Article
Biotechnology & Applied Microbiology
Zhongquan Cheng, Yushen Jin, Jiaqian Li, Guangyuan Shi, Leyi Yu, Bing Shao, Jie Tian, Yang Du, Zhu Yuan
Summary: A smart fibronectin-targeting and metalloproteinase-activatable imaging probe CREKA-GK8-QC is developed to detect breast cancer and lung micro-metastatic lesions, improving surgery prognosis.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
F. B. Achterberg, M. M. Deken, R. P. J. Meijer, J. S. D. Mieog, J. Burggraaf, C. J. H. van de Velde, R. J. Swijnenburg, A. L. Vahrmeijer
Summary: Transitioning tumor-specific fluorescence-guided surgery from phase I-II studying imaging agent efficacy to phase III proving patient benefit can be challenging. It is vital to establish a trial team overseeing the translational process and providing participating clinicians with well-defined protocols to gather reliable trial data. Successful clinical translation of imaging agents for image-guided cancer surgery requires collaboration with all stakeholders involved in the process.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Materials Science, Multidisciplinary
Yinghua Liu, Jianfeng Zeng, Qing Li, Minqian Miao, Zhuorun Song, Min Zhao, Qingqing Miao, Mingyuan Gao
Summary: Developing smart molecular probes for precise cancer detection and removal during surgery is urgently needed. A new chemiluminescent probe shows potential for sensitive imaging and precise resection of malignant tumors, allowing for rapid detection and surgical removal of tumors.
ADVANCED OPTICAL MATERIALS
(2022)
Article
Engineering, Biomedical
Robert Pola, Eliska Grosmanova, Michal Pechar, Dominik Horak, Tereza Krunclova, Jan Pankrac, Maxime Henry, Martin Kana, Jan Boucek, Ludek Sefc, Jean-Luc Coll, Tomas Etrych
Summary: In this study, long-circulating stimuli-responsive polymer nanoprobes were developed for fluorescently-guided surgery of solid tumors. The nanoprobes were designed to accumulate preferentially in solid tumors, showing stimuli-sensitive release behavior and activating fluorescent signals. These probes demonstrated excellent diagnostic potential for surgical removal of tumors with high efficacy and accuracy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Oncology
Tessa Buckle, Maarten van Alphen, Matthias N. van Oosterom, Florian van Beurden, Nina Heimburger, Jaqueline E. van der Wal, Michiel van den Brekel, Fijs W. B. van Leeuwen, Baris Karakullukcu
Summary: Translation of tumor-specific fluorescent tracers is essential for fluorescence-guided surgery to identify tumors intraoperatively. In this study, the c-Met receptor was identified as a potential candidate for fluorescence-guided surgery in oral cavity cancer, with ex vivo evaluation of freshly excised tumor specimens showing promising results. Improved tumor assessment was achieved through video representation of the tumor-to-background ratio, suggesting the feasibility of using c-Met as a surgical target in oral cavity cancer.
Article
Chemistry, Multidisciplinary
Rui-Qin Yang, Pei-Yuan Wang, Kang-Liang Lou, Yong-Ying Dang, Hai-Na Tian, Yang Li, Yi-Yang Gao, Wen-He Huang, Yong-Qu Zhang, Xiao-Long Liu, Guo-Jun Zhang
Summary: A biodegradable cyclic RGD pentapeptide/hollow virus-like gadolinium-based indocyanine green nanoprobe is developed for fluorescence image-guided surgery and radiotherapy in breast cancer, showing improved efficacy and diagnostic accuracy, and providing a basis for developing precision treatment strategies.
Article
Chemistry, Multidisciplinary
Fabio de Moliner, Zuzanna Konieczna, Lorena Mendive-Tapia, Rebecca S. Saleeb, Katie Morris, Juan Antonio Gonzalez-Vera, Takeshi Kaizuka, Seth G. N. Grant, Mathew H. Horrocks, Marc Vendrell
Summary: The multiple applications of super-resolution microscopy have led to the need for minimally invasive labeling strategies for peptide-guided fluorescence imaging. In this study, we have built a library of benzodiazole amino acids and examined their potential as background-free fluorescence microscopy probes. The results show that benzodiazole amino acids retain the binding capabilities of bioactive peptides and exhibit excellent signal-to-background ratios.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Caiting Deng, Meichen Zheng, Shupeng Han, Yuanjie Wang, Jingqi Xin, Omer Aras, Liang Cheng, Feifei An
Summary: Sonodynamic therapy (SDT) is a promising cancer therapy that uses ultrasound to trigger a sonosensitizer to generate reactive oxygen species (ROS) with excellent tissue penetration depth. However, the spread of the sonosensitizer to healthy tissue beyond the tumor can cause undesired side effects. In this study, a GSH-activatable sonosensitizer prodrug is designed by attaching a quencher to tetraphydroxy porphyrin, which shows high tumor selectivity and activation in the presence of overexpressed GSH. The prodrug demonstrates effective tumor growth inhibition under ultrasound irradiation, highlighting its potential as a highly effective cancer treatment.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Oncology
Yu Tian, Chu Tang, Guangyuan Shi, Guorong Wang, Yang Du, Jie Tian, Haizhong Zhang
Summary: A novel fluorescent imaging probe, WZB117-IR820, was synthesized for early detection and fluorescence image-guided surgery in oral squamous cell carcinoma (OSCC), with potential clinical applications.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Review
Chemistry, Analytical
Hazel L. Stewart, David J. S. Birch
Summary: Fluorescence guided surgery, with its advantages such as higher contrast, sensitivity, and ease of operation, is gaining more interest. Despite some developments, there are still limitations that need to be overcome.
METHODS AND APPLICATIONS IN FLUORESCENCE
(2021)
Article
Oncology
Zuhong Tian, Shuhui Liang, Xinmin Zhou, Hui Luo, Miaomiao Tian, Xianghan Zhang, Changcun Guo, Jing Zhang
Summary: This study developed a tumor-specific probe for real-time intraoperative NIR fluorescence imaging guidance in gastric cancer surgery. The probe showed specific binding to tumor vascular endothelial cells and produced strong NIR signals at the tumor site. Using the probe in real-time surgery allowed clear visualization of tumor margins and peritoneal metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Imke Boekestijn, Matthias N. van Oosterom, Paolo Dell'Oglio, Floris H. P. van Velden, Martin Pool, Tobias Maurer, Daphne D. D. Rietbergen, Tessa Buckle, Fijs W. B. van Leeuwen
Summary: Molecular imaging technologies are increasingly important in the diagnosis, monitoring, and treatment of cancer. The relevance and accessibility of surgical targets, as well as the selection of the correct combination of imaging agents for visualizing disease sites with high affinity and specificity are crucial. Developments within engineering/imaging physics continue to drive image-guided surgery, enhancing sensitivity and spatial resolution to ensure cancer sites are not overlooked during surgery.
Article
Multidisciplinary Sciences
Feifei Wang, Liangqiong Qu, Fuqiang Ren, Ani Baghdasaryan, Yingying Jiang, RuSiou Hsu, Peng Liang, Jiachen Li, Guanzhou Zhu, Zhuoran Ma, Hongjie Dai
Summary: This study developed a compact imager capable of simultaneous visible photographic and near-infrared II (NIR-II) fluorescence imaging for preclinical image-guided surgery. Using molecular imaging of angiogenesis markers in a murine breast tumor model, high-resolution noninvasive tumor imaging was achieved with NIR-IIb imaging, enabling clear identification of tumor margin and residual cancer cells during surgery.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Oncology
Marco Stefano Demarchi, Barbara Seeliger, Jean-Christophe Lifante, Pier Francesco Alesina, Frederic Triponez
Summary: The most common post-operative complication in thyroid surgery is hypoparathyroidism, especially in cases of thyroid cancer requiring lymph node dissection. Fluorescence imaging is a valuable tool to preserve parathyroid glands and prevent hypoparathyroidism, particularly in cases involving lymphadenectomy.
Article
Engineering, Biomedical
S. Liu, Y. Li, J. Zhang, H. Zhang, Y. Wang, C. Chuah, Y. Tang, J. W. Y. Lam, R. T. K. Kwok, H. Ou, D. Ding, B. Z. Tang
Summary: This study proposed a method for designing Janus NIR-II fluorophores by incorporating different electronic donors into one molecule, resulting in balanced absorption and emission properties in fluorescent dyes. The approach combines the advantages of intense absorption from planar architecture and high fluorescence quantum yield from twisted motif.
MATERIALS TODAY BIO
(2021)
