Management of Neisseria gonorrhoeae in the United States: Summary of Evidence From the Development of the 2020 Gonorrhea Treatment Recommendations and the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infection Treatment Guidelines

Implementation and evaluation of gradient strip antimicrobial susceptibility testing in US public health laboratories to respond to resistant gonorrhea

(2021) Brian H. Raphael et al.   SEXUALLY TRANSMITTED DISEASES

Sexually Transmitted Infections Treatment Guidelines, 2021

(2021) Kimberly A. Workowski et al.   MMWR Recommendations and Reports

Aztreonam for Neisseria gonorrhoeae: a systematic review and meta-analysis

(2020) Lindley A Barbee et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

A Single-arm Open-label Clinical Trial of 2g Aztreonam for the treatment of N. gonorrhoeae

(2020) Lindley A. Barbee et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Update to CDC's Treatment Guidelines for Gonococcal Infection, 2020

(2020) Sancta St. Cyr et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Evaluation and Management of Penicillin Allergy

(2019) Erica S. Shenoy et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Extragenital Gonorrhea and Chlamydia Among Men and Women According to Type of Sexual Exposure

(2019) David M. Bamberger et al.   SEXUALLY TRANSMITTED DISEASES

Efficacy and safety of single dose oral delafloxacin compared with intramuscular ceftriaxone for uncomplicated gonorrhea treatment

(2019) Edward W. Hook et al.   SEXUALLY TRANSMITTED DISEASES

Evaluation of the ResistancePlus GC (beta) assay: a commercial diagnostic test for the direct detection of ciprofloxacin susceptibility or resistance in Neisseria gonorrhoeae

(2019) Samantha Ebeyan et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Detection in the United Kingdom of the Neisseria gonorrhoeae FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, October to December 2018

(2019) David W Eyre et al.   Eurosurveillance

Widespread Use of High-dose Ceftriaxone Therapy for Uncomplicated Gonorrhea without Reported Ceftriaxone Treatment Failure: Results from 5-year's Multicenter-surveillance Data in China

(2019) Yan Han et al.   CLINICAL INFECTIOUS DISEASES

Gentamicin compared with ceftriaxone for the treatment of gonorrhoea (G-ToG): a randomised non-inferiority trial

(2019) Jonathan D C Ross et al.   LANCET

Exploitation of Neisseria meningitidis Group B OMV Vaccines Against N. gonorrhoeae to Inform the Development and Deployment of Effective Gonorrhea Vaccines

(2019) Helen Petousis-Harris et al.   Frontiers in Immunology

Gentamicin 240 mg plus azithromycin 2 g vs. ceftriaxone 500 mg plus azithromycin 2 g for treatment of rectal and pharyngeal gonorrhoea: a randomized controlled trial

(2019) F. Rob et al.   CLINICAL MICROBIOLOGY AND INFECTION

Solithromycin versus ceftriaxone plus azithromycin for the treatment of uncomplicated genital gonorrhoea (SOLITAIRE-U): a randomised phase 3 non-inferiority trial

(2019) Marcus Y Chen et al.   LANCET INFECTIOUS DISEASES

Gentamicin Alone Inadequate to Eradicate Neisseria Gonorrhoeae from the Pharynx

(2019) Lindley A Barbee et al.   CLINICAL INFECTIOUS DISEASES

Gepotidacin for the Treatment of Uncomplicated Urogenital Gonorrhea: A Phase 2, Randomized, Dose-Ranging, Single-Oral Dose Evaluation

(2018) Stephanie N Taylor et al.   CLINICAL INFECTIOUS DISEASES

A Brief History of Evolving Diagnostics and Therapy for Gonorrhea: Lessons Learned

(2018) Edward W Hook et al.   CLINICAL INFECTIOUS DISEASES

Accuracy and reproducibility of the Etest to detect drug-resistant Neisseria gonorrhoeae to contemporary treatment

(2018) John R. Papp et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Monoarthrite septique à gonocoque : difficultés diagnostiques et intérêt de la PCR dans le liquide articulaire

(2018) N. Rouanes et al.   REVUE DE MEDECINE INTERNE

A phase 1 pharmacokinetic and safety study of extended duration, high-dose cefixime for cephalosporin-resistant Neisseria gonorrhoeae in the pharynx

(2018) Lindley A. Barbee et al.   SEXUALLY TRANSMITTED DISEASES

Does HIV pre-exposure prophylaxis use lead to a higher incidence of sexually transmitted infections? A case-crossover study of men who have sex with men in Los Angeles, California

(2018) Matthew R Beymer et al.   SEXUALLY TRANSMITTED INFECTIONS

Rectal Chlamydia trachomatis and Neisseria gonorrhoeae Infections Among Women Reporting Anal Intercourse

(2018) Eloisa Llata et al.   OBSTETRICS AND GYNECOLOGY

Use of a Rapid Diagnostic for Chlamydia trachomatis and Neisseria gonorrhoeae for Women in the Emergency Department Can Improve Clinical Management: Report of a Randomized Clinical Trial

(2018) Charlotte A. Gaydos et al.   ANNALS OF EMERGENCY MEDICINE

Stably high azithromycin resistance and decreasing ceftriaxone susceptibility in Neisseria gonorrhoeae in 25 European countries, 2016

(2018) Michaela J. Day et al.   BMC INFECTIOUS DISEASES

Disseminated Gonococcal Infections in Patients Receiving Eculizumab: A Case Series

(2018) Page E Crew et al.   CLINICAL INFECTIOUS DISEASES

Unusual Neisseria species as a cause of infection in patients taking eculizumab

(2018) Page E. Crew et al.   JOURNAL OF INFECTION

Antibiotic allergy

(2018) Kimberly G Blumenthal et al.   LANCET

Single-Dose Zoliflodacin (ETX0914) for Treatment of Urogenital Gonorrhea

(2018) Stephanie N. Taylor et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multiplex Real-Time PCR Assay for Simultaneous Identification of Neisseria gonorrhoeae and Its Ciprofloxacin Susceptibility Status

(2017) Sumudu R. Perera et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Impact of Rapid Susceptibility Testing and Antibiotic Selection Strategy on the Emergence and Spread of Antibiotic Resistance in Gonorrhea

(2017) Ashleigh R Tuite et al.   JOURNAL OF INFECTIOUS DISEASES

Effectiveness of a group B outer membrane vesicle meningococcal vaccine against gonorrhoea in New Zealand: a retrospective case-control study

(2017) Helen Petousis-Harris et al.   LANCET

Self-Reported Use of Mouthwash and Pharyngeal Gonorrhoea Detection by Nucleic Acid Amplification Test

(2017) Eric P.F. Chow et al.   SEXUALLY TRANSMITTED DISEASES

Wild-Type Gyrase A Genotype of Neisseria gonorrhoeae Predicts In Vitro Susceptibility to Ciprofloxacin

(2017) Lao-Tzu Allan-Blitz et al.   SEXUALLY TRANSMITTED DISEASES

Persistence after treatment of pharyngeal gonococcal infections in patients of the STI clinic, Amsterdam, the Netherlands, 2012–2015: a retrospective cohort study

(2017) I Putu Yuda Hananta et al.   SEXUALLY TRANSMITTED INFECTIONS

Analysis of the potential for point-of-care test to enable individualised treatment of infections caused by antimicrobial-resistant and susceptible strains ofNeisseria gonorrhoeae: a modelling study

(2017) Katy ME Turner et al.   BMJ Open

Estimating the fitness cost and benefit of cefixime resistance in Neisseria gonorrhoeae to inform prescription policy: A modelling study

(2017) Lilith K. Whittles et al.   PLOS MEDICINE

Two cases of verified clinical failures using internationally recommended first-line cefixime for gonorrhoea treatment, Norway, 2010

(2017) M Unemo et al.   Eurosurveillance

Azithromycin-resistant Neisseria gonorrhoeae isolates in Guangzhou, China (2009–2013): coevolution with decreased susceptibilities to ceftriaxone and genetic characteristics

(2016) Jing-Yao Liang et al.   BMC INFECTIOUS DISEASES

Antimicrobial susceptibility testing of Neisseria gonorrhoeae isolates in Pakistan by Etest compared to Calibrated Dichotomous Sensitivity and Clinical Laboratory Standards Institute disc diffusion techniques

(2016) Pushpa Bhawan Mal et al.   BMC MICROBIOLOGY

Test of Cure for Anogenital Gonorrhoea Using Modern RNA-Based and DNA-Based Nucleic Acid Amplification Tests: A Prospective Cohort Study

(2016) Carolien M. Wind et al.   CLINICAL INFECTIOUS DISEASES

A comparison of agar dilution with the Calibrated Dichotomous Sensitivity (CDS) and Etest methods for determining the minimum inhibitory concentration of ceftriaxone against Neisseria gonorrhoeae

(2016) Rodney P. Enriquez et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Repeat infection with Neisseria gonorrhoeae among active duty U.S. Army personnel: a population-based case-series study

(2016) Christian T Bautista et al.   INTERNATIONAL JOURNAL OF STD & AIDS

Implementation and Operational Research

(2016) Lindley A. Barbee et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Microbiological efficacy and tolerability of a single-dose regimen of 1 g of ceftriaxone in men with gonococcal urethritis

(2016) Shin Ito et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Accurate detection ofNeisseria gonorrhoeaeciprofloxacin susceptibility directly from genital and extragenital clinical samples: towards genotype-guided antimicrobial therapy

(2016) Marcus J. Pond et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Performance and Verification of a Real-Time PCR Assay Targeting thegyrAGene for Prediction of Ciprofloxacin Resistance in Neisseria gonorrhoeae: TABLE 1

(2016) P. Hemarajata et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Genomic Epidemiology of Gonococcal Resistance to Extended-Spectrum Cephalosporins, Macrolides, and Fluoroquinolones in the United States, 2000–2013

(2016) Yonatan H. Grad et al.   JOURNAL OF INFECTIOUS DISEASES

Failure of Dual Antimicrobial Therapy in Treatment of Gonorrhea

(2016) Helen Fifer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gonorrhea Control, United States, 1972–2015, A Narrative Review

(2016) Thomas A. Peterman et al.   SEXUALLY TRANSMITTED DISEASES

Antiseptic mouthwash against pharyngealNeisseria gonorrhoeae: a randomised controlled trial and an in vitro study

(2016) Eric PF Chow et al.   SEXUALLY TRANSMITTED INFECTIONS

What is needed to guide testing for anorectal and pharyngeal Chlamydia trachomatis and Neisseria gonorrhoeae in women and men? Evidence and opinion

(2015) Nicole H. T. M. Dukers-Muijrers et al.   BMC INFECTIOUS DISEASES

Centers for Disease Control and Prevention Sexually Transmitted Diseases Treatment Guidelines

(2015) Kimberly A. Workowski   CLINICAL INFECTIOUS DISEASES

A Qualitative Review on the Pharmacokinetics of Antibiotics in Saliva: Implications on Clinical Pharmacokinetic Monitoring in Humans

(2015) Tony K. L. Kiang et al.   CLINICAL PHARMACOKINETICS

Gonococcal tenosynovitis in two HIV-infected heterosexual men: delayed diagnoses following negative urine nucleic acid amplification testing

(2015) Jonathan W Shaw et al.   INTERNATIONAL JOURNAL OF STD & AIDS

The efficacy of azithromycin and doxycycline for the treatment of rectal chlamydia infection: a systematic review and meta-analysis

(2015) Fabian Yuh Shiong Kong et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Molecular Assay for Detection of Ciprofloxacin Resistance in Neisseria gonorrhoeae Isolates from Cultures and Clinical Nucleic Acid Amplification Test Specimens

(2015) S. W. Peterson et al.   JOURNAL OF CLINICAL MICROBIOLOGY

High Prevalence of Rectal Gonorrhea and Chlamydia Infection in Women Attending a Sexually Transmitted Disease Clinic

(2015) Jose A. Bazan et al.   JOURNAL OF WOMENS HEALTH

High Prevalence of Azithromycin-Resistant Neisseria gonorrhoeae Isolates With a Multidrug Resistance Phenotype in Fukuoka, Japan

(2015) Masatoshi Tanaka et al.   SEXUALLY TRANSMITTED DISEASES

Gonorrhea Treatment Failures With Oral and Injectable Expanded Spectrum Cephalosporin Monotherapy vs Dual Therapy at 4 Canadian Sexually Transmitted Infection Clinics, 2010–2013

(2015) Ameeta E. Singh et al.   SEXUALLY TRANSMITTED DISEASES

Community-Based Sexually Transmitted Infection Screening and Increased Detection of Pharyngeal and Urogenital Chlamydia trachomatis and Neisseria gonorrhoeae Infections in Female Sex Workers in Hong Kong

(2015) Horas T.H. Wong et al.   SEXUALLY TRANSMITTED DISEASES

Neisseria gonorrhoeae and Chlamydia trachomatis Among Women Reporting Extragenital Exposures

(2015) Joshua D. Trebach et al.   SEXUALLY TRANSMITTED DISEASES

The epidemiology of gonococcal arthritis in an Indigenous Australian population

(2015) Camilla S L Tuttle et al.   SEXUALLY TRANSMITTED INFECTIONS

A mixed methods approach to assess the likelihood of testing for STI using self-collected samples among behaviourally bisexual women

(2015) Vanessa Schick et al.   SEXUALLY TRANSMITTED INFECTIONS

The potential impact of vaccination on the prevalence of gonorrhea

(2015) Andrew P. Craig et al.   VACCINE

Uptake and Population-Level Impact of Expedited Partner Therapy (EPT) on Chlamydia trachomatis and Neisseria gonorrhoeae: The Washington State Community-Level Randomized Trial of EPT

(2015) Matthew R. Golden et al.   PLOS MEDICINE

Self-Collected versus Clinician-Collected Sampling for Chlamydia and Gonorrhea Screening: A Systemic Review and Meta-Analysis

(2015) Carole Lunny et al.   PLoS One

Analysis of Neisseria gonorrhoeae Azithromycin Susceptibility in the United States by the Gonococcal Isolate Surveillance Project, 2005 to 2013

(2014) Robert D. Kirkcaldy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Persistence of Neisseria gonorrhoeae DNA Following Treatment for Pharyngeal and Rectal Gonorrhea Is Influenced by Antibiotic Susceptibility and Reinfection

(2014) M. Bissessor et al.   CLINICAL INFECTIOUS DISEASES

Macrolide Resistance and Azithromycin Failure in a Mycoplasma genitalium-Infected Cohort and Response of Azithromycin Failures to Alternative Antibiotic Regimens

(2014) M. Bissessor et al.   CLINICAL INFECTIOUS DISEASES

The Efficacy and Safety of Gentamicin Plus Azithromycin and Gemifloxacin Plus Azithromycin as Treatment of Uncomplicated Gonorrhea

(2014) Robert D. Kirkcaldy et al.   CLINICAL INFECTIOUS DISEASES

Four treatment failures of pharyngeal gonorrhoea with ceftriaxone (500 mg) or cefotaxime (500 mg), Sweden, 2013 and 2014

(2014) D Golparian et al.   Eurosurveillance

Should we screen heterosexuals for extra-genital chlamydial and gonococcal infections?

(2014) Anna L Garner et al.   INTERNATIONAL JOURNAL OF STD & AIDS

Detecting re-infection in patients after an initial diagnosis of gonorrhoea: is routine recall for re-screening useful?

(2014) KA Fernando et al.   INTERNATIONAL JOURNAL OF STD & AIDS

Treatment failure with 2 g of azithromycin (extended-release formulation) in gonorrhoea in Japan caused by the international multidrug-resistant ST1407 strain of Neisseria gonorrhoeae

(2014) T. Morita-Ishihara et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Assessment of Etest as an Alternative to Agar Dilution for Antimicrobial Susceptibility Testing of Neisseria gonorrhoeae

(2014) H. Liu et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Evaluation of Gonorrhea Test of Cure at 1 Week in a Los Angeles Community-Based Clinic Serving Men Who Have Sex With Men

(2014) Matthew R. Beymer et al.   SEXUALLY TRANSMITTED DISEASES

Potential Deleterious Effects of Promoting the Use of Ceftriaxone in the Treatment of Neisseria gonorrhoeae

(2014) Matthew R. Golden et al.   SEXUALLY TRANSMITTED DISEASES

Potential impact of vaccination against Neisseria meningitidis on Neisseria gonorrhoeae in the United States: Results from a decision-analysis model

(2014) Stéphane A Régnier et al.   Human Vaccines & Immunotherapeutics

Appropriate Time for Test-of-Cure when Diagnosing Gonorrhoea with a Nucleic Acid Amplification Test

(2013) S Hjelmevoll et al.   ACTA DERMATO-VENEREOLOGICA

Emerging Antimicrobial Resistance in Neisseria gonorrhoeae: Urgent Need to Strengthen Prevention Strategies

(2013) Kimberly A. Workowski et al.   ANNALS OF INTERNAL MEDICINE

Neisseria gonorrhoeae Treatment Failure and Susceptibility to Cefixime in Toronto, Canada

(2013) Vanessa G. Allen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Failure of 500 mg of ceftriaxone to eradicate pharyngeal gonorrhoea, Australia

(2013) M. Y. Chen et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Performance of the Cepheid CT/NG Xpert Rapid PCR Test for Detection of Chlamydia trachomatis and Neisseria gonorrhoeae

(2013) C. A. Gaydos et al.   JOURNAL OF CLINICAL MICROBIOLOGY

One confirmed and one suspected case of pharyngeal gonorrhoea treatment failure following 500mg ceftriaxone in Sydney, Australia

(2013) Phillip J. Read et al.   Sexual Health

Retrospective Review of Pharyngeal Gonorrhea Treatment Failures in Alberta, Canada

(2013) Jennifer Gratrix et al.   SEXUALLY TRANSMITTED DISEASES

Changing patterns of disseminated gonococcal infection in France: cross-sectional data 2009–2011: Table 1

(2013) Anna Belkacem et al.   SEXUALLY TRANSMITTED INFECTIONS

The Emerging Threat of Untreatable Gonococcal Infection

(2012) Gail A. Bolan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effectiveness of gentamicin for gonorrhoea treatment: systematic review and meta-analysis

(2012) Deborah Dowell et al.   SEXUALLY TRANSMITTED INFECTIONS

High-Level Cefixime- and Ceftriaxone-Resistant Neisseria gonorrhoeae in France: NovelpenAMosaic Allele in a Successful International Clone Causes Treatment Failure

(2011) Magnus Unemo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

High-Level Azithromycin Resistance Occurs in Neisseria gonorrhoeae as a Result of a Single Point Mutation in the 23S rRNA Genes

(2010) S. A. Chisholm et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cephalosporin MIC creep among gonococci: time for a pharmacodynamic rethink?

(2010) S. A. Chisholm et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Two cases of failed ceftriaxone treatment in pharyngeal gonorrhoea verified by molecular microbiological methods

(2009) J. Tapsall et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Repeat Infection With Chlamydia and Gonorrhea Among Females: A Systematic Review of the Literature

(2009) Christina B. Hosenfeld et al.   SEXUALLY TRANSMITTED DISEASES

Neisseria gonorrhoeae Endocarditis Confirmed by Nucleic Acid Amplification Assays Performed on Aortic Valve Tissue

(2008) U. S. Nielsen et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Identification ofNeisseria gonorrhoeaeas the Causative Agent in a Case of Culture‐Negative Dermatitis–Arthritis Syndrome Using Real‐Time PCR

(2008) Patrick T. Kimmitt et al.   JOURNAL OF TRAVEL MEDICINE