Metabolic Activation of the Acrylamide Michael Acceptor Warhead in Futibatinib to an Epoxide Intermediate Engenders Covalent Inactivation of Cytochrome P450 3A

Published 2022 View Full Article

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Title
Metabolic Activation of the Acrylamide Michael Acceptor Warhead in Futibatinib to an Epoxide Intermediate Engenders Covalent Inactivation of Cytochrome P450 3A
Authors
Keywords
-
Journal
DRUG METABOLISM AND DISPOSITION
Volume -, Issue -, Pages DMD-AR-2022-000895
Publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)
Online
2022-05-05
DOI
10.1124/dmd.122.000895

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