Application of Mouse Models to Research in Hearing and Balance

Super-resolution structured illumination fluorescence microscopy of the lateral wall of the cochlea: the Connexin26/30 proteins are separately expressed in man

(2016) Wei Liu et al.   CELL AND TISSUE RESEARCH

Area-Specific Features of Pyramidal Neurons—a Comparative Study in Mouse and Rhesus Monkey

(2016) Joshua P. Gilman et al.   CEREBRAL CORTEX

Large-scale phenotyping of noise-induced hearing loss in 100 strains of mice

(2016) Anthony Myint et al.   HEARING RESEARCH

Sound coding in the auditory nerve of gerbils

(2016) Antoine Huet et al.   HEARING RESEARCH

Human audiometric thresholds do not predict specific cellular damage in the inner ear

(2016) Lukas D. Landegger et al.   HEARING RESEARCH

Comprehensive genetic testing in the clinical evaluation of 1119 patients with hearing loss

(2016) Christina M. Sloan-Heggen et al.   HUMAN GENETICS

QTL Mapping of Endocochlear Potential Differences between C57BL/6J and BALB/cJ mice

(2016) Kevin K. Ohlemiller et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Scanning Electron Microscopic Examination of the Extracellular Matrix in the Decellularized Mouse and Human Cochlea

(2016) Peter A. Santi et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Differential effects of Cdh23 753A on auditory and vestibular functional aging in C57BL/6J mice

(2016) Bruce E. Mock et al.   NEUROBIOLOGY OF AGING

Overlapping expression of anion exchangers in the cochlea of a non-human primate suggests functional compensation

(2016) Makoto Hosoya et al.   NEUROSCIENCE RESEARCH

Noise exposure modulates cochlear inner hair cell ribbon volumes, correlating with changes in auditory measures in the FVB/nJ mouse

(2016) Stephen T. Paquette et al.   Scientific Reports

Correction of the auditory phenotype in C57BL/6N mice via CRISPR/Cas9-mediated homology directed repair

(2016) Joffrey Mianné et al.   Genome Medicine

Distinct Expression Patterns Of Causative Genes Responsible For Hereditary Progressive Hearing Loss In Non-Human Primate Cochlea

(2016) Makoto Hosoya et al.   Scientific Reports

Coding deficits in hidden hearing loss induced by noise: the nature and impacts

(2016) Qiang Song et al.   Scientific Reports

Noise induced reversible changes of cochlear ribbon synapses contribute to temporary hearing loss in mice

(2015) Lin Shi et al.   ACTA OTO-LARYNGOLOGICA

Reversal of Mitochondrial Transhydrogenase Causes Oxidative Stress in Heart Failure

(2015) Alexander G. Nickel et al.   Cell Metabolism

The application of genome editing in studying hearing loss

(2015) Bing Zou et al.   HEARING RESEARCH

Fractalkine Signaling Regulates Macrophage Recruitment into the Cochlea and Promotes the Survival of Spiral Ganglion Neurons after Selective Hair Cell Lesion

(2015) T. Kaur et al.   JOURNAL OF NEUROSCIENCE

A QTL on Chr 5 modifies hearing loss associated with the fascin-2 variant of DBA/2J mice

(2015) Kenneth R. Johnson et al.   MAMMALIAN GENOME

Vestibular dysfunction, altered macular structure and trait localization in A/J inbred mice

(2015) Sarath Vijayakumar et al.   MAMMALIAN GENOME

New treatment options for hearing loss

(2015) Ulrich Müller et al.   NATURE REVIEWS DRUG DISCOVERY

Mouse genome database 2016

(2015) Carol J. Bult et al.   NUCLEIC ACIDS RESEARCH

Immediate and Delayed Cochlear Neuropathy after Noise Exposure in Pubescent Mice

(2015) Jane Bjerg Jensen et al.   PLoS One

Genome-Wide Association Study Identifies Nox3 as a Critical Gene for Susceptibility to Noise-Induced Hearing Loss

(2015) Joel Lavinsky et al.   PLoS Genetics

Is mouse embryonic stem cell technology obsolete?

(2015) William C Skarnes   GENOME BIOLOGY

Gap-Prepulse Inhibition of the Acoustic Startle Reflex (GPIAS) for Tinnitus Assessment: Current Status and Future Directions

(2015) Alexander Galazyuk et al.   Frontiers in Neurology

Parallel universes of Black Six biology

(2014) Alexander Kraev   Biology Direct

TrkB-Mediated Protection against Circadian Sensitivity to Noise Trauma in the Murine Cochlea

(2014) Inna Meltser et al.   CURRENT BIOLOGY

Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment

(2014) Erik Fransen et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The Mouse as a Model for Age-Related Hearing Loss - A Mini-Review

(2014) Michael R. Bowl et al.   GERONTOLOGY

A familial form of benign paroxysmal positional vertigo maps to chromosome 15

(2014) Martin S. Gizzi et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Cytoarchitecture of the Mouse Organ of Corti from Base to Apex, Determined Using In Situ Two-Photon Imaging

(2014) Joris A. M. Soons et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Genetics of Peripheral Vestibular Dysfunction: Lessons from Mutant Mouse Strains

(2014) Sherri M. Jones et al.   Journal of the American Academy of Audiology

Early prognosis of noise-induced hearing loss

(2014) Hanns Moshammer et al.   OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Expression and Replication Studies to Identify New Candidate Genes Involved in Normal Hearing Function

(2014) Giorgia Girotto et al.   PLoS One

Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution

(2014) J. Vierstra et al.   SCIENCE

Quantitative Trait Locus Mapping Methods for Diversity Outbred Mice

(2014) D. M. Gatti et al.   G3-Genes Genomes Genetics

One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering

(2013) Haoyi Wang et al.   CELL

One-Step Generation of Mice Carrying Reporter and Conditional Alleles by CRISPR/Cas-Mediated Genome Engineering

(2013) Hui Yang et al.   CELL

Controlling complexity: the clinical relevance of mouse complex genetics

(2013) Klaus Schughart et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Estrogenic modulation of auditory processing: A vertebrate comparison

(2013) Melissa L. Caras   FRONTIERS IN NEUROENDOCRINOLOGY

Is noise-induced cochlear neuropathy key to the generation of hyperacusis or tinnitus?

(2013) Ann E. Hickox et al.   JOURNAL OF NEUROPHYSIOLOGY

Noddy, a Mouse Harboring a Missense Mutation in Protocadherin-15, Reveals the Impact of Disrupting a Critical Interaction Site between Tip-Link Cadherins in Inner Ear Hair Cells

(2013) R. Geng et al.   JOURNAL OF NEUROSCIENCE

Diverse Visual Features Encoded in Mouse Lateral Geniculate Nucleus

(2013) D. M. Piscopo et al.   JOURNAL OF NEUROSCIENCE

Parvalbumin-Expressing Inhibitory Interneurons in Auditory Cortex Are Well-Tuned for Frequency

(2013) A. K. Moore et al.   JOURNAL OF NEUROSCIENCE

Neuroscience: Through the eyes of a mouse

(2013) Monya Baker   NATURE

Intracortical multiplication of thalamocortical signals in mouse auditory cortex

(2013) Ling-yun Li et al.   NATURE NEUROSCIENCE

Choosing an animal model for the study of Huntington's disease

(2013) Mahmoud A. Pouladi et al.   NATURE REVIEWS NEUROSCIENCE

Optogenetic Activation of an Inhibitory Network Enhances Feedforward Functional Connectivity in Auditory Cortex

(2013) Liberty S. Hamilton et al.   NEURON

The Mouse Age Phenome Knowledgebase and Disease-Specific Inter-Species Age Mapping

(2013) Nophar Geifman et al.   PLoS One

Comparison of Cochlear Cell Death Caused by Cisplatin, Alone and in Combination with Furosemide

(2013) Li Xia et al.   TOXICOLOGIC PATHOLOGY

ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

(2013) Thomas Gaj et al.   TRENDS IN BIOTECHNOLOGY

The mouse as a model organism in aging research: Usefulness, pitfalls and possibilities

(2012) Valerie Vanhooren et al.   AGEING RESEARCH REVIEWS

Genetics

(2012) A. Eliot Shearer et al.   CURRENT OPINION IN PEDIATRICS

Digital Music Exposure Reliably Induces Temporary Threshold Shift in Normal-Hearing Human Subjects

(2012) Colleen G. Le Prell et al.   EAR AND HEARING

microRNAs: the art of silencing in the ear

(2012) Anya Rudnicki et al.   EMBO Molecular Medicine

Advantages of a Mouse Model for Human Hearing Impairment

(2012) Yoshiaki Kikkawa et al.   EXPERIMENTAL ANIMALS

High-Resolution Genetic Mapping Using the Mouse Diversity Outbred Population

(2012) Karen L. Svenson et al.   GENETICS

The gap-startle paradigm for tinnitus screening in animal models: Limitations and optimization

(2012) Edward Lobarinas et al.   HEARING RESEARCH

Time course of tinnitus development following noise exposure in mice

(2012) Jeremy Turner et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Association studies in outbred mice in a new era of full-genome sequencing

(2012) Binnaz Yalcin et al.   MAMMALIAN GENOME

Ten Years of the Collaborative Cross

(2012) David W. Threadgill et al.   G3-Genes Genomes Genetics

An ENU-Induced Mutation of Cdh23 Causes Congenital Hearing Loss, but No Vestibular Dysfunction, in Mice

(2011) Shehnaaz S.M. Manji et al.   AMERICAN JOURNAL OF PATHOLOGY

Genetics of Recurrent Vertigo and Vestibular Disorders

(2011) Irene Gazquez et al.   CURRENT GENOMICS

Genetic disorders of the vestibular system

(2011) Robert W. Eppsteiner et al.   Current Opinion in Otolaryngology & Head and Neck Surgery

Protection by low-dose kanamycin against noise-induced hearing loss in mice: Dependence on dosing regimen and genetic background

(2011) Kevin K. Ohlemiller et al.   HEARING RESEARCH

Genetic background effects on age-related hearing loss associated with Cdh23 variants in mice

(2011) Kelly L. Kane et al.   HEARING RESEARCH

Relative Time Course of Degeneration of Different Cochlear Structures in the CD/1 Mouse Model of Accelerated Aging

(2011) Shanthini Mahendrasingam et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Association of Skin Color, Race/Ethnicity, and Hearing Loss Among Adults in the USA

(2011) Frank R. Lin et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Development of Tinnitus in CBA/CaJ Mice Following Sound Exposure

(2011) Ryan J. Longenecker et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Hearing Loss Prevalence and Risk Factors Among Older Adults in the United States

(2011) F. R. Lin et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Dark Matter: Are Mice the Solution to Missing Heritability?

(2011) Clarissa C. Parker et al.   Frontiers in Genetics

A high-resolution association mapping panel for the dissection of complex traits in mice

(2010) B. J. Bennett et al.   GENOME RESEARCH

Comparative analysis of combination kanamycin-furosemide versus kanamycin alone in the mouse cochlea

(2010) Keiko Hirose et al.   HEARING RESEARCH

Divergence of noise vulnerability in cochleae of young CBA/J and CBA/CaJ mice

(2010) Kevin K. Ohlemiller et al.   HEARING RESEARCH

Protection against Noise-Induced Hearing Loss in Young CBA/J Mice by Low-Dose Kanamycin

(2010) Elizabeth A. Fernandez et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Divergent Aging Characteristics in CBA/J and CBA/CaJ Mouse Cochleae

(2010) Kevin K. Ohlemiller et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Different Cellular and Genetic Basis of Noise-Related Endocochlear Potential Reduction in CBA/J and BALB/cJ Mice

(2010) Kevin K. Ohlemiller et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Effects of chronic estrogen treatment on modulating age-related bone loss in female mice

(2010) Farhan A Syed et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Unmyelinated auditory type I spiral ganglion neurons in congenic Ly5.1 mice

(2010) Vinu Jyothi et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The R109H Variant of Fascin-2, a Developmentally Regulated Actin Crosslinker in Hair-Cell Stereocilia, Underlies Early-Onset Hearing Loss of DBA/2J Mice

(2010) J.-B. Shin et al.   JOURNAL OF NEUROSCIENCE

Hearing Impairment: A Panoply of Genes and Functions

(2010) Amiel A. Dror et al.   NEURON

A combination antioxidant therapy prevents age-related hearing loss in C57BL/6 mice

(2010) Selena E. Heman Ackah et al.   OTOLARYNGOLOGY-HEAD AND NECK SURGERY

Phenotype and Genetics of Progressive Sensorineural Hearing Loss (Snhl1) in the LXS Set of Recombinant Inbred Strains of Mice

(2010) Konrad Noben-Trauth et al.   PLoS One

Inbred Strains Should Replace Outbred Stocks in Toxicology, Safety Testing, and Drug Development

(2010) Michael F. W. Festing   TOXICOLOGIC PATHOLOGY

N-Acetyl L-Cysteine does not protect mouse ears from the effects of noise*

(2010) Rickie R Davis et al.   Journal of Occupational Medicine and Toxicology

Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels

(2009) Rong Yuan et al.   AGING CELL

Amyloid precursor protein transgenic mouse models and Alzheimer's disease: Understanding the paradigms, limitations, and contributions

(2009) Tyler A. Kokjohn et al.   Alzheimers & Dementia

Principles of Local Drug Delivery to the Inner Ear

(2009) Alec N. Salt et al.   AUDIOLOGY AND NEURO-OTOLOGY

Mechanisms and genes in human strial presbycusis from animal models

(2009) Kevin K. Ohlemiller   BRAIN RESEARCH

Connections of Auditory and Visual Cortex in the Prairie Vole (Microtus ochrogaster): Evidence for Multisensory Processing in Primary Sensory Areas

(2009) K. L. Campi et al.   CEREBRAL CORTEX

Recent advances in the genetics of recurrent vertigo and vestibulopathy

(2009) Joanna C Jen   CURRENT OPINION IN NEUROLOGY

Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, diminishes lymphoproliferation in the Fas -deficient MRL/lpr−/− murine model of autoimmune lymphoproliferative syndrome (ALPS)

(2009) Kennichi C. Dowdell et al.   EXPERIMENTAL HEMATOLOGY

Hormone replacement therapy diminishes hearing in peri-menopausal mice

(2009) Katharine Price et al.   HEARING RESEARCH

The menopause triggers hearing decline in healthy women

(2009) C. Hederstierna et al.   HEARING RESEARCH

Adding Insult to Injury: Cochlear Nerve Degeneration after "Temporary" Noise-Induced Hearing Loss

(2009) S. G. Kujawa et al.   JOURNAL OF NEUROSCIENCE

Abnormal circling behavior in rat mutants and its relevance to model specific brain dysfunctions

(2009) Wolfgang Löscher   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Vestibular Evoked Myogenic Potentials in Normal Mice and Phex Mice With Spontaneous Endolymphatic Hydrops

(2009) Kianoush Sheykholeslami et al.   OTOLOGY & NEUROTOLOGY

Risk Factors for Hearing Loss in US Adults

(2009) Yuri Agrawal et al.   OTOLOGY & NEUROTOLOGY

A mouse model for nonsyndromic deafness (DFNB12) links hearing loss to defects in tip links of mechanosensory hair cells

(2009) M. Schwander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ototoxic drugs: Difference in sensitivity between mice and guinea pigs

(2009) A.L. Poirrier et al.   TOXICOLOGY LETTERS

Wild-derived mouse stocks: an underappreciated tool for aging research

(2008) James M. Harper   AGE

Communication routes between intracranial spaces and inner ear: function, pathophysiologic importance and relations with inner ear diseases

(2008) Raphael R. Ciuman   AMERICAN JOURNAL OF OTOLARYNGOLOGY

Absence of strial melanin coincides with age-associated marginal cell loss and endocochlear potential decline

(2008) Kevin K. Ohlemiller et al.   HEARING RESEARCH

Iris pigmentation and susceptibility to noise-induced hearing loss

(2008) E.A. Da Costa et al.   INTERNATIONAL JOURNAL OF AUDIOLOGY

Hormones and the auditory system: A review of physiology and pathophysiology

(2008) D. Al-Mana et al.   NEUROSCIENCE