Rapid and efficient degradation of endogenous proteins in vivo identifies stage-specific roles of RNA Pol II pausing in mammalian development

RNA polymerase II pausing in development: orchestrating transcription

(2022) Abderhman Abuhashem et al.   Open Biology

Fast-acting chemical tools to delineate causality in transcriptional control

(2021) Martin G. Jaeger et al.   MOLECULAR CELL

Harnessing the Power of Proteolysis for Targeted Protein Inactivation

(2020) Rati Verma et al.   MOLECULAR CELL

Maternal factor NELFA drives a 2C-like state in mouse embryonic stem cells

(2020) Zhenhua Hu et al.   NATURE CELL BIOLOGY

Mouse gastrulation: Coordination of tissue patterning, specification and diversification of cell fate

(2020) Evan S. Bardot et al.   MECHANISMS OF DEVELOPMENT

Targeted protein degradation as a powerful research tool in basic biology and drug target discovery

(2020) Tao Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A super-sensitive auxin-inducible degron system with an engineered auxin-TIR1 pair

(2020) Kohei Nishimura et al.   NUCLEIC ACIDS RESEARCH

Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules

(2020) Behnam Nabet et al.   Nature Communications

A single-cell molecular map of mouse gastrulation and early organogenesis

(2019) Blanca Pijuan-Sala et al.   NATURE

Promoter-proximal pausing of RNA polymerase II: a nexus of gene regulation

(2019) Leighton Core et al.   GENES & DEVELOPMENT

The emergent landscape of the mouse gut endoderm at single-cell resolution

(2019) Sonja Nowotschin et al.   NATURE

High-dimensional cell-level analysis of tissues with Ce3D multiplex volume imaging

(2019) Weizhe Li et al.   Nature Protocols

The next generation of CRISPR–Cas technologies and applications

(2019) Adrian Pickar-Oliver et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tamoxifen administration in pregnant mice can be deleterious to both mother and embryo

(2019) Nikita Ved et al.   LABORATORY ANIMALS

Biological plasticity rescues target activity in CRISPR knock outs

(2019) Arne H. Smits et al.   NATURE METHODS

Evolution of Cereblon-Mediated Protein Degradation as a Therapeutic Modality

(2019) Philip P. Chamberlain et al.   ACS Medicinal Chemistry Letters

Refinement of inducible gene deletion in embryos of pregnant mice

(2019) Dawn Savery et al.   Birth Defects Research

The dTAG system for immediate and target-specific protein degradation

(2018) Behnam Nabet et al.   Nature Chemical Biology

Minor zygotic gene activation is essential for mouse preimplantation development

(2018) Ken-ichiro Abe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of paused transcription complex Pol II–DSIF–NELF

(2018) Seychelle M. Vos et al.   NATURE

Structure of activated transcription complex Pol II–DSIF–PAF–SPT6

(2018) Seychelle M. Vos et al.   NATURE

Asynchronous fate decisions by single cells collectively ensure consistent lineage composition in the mouse blastocyst

(2016) Néstor Saiz et al.   Nature Communications

Pausing of RNA Polymerase II Regulates Mammalian Developmental Potential through Control of Signaling Networks

(2015) Lucy H. Williams et al.   MOLECULAR CELL

Single cells get together: High-resolution approaches to study the dynamics of early mouse development

(2015) Néstor Saiz et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A Rapid and Efficient 2D/3D Nuclear Segmentation Method for Analysis of Early Mouse Embryo and Stem Cell Image Data

(2014) Xinghua Lou et al.   Stem Cell Reports

Control of Transcriptional Elongation

(2013) Hojoong Kwak et al.   Annual Review of Genetics

Generation and characterization of a tamoxifen-inducible EomesCreERmouse line

(2013) Inga-Marie Pimeisl et al.   GENESIS

Anatomy of a blastocyst: Cell behaviors driving cell fate choice and morphogenesis in the early mouse embryo

(2013) Nadine Schrode et al.   GENESIS

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans

(2012) Karen Adelman et al.   NATURE REVIEWS GENETICS

c-Myc Regulates Transcriptional Pause Release

(2010) Peter B. Rahl et al.   CELL

The maternal-to-zygotic transition: a play in two acts

(2009) W. Tadros et al.   DEVELOPMENT

An auxin-based degron system for the rapid depletion of proteins in nonplant cells

(2009) Kohei Nishimura et al.   NATURE METHODS

Mouse Cofactor of BRCA1 (Cobra1) Is Required for Early Embryogenesis

(2009) Asma Amleh et al.   PLoS One

Oocyte-Specific Knockout: A Novel In Vivo Approach for Studying Gene Functions During Folliculogenesis, Oocyte Maturation, Fertilization, and Embryogenesis1

(2008) Qing-Yuan Sun et al.   BIOLOGY OF REPRODUCTION