Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL
Authors
Keywords
-
Journal
CELL DEATH AND DIFFERENTIATION
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2022-03-10
DOI
10.1038/s41418-022-00965-6
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The regulation of necroptosis by post-translational modifications
- (2021) Yanxiang Meng et al. CELL DEATH AND DIFFERENTIATION
- A class of viral inducer of degradation of the necroptosis adaptor RIPK3 regulates virus-induced inflammation
- (2021) Zhijun Liu et al. IMMUNITY
- A toolbox for imaging RIPK1, RIPK3, and MLKL in mouse and human cells
- (2021) André L. Samson et al. CELL DEATH AND DIFFERENTIATION
- Location, location, location: A compartmentalized view of TNF-induced necroptotic signaling
- (2021) André L. Samson et al. Science Signaling
- A family harboring an MLKL loss of function variant implicates impaired necroptosis in diabetes
- (2021) Joanne M. Hildebrand et al. Cell Death & Disease
- Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis
- (2021) Sarah E. Garnish et al. Nature Communications
- Oligomerization‐driven MLKL ubiquitylation antagonizes necroptosis
- (2021) Zikou Liu et al. EMBO JOURNAL
- Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis
- (2021) Yanxiang Meng et al. Nature Communications
- Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies
- (2020) Emma J. Petrie et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Human cytomegalovirus protein pUL36: A dual cell death pathway inhibitor
- (2020) Alice Fletcher-Etherington et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis
- (2020) Andre L. Samson et al. Nature Communications
- Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues
- (2020) Katherine A. Davies et al. Nature Communications
- A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction
- (2020) Joanne M. Hildebrand et al. Nature Communications
- Varicella zoster virus encodes a viral decoy RHIM to inhibit cell death
- (2020) Megan Steain et al. PLoS Pathogens
- Discovery of a Family of Mixed Lineage Kinase Domain-like Proteins in Plants and Their Role in Innate Immune Signaling
- (2020) Lisa K. Mahdi et al. Cell Host & Microbe
- Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis
- (2020) Martin Rübbelke et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulated necrosis in kidney ischemia-reperfusion injury
- (2019) Aspasia Pefanis et al. KIDNEY INTERNATIONAL
- Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3
- (2019) Emma J. Petrie et al. Cell Reports
- The Killer Pseudokinase Mixed Lineage Kinase Domain-Like Protein (MLKL)
- (2019) James M. Murphy Cold Spring Harbor Perspectives in Biology
- The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis
- (2018) Katherine A. Davies et al. CELL DEATH AND DIFFERENTIATION
- MLKL Requires the Inositol Phosphate Code to Execute Necroptosis
- (2018) Cole M. Dovey et al. MOLECULAR CELL
- Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis
- (2018) Emma J. Petrie et al. Nature Communications
- The Structural Basis of Necroptotic Cell Death Signaling
- (2018) Emma J. Petrie et al. TRENDS IN BIOCHEMICAL SCIENCES
- A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs
- (2018) Shin Murai et al. Nature Communications
- Insane in the membrane: a structural perspective of MLKL function in necroptosis
- (2017) Emma J Petrie et al. IMMUNOLOGY AND CELL BIOLOGY
- EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation
- (2017) Jaclyn S. Pearson et al. Nature Microbiology
- Necroptosis and Inflammation
- (2016) Kim Newton et al. Annual Review of Biochemistry
- Evolutionary divergence of the necroptosis effector MLKL
- (2016) M C Tanzer et al. CELL DEATH AND DIFFERENTIATION
- RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury
- (2016) K Newton et al. CELL DEATH AND DIFFERENTIATION
- Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis
- (2016) Giovanni Quarato et al. MOLECULAR CELL
- RIPK1 inhibits ZBP1-driven necroptosis during development
- (2016) Kim Newton et al. NATURE
- The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia
- (2016) Gabriela Brumatti et al. Science Translational Medicine
- HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death
- (2016) A V Jacobsen et al. Cell Death & Disease
- Necroptosis Promotes Staphylococcus aureus Clearance by Inhibiting Excessive Inflammatory Signaling
- (2016) Kipyegon Kitur et al. Cell Reports
- Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop
- (2015) M. C. Tanzer et al. BIOCHEMICAL JOURNAL
- Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis
- (2015) D A Rodriguez et al. CELL DEATH AND DIFFERENTIATION
- NMRFAM-SPARKY: enhanced software for biomolecular NMR spectroscopy
- (2014) Woonghee Lee et al. BIOINFORMATICS
- RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis
- (2014) James A. Rickard et al. CELL
- RIPK1- and RIPK3-induced cell death mode is determined by target availability
- (2014) W D Cook et al. CELL DEATH AND DIFFERENTIATION
- RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis
- (2014) S Orozco et al. CELL DEATH AND DIFFERENTIATION
- Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3
- (2014) Huayi Wang et al. MOLECULAR CELL
- RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis
- (2014) Marius Dannappel et al. NATURE
- Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death
- (2014) Joanne M. Hildebrand et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Plug Release Mechanism for Membrane Permeation by MLKL
- (2014) Lijing Su et al. STRUCTURE
- MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates
- (2014) Yves Dondelinger et al. Cell Reports
- TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice
- (2014) James A Rickard et al. eLife
- Necroptosis Is Active in Children With Inflammatory Bowel Disease and Contributes to Heighten Intestinal Inflammation
- (2013) Maria Pierdomenico et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL
- (2013) James M. Murphy et al. BIOCHEMICAL JOURNAL
- A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties
- (2013) James M. Murphy et al. BIOCHEMICAL JOURNAL
- The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism
- (2013) James M. Murphy et al. IMMUNITY
- High Yield Production of a Soluble Human Interleukin-3 Variant from E. coli with Wild-Type Bioactivity and Improved Radiolabeling Properties
- (2013) Timothy R. Hercus et al. PLoS One
- Structural Insights into RIP3-Mediated Necroptotic Signaling
- (2013) Tian Xie et al. Cell Reports
- Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase
- (2012) Liming Sun et al. CELL
- DAI/ZBP1/DLM-1 Complexes with RIP3 to Mediate Virus-Induced Programmed Necrosis that Is Targeted by Murine Cytomegalovirus vIRA
- (2012) Jason W. Upton et al. Cell Host & Microbe
- Accelerated NMR Spectroscopy by Using Compressed Sensing
- (2011) Krzysztof Kazimierczuk et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- relaxGUI: a new software for fast and simple NMR relaxation data analysis and calculation of ps-ns and μs motion of proteins
- (2011) Michael Bieri et al. JOURNAL OF BIOMOLECULAR NMR
- Poisson-Gap Sampling and Forward Maximum Entropy Reconstruction for Enhancing the Resolution and Sensitivity of Protein NMR Data
- (2010) Sven G. Hyberts et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation
- (2009) YoungSik Cho et al. CELL
- Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α
- (2009) Sudan He et al. CELL
- A convenient method for preparation of an engineered mouse interleukin-3 analog with high solubility and wild-type bioactivity
- (2009) James M. Murphy et al. GROWTH FACTORS
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started