Simultaneous proteasome and autophagy inhibition synergistically enhances cytotoxicity of doxorubicin in breast cancer cells

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Autophagy, an accomplice or antagonist of drug resistance in HCC?

(2021) Yafei Wu et al.   Cell Death & Disease

Glutathione S-transferases P1 protects breast cancer cell from adriamycin-induced cell death through promoting autophagy

(2019) Xiaoliang Dong et al.   CELL DEATH AND DIFFERENTIATION

Cellular quality control by the ubiquitin-proteasome system and autophagy

(2019) Christian Pohl et al.   SCIENCE

Chemoresistance Evolution in Triple-Negative Breast Cancer Delineated by Single-Cell Sequencing

(2018) Charissa Kim et al.   CELL

Autophagy, Cell Viability, and Chemoresistance Are Regulated By miR-489 in Breast Cancer

(2018) Mithil Soni et al.   MOLECULAR CANCER RESEARCH

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

2-Aminoethoxydiphenylborane sensitizes anti-tumor effect of bortezomib via suppression of calcium-mediated autophagy

(2018) Yuan Qing Qu et al.   Cell Death & Disease

Oncogenic addiction to high 26S proteasome level

(2018) Peter Tsvetkov et al.   Cell Death & Disease

Accumulation of autophagosomes confers cytotoxicity

(2017) Robert W. Button et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C10ORF10/DEPP-mediated ROS accumulation is a critical modulator of FOXO3-induced autophagy

(2017) S. Salcher et al.   Molecular Cancer

Proteasome inhibitors in cancer therapy

(2017) Elisabet E. Manasanch et al.   Nature Reviews Clinical Oncology

The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis

(2016) Megan L. Goodall et al.   DEVELOPMENTAL CELL

Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease

(2016) Giampaolo Bianchini et al.   Nature Reviews Clinical Oncology

Next-generation proteasome inhibitor MLN9708 sensitizes breast cancer cells to doxorubicin-induced apoptosis

(2016) Hao Wang et al.   Scientific Reports

A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission

(2015) Jing Zhou et al.   Autophagy

Acetylation of Beclin 1 inhibits autophagosome maturation and promotes tumour growth

(2015) Ting Sun et al.   Nature Communications

DNA damage-induced ubiquitylation of proteasome controls its proteolytic activity

(2015) Tatiana N Moiseeva et al.   Oncotarget

20(S)-Ginsenoside Rg3 is a novel inhibitor of autophagy and sensitizes hepatocellular carcinoma to doxorubicin

(2015) Dong-Gun Kim et al.   Oncotarget

Inhibition of autophagy as a new means of improving chemotherapy efficiency in high-LC3B triple-negative breast cancers

(2014) Sylvain Lefort et al.   Autophagy

STAT3-Mediated Autophagy Dependence Identifies Subtypes of Breast Cancer Where Autophagy Inhibition Can Be Efficacious

(2014) P. Maycotte et al.   CANCER RESEARCH

Autophagy Inhibition Augments the Anticancer Effects of Epirubicin Treatment in Anthracycline-Sensitive and -Resistant Triple-Negative Breast Cancer

(2014) S. Chittaranjan et al.   CLINICAL CANCER RESEARCH

A Genome-wide siRNA Screen Identifies Proteasome Addiction as a Vulnerability of Basal-like Triple-Negative Breast Cancer Cells

(2013) Fabio Petrocca et al.   CANCER CELL

Characterization of the protein ubiquitination response induced by Doxorubicin

(2012) Giorgia Mandili et al.   FEBS Journal

The spatial and temporal organization of ubiquitin networks

(2011) Caroline Grabbe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

(2011) M. Michaud et al.   SCIENCE

Evaluation of the Proteasome Inhibitor MLN9708 in Preclinical Models of Human Cancer

(2010) E. Kupperman et al.   CANCER RESEARCH

A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2–Beclin1 interaction at endoplasmic reticulum

(2010) J Lian et al.   CELL DEATH AND DIFFERENTIATION

Dual Role of 3-Methyladenine in Modulation of Autophagy via Different Temporal Patterns of Inhibition on Class I and III Phosphoinositide 3-Kinase

(2010) You-Tong Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Triple-Negative Breast Cancer

(2010) William D. Foulkes et al.   NEW ENGLAND JOURNAL OF MEDICINE