Journal
COMPOSITES PART B-ENGINEERING
Volume 234, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.compositesb.2022.109746
Keywords
Chitosan; Graphene oxide; Tannic acid; Shape memory; Hemostasis; Wound healing
Funding
- Shandong Laboratory of Advanced Materials and Green Manufacturing [AMGM2021F02]
- State Key Laboratory of Advanced Technology for Materials Synthesis and Processing (WUT) [2022-KF-13]
- Physical-Chemical Materials Analytical & Testing Center of Shandong University at Weihai
Ask authors/readers for more resources
In this study, an elastic and biodegradable wound dressing with antibacterial and hemostatic properties was designed and its potential clinical application was demonstrated through in vitro and in vivo experiments.
Skin trauma with uncontrolled bleeding and bacterial infection are major challenges in clinical wound management. Therefore, the design of elastic and biodegradability wound dressing with antibacterial and hemostatic properties are attracting increasing attention. In the study, chitosan (CS) and graphene oxide (GO) are covalently bound by EDC/NHS to form a complex and followed by the introduction of tannic acid (TA) as secondary cross linking agent after removing the acidity of chitosan. CS/GO/TA sponges can exist stably in aqueous solution and has good compression recovery performance. In vitro experiments showed that CS/GO/TA sponges have antibacterial, antioxidant, non-hemolysis, blood cell adhesion and cytocompatibility. In vivo experiments in rats showed that CS/GO/TA sponges can quickly stop bleeding and promote wound healing, which has good clinical application potential.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available