Article
Environmental Sciences
Siyu Xia, Xinhong Zhu, Yuepei Yan, Tao Zhang, Guoliang Chen, Daoxi Lei, Guixue Wang
Summary: This study revealed the neurotoxic and developmental toxicity of antimony on zebrafish embryos, primarily affecting neurotransmitter systems and oxidative stress, thereby altering behavior. The findings advance the understanding of antimony-induced neurotoxicity, environmental issues, and health hazards.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Zhong-Shang Xia, Er-Wei Hao, Yan-ting Wei, Xiao-Tao Hou, Zhang-mei Chen, Man Wei, Zheng-Cai Du, Jia-Gang Deng
Summary: The study demonstrated that genipin treatment inhibited hatching rates and body length, induced pericardial edema, cardiotoxicity, hepatotoxicity, and nephrotoxicity in zebrafish embryos/larvae. Genipin also increased oxidative stress and apoptosis in zebrafish, indicating a potential developmental toxicity mechanism associated with oxidative stress and apoptosis increase.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Environmental Sciences
Jiangfei Chen, Jiani Li, Hao Jiang, Jiajian Yu, Hongzhu Wang, Nengzhuang Wang, Shan Chen, Wen Mo, Ping Wang, Robyn L. Tanguay, Qiaoxiang Dong, Changjiang Huang
Summary: The study examined the neurotoxicity of TBBPA/TiO2 NP mixtures on zebrafish and found that exposure to the mixtures led to changes in behavior, cell apoptosis, and oxidative stress. The findings suggest that TiO2 NP may act as carriers for increased accumulation of TBBPA, leading to heightened responses in zebrafish. This study highlights the importance of assessing toxicity using chemical mixtures.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Yuxin Shi, Lei Li, Chuansen Wang, Jing Huang, Lixin Feng, Xiqiang Chen, Attila Gabor Sik, Kechun Liu, Meng Jin, Rongchun Wang
Summary: This study investigates the developmental toxicity of Chelerythrine in zebrafish and finds that it leads to a significant increase in mortality and malformation rate, as well as a reduction in hatching rate and body length. Chelerythrine also affects the normal development processes of the heart, liver, and phagocytes in zebrafish, and increases levels of reactive oxygen species (ROS) and apoptosis.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Environmental Sciences
Fei Liu, Ying Zhang, Fan Wang
Summary: This study exposed zebrafish embryos to TCS and evaluated its developmental toxicity. The results showed that TCS can induce oxidative stress and apoptosis, potentially through the ROS-p53-caspase dependent pathway.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Mengqi Wan, Ling Huang, Jieping Liu, Fasheng Liu, Guilan Chen, Huiwen Ni, Guanghua Xiong, Xinjun Liao, Huiqiang Lu, Juhua Xiao, Qiang Tao, Zigang Cao
Summary: This study assessed the toxicity of Cyclosporine A on embryonic development using zebrafish as a model organism, revealing its potential to induce cardiac developmental abnormalities by upregulating oxidative stress and Wnt signaling pathway. Treatment with Astaxanthin and an inhibitor of Wnt signaling pathway showed promising results in alleviating the toxic effects caused by CsA.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Environmental Sciences
Shukai Zheng, Qiong Zhang, Xiaoling Shi, Congying Luo, Jiasheng Chen, Wancong Zhang, Kusheng Wu, Shijie Tang
Summary: Polybrominated diphenyl ether flame retardants, specifically 2,2',4,4'-tetrabromodiphenyl ether (BDE-47), have been found to have adverse effects on the development of zebrafish. This study investigated the molecular mechanisms behind these developmental hazards, with a focus on endoplasmic reticulum stress (ERS), oxidative stress, and apoptosis, as well as the behavioral and morphological alterations observed. The findings suggest that exposure to BDE-47 induces ERS, oxidative stress, and apoptosis in zebrafish, leading to behavioral abnormalities and craniofacial malformations. Understanding these mechanisms is crucial for understanding the toxicological effects of environmental contaminants and developing strategies to mitigate their adverse effects.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Wei Yuan, Zhaopeng Xu, You Wei, Wuting Lu, Kun Jia, Jing Guo, Yunlong Meng, Yuyang Peng, Zhanfeng Wu, Zulin Zhu, Fei Ma, Fenghua Wei, Guiyou Tian, Zhou Liu, Qiang Luo, Jinze Ma, Hao Zhang, Wenjin Liu, Huiqiang Lu
Summary: Exposure to Sulfometuron methyl (SM) led to toxicity in zebrafish early developmental stages, affecting development, immune system, locomotor behavior, oxidative stress, and cell apoptosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Pharmacology & Pharmacy
Qing Xia, Shuo Gao, Samuel Rajendran Rapael Gnanamuthu, Kaiyan Zhuang, Zhenzhen Song, Yun Zhang, Xue Wang, Pengfei Tu, Jianheng Li, Kechun Liu
Summary: Aconitine (AC) exerts severe toxic effects on zebrafish embryo development, including cardiac, liver, and neurodevelopment impairment, as well as ROS-mediated mitochondrial apoptosis. High-concentration AC exposure results in deficient cardiovascular system and cell apoptosis in the heart and brain regions.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Environmental Sciences
Taeyeon Hong, Hahyun Park, Garam An, Gwonhwa Song, Whasun Lim
Summary: This study investigated the effects of ethalfluralin on the development of zebrafish embryos. The results showed that ethalfluralin decreased the survival rate, hatching ratio, and heartbeat of zebrafish embryos. It also caused edema, apoptosis, and changes in gene expression related to apoptosis, inflammation, and angiogenesis. The study suggests that ethalfluralin can induce oxidative stress and have toxic effects on the development of zebrafish embryos.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Plant Sciences
Thu Hang Nguyen, Phuc-Dam Nguyen, Joelle Quetin-Leclercq, Marc Muller, Duong Thi Ly Huong, Hai The Pham, Patrick Kestemont
Summary: The study found that the ethanol extract of Clerodendrum cyrtophyllum has developmental toxicity in zebrafish embryos, leading to mortality and malformations. Through molecular analysis, it was shown that multiple genes were significantly affected by the extract exposure, providing insights into potential toxicity mechanisms.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Murugesh Gayathri, Jesudass Sutha, Sundaram Mohanthi, Mathan Ramesh, Rama-Krishnan Poopal
Summary: The UV-filter Octocrylene has been found to cause developmental abnormalities, oxidative stress, neurotoxicity, and histopathological damage in embryonic zebrafish. High concentrations of Octocrylene resulted in decreased hatching and heartbeat rates, elevated oxidative damage and antioxidant enzyme activities, inhibited AChE activity, and induced apoptosis. These findings highlight the potential harm of Octocrylene on the development and health of aquatic organisms.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rui Yan, Jie Ding, Yuanjie Wei, Qianlei Yang, Xiaoyun Zhang, Hairu Huang, Zhuoyue Shi, Yue Feng, Heran Li, Hengdong Zhang, Wenjun Ding, Yan An
Summary: Melatonin protects against NaAsO2-induced heart malformations in zebrafish by inhibiting oxidative stress and apoptosis.
Article
Engineering, Environmental
Nayoung Min, Hahyun Park, Taeyeon Hong, Garam An, Gwonhwa Song, Whasun Lim
Summary: This study evaluated the developmental toxicity of the herbicide prometryn in zebrafish embryos, revealing that it shortened body length, induced organ development defects, reactive oxygen species accumulation, and cell death. It was also found to interfere with mitochondrial function and energy metabolism.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Marine & Freshwater Biology
Xin Chen, Tiantong Qiu, Peng Xiao, Wenhua Li
Summary: Isoflucypram has been found to have teratogenic effects on retinogenesis in zebrafish, causing abnormalities in retinal development and increased retinal cell apoptosis. This SDHI fungicide also demonstrates toxic effects on non-target aquatic organisms, highlighting the need for further investigation.
AQUATIC TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ajay Guru, Jesu Arockiaraj
Summary: This study investigated the protective effect of peptide WL15 from a teleost of aquatic resource on Bisphenol A-induced lipid accumulation in zebrafish larvae. The results showed that WL15 can prevent lipid accumulation by inhibiting oxidative stress, reducing lipid accumulation, and promoting glucose uptake, and by downregulating lipogenesis-specific genes.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Multidisciplinary Sciences
Purabi Sarkar, Stefi Raju, Manikandan Velayutham, Ajay Guru, Mukesh Pasupuleti, Ebtesam M. Al Olayan, Amy F. Boushra, Annie Juliet, Jesu Arockiaraj
Summary: Diabetes-induced oxidative stress can damage organs and lead to various problems. Antioxidant therapy, such as GP13 peptide, shows promise in preventing diabetes and its complications. This study investigated the activity of GP13 peptide in an in-vitro diabetic model.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Ajay Guru, Gokul Sudhakaran, S. Karthick Raja Namasivayam, Boopathi Seenivasan, Mukesh Pasupulieti, Jesu Arockiaraj, Meivelu Moovendhan
Summary: Obesity is associated with the development of metabolic disorders, and recent research has explored the molecular link between obesity and oxidative stress. This study investigated the effect of IW13 peptide on lipid metabolism in zebrafish larvae. The results showed that IW13 peptide co-treatment had a protective effect and reduced triglyceride and cholesterol levels, as well as increasing antioxidant enzyme activity. IW13 peptide also downregulated lipogenic gene expression and inhibited lipid peroxidation and superoxide anion formation, suggesting its potential as a future drug for obesity and oxidative stress-related diseases.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Fisheries
Seenivasan Boopathi, Ramu Meenatchi, Pownraj Brindangnanam, Gokul Sudhakaran, Mohane Selvaraj Coumar, Jesu Arockiaraj
Summary: The diversity of the gut microbiota has a significant impact on the health of hosts, including shrimps. White faeces syndrome (WFS) is a shrimp disease caused by Enterocytozoon hepatopenaei infection and gut microbial dysbiosis, specifically Vibrio species. This study aims to explore the gut microbiota composition in Litopenaeus vannamei shrimps and investigate the genetic factors associated with WFS development. The results show significant variations in intestinal bacterial abundance between healthy and WFS-affected shrimps, with different genera present in each group. Vibrio parahaemolyticus was identified as the predominant species in WFS samples. Function prediction analysis revealed metabolic pathway differences between healthy and diseased shrimps. This study provides valuable insights into the gut microbial community and highlights the importance of Vibrio in WFS development.
Review
Microbiology
J. Narayanan, T. Tamilanban, P. Senthil Kumar, Ajay Guru, Saravanan Muthupandian, M. K. Kathiravan, Jesu Arockiaraj
Summary: Kinases play a crucial role in regulating neoplasia, metastasis, and cytokine suppression. Mutations in kinases or their regulated pathways lead to the progression of diseases. Targeted therapy against cancer-specific cells and signaling pathways is a valuable avenue of research.
ARCHIVES OF MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
B. Haridevamuthu, Tamilvelan Manjunathan, Carlton Ranjith Wilson Alphonse, Rajendran Saravana Kumar, Sundaram Thanigaivel, Somasundaram Chandra Kishore, Vickram Sundaram, Pushparathinam Gopinath, Jesu Arockiaraj, Stefano Bellucci
Summary: In this study, hydroxyl-containing benzo[b]thiophene analogs BP and EP were found to possess antiproliferative activity against laryngeal cancer cells. The hydroxyl group present in BP and EP was responsible for the anticancer activity, which was completely lost when the hydroxyl group was masked. BP and EP enhanced antioxidant enzyme activity, reduced ROS production, and induced apoptosis in the HEp-2 cells. Molecular docking and simulation studies suggested a strong interaction between BP and the CYP1A2 protein, which could enhance drug bioavailability for combinational therapy. BP and EP showed low antiproliferative effects as standalone drugs, but could be combined with other drugs for more effective chemotherapy.
Article
Marine & Freshwater Biology
Raghul Murugan, Senthil Subramaniyan, Snega Priya, Chinnasamy Ragavendran, Mariadhas Valan Arasu, Naif Abdullah Al-Dhabi, Ki Choon Choi, Ajay Guru, Jesu Arockiaraj
Summary: The plant compound Withaferin A has antibacterial, antibiofilm, and anti-inflammatory activities, which can be used to treat Staphylococcus aureus infections.
AQUATIC TOXICOLOGY
(2023)
Review
Environmental Sciences
P. Snega Priya, P. Pratiksha Nandhini, Jesu Arockiaraj
Summary: This article explores the impact of environmental pollution on osteoporosis and analyzes the role of environmental factors in bone health. The article highlights the influence of environmental pollutants on the risk of osteoporosis and emphasizes the importance of understanding molecular mechanisms.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
P. Snega Priya, Raghul Murugan, Bader O. Almutairi, Selvaraj Arokiyaraj, P. Shanjeev, Jesu Arockiaraj
Summary: This study investigated the protective effects of cordycepin against gut inflammation induced by Cadmium (Cd) exposure. The results showed that cordycepin significantly reduced Cd-induced embryotoxicity and oxidative stress. It also normalized the levels of liver-related biomarkers affected by Cd exposure and downregulated the expression of inflammatory genes.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Gokul Sudhakaran, Manikandan Velayutham, Nada H. Aljarba, Tahani Mohamad AL-Hazani, Selvaraj Arokiyaraj, Ajay Guru, Jesu Arockiaraj
Summary: In this study, N1 and N3 compounds derived from Azadirachta indica were found to exhibit anti-cancer activity against MG-63 osteosarcoma cells while being non-toxic to normal L6 cells. These compounds induced mitochondrial dysfunction, nuclear damage, and apoptosis in cancer cells, and also inhibited cell proliferation and migration. The activation of the caspase cascade and cell cycle arrest were also observed. These findings suggest that N1 and N3 have potential as anti-cancer agents and should be further investigated and developed.
MOLECULAR BIOLOGY REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Kadhirmathiyan Velumani, Abirami Arasu, Praveen Kumar Issac, Meenakshi Sundaram Kishore Kumar, Ajay Guru, Jesu Arockiaraj
Summary: Mucormycosis is a major obstacle in the treatment of diabetes consequences, and fish-derived peptides have emerged as viable options in combating this fungal infection. This review examines the potential application of fish-derived peptides in diagnosing and managing mucormycosis, highlighting the need for alternative therapeutic methods.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Gokul Sudhakaran, Abhirami Chandran, A. R. Sreekutty, S. Madesh, Raman Pachaiappan, Bader O. Almutairi, Selvaraj Arokiyaraj, Zulhisyam Abdul Kari, Guillermo Tellez-Isaias, Ajay Guru, Jesu Arockiaraj
Summary: Diabetes Mellitus is a metabolic disease that causes microvascular complications, including Diabetic retinopathy (DR), which is a leading cause of blindness worldwide. Current medications for DR have drawbacks, and there is a need for alternative medications. Interventional approaches targeting vascular endothelial growth factor (VEGF) are being investigated for treating DR. This study explored the effects of the flavonoid naringenin (NG) from citrus fruits on inhibiting early DR in zebrafish. The results showed that NG reduced oxidative stress and cellular damage in zebrafish larvae exposed to high glucose, and it also inhibited macular degeneration and normalized VEGF overexpression in adult zebrafish. The intervention of NG shows promise in ophthalmic research for treating DR.
Article
Biochemistry & Molecular Biology
Manikandan Velayutham, P. Snega Priya, Purabi Sarkar, Raghul Murugan, Bader O. Almutairi, Selvaraj Arokiyaraj, Zulhisyam Abdul Kari, Guillermo Tellez-Isaias, Ajay Guru, Jesu Arockiaraj
Summary: Small molecules and peptide-based therapeutic approaches have attracted interest due to their lower toxicity and potential in addressing various health complications. This study introduces a peptide, GE18, derived from a pathogenic fungus, which exhibits anti-cancer and anti-microbial activities. In silico and in vitro experiments demonstrate the strong anti-cancer and anti-microbial properties of GE18. The peptide shows no toxicity to normal cells and significantly inhibits cancer cell proliferation, as well as bacterial biofilm formation.
Article
Biotechnology & Applied Microbiology
Ajay Guru, Raghul Murugan, Jesu Arockiaraj
Summary: Pseudomonas is a group of bacteria that can cause various infections in weakened immune systems. In this study, an antimicrobial peptide called RW20 was derived from freshwater fish and tested against Pseudomonas aeruginosa. The results showed that RW20 had antibacterial properties and protected against Pseudomonas infection in both in vitro and in vivo experiments.
INTERNATIONAL MICROBIOLOGY
(2023)
Article
Engineering, Environmental
B. Haridevamuthu, Raghul Murugan, Boopathi Seenivasan, Ramu Meenatchi, Raman Pachaiappan, Bader O. Almutairi, Selvaraj Arokiyaraj, M. K. Kathiravan, Jesu Arockiaraj
Summary: Tartrazine is a commonly used azo dye that poses a threat to human health and the aquatic environment when used in excessive amounts. This study comprehensively evaluated the neurodevelopmental toxicity of Tartrazine and explored its underlying mechanisms through biochemical and behavioral examinations. The study found that Tartrazine exposure at environmentally relevant concentrations induced oxidative stress, cellular damage, and neuro-biochemical changes. Gene expression analyses revealed disruptions in genes associated with antioxidant defense, mitochondrial dysfunction, inflammatory response, apoptosis activation, and neural development. The study also showed altered behavior depending on the concentration of Tartrazine exposure. These findings highlight the neurodevelopmental effects of Tartrazine at environmentally relevant concentrations and provide valuable insights into the molecular mechanisms involved, particularly mitochondria-mediated apoptosis.
JOURNAL OF HAZARDOUS MATERIALS
(2024)