Neutralizing the free radicals could alleviate the disease severity following an infection by positive strand RNA viruses

Free radical release due to oxidative stress is gaining importance in the field of viral pathogenesis. Recent studies suggest the involvement of oxidative stress and ROS levels in regulating disease virulence during RNA virus infection. Most of the RNA virus infections lead to vascular dysfunction and disease severity. However, the biology of free radicals in maintaining vascular endothelium integrity is not completely understood. In the present review, we discuss some of the common features in positive-strand RNA virus infections such as dengue and SARS-CoV-2 and suggest that anti-oxidant therapy could pave the way to develop therapeutic strategies in combating emerging and re-emerging RNA viruses.

Automated summary

The release of free radicals caused by oxidative stress is increasingly important in the study of viral pathogenesis. Recent studies suggest that oxidative stress and levels of reactive oxygen species (ROS) play a role in regulating disease virulence during RNA virus infections. Most RNA virus infections lead to vascular dysfunction and increased disease severity. However, the biological mechanisms of free radicals in maintaining vascular endothelium integrity are not fully understood. This review discusses common features in positive-strand RNA virus infections such as dengue and SARS-CoV-2 and suggests that antioxidant therapy may pave the way for developing therapeutic strategies against emerging and re-emerging RNA viruses.