Editorial Material
Geriatrics & Gerontology
Rodrigo Nunez-Cortes, Ruben Lopez-Bueno, Rodrigo Torres-Castro, Camilo Soto-Carmona, Maritza Ortega-Palavecinos, Sofia Perez-Alenda, Lilian Solis-Navarro, Oscar Diaz-Cambronero, Francisco M. Martinez-Arnau, Joaquin Calatayud
Summary: The aim of this prospective study was to examine the risk factors most associated with mortality one year after diagnosis of COVID-19. The study found that age was the most important risk factor, and disabilities, institutionalization, and socioeconomic status were also significantly associated with mortality.
Article
Medicine, General & Internal
Min-Taek Lee, Moon Seong Baek, Tae Wan Kim, Sun-Young Jung, Won-Young Kim
Summary: This nationwide population-based study aimed to determine whether COVID-19 hospitalization was associated with incident cardiovascular outcomes. The study found that hospitalized patients with COVID-19 were not at an increased risk of cardiovascular outcomes compared to patients with non-COVID-19 pneumonia.
Article
Public, Environmental & Occupational Health
Namin Wei, Yan Xu, Huan Wang, Qiulei Jia, Xintian Shou, Xuesong Zhang, Nan Zhang, Yanan Li, Huaqiang Zhai, Yuanhui Hu
Summary: This study conducted a bibliometric and visual analysis of the published relationship between cardiovascular diseases (CVDs) and COVID-19, revealing a wide range of research interests in specific diseases, pathogenesis, therapeutic drugs, and clinical characteristics.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Nan Zhang, Ziheng Jia, Tianshu Gu, Yi Zheng, Yunpeng Zhang, Wenhua Song, Ziliang Chen, Guangping Li, Gary Tse, Tong Liu
Summary: This study explores the causal relationships between genetically predicted risk factors and frailty, finding significant associations between genetic liability to certain diseases and lifestyle factors with increased risk of frailty. It also identifies a negative association between college education and high-density lipoprotein cholesterol level with frailty risk.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2023)
Article
Cardiac & Cardiovascular Systems
Fatima Rodriguez, Nicole Solomon, James A. de Lemos, Sandeep R. Das, David A. Morrow, Steven M. Bradley, Mitchell S. Elkind, Joseph H. Williams, DaJuanicia Holmes, Roland A. Matsouaka, Divya Gupta, Ty J. Gluckman, Marwah Abdalla, Michelle A. Albert, Clyde W. Yancy, Tracy Y. Wang
Summary: The study aimed to identify racial and ethnic differences in presentation and outcomes for COVID-19 patients hospitalized in the United States. Despite adjusting for sociodemographic and clinical differences, Black and Hispanic patients had a greater burden of mortality and morbidity compared to non-Hispanic White patients. Although in-hospital mortality and major adverse cardiovascular events did not differ by race/ethnicity after adjustment, disparities in health outcomes still exist among different racial and ethnic groups in COVID-19 hospitalizations.
Review
Cell Biology
Fan Liu, Feng Liu, Lu Wang
Summary: COVID-19, caused by SARS-CoV-2, not only affects the lungs but also has severe implications in the cardiovascular system. Understanding the mechanisms of cardiovascular injury in COVID-19 patients is crucial for appropriate identification and treatment.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2021)
Article
Clinical Neurology
Saate S. Shakil, Sophia Emmons-Bell, Christine Rutan, Jason Walchok, Babak Navi, Richa Sharma, Kevin Sheth, Gregory A. Roth, Mitchell S. Elkind
Summary: The risk of ischemic stroke in COVID-19 patients is not affected by race, but is associated with middle-aged adults, hypertension, diabetes, and atrial fibrillation. The mechanism for ischemic stroke in COVID-19 may be independent of age-related atherosclerotic pathways.
Review
Geriatrics & Gerontology
Hongyang Shu, Zheng Wen, Na Li, Zixuan Zhang, Bala Musa Ceesay, Yizhong Peng, Ning Zhou, Dao Wen Wang
Summary: Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread globally, resulting in over 581 million confirmed cases and over 6 million deaths as of August 1, 2022. The binding of the viral surface spike protein to the human angiotensin-converting enzyme 2 (ACE2) receptor is the primary mechanism of SARS-CoV-2 infection. COVID-19 is strongly associated with cardiovascular disease (CVD), and preexisting CVD risk factors increase susceptibility to COVID-19, while COVID-19 exacerbates the progression of CVD. This review provides a detailed illustration of the impact of COVID-19 on different cells in myocardial tissue and an overview of the clinical manifestations of cardiovascular involvements in the pandemic. The issues related to myocardial injury post recovery and vaccination-induced CVD are also emphasized.
Review
Cardiac & Cardiovascular Systems
Somasundaram Raghavan, R. Gayathri, Sudhakar Kancharla, Prachetha Kolli, J. Ranjitha, Vijayalakshmi Shankar
Summary: The SARS-CoV-2 virus not only primarily infects the lungs and respiratory system, but also affects the cardiovascular system and coagulation mechanisms, leading to various cardiovascular diseases. The virus enters endothelial cells through ACE2 receptors, thereby impacting the cardiovascular system.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Geriatrics & Gerontology
Nathalia Fidelis Lins Vieira, Carlos Queiroz do Nascimento, Janaina da Silva Nascimento, Sandra Mary Lima Vasconcelos, Joao Araujo Barros-Neto, Ana Celia Oliveira dos Santos
Summary: The study found an association between low serum levels of 25(OH)D, inflammation, and a high risk for cardiovascular diseases in older adults.
EXPERIMENTAL GERONTOLOGY
(2022)
Review
Virology
Jing Liu, Salim S. Virani, Mahboob Alam, Ali E. Denktas, Ihab Hamzeh, Umair Khalid
Summary: The SARS-CoV-2 virus not only causes severe respiratory infections, but also leads to a variety of cardiac manifestations through multiple mechanisms of cardiac injury. Treatment for COVID-19 patients need to consider cardiovascular side effects, and healthcare structures have been adapted in response to the pandemic.
REVIEWS IN MEDICAL VIROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Eric Yuk Fai Wan, Sukriti Mathur, Ran Zhang, Vincent Ka Chun Yan, Francisco Tsz Tsun Lai, Celine Sze Ling Chui, Xue Li, Carlos King Ho Wong, Esther Wai Yin Chan, Kai Hang Yiu, Ian Chi Kei Wong
Summary: This study aims to evaluate the short- and long-term associations between COVID-19 and development of cardiovascular disease (CVD) outcomes and mortality. The study found that COVID-19 infection is associated with significantly increased short- and long-term risks of CVD and mortality.
CARDIOVASCULAR RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Francesca Megiorni, Paola Pontecorvi, Giulia Gerini, Eleni Anastasiadou, Cinzia Marchese, Simona Ceccarelli
Summary: This review discusses the gender differences in COVID-19, highlighting the impact of gender on susceptibility, disease severity, and treatment outcomes. The relationship between gender and cardiovascular diseases in COVID-19 is particularly important, and gender also affects the variability of certain biomarkers. Gendered medicine plays a significant role in developing personalized prevention, evaluation, and treatment strategies.
Review
Nutrition & Dietetics
Paolo Severino, Andrea D'Amato, Silvia Prosperi, Vincenzo Myftari, Aurora Labbro Francia, Merve Onkaya, Claudia Notari, Ilaria Papisca, Elena Sofia Canuti, Mia Yarden Revivo, Lucia Ilaria Birtolo, Paola Celli, Gioacchino Galardo, Viviana Maestrini, Gabriella d'Ettorre, Massimo Mancone, Francesco Fedele
Summary: Micronutrient imbalance is strongly associated with potentially-fatal complications and cardiovascular diseases in COVID-19 patients.
Article
Psychiatry
Mihailo Nesic, Julia Vogel, Jan Philipp Krueger, Werner Wenzel, Ali Sahebi, Tienush Rassaf, Johannes Siebermair, Ulrich Wesemann
Summary: The common factor between PTSD and cardiovascular diseases lies in the disruption of the stress processing system. Anger regulation is considered to be a relevant factor for both cardiac diseases and PTSD. The study results can be used for prevention, rehabilitation, and therapeutic measures. However, further research is needed to confirm the impact of inward anger on PTSD.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Cardiac & Cardiovascular Systems
Emily S. Lau, Aleksandra Binek, Sarah J. Parker, Svati H. Shah, Markella Zanni, Jennifer E. Van Eyk, Jennifer E. Ho
Summary: Sex-based differences in cardiovascular disease presentation, diagnosis, and response to therapies have important implications. Understanding the relationship between blood-based biomarkers and cardiovascular disease in women can lead to improved individualized care. This review examines the differential levels of blood-based biomarkers in men and women and their influence on disease outcomes, providing recommendations for future research and clinical innovation.
CIRCULATION RESEARCH
(2022)
Review
Cardiac & Cardiovascular Systems
Leili Behrooz, Maria Barillas-Lara, Michael Fattouh, Berenice Loubeau, Michel Ibrahim
Summary: This study systematically reviewed the role of invasive cardiopulmonary testing in the evaluation of chronic dyspnoea and/or exercise intolerance. The findings suggest that invasive cardiopulmonary exercise test can be a useful tool for identifying the cause of unexplained dyspnoea, as well as for early recognition and prognostication of patients with heart failure with preserved ejection fraction and pulmonary hypertension. It can also contribute to the multidisciplinary approach to chronic dyspnoea.
Article
Cardiac & Cardiovascular Systems
Katherine S. S. Takvorian, Dongyu Wang, Paul Courchesne, Ramachandran S. S. Vasan, Emelia J. J. Benjamin, Susan Cheng, Martin G. G. Larson, Daniel Levy, Jennifer E. E. Ho
Summary: We identified 5 protein biomarkers associated with incident HFpEF, including NT-proBNP, growth differentiation factor-15, adrenomedullin, uncarboxylated matrix Gla protein, and C-reactive protein. We also found 14 biomarkers associated with incident HFrEF, including myeloperoxidase, resistin, and paraoxanase-1. These findings provide insights into similarities and differences in the development of HF subtypes.
CIRCULATION-HEART FAILURE
(2023)
Article
Multidisciplinary Sciences
Sana Majid, Robert M. Weisbrod, Jessica L. Fetterman, Rachel J. Keith, Syed H. M. Rizvi, Yuxiang Zhou, Leili Behrooz, Rose Marie Robertson, Aruni Bhatnagar, Daniel J. Conklin, Naomi M. Hamburg
Summary: Pod-based e-liquids and their components impair endothelial cell function, potentially causing cardiovascular harm.
Article
Cardiac & Cardiovascular Systems
Jose I. Nunez, E. Wilson Grandin, Tiago Reyes-Castro, Marwa Sabe, Pablo Quintero, Shweta Motiwala, Lisa M. Fleming, Roy Sriwattanakomen, Jennifer E. Ho, Kevin Kennedy, Joseph E. Tonna, A. Reshad Garan
Summary: Acute myocarditis requiring venoarterial extracorporeal membrane oxygenation (VA-ECMO) treatment is associated with improved survival rates compared to overall population receiving VA-ECMO therapy. Major modifiable risk factors for mortality in myocarditis patients include ongoing cardiopulmonary resuscitation requiring ECMO and markers of illness severity prior to ECMO.
CIRCULATION-HEART FAILURE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Carolyn S. P. Lam, Jennifer E. Ho
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Gary F. Mitchell, Jian Rong, Martin G. Larson, Leroy L. Cooper, Vanessa Xanthakis, Emelia J. Benjamin, Naomi M. Hamburg, Ramachandran S. Vasan
Summary: Systolic blood pressure increases with age after midlife, particularly in women, and contributes to development of wide pulse pressure hypertension in middle-aged and older adults. The relative contributions of aortic stiffness and premature wave reflection to increases in pulse pressure remain controversial.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Christy N. N. Taylor, Dongyu Wang, Martin G. G. Larson, Emily S. S. Lau, Emelia J. J. Benjamin, Ralph B. B. D'Agostino, Ramachandran S. S. Vasan, Daniel Levy, Susan Cheng, Jennifer E. E. Ho
Summary: A parental history of cardiovascular disease (CVD) increases the risk of future CVD in offspring. However, it is unclear whether parental modifiable risk factors contribute to or modify this risk.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Biochemistry & Molecular Biology
Carolyn S. P. Lam, Kieran F. Docherty, Jennifer E. Ho, John J. V. McMurray, Peder L. Myhre, Torbjorn Omland
Summary: Recent advances in heart failure have greatly improved survival and outcomes for patients with reduced ejection fraction. Novel genetic and molecular approaches have also shown promise in managing previously incurable conditions. However, there are still significant gaps and disparities in care, implementation, and understanding of the socioeconomic determinants of outcomes. Ongoing clinical trials and technological advancements provide hope for addressing these issues in the future.
Article
Cell Biology
Jason Cunha, Melissa V. Chan, Bongani B. Nkambule, Florian Thibord, Amber Lachapelle, Robin E. Pashek, Ramachandran S. Vasan, Jian Rong, Emelia J. Benjamin, Naomi M. Hamburg, Ming-Huei Chen, Gary F. Mitchell, Andrew D. Johnson
Summary: Arterial tonometry and vascular calcification measures are valuable in assessing cardiovascular disease (CVD) risk. This study examined the relationship between arterial tonometry, platelet function, arterial calcium, and aortic diameter. The results suggest that higher arterial calcium may be associated with increased platelet reactivity, while larger aortic diameter may be linked to lower platelet reactivity. These findings indicate the potential interplay between subclinical atherosclerosis, platelet activation, and vascular structure.
Article
Cardiac & Cardiovascular Systems
Mariana F. Ramirez, Michael Honigberg, Dongyu Wang, Juhi K. Parekh, Kamila Bielawski, Paul Courchesne, Martin D. Larson, Daniel Levy, Joanne M. Murabito, Jennifer E. Ho, Emily S. Lau
Summary: Premature and early menopause are associated with increased risk of cardiovascular disease (CVD). This study found that early menopause is associated with specific biomarkers related to CVD and modifies the association between certain biomarkers and cardiovascular outcomes. The identified biomarkers reflect various biological pathways including inflammation, adiposity, and neurohormonal regulation.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Cardiac & Cardiovascular Systems
Gillian Murtagh, James L. Januzzi, Marielle Scherrer-Crosbie, Tomas G. Neilan, Susan Dent, Jennifer E. Ho, Vinesh Appadurai, Ray McDermott, Nausheen Akhter
Summary: Cardiotoxicity is a growing concern in the oncology population. Current imaging techniques for surveillance are relatively insensitive and resource intensive, highlighting the need for more sensitive and cost-effective strategies. Circulating cardiovascular biomarkers offer a promising solution, but there are limitations to their use. This review discusses the challenges in biomarker measurement and interpretation, and suggests improved study designs and harmonization efforts to enhance their predictive value.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Cardiac & Cardiovascular Systems
Leili Behrooz, Carrie G. Lenneman, Naomi M. Hamburg
Summary: This review discusses the impact of obesity on cardiovascular disease in women and the emerging anti-obesity pharmacologic treatments. The evidence shows that obesity burdens women across their lifespan and is linked to a variety of cardiovascular diseases. Female-specific risk factors, such as sex hormones and pregnancy factors, intersect with obesity and cardiovascular risk. Sustained weight loss has the potential for cardiovascular benefits. Recent trials demonstrate the cardiovascular benefits of emerging agents with weight loss effects, such as GLP-1 RA and SGLT2 inhibitors, in women.
CURRENT CARDIOLOGY REPORTS
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Ross Okazaki, Naomi M. Hamburg
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
