Article
Medicine, General & Internal
Jason E. Goldstick, Gery P. Guy, Jan L. Losby, Grant Baldwin, Matthew Myers, Amy S. B. Bohnert
Summary: This study found that patients who were opioid naive continued to initiate opioid therapy after the release of CDC opioid prescribing guidelines, but trends in prescribing duration reversed and decreased. High-dose prescribing rates were already decreasing, but those trends reversed and decreased further after the release of the guidelines.
Article
Medicine, General & Internal
Xiru Lyu, Gery P. Guy, Grant T. Baldwin, Jan L. Losby, Amy S. B. Bohnert, Jason E. Goldstick
Summary: The release of the 2016 CDC guideline for prescribing opioids led to a reduction in opioid dispensing nationwide. However, there is variability among states in the post-guideline changes, which could suggest further opportunities for reducing opioid-related harms.
Article
Public, Environmental & Occupational Health
Jane Tucker, Joanne Salas, Zidong Zhang, Richard Grucza, Jeffrey F. Scherrer
Summary: This study used Optum(R) electronic health record database to examine the trends in new Schedule II opioid prescriptions and tramadol after the CDC guideline, showing an increased likelihood of starting tramadol prescriptions in emergency care and primary care after the guideline.
PREVENTIVE MEDICINE
(2021)
Article
Substance Abuse
Joanne Salas, Xue Li, Hong Xian, Mark D. Sullivan, Jane C. Ballantyne, Patrick J. Lustman, Richard Grucza, Jeffrey F. Scherrer
Summary: The study found that there was a modest change in opioid dosing among patients on long-term opioid therapy after the CDC guideline was published, especially for those using very high doses. However, the guideline was not associated with decreasing MME among lower-dose, long-term users.
INTERNATIONAL JOURNAL OF DRUG POLICY
(2021)
Article
Surgery
Richard J. Barth Jr, Eleah D. Porter, Julia L. Kelly, Sarah Y. Bessen, Lida B. Molloy, Joseph D. Phillips, Andrew P. Loehrer, Matthew Z. Wilson, Srinivas J. Ivatury, Sarah E. Billmeier, John D. Seigne, Sandra L. Wong, Ivy Wilkinson-Ryan
Summary: The aim of this study was to determine the frequency and reasons for long-term opioid prescriptions after surgery in the setting of guideline-directed prescribing and a high rate of excess opioid disposal. The results showed that 15.3% of patients filled an opioid prescription 3 to 12 months after surgery, mainly due to new painful medical conditions and new surgeries. The conclusion is that none of the patients in this study became persistent opioid users solely as a result of the opioid prescription given after their index surgery.
Article
Anesthesiology
Phillip P. Salvatore, Gery P. Guy, Christina A. Mikosz
Summary: The study examines the changes in opioid prescribing across different medical specialties after the release of the 2016 CDC Guideline. The results show that opioid dispensing has declined, especially among primary care clinicians. However, specialties outside the scope of the guideline also exhibited accelerated decreases in prescribing.
Article
Surgery
Joshua D. Billings, Victoria Huynh, Laura D. Leonard, Alexandra Kovar, Teresa S. Jones, Ethan Cumbler, Nicole Christian, Kristin E. Rojas, Randall Meacham, Sarah E. Tevis
Summary: This study presents a successful quality improvement initiative in an academic medical center to improve adherence to guidelines for opioid prescribing. Through physician education and feedback reports, the study achieved an improvement in guideline-concordant opioid discharge prescriptions and a decrease in overprescribing.
Article
Surgery
David C. Meyer, Susanna S. Hill, Richard Pavao, Adam J. Resnick, Ayan Purkayastha, Jennifer S. Davids, Paul R. Sturrock, Justin A. Maykel, Karim Alavi
Summary: This study aimed to validate a prospective institutional prescribing guideline based on previously defined opioid consumption patterns following inpatient colorectal operations. The results showed that adoption of a tiered opioid prescribing guideline significantly reduced the quantity of opioid prescriptions, with no change in patient consumption or refill rates.
Review
Medicine, General & Internal
Heather Dawson
Summary: This review aims to provide a practical and concise summary of issues related to implementing and developing digital diagnostics in the pathology laboratory. It covers important initial considerations, possible approaches to overcome common challenges, potential diagnostic pitfalls, validation and regulatory issues, and an introduction to the emerging field of image analysis in routine.
FRONTIERS IN MEDICINE
(2022)
Article
Otorhinolaryngology
Samantha Anne, James Mims, David E. Tunkel, Richard M. Rosenfeld, David S. Boisoneau, Michael J. Brenner, John D. Cramer, David Dickerson, Sandra A. Finestone, Adam J. Folbe, Deepa J. Galaiya, Anna H. Messner, Allison Paisley, Ahmad R. Sedaghat, Kerstin M. Stenson, Angela K. Sturm, Erin M. Lambie, Nui Dhepyasuwan, Taskin M. Monjur
Summary: Opioid use disorder (OUD), including dependence and overdose, has become epidemic in the United States. Surgeons play a significant role in prescribing opioids, and reducing extra opioid availability after surgery through smaller prescriptions, safe storage, and disposal can decrease the risk of OUD in otolaryngology patients and families.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Medicine, General & Internal
Tori N. Sutherland, Hannah Wunsch, Ruxandra Pinto, Craig Newcomb, Colleen Brensinger, Lakisha Gaskins, Brian T. Bateman, Mark D. Neuman
Summary: This study included 361,556 opioid-naive patients who underwent surgery and found a substantial decrease in postoperative opioid dispensing after the release of the 2016 CDC guideline, compared to an increasing trend in the previous two years. However, the absolute amounts prescribed remained high, indicating the need for further improvement in postoperative pain management.
Article
Anesthesiology
Elizabeth C. Danielson, Christopher A. Harle, Ross Silverman, Justin Blackburn, Nir Menachemi
Summary: This study reviewed state tapering laws related to opioid therapy and found that while most laws incorporated some federal guideline attributes, many critical aspects recommended by experts were missing. This may result in patients facing risks of inappropriate tapering or discontinuation of opioid therapy.
Editorial Material
Oncology
Emily C. Serrell, Caprice C. Greenberg, Tudor Borza
Summary: Opioid prescribing after surgery remains a significant contributor to the national opioid epidemic, highlighting the need for direct engagement with surgeons and detailed data to address the limited response to current policies.
Editorial Material
Biochemistry & Molecular Biology
Mildred K. Cho
Summary: AI-based models can exacerbate existing human bias in datasets, necessitating a fundamental realignment of software development culture.
Article
Biochemistry & Molecular Biology
Birgit H. M. Meldal, Carles Pons, Livia Perfetto, Noemi Del-Toro, Edith Wong, Patrick Aloy, Henning Hermjakob, Sandra Orchard, Pablo Porras
Summary: The EMBL-EBI Complex Portal is a knowledgebase of macromolecular complexes that provides persistent stable identifiers, with data freely available and downloadable. In collaboration with other databases, the yeast complexome was curated, leading to an increase in curated complexes compared to the previous dataset. The analysis showed that genes in complexes have more genetic interactions, are more multifunctional, and are often involved in nucleic acid-related metabolic processes.
NUCLEIC ACIDS RESEARCH
(2021)
