Article
Immunology
Elizabeth T. Jacobs, Collin J. Catalfamo, Paulina M. Colombo, Sana M. Khan, Erika Austhof, Felina Cordova-Marks, Kacey C. Ernst, Leslie V. Farland, Kristen Pogreba-Brown
Summary: Post-acute sequelae of COVID-19 (PASC) are conditions that occur or remain at least 28 days after SARS-CoV-2 infection. Pre-existing conditions such as asthma, chronic constipation, reflux, rheumatoid arthritis, seasonal allergies, and depression/anxiety are associated with an increased risk for PASC. Respiratory, gastrointestinal, and autoimmune conditions also show significant associations with PASC.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Biochemistry & Molecular Biology
Andrea C. Wong, Ashwarya S. Devason, Iboro C. Umana, Timothy O. Cox, Lenka Dohnalova, Lev Litichevskiy, Jonathan Perla, Patrick Lundgren, Zienab Etwebi, Luke T. Izzo, Jihee Kim, Monika Tetlak, Helene C. Descamps, Simone L. Park, Stephen Wisser, Aaron D. Mcknight, Ryan D. Pardy, Junwon Kim, Niklas Blank, Shaan Patel, Katharina Thum, Sydney Mason, Jean-Christophe Beltra, Michael F. Michieletto, Shin Foong Ngiow, Brittany M. Miller, Megan J. Liou, Bhoomi Madhu, Oxana Dmitrieva-Posocco, Alex S. Huber, Peter Hewins, Christopher Petucci, Candice P. Chu, Gwen Baraniecki-Zwil, Leila B. Giron, Amy E. Baxter, Allison R. Greenplate, Charlotte Kearns, Kathleen Montone, Leslie A. Litzky, Michael Feldman, Jorge Henao-Mejia, Boris Striepen, Holly Ramage, Kellie A. Jurado, Kathryn E. Wellen, Una O'Doherty, Mohamed Abdel-Mohsen, Alan L. Landay, Ali Keshavarzian, Timothy J. Henrich, Steven G. Deeks, Michael J. Peluso, Nuala J. Meyer, E. John Wherry, Benjamin A. Abramoff, Sara Cherry, Christoph A. Thaiss, Maayan Levy
Summary: Post-acute sequelae of COVID-19 (PASC, Long COVID) present a significant global health challenge. The underlying causes are still unknown, and effective treatment options have not been identified yet. This study proposes a mechanism that links viral persistence, chronic inflammation, hypercoagulability, and autonomic dysfunction in PASC through serotonin reduction, which impairs hippocampal responses and memory. These findings provide insights for potential therapeutic interventions and offer a possible explanation for the neurocognitive symptoms associated with viral persistence in Long COVID and other post-viral syndromes.
Article
Cardiac & Cardiovascular Systems
Tamanna K. Singh, David A. Zidar, Keith McCrae, Kristin B. Highland, Kristin Englund, Scott J. Cameron, Mina K. Chung
Summary: COVID-19 has become the first modern-day pandemic of historic proportion, affecting over 600 million individuals worldwide and causing more than 6.5 million deaths. Postacute sequelae of SARS-CoV-2 infection, which impacts up to one-third of survivors and often manifests as cardiovascular symptoms, appears to be a pandemic of its own. This review will discuss the suspected pathophysiology of postacute sequelae of SARS-CoV-2, its impact on the cardiovascular system, and potential treatment strategies.
CIRCULATION RESEARCH
(2023)
Article
Immunology
Bruce K. Patterson, Edgar B. Francisco, Ram Yogendra, Emily Long, Amruta Pise, Hallison Rodrigues, Eric Hall, Monica Herrera, Purvi Parikh, Jose Guevara-Coto, Timothy J. Triche, Paul Scott, Saboor Hekmati, Dennis Maglinte, Xaiolan Chang, Rodrigo A. Mora-Rodriguez, Javier Mora
Summary: The recent study found that patients with post-acute sequelae of COVID-19 (PASC) had significantly elevated levels of intermediate and non-classical monocytes, and these cells contained SARS-CoV-2 S1 protein up to 15 months after infection. However, fragmented SARS-CoV-2 RNA was found in PASC patients with no full-length sequences identified. This suggests that non-classical monocytes may play a role in the inflammation seen in PASC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Benjamin Bowe, Yan Xie, Ziyad Al-Aly
Summary: A new analysis using US Department of Veterans Affairs databases showed that reinfection is associated with increased risk of all-cause mortality, hospitalization and a wide range of long COVID complications in individuals who have had SARS-CoV-2 compared to those with no reinfection.
Article
Biochemistry & Molecular Biology
Aurelien Sokal, Pascal Chappert, Giovanna Barba-Spaeth, Anais Roeser, Slim Fourati, Imane Azzaoui, Alexis Vandenberghe, Ignacio Fernandez, Annalisa Meola, Magali Bouvier-Alias, Etienne Crickx, Asma Beldi-Ferchiou, Sophie Hue, Laetitia Languille, Marc Michel, Samia Baloul, France Noizat-Pirenne, Marine Luka, Jerome Megret, Mickael Menager, Jean-Michel Pawlotsky, Simon Fillatreau, Felix A. Rey, Jean-Claude Weill, Claude-Agnes Reynaud, Matthieu Mahevas
Summary: Memory B cells play a crucial role in host defense against SARS-CoV-2, with distinct B cell clone responses to the virus contributing to long-lasting immune protection. The study also highlights the significance of somatic mutations in the variable region genes of memory B cells over time, indicating continued maturation and long-term immune memory post-infection.
Article
Medicine, Research & Experimental
Elisa Brauns, Abdulkader Azouz, David Grimaldi, Hanxi Xiao, Severine Thomas, Muriel Nguyen, Veronique Olislagers, Ines Vu Duc, Carmen Orte Cano, Veronique Del Marmol, Pieter Pannus, Frederick Libert, Sven Saussez, Nicolas Dauby, Jishnu Das, Arnaud Marchant, Stanislas Goriely
Summary: Severe COVID-19 disease can lead to dysregulation of the myeloid compartment during acute infection. In this study, impaired cytokine production by monocytes was observed in patients with severe COVID-19 during the acute phase, but was restored in convalescent patients. However, recovered patients showed increased responsiveness to TLR1/2 ligation, suggesting different functional properties of these cells at different stages of the disease.
Review
Clinical Neurology
Narges Moghimi, Mario Di Napoli, Jose Biller, James E. Siegler, Rahul Shekhar, Louise D. McCullough, Michelle S. Harkins, Emily Hong, Danielle A. Alaouieh, Gelsomina Mansueto, Afshin A. Divani
Summary: Neuro-PASC, a global health challenge following COVID-19 infection, presents with diverse pathophysiological mechanisms such as viral invasion and immune dysregulation. Comprehensive treatment involving rehabilitation, cognitive therapy, and medications is essential for affected individuals, emphasizing the importance of early recognition and effective intervention.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2021)
Article
Multidisciplinary Sciences
Michael A. Horberg, Eric Watson, Mamta Bhatia, Celeena Jefferson, Julia M. Certa, Seohyun Kim, Lily Fathi, Keri N. Althoff, Carolyn Williams, Richard Moore
Summary: This study used longitudinal data and matched control groups to analyze the disease characterization of Post-Acute Sequelae of SARS-CoV-2 (PASC). The results showed that PCR-positive patients had a 12% higher risk of PASC conditions compared to PCR-negative patients in the late period.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Yapeng Su, Dan Yuan, Daniel G. Chen, Rachel H. Ng, Kai Wang, Jongchan Choi, Sarah Li, Sunga Hong, Rongyu Zhang, Jingyi Xie, Sergey A. Kornilov, Kelsey Scherler, Ana Jimena Pavlovitch-Bedzyk, Shen Dong, Christopher Lausted, Inyoul Lee, Shannon Fallen, Chengzhen L. Dai, Priyanka Baloni, Brett Smith, Venkata R. Duvvuri, Kristin G. Anderson, Jing Li, Fan Yang, Caroline J. Duncombe, Denise J. McCulloch, Clifford Rostomily, Pamela Troisch, Jing Zhou, Sean Mackay, Quinn DeGottardi, Damon H. May, Ruth Taniguchi, Rachel M. Gittelman, Mark Klinger, Thomas M. Snyder, Ryan Roper, Gladys Wojciechowska, Kim Murray, Rick Edmark, Simon Evans, Lesley Jones, Yong Zhou, Lee Rowen, Rachel Liu, William Chour, Heather A. Algren, William R. Berrington, Julie A. Wallick, Rebecca A. Cochran, Mary E. Micikas, Terri Wrin, Christos J. Petropoulos, Hunter R. Cole, Trevan D. Fischer, Wei Wei, Dave S. B. Hoon, Nathan D. Price, Naeha Subramanian, Joshua A. Hill, Jennifer Hadlock, Andrew T. Magis, Antoni Ribas, Lewis L. Lanier, Scott D. Boyd, Jeffrey A. Bluestone, Helen Chu, Leroy Hood, Raphael Gottardo, Philip D. Greenberg, Mark M. Davis, Jason D. Goldman, James R. Heath
Summary: Post-acute sequelae of COVID-19 (PASC) is an emerging global crisis, and the quantifiable risk factors and biological associations are not well understood. In this study, a deep multi-omic investigation was conducted on 309 COVID-19 patients, and four PASC-anticipating risk factors were identified at the time of initial diagnosis. The study also observed changes in immune states during recovery from COVID-19.
Article
Medicine, General & Internal
George A. Alba, David R. Ziehr, Jennifer N. Rouvina, Lida P. Hariri, Rachel S. Knipe, Benjamin D. Medoff, Kathryn A. Hibbert, Alyssa Kowal, Casey Hoenstine, Leo C. Ginns, Gregory D. Lewis, C. Corey Hardin
Summary: In a retrospective cohort study comparing patients with post-acute sequelae of SARS-CoV-2 infection (PASC) to age-and sex-matched patients with unexplained dyspnea, it was found that physiological abnormalities on cardiopulmonary exercise testing (CPET) were mild in PASC patients. Despite prominent dyspnea, CPET findings were similar to those of patients referred for dyspnea without prior SARS-CoV-2 infection.
Article
Biochemistry & Molecular Biology
Hao Zhang, Chengxi Zang, Zhenxing Xu, Yongkang Zhang, Jie Xu, Jiang Bian, Dmitry Morozyuk, Dhruv Khullar, Yiye Zhang, Anna S. S. Nordvig, Edward J. J. Schenck, Elizabeth A. A. Shenkman, Russell L. L. Rothman, Jason P. P. Block, Kristin Lyman, Mark G. G. Weiner, Thomas W. W. Carton, Fei Wang, Rainu Kaushal
Summary: This study utilized electronic health record data from two large cohorts to identify four reproducible subphenotypes of post-acute sequelae of SARS-CoV-2 infection. These subphenotypes were associated with patient demographics, underlying conditions before infection, and severity of acute infection.
Review
Biochemistry & Molecular Biology
Ian Z. Z. Ong, Dennis L. L. Kolson, Matthew K. K. Schindler
Summary: With more and more patients recovering from SARS-CoV-2 infection, understanding the long-term neurological consequences of the disease is crucial for their care. The neurological complications, known as NC-PASC, include symptoms such as headaches, brain fog, and numbness/tingling, which many people experience long after the acute infection has resolved. Limited knowledge of disease mechanisms has hindered therapeutic efforts, but emerging reports and reviews aim to address these issues and explore potential clinical interventions.
Article
Public, Environmental & Occupational Health
Cozie Gwaikolo, Yatta Sackie-Wapoe, Moses Badio, David Glidden, Christina Lindan, Jeffrey Martin
Summary: Evidence from a study conducted in Liberia shows that common persistent symptoms among COVID-19 patients with post-acute sequelae of COVID-19 (PASC) include fatigue, headache, and cough, with disease severity associated with the occurrence of PASC, and females more likely to report persistent fatigue.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Review
Microbiology
Amy D. Proal, Michael B. VanElzakker
Summary: The novel coronavirus SARS-CoV-2 has led to a pandemic of COVID-19, with some patients developing persistent symptoms known as Long COVID or PASC. These patients may have different underlying biological factors driving their symptoms, such as organ damage, persistent viral reservoirs, re-activation of pathogens, and immune dysregulation. Therapeutic approaches may need to be individualized to effectively manage care for specific patients with PASC.
FRONTIERS IN MICROBIOLOGY
(2021)