Article
Oncology
Yilin Cao, Hanbo Chen, Arjun Sahgal, Darby Erler, Serena Badellino, Tithi Biswas, Roi Dagan, Matthew C. Foote, Alexander V. Louie, Ian Poon, Umberto Ricardi, Kristin J. Redmond
Summary: This study investigated the impact of local control (LC) on widespread progression (WSP) and overall survival (OS) in patients treated to all extracranial oligometastases (OMs) at presentation to SBRT. The study found that patients who failed locally within 6 months after SBRT were at a significantly higher risk of death and WSP compared to those who remained locally-controlled. The duration of LC following OM-directed SBRT strongly correlated with WSP and OS. Rating: 6 out of 10.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Dennis Winkel, Anita M. Werensteijn-Honingh, Wietse S. C. Eppinga, Martijn P. W. Intven, Jochem Hes, Louk M. W. Snoeren, Sanne A. Visser, Gijsbert H. Bol, Bas W. Raaymakers, Ina M. Jurgenliemk-Schulz, Petra S. Kroon
Summary: The study investigated the dosimetric feasibility and plan quality of hypofractionated radiotherapy for patients with lymph node oligometastases using the 1.5T MR-linac system. The results showed that hypofractionated treatment is feasible based on dose criteria and plan quality metrics, but it is important to consider the location of the target relative to critical structures when choosing the fractionation scheme. Meeting all dose criteria in the pre-treatment situation does not guarantee the same outcome during online treatment.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Health Care Sciences & Services
Giuseppe Facondo, Gianluca Vullo, Vitaliana De Sanctis, Margherita Rotondi, Riccardo Carlo Sigillo, Maurizio Valeriani, Mattia Falchetto Osti
Summary: This study retrospectively analyzed the clinical outcomes of stereotactic body radiation therapy (SBRT) for lymph node metastases from gynecological cancers. The results showed that SBRT achieved excellent tumor control with low toxicities.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Francesco Cuccia, Edoardo Pastorello, Claudio Vitale, Luca Nicosia, Rosario Mazzola, Vanessa Figlia, Niccolo Giaj-Levra, Francesco Ricchetti, Michele Rigo, Giorgio Attina, Marcello Ceccaroni, Ruggero Ruggieri, Filippo Alongi
Summary: The study showed promising results in terms of clinical outcomes for SBRT in oligometastatic gynecological malignancies, with excellent local control and no severe toxicity observed. The median follow-up of 27 months revealed no local failures and overall survival rates of 70% at 1 and 2 years. Prospective studies are advocated to further explore this therapeutic option in this setting.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Oncology
Raquel Ciervide, Ovidio Hernando, Mercedes Lopez, Angel Montero, Daniel Zucca, Emilio Sanchez, Beatriz Alvarez, Mariola Garcia-Aranda, Xin Chen Zhao, Jeannette Valero, Rosa Alonso, Jaime Marti, Miguel Angel de la Casa, Leire Alonso, Juan Garcia, Paz Garcia de Acilu, Alejandro Prado, Pedro Fernandez Leton, Carmen Rubio
Summary: This study evaluated the clinical outcomes of patients with spine metastases treated with SBRT. The results showed that SBRT was effective in providing pain relief and achieving local control. The overall survival rate was also relatively high.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Oncology
Shigeru Imoto, Kun Wang, Xi-wen Bi, Guangyu Liu, Young-Hyuck Im, Seock-Ah Im, Sung Hoon Sim, Takayuki Ueno, Manabu Futamura, Masakazu Toi, Yasuhiro Fujiwara, Sung Gwe Ahn, Jeong Eon Lee, Yeon Hee Park, Shintaro Takao, Mari Saito Oba, Yuko Kitagawa, Masahiko Nishiyama
Summary: This international retrospective cohort study aimed to clarify the survival advantage of combination therapy with locoregional and systemic therapy (ST) in patients with oligometastatic breast cancer. The results showed that under certain conditions, combination therapy may help prolong the survival of patients with oligometastatic breast cancer.
Article
Medicine, General & Internal
Luca Nicosia, Giovanna Trapani, Michele Rigo, Matilde Fiorini, Niccolo Giaj-Levra, Rosario Mazzola, Edoardo Pastorello, Francesco Ricchetti, Filippo Alongi, Francesco Cuccia, Vanessa Figlia
Summary: This study evaluated the efficacy and toxicity of daily adaptive MR-guided SBRT on a 1.5 T MR-linac for treating lymph node oligometastases from PCa. The results showed that lymph node SBRT on a 1.5 T MR-linac provides high local control rates with an excellent toxicity profile.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Ping-Chung Tsai, Hung-Che Chien, Po-Kuei Hsu, Jung-Jyh Hung, Chien-Sheng Huang, Wen-Hu Hsu, Han-Shui Hsu
Summary: This study aimed to evaluate the role of surgical resection in patients with resectable recurrences after curative esophagectomy and to identify their prognostic factors. The study found that mediastinum lymph node recurrence and pathologic T3 stage were associated with worse overall survival (OS) and post-recurrence survival (PRS). No definite survival benefit was noted in patients undergoing surgery for resectable recurrence, except in those without comorbidities.
Review
Oncology
Stanley Gutiontov, Sean P. Pitroda, Phuoc T. Tran, Ralph R. Weichselbaum
Summary: The understanding of oligometastatic state has evolved, emphasizing that cancer metastasis represents a spectrum of disease. Recent clinical trials have shown improvements in cancer-specific outcomes with the use of metastasis-directed local therapies. Biological aspects of oligometastases, including genetic, epigenetic, and immune determinants, were discussed along with considerations for future clinical trial design for patients with oligometastatic disease.
Article
Biology
Qingren Lin, Ning Zhou, Xiang Zhu, Juan Lin, Jun Fang, Feiying Gu, Xiaojiang Sun, Yuezhen Wang
Summary: This study investigated the outcomes of stereotactic body radiation therapy (SBRT) for lung oligo-recurrence in patients with non-small cell lung cancer (NSCLC). The study found that SBRT had high rates of local control and low toxicity in these patients. LAT to all residual diseases was associated with better survival outcomes.
JOURNAL OF RADIATION RESEARCH
(2022)
Article
Oncology
Francesco Cuccia, Rosario Mazzola, Edoardo Pastorello, Vanessa Figlia, Niccolo Giaj-Levra, Luca Nicosia, Francesco Ricchetti, Michele Rigo, Giorgio Attina, Claudio Vitale, Ruggero Ruggieri, Filippo Alongi
Summary: This study focused on 61 elderly oligometastatic patients over the age of 80 who received SBRT treatment, showing promising results in terms of local control rates and survival rates. Colorectal cancer patients had lower local control rates, while oligorecurrent lesions and single oligometastases were associated with better progression-free survival rates.
CLINICAL & EXPERIMENTAL METASTASIS
(2021)
Article
Oncology
Francesco Cuccia, Michele Rigo, Davide Gurrera, Luca Nicosia, Rosario Mazzola, Vanessa Figlia, Niccolo Giaj-Levra, Francesco Ricchetti, Giorgio Attina, Edoardo Pastorello, Antonio De Simone, Stefania Naccarato, Gianluisa Sicignano, Ruggero Ruggieri, Filippo Alongi
Summary: The study reported preliminary dosimetric data on the use of 1.5T MR-guided daily-adaptive radiotherapy for abdomino-pelvic lymph-nodal oligometastases. The technology showed potential in improving target coverage and reducing OARs risks, especially in significantly sparing single intestinal loops.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
News Item
Physics, Multidisciplinary
Jack Binysh, Anton Souslov
Summary: An active solid made up of confined robots has been developed, where the robots can synchronize their motion through elastic interactions, leading to the emergence of novel coherent states.
Article
Oncology
Shu Zhang, Weiyi Zhan, Ni Zeng, Jiangping Yang, Maoqi Xiong, Wenjun Liao, Nianyong Chen, Jianghong Xiao
Summary: This study aimed to compare the dosimetric distribution of VMAT plans in liver SBRT by increasing the number of half arcs and investigate the effect using automatic plan software in plan optimization.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Luca Nicosia, Vanessa Figlia, Nicola Ricottone, Francesco Cuccia, Rosario Mazzola, Niccolo Giaj-Levra, Francesco Ricchetti, Michele Rigo, Fatemeh Jafari, Stefano Maria Magrini, Andrea Girlando, Filippo Alongi
Summary: This study aims to demonstrate the effectiveness of stereotactic body radiotherapy (SBRT) in delaying the switch to a subsequent systemic treatment in patients with oligoprogressive breast cancer. The results show that SBRT can delay the progression of treatment, but patient selection is necessary, and several predictive factors for individualized treatment have been identified.
CLINICAL & EXPERIMENTAL METASTASIS
(2022)
Article
Oncology
Noriyoshi Takahashi, Rei Umezawa, Kentaro Takanami, Takaya Yamamoto, Youjirou Ishikawa, Maiko Kozumi, Kazuya Takeda, Noriyuki Kadoya, Keiichi Jingu
RADIOTHERAPY AND ONCOLOGY
(2018)
Article
Oncology
Takaya Yamamoto, Noriyuki Kadoya, Yoshinao Sato, Haruo Matsushita, Rei Umezawa, Masaki Kubozono, Yojiro Ishikawa, Maiko Kozumi, Noriyoshi Takahashi, Yohei Morishita, Yu Katagiri, Kiyokazu Sato, Kengo Ito, Ken Takeda, Keiichi Jingu
CLINICAL LUNG CANCER
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Maiko Kozumi, Hideki Ota, Takaya Yamamoto, Rei Umezawa, Haruo Matsushita, Yojiro Ishikawa, Noriyoshi Takahashi, Tomonori Matsuura, Kei Takase, Keiichi Jingu
EUROPEAN RADIOLOGY
(2018)
Article
Biology
Kota Abe, Noriyuki Kadoya, Shinya Sato, Shimpei Hashimoto, Yujiro Nakajima, Yuya Miyasaka, Kengo Ito, Rei Umezawa, Takaya Yamamoto, Noriyoshi Takahashi, Ken Takeda, Keiichi Jingu
JOURNAL OF RADIATION RESEARCH
(2018)
Article
Oncology
Noriyuki Kadoya, Kei Ichiji, Tomoya Uchida, Yujiro Nakajima, Ryutaro Ikeda, Yosuke Uozumi, Xiaoyong Zhang, Ivo Bukovsky, Takaya Yamamoto, Ken Takeda, Yoshihiro Takai, Keiichi Jingu, Noriyasu Homma
Article
Radiology, Nuclear Medicine & Medical Imaging
Takayuki Kanai, Noriyuki Kadoya, Yujiro Nakajima, Yuya Miyasaka, Yoshiro Ieko, Tomohiro Kajikawa, Kengo Ito, Takaya Yamamoto, Suguru Dobashi, Ken Takeda, Kenji Nemoto, Keiichi Jingu
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2018)
Article
Multidisciplinary Sciences
Takaya Yamamoto, Noriyuki Kadoya, Yohei Morishita, Yoshinao Sato, Haruo Matsushita, Rei Umezawa, Yojiro Ishikawa, Noriyoshi Takahashi, Yu Katagiri, Ken Takeda, Keiichi Jingu
Article
Oncology
Takaya Yamamoto, Yuzuru Niibe, Masahiko Aoki, Takashi Shintani, Kazunari Yamada, Mitsuru Kobayashi, Hideomi Yamashita, Masatoki Ozaki, Yoshihiko Manabe, Hiroshi Onishi, Katsuya Yahara, Atsushi Nishikawa, Kuniaki Katsui, Ryoong-Jin Oh, Atsuro Terahara, Keiichi Jingu
Article
Oncology
Takaya Yamamoto, Yuzuru Niibe, Yasuo Matsumoto, Masahiko Aoki, Ryoong-Jin Oh, Masatoki Ozaki, Mitsuru Kobayashi, Yoshihiko Manabe, Takashi Shintani, Yasuhiro Dekura, Hiroshi Onishi, Hideomi Yamashita, Keiichi Jingu
Article
Oncology
Takaya Yamamoto, Yu Katagiri, Yoko Tsukita, Haruo Matsushita, Rei Umezawa, Yoshiyuki Katsuta, Noriyuki Kadoya, Noriyoshi Takahashi, Yu Suzuki, Kazuya Takeda, Keita Kishida, So Omata, Eisaku Miyauchi, Ryota Saito, Keiichi Jingu
Summary: This study evaluated the efficacy of a risk-adapted strategy of SRS for lung cancer, and the results showed a low rate of 3-year local recurrence and tolerable toxicity.
Article
Multidisciplinary Sciences
Takaya Yamamoto, Yoshiyuki Katsuta, Kiyokazu Sato, Yoko Tsukita, Rei Umezawa, Noriyoshi Takahashi, Yu Suzuki, Kazuya Takeda, Keita Kishida, So Omata, Eisaku Miyauchi, Ryota Saito, Noriyuki Kadoya, Keiichi Jingu
Summary: This prospective study investigated the changes in longitudinal parameters after stereotactic radiotherapy for lung cancer and identified possible factors related to radiation-induced lung toxicity and decline in pulmonary function. The results showed that certain parameters reached their peak at 4 months, while pulmonary function tests were lowest at 12 months. Significant correlations were observed between lung dose and changes in pulmonary function.
Article
Oncology
Rei Umezawa, Hideki Tokunaga, Takaya Yamamoto, Shogo Shigeta, Noriyoshi Takahashi, Kazuya Takeda, Yu Suzuki, Keita Kishida, Kengo Ito, Noriyuki Kadoya, Muneaki Shimada, Keiichi Jingu
Summary: This study retrospectively analyzed patients with LACC treated with ICBT/ISBT, showing 3-year rates of 88.2% for LC, 56.6% for PFS, and 65.4% for OS. Corpus invasion and large HR-CTV were significant prognostic factors for LC, PFS, and OS, with late toxicities detected in 6.8% of patients.
Article
Biology
Erika Segawa, Keiichi Jingu, Rei Umezawa, Takaya Yamamoto, Noriyoshi Takahashi, Noriyuki Kadoya, Ken Takeda
Summary: This study evaluated the association between radiotherapy after breast-conserving surgery and the frequency of cardiac events in Japanese patients with breast cancer. The results showed that postoperative radiotherapy did not increase the incidence of cardiac events. The study also identified hypertension as a significant risk factor for cardiac events.
JOURNAL OF RADIATION RESEARCH
(2023)
Article
Biology
Rei Umezawa, Hideki Ota, Hidenobu Takagi, Noriyuki Kadoya, Yujiro Nakajima, Noriyoshi Takahashi, Takaya Yamamoto, Kei Takase, Keiichi Jingu
Summary: This prospective study aimed to determine whether radiation-induced myocardial damage detected by cardiac magnetic resonance imaging can predict cardiac events after chemoradiotherapy for esophageal cancer and evaluate the role of left ventricle dose-volume histogram parameters. The study included 23 patients who underwent CMR imaging before and after chemoradiotherapy. Radiation-induced myocardial damage was defined as abnormal CMR findings indicating myocardial fibrosis in areas receiving a dose of 30 Gy or higher. The results showed that radiation-induced myocardial damage and LV V45 were significant risk factors for cardiac events.
JOURNAL OF RADIATION RESEARCH
(2023)
Article
Oncology
Rei Umezawa, Noriyuki Kadoya, Hideki Ota, Yujiro Nakajima, Masahide Saito, Hidenobu Takagi, Kentaro Takanami, Noriyoshi Takahashi, Yojiro Ishikawa, Takaya Yamamoto, Haruo Matsushita, Ken Takeda, Kei Takase, Keiichi Jingu
ADVANCES IN RADIATION ONCOLOGY
(2020)