Monogenic Versus Polygenic Forms of Hypercholesterolemia and Cardiovascular Risk: Are There Any Differences?

Polygenic scores for dyslipidemia

(2021) Mark Trinder et al.   CURRENT OPINION IN LIPIDOLOGY

The need for polygenic score reporting standards in evidence-based practice: lipid genetics use case

(2021) Hannah Wand et al.   CURRENT OPINION IN LIPIDOLOGY

The clinical applicability of polygenic risk scores for LDL-cholesterol: considerations, current evidence and future perspectives

(2021) Arjen J. Cupido et al.   CURRENT OPINION IN LIPIDOLOGY

Improving reporting standards for polygenic scores in risk prediction studies

(2021) Hannah Wand et al.   NATURE

Polygenic risk scores: how much do they add?

(2021) Mette Christoffersen et al.   CURRENT OPINION IN LIPIDOLOGY

Clinical Implications of Monogenic Versus Polygenic Hypercholesterolemia: Long‐Term Response to Treatment, Coronary Atherosclerosis Burden, and Cardiovascular Events

(2021) Laura D’Erasmo et al.   Journal of the American Heart Association

A Modern Approach to Dyslipidemia

(2021) Amanda J Berberich et al.   ENDOCRINE REVIEWS

Clinical utility of polygenic risk scores for coronary artery disease

(2021) Derek Klarin et al.   Nature Reviews Cardiology

The familial hypercholesterolaemia phenotype: Monogenic familial hypercholesterolaemia, polygenic hypercholesterolaemia and other causes

(2020) Cibelle Mariano et al.   CLINICAL GENETICS

Association of Monogenic vs Polygenic Hypercholesterolemia With Risk of Atherosclerotic Cardiovascular Disease

(2020) Mark Trinder et al.   JAMA Cardiology

Genetic testing in dyslipidemia: A scientific statement from the National Lipid Association

(2020) Emily E. Brown et al.   Journal of Clinical Lipidology

Familial hypercholesterolemia

(2020) Julia Brandts et al.   CURRENT OPINION IN LIPIDOLOGY

Can genetic testing help in the management of dyslipidaemias?

(2020) Julieta Lazarte et al.   CURRENT OPINION IN LIPIDOLOGY

Tutorial: a guide to performing polygenic risk score analyses

(2020) Shing Wan Choi et al.   Nature Protocols

Polygenic Contribution to Low-density Lipoprotein Cholesterol Levels and Cardiovascular Risk in Monogenic Familial Hypercholesterolemia

(2020) Mark Trinder et al.   Circulation-Genomic and Precision Medicine

Higher Responsiveness to Rosuvastatin in Polygenic versus Monogenic Hypercholesterolemia: A Propensity Score Analysis

(2020) Agnieszka Mickiewicz et al.   Life-Basel

Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions

(2020) Akl C. Fahed et al.   Nature Communications

Whole Genome Sequencing to Characterize Monogenic and Polygenic Contributions in Patients Hospitalized with Early-Onset Myocardial Infarction

(2019) Amit V. Khera et al.   CIRCULATION

The evolution of genetic-based risk scores for lipids and cardiovascular disease

(2019) Jacqueline S. Dron et al.   CURRENT OPINION IN LIPIDOLOGY

Polygenic Hypercholesterolemia and Cardiovascular Disease Risk

(2019) Mahtab Sharifi et al.   Current Cardiology Reports

Risk of Premature Atherosclerotic Disease in Patients With Monogenic Versus Polygenic Familial Hypercholesterolemia

(2019) Mark Trinder et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Polygenic Risk Scores in Familial Hypercholesterolemia

(2019) Daniel J. Rader et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Genetic correlations of polygenic disease traits: from theory to practice

(2019) Wouter van Rheenen et al.   NATURE REVIEWS GENETICS

Patients with High Genome-Wide Polygenic Risk Scores for Coronary Artery Disease May Receive Greater Clinical Benefit from Alirocumab Treatment in the Odyssey Outcomes Trial

(2019) Amy Damask et al.   CIRCULATION

Reducing cardiovascular risk in patients with familial hypercholesterolemia: Risk prediction and lipid management

(2019) Marcio H. Miname et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Quantifying the polygenic contribution to variable expressivity in eleven rare genetic disorders

(2019) M. T. Oetjens et al.   Nature Communications

The complex molecular genetics of familial hypercholesterolaemia

(2018) Amanda J. Berberich et al.   Nature Reviews Cardiology

Deep-coverage whole genome sequences and blood lipids among 16,324 individuals

(2018) Pradeep Natarajan et al.   Nature Communications

Polygenic Versus Monogenic Causes of Hypercholesterolemia Ascertained ClinicallyHighlights

(2016) Jian Wang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Children with hypercholesterolemia of unknown cause: Value of genetic risk scores

(2016) Barbara Sjouke et al.   Journal of Clinical Lipidology

Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia

(2016) Amit V. Khera et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials

(2015) Jessica L Mega et al.   LANCET

Refinement of Variant Selection for the LDL Cholesterol Genetic Risk Score in the Diagnosis of the Polygenic Form of Clinical Familial Hypercholesterolemia and Replication in Samples from 6 Countries

(2014) M. Futema et al.   CLINICAL CHEMISTRY

Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control study

(2013) Philippa J Talmud et al.   LANCET

Biological, clinical and population relevance of 95 loci for blood lipids

(2010) Tanya M. Teslovich et al.   NATURE