Transfer inhibitory potency prediction to binary classification: A model only needs a small training set

Macrophages provide a transient muscle stem cell niche via NAMPT secretion

(2021) Dhanushika Ratnayake et al.   NATURE

A Stat1 bound enhancer promotes Nampt expression and function within tumor associated macrophages

(2021) Thomas B. Huffaker et al.   Nature Communications

Anti-tumor NAMPT inhibitor, KPT-9274, mediates gender-dependent murine anemia and nephrotoxicity by regulating SIRT3-mediated SOD deacetylation

(2021) Shaneice Mitchell et al.   Journal of Hematology & Oncology

Attention meets long short-term memory: A deep learning network for traffic flow forecasting

(2021) Weiwei Fang et al.   PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS

Deep Learning-Based Prediction of Drug-Induced Cardiotoxicity

(2019) Chuipu Cai et al.   Journal of Chemical Information and Modeling

Deep Learning and Random Forest Approach for Finding Optimal TCM Formula for Treatment of Alzheimer’s Disease

(2019) Hsin-Yi Chen et al.   Journal of Chemical Information and Modeling

Feature Selection for Neural Networks Using Group Lasso Regularization

(2019) Huaqing Zhang et al.   IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING

Prediction of Human Cytochrome P450 Inhibition Using a Multitask Deep Autoencoder Neural Network

(2018) Xiang Li et al.   MOLECULAR PHARMACEUTICS

A Learning-Based Multimodel Integrated Framework for Dynamic Traffic Flow Forecasting

(2018) Teng Zhou et al.   NEURAL PROCESSING LETTERS

Integration of deep feature representations and handcrafted features to improve the prediction of N 6 -methyladenosine sites

(2018) Leyi Wei et al.   NEUROCOMPUTING

Chemical Topic Modeling: Exploring Molecular Data Sets Using a Common Text-Mining Approach

(2017) Nadine Schneider et al.   Journal of Chemical Information and Modeling

Discovery of a Highly Selective NAMPT Inhibitor That Demonstrates Robust Efficacy and Improved Retinal Toxicity with Nicotinic Acid Coadministration

(2017) Genshi Zhao et al.   MOLECULAR CANCER THERAPEUTICS

Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors

(2017) Julie L. Wilsbacher et al.   MOLECULAR CANCER THERAPEUTICS

Novel naïve Bayes classification models for predicting the chemical Ames mutagenicity

(2017) Hui Zhang et al.   TOXICOLOGY IN VITRO

REVEL: An Ensemble Method for Predicting the Pathogenicity of Rare Missense Variants

(2016) Nilah M. Ioannidis et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Profiling Prediction of Kinase Inhibitors: Toward the Virtual Assay

(2016) Benjamin Merget et al.   JOURNAL OF MEDICINAL CHEMISTRY

ADMET Evaluation in Drug Discovery. 16. Predicting hERG Blockers by Combining Multiple Pharmacophores and Machine Learning Approaches

(2016) Shuangquan Wang et al.   MOLECULAR PHARMACEUTICS

Deep learning

(2015) Yann LeCun et al.   NATURE

Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers

(2015) G. Fibriansah et al.   SCIENCE

Structural and Biochemical Analyses of the Catalysis and Potency Impact of Inhibitor Phosphoribosylation by Human Nicotinamide Phosphoribosyltransferase

(2014) Angela Oh et al.   CHEMBIOCHEM

PaDEL-descriptor: An open source software to calculate molecular descriptors and fingerprints

(2010) Chun Wei Yap   JOURNAL OF COMPUTATIONAL CHEMISTRY

NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response

(2010) B Wang et al.   ONCOGENE