A platform for the rapid synthesis of proteolysis targeting chimeras (Rapid-TAC) under miniaturized conditions

Targeted protein degraders crowd into the clinic

(2021) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Strategies toward Discovery of Potent and Orally Bioavailable Proteolysis Targeting Chimera Degraders of Androgen Receptor for the Treatment of Prostate Cancer

(2021) Xin Han et al.   JOURNAL OF MEDICINAL CHEMISTRY

Two-Stage Strategy for Development of Proteolysis Targeting Chimeras and its Application for Estrogen Receptor Degraders

(2020) Brett L. Roberts et al.   ACS Chemical Biology

Prey for the Proteasome: Targeted Protein Degradation – A Medicinal Chemist´s Perspective

(2020) Laura M. Luh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent Progress in PROTACs and Other Chemical Protein Degradation Technologies for the Treatment of Neurodegenerative Disorders

(2020) Shusuke Tomoshige et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemoselective Synthesis of Lenalidomide-Based PROTAC Library Using Alkylation Reaction

(2019) Xing Qiu et al.   ORGANIC LETTERS

Chemoselective Peptide Cyclization and Bicyclization Directly on Unprotected Peptides

(2019) Yue Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

OPA-Based Bifunctional Linker for Protein Labeling and Profiling

(2019) Qing Zhang et al.   BIOCHEMISTRY

Assessment of the regioselectivity in the condensation reaction of unsymmetrical o -phthaldialdehydes with alanine

(2018) Agathe C.A. D'Hollander et al.   TETRAHEDRON

A “Click Chemistry Platform” for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation

(2017) Ryan P. Wurz et al.   JOURNAL OF MEDICINAL CHEMISTRY

A General Strategy for the Preparation of Thalidomide-Conjugate Linkers

(2017) Darren Derksen et al.   SYNLETT

Small-Molecule PROTACS: New Approaches to Protein Degradation

(2016) Momar Toure et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Traceless and Chemoselective Amine Bioconjugation via Phthalimidine Formation in Native Protein Modification

(2016) Chun Ling Tung et al.   ORGANIC LETTERS

Small-Molecule Control of Intracellular Protein Levels through Modulation of the Ubiquitin Proteasome System

(2014) Dennis L. Buckley et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dialdehydes Lead to Exceptionally Fast Bioconjugations at Neutral pH by Virtue of a Cyclic Intermediate

(2014) Pascal Schmidt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery of Aryloxy Tetramethylcyclobutanes as Novel Androgen Receptor Antagonists

(2011) Chuangxing Guo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Reactions of orthophthalaldehyde with ammonia and 2-aminoethanol

(2008) Eliona Kulla et al.   ORGANIC & BIOMOLECULAR CHEMISTRY