions, anhedonia, and anxiety.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Psychiatry
Chu-Chun Lin, Ling-Ling Yeh, Yi-Ju Pan
Summary: The study found that mood stabilizers are associated with a decreased overall mortality in patients with bipolar disorder, while the use of antipsychotics appears to be associated with an increased mortality risk, with the risk increasing with dosage. Researchers suggest carefully considering potential adverse effects and benefits when prescribing psychotropic medications for long-term use in bipolar disorder patients.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Letter
Clinical Neurology
Precious Obehi Eseaton, Adeolu Funso Oladunjoye, Gibson Anugwom, Henry Onyeaka, Ehizogie Edigin, Kenneth Osiezagha
Summary: This study provides insights into the common reasons and baseline characteristics of emergency department visits of patients with bipolar disorder in the United States. Mental disorders such as bipolar disorder, suicidal ideation, and anxiety disorders were found to be the most common specific psychiatric reasons for emergency department visits among patients with bipolar disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Masataka Shinozaki, Norio Yasui-Furukori, Naoto Adachi, Hitoshi Ueda, Seiji Hongo, Takaharu Azekawa, Yukihisa Kubota, Eiichi Katsumoto, Koji Edagawa, Eiichiro Goto, Kazuhira Miki, Masaki Kato, Atsuo Nakagawa, Toshiaki Kikuchi, Takashi Tsuboi, Koichiro Watanabe, Kazutaka Shimoda, Reiji Yoshimura
Summary: The study found significant differences in the prescription rates of mood stabilizers, antipsychotics, and antidepressants between patients with BD-I and BD-II. BD-I patients were more commonly prescribed mood stabilizers and antipsychotics, while BD-II patients were more commonly prescribed antidepressants.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Clinical Neurology
Balwinder K. Singh, Anastasia Yocum, Rebecca E. Strawbridge, Katherine E. Burdick, Caitlin T. Millett, Amy H. Peters, Sarah Sperry, Giovanna Fico, Eduard Vieta, Norma Verdolini, Ophelia Godin, Marion Leboyer, Etain F. Bruno, Ivy J. Tso, Brandon G. Coombes, Melvin A. McInnis, Andrew H. Nierenberg, Allan M. Young, Melanie Ashton, Michael J. Berk, Lana Williams, Kamyar N. Keramatian, Lakshmi J. Yatham, Bronwyn M. Overs, Janice Fullerton, Gloria B. Roberts, Philip A. Mitchell, Ole C. Andreassen, Ana P. Andreazza, Peter Zandi, Daniel M. Pham, Joanna A. Biernacka, Mark Frye, FACE BD Collaborators, Global Bipolar Cohort Collaborativ
Summary: This study investigated pharmacotherapeutic treatment patterns in multiple cohorts of individuals with bipolar disorder (BD) in North America, Europe, and Australia. Mood-stabilizing anticonvulsants, second-generation antipsychotics, and antidepressants were the most commonly prescribed medications. There were significant differences in prescription practices among different geographic regions.
Review
Neurosciences
Gianluca Sesso, Giulio Emilio Brancati, Gabriele Masi
Summary: This review explores the clinical and treatment implications of comorbidities in Bipolar Disorder (BD). It emphasizes the complexity of these comorbid conditions and the need for personalized therapies. Pharmacological treatments can improve symptoms but may also worsen BD by inducing mood switches.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Neurosciences
Tyra Lagerberg, Seena Fazel, Arvid Sjoelander, Clara Hellner, Paul Lichtenstein, Zheng Chang
Summary: Using nationwide Swedish registers, researchers found that SSRI treatment did not increase the risk of suicidal behavior, but may actually reduce it. The risk of suicidal behavior decreased over time after SSRI treatment initiation, across different age groups and history of suicide attempts. Further research with different study designs and populations is warranted to confirm these findings.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychiatry
Pao-Huan Chen, Shang-Ying Tsai, Po-Yu Chen, Chun-Hung Pan, Sheng-Siang Su, Chiao-Chicy Chen, Chian-Jue Kuo
Summary: This study evaluated the association between the use of mood stabilizers and the risks of mortality in people with bipolar disorder. The results showed that the use of mood stabilizers was significantly associated with decreased risks of all-cause mortality, suicide, and natural mortality, with lithium associated with the lowest risk.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Clinical Neurology
Kelly A. Ryan, Peisong Han, Yuhua Zhang, David F. Marshall, Anastasia K. Yocum, Melvin G. McInnis, Sebastian Zollner
Summary: Individuals with bipolar disorder tend to have higher neuroticism and lower extraversion and consciousness compared to healthy controls. Personality traits show only small changes over time, with neuroticism being the only trait associated with changes in mood state. Other factors beyond mood changes may influence changes in personality traits.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Jian-An Su, Chih-Cheng Chang, Yao-Hsu Yang, Chuan-pin Lee, Ko-Jung Chen, Chung-Ying Lin
Summary: In this study, the effects of antidepressant use and underlying depression on pregnancy and neonatal complications were evaluated separately, considering confounding factors. The results showed that mothers with depression but no antidepressant use had increased risks of intrauterine growth restriction and preterm delivery compared to those without depression. Antidepressant use during pregnancy increased the risks of gestational diabetes, malpresentation, preterm delivery, cardiovascular anomalies, anemia, low Apgar score, preterm delivery, and genitourinary defects. However, the use of antidepressants before and during pregnancy did not increase the risk of stillbirth. Therefore, physicians should consider the risks and benefits to both the mother and fetus when treating depression during pregnancy with antidepressants.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Psychology, Clinical
Christy Lai Ming Hui, Andreas Kar Hin Wong, Elise Chun Ning Ho, Bertha Sze Ting Lam, Priscilla Wing Man Hui, Tiffany Junchen Tao, Wing Chung Chang, Sherry Kit Wa Chan, Edwin Ho Ming Lee, Yi Nam Suen, May Mei Ling Lam, Cindy Pui Yu Chiu, Frendi Wing Sai Li, Kwok Fai Leung, Sarah M. McGhee, Chi Wing Law, Dicky Wai Sau Chung, Wai Song Yeung, Michael Gar Chung Yiu, Edwin Pui Fai Pang, Steve Tso, Simon Sai Yu Lui, Se Fong Hung, Wing King Lee, Ka Chee Yip, Ka Lik Kwan, Roger Man Kin Ng, Pak Chung Sham, William G. Honer, Eric Yu Hai Chen
Summary: Specialized early intervention treatment should be provided for at least the initial 2 years for adult-onset psychosis patients aged 26-55. Further treatment up to 4 years confers little benefits in this age range over the course of the study.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Stephanie M. Y. Wong, Charlie H. Ip, Christy L. M. Hui, Y. N. Suen, Corine S. M. Wong, W. C. Chang, Sherry K. W. Chan, Edwin H. M. Lee, Simon S. Y. Lui, K. T. Chan, Michael T. H. Wong, Eric Y. H. Chen
Summary: This study examined suicidal ideation and behaviors among young people in Hong Kong and identified factors associated with these behaviors. The results showed that suicide-related rumination was the only factor associated with all four suicidal outcomes. The study also found that external factors such as COVID-19 stressors, poor family functioning, and personal life stressors were specifically associated with suicide attempts.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Chun Hung, Joe Kwun Nam Chan, Corine Sau Man Wong, Vivian Shi Cheng Fung, Krystal Chi Kei Lee, Wing Chung Chang
Summary: This study aimed to examine antidepressant prescribing practice among Chinese pregnant women in Hong Kong. Results showed an increasing trend of prenatal antidepressant use over time, and half of the pregnant women discontinued antidepressants within 3 months before or after conception. Factors such as age, delivery year, pre-existing depression/anxiety disorders, and previous psychotropic medication use were associated with antidepressant continuation.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Clinical Neurology
Christy Lai-Ming Hui, Stephanie Ming-Yin Wong, Terrence Yat-To Yu, Terry Tak-Yee Lau, Olivia Choi, Samantha Tsang, Yi-Nam Suen, Bess Yin-Hung Lam, Corine Sau-Man Wong, Simon Sai-Yu Lui, Kai-Tai Chan, Michael Tak-Hing Wong, Gloria Hoi-Yan Wong, Sherry Kit-Wa Chan, Edwin Ho-Ming Lee, Wing-Chung Chang, Arnold Wilkins, Eric Yu-Hai Chen
Summary: Visual stress is associated with symptoms of depression and anxiety and may be an important predictor of poor mental health outcomes.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Clinical Neurology
Jenny Wai Yiu Law, Joe Kwun Nam Chan, Corine Sau Man Wong, Eric Yu Hai Chen, Wing Chung Chang
Summary: Despite the lack of research on prenatal antipsychotic prescribing practices for psychotic disorders, this population-based cohort study in Hong Kong found that 65% of women with psychotic disorders redeemed at least one prescription for antipsychotics during pregnancy. Older age at conception and antipsychotic treatment within 12 months pre-pregnancy were significantly associated with prenatal antipsychotic use. The study also revealed that second-generation antipsychotic use during pregnancy increased over the 16-year study period, while prenatal first-generation antipsychotic use showed a declining trend.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Psychiatry
Nicholas Chak Lam Yung, Corine Sau Man Wong, Joe Kwun Nam Chan, Wing Chung Chang
Summary: This study found a high mortality rate among early-stage schizophrenia patients, especially in the first year after diagnosis and shortly after discharge. Inpatient-diagnosed patients had significantly higher all-cause and unnatural-cause mortality rates within the first 3 years of treatment compared to outpatient-diagnosed patients. The study highlights the urgent need for targeted early intervention to prevent suicide and improve physical health in this population.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Corine Sau-Man Wong, Christy Lai-Ming Hui, Yi-Nam Suen, Stephanie Ming-Yin Wong, Wing-Chung Chang, Sherry Kit-Wa Chan, Edwin Ho-Ming Lee, Simon Sai-Yu Lui, Kai-Tai Chan, Michael Tak-Hing Wong, Eric Yu-Hai Chen
Summary: The Hong Kong Youth Epidemiological Study of Mental Health (HK-YES) aims to provide the first representative data on the prevalence and correlates of mental disorders among young people in Hong Kong. It will also examine help-seeking behaviors, treatment rates, quality of life, and functional outcomes. Additionally, the study will estimate the economic costs of mental disorders in youths.
EARLY INTERVENTION IN PSYCHIATRY
(2023)
Correction
Psychiatry
Wesley Chor-yin Tang, Corine Sau-man Wong, Ting-yat Wong, Christy Lai-ming Hui, Stephanie Ming -yin Wong, Yi-nam Suen, Sherry Kit-wa Chan, Wing-chung Chang, Edwin Ho-ming Lee, Simon Sai-yu Lui, Kai -tai Chan, Michael Tak-hing Wong, Inez Myin-Germeys, Eric Yu-hai Chen
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Clinical Neurology
Heidi Ka Ying Lo, Gabbie Hou Sem Wong, Joe Kwun Nam Chan, Corine Sau Man Wong, Janet Hiu Ching Lei, Yuen Kiu So, Vivian Shi Cheng Fung, Ryan Sai Ting Chu, Albert Kar Kin Chung, Krystal Chi Kei Lee, Calvin Pak Wing Cheng, Wai Chi Chan, Wing Chung Chang
Summary: This study found a relationship between persistent thinking about COVID-19 and depression, and identified the moderating effects of resilience, loneliness, and coping strategies. The findings suggest that enhancing personal resilience and social support, and adopting emotion-focused coping can mitigate the negative impact of COVID-19 related maladaptive thinking on depression severity.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Vivian Shi Cheng Fung, Joseph Ching Yui Chan, Sandra Chi Yiu Wong, Corine Sau Man Wong, Olivia Kirtley, Inez Myin-Germeys, Gregory P. Strauss, Wing Chung Chang
Summary: Negative symptoms in early psychosis are not associated with blunted affective experiences, anhedonia or asociality, according to a study using an experience-sampling methodology. The study found higher intensity and variability of negative affect in patients compared to controls, but no group differences in affect instability or positive affect. Patients also had a preference for company when alone and a preference for being alone when with others. Future research combining experience-sampling methodology with other measures will provide a more refined assessment of negative symptoms in daily life.
PSYCHIATRY RESEARCH
(2023)
Article
Clinical Neurology
Hannah Meijs, Helena Voetterl, Alexander T. Sack, Hanneke van Dijk, Bieke De Wilde, Jan Van Hecke, Peter Niemegeers, Evian Gordon, Jurjen J. Luykx, Martijn Arns
Summary: This study used a polygenic score (PGS) and electroencephalography (EEG) data analysis to identify potential predictors for treatment outcomes in major depressive disorder (MDD). The results suggest the existence of a stable EEG network related to antidepressant-response that has potential as a predictor for MDD treatment, particularly in the case of venlafaxine.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2024)