Article
Cell Biology
Nan Wang, Yetong Dong, Xiejun Xu, Yingjie Shen, Zhiyuan Huang, Yin Yu, Zhili Liu, Wenjie Gong, Siyi Zhang, Yeyi Zheng, Yonghuan Song, Zhongxin Zhu, Litai Jin, Weitao Cong
Summary: The study found that FGF10 promotes keratinocyte proliferation and plays a protective role against UVB-induced skin damage. Additionally, FGF10 alleviates the downregulation of YAP activity induced by UVB, promoting keratinocyte proliferation.
CELL PROLIFERATION
(2022)
Article
Biochemistry & Molecular Biology
Chunle Zhao, Jun Gong, Yu Bai, Taoyuan Yin, Min Zhou, Shutao Pan, Yuhui Liu, Yang Gao, Zhenxiong Zhang, Yongkang Shi, Feng Zhu, Hang Zhang, Min Wang, Renyi Qin
Summary: With a 5-year survival rate of approximately 10%, pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid malignancies in humans. A study found that the transcriptional coactivator TAZ could be a potential therapeutic target in PDAC. Through unbiased deubiquitinase (DUB) library screening, researchers identified USP14 as a key regulator of TAZ stabilization, and the USP14-TAZ loop was found to promote cancer progression and liver metastasis in PDAC models. Inhibition of USP14 with the small molecule inhibitor IU1 showed promising anti-cancer effects in PDAC models.
CELL DEATH AND DIFFERENTIATION
(2023)
Review
Medicine, Research & Experimental
Jordan H. Driskill, Duojia Pan
Summary: Research on the Hippo pathway has shown its significant role in liver size, regeneration, development, metabolism, and homeostasis, as well as its impact on common liver diseases. Targeting the Hippo pathway pharmacologically may help boost liver regeneration and prevent disease progression.
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 16, 2021
(2021)
Review
Biochemistry & Molecular Biology
Filippos Koinis, Evangelia Chantzara, Michael Samarinas, Anastasia Xagara, Zisis Kratiras, Vasiliki Leontopoulou, Athanasios Kotsakis
Summary: This article summarizes the role of the Hippo pathway in prostate cancer and identifies knowledge gaps that need to be addressed for the development of YAP-targeted treatment strategies.
Review
Oncology
Kelly Coffey
Summary: Prostate cancer is a common cancer in men, and targeting the Hippo pathway for new treatment approaches may help improve the management of this disease.
Review
Oncology
Haofeng Wu, Yachong Liu, Zhibin Liao, Jie Mo, Qiaofeng Zhang, Bixiang Zhang, Lei Zhang
Summary: This article reviews the role of YAP1 in liver cancer stem cells and its correlation with tumor initiation and progression.
BIOMARKER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Dimitrios Matthaios, Maria Tolia, Davide Mauri, Konstantinos Kamposioras, Michalis Karamouzis
Summary: The YAP and Hippo pathway play crucial roles in immune system and cancer, with effects such as modulating immune response, enhancing tumor microenvironment, and regulating immune suppression, suggesting their potential applications in cancer immunotherapy.
Article
Oncology
Fu-Long Li, Kun-Liang Guan
Summary: The Hippo signaling pathway is an important regulatory pathway that plays a vital role in animal development and tissue homeostasis. It regulates tissue growth and organ size and is associated with various diseases, particularly cancer.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Iwao Shimomura, Naoaki Watanabe, Tomofumi Yamamoto, Minami Kumazaki, Yuji Tada, Koichiro Tatsumi, Takahiro Ochiya, Yusuke Yamamoto
Summary: The study found that verteporfin can effectively inhibit the viability of KRAS-mutant lung cancer cells and suppress KRAS-driven lung tumors. The mechanism of verteporfin action is partially independent of YAP1 inhibition and leads to apoptotic cell death in KRAS-mutant lung cancer cells by inducing endoplasmic reticulum stress pathway.
Article
Biochemistry & Molecular Biology
Lingquan Wang, Wei Xu, Yu Mei, Xufeng Wang, Wentao Liu, Zhenggang Zhu, Zhentian Ni
Summary: This study found that CHRDL2 is abnormally upregulated in gastric cancer and is associated with tumor progression and poor patient prognosis. CHRDL2 overexpression promotes proliferation and cell cycle transition of gastric cancer cells, and it plays a key role by activating the YAP/TAZ pathway.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Oncology
Taruna Arora, Mohd Adnan Kausar, Shimaa Mohammed Aboelnaga, Sadaf Anwar, Malik Asif Hussain, Sadaf Sadaf, Simran Kaur, Alaa Abdulaziz Eisa, Vyas Murti Madhavrao Shingatgeri, Mohammad Zeeshan Najm, Abdulaziz A. Aloliqi
Summary: This review article discusses the impact of the hippo signaling pathway, miRNA biogenesis, and the crosslinks between miRNA and the hippo pathway on cancer. Understanding these processes can enhance the effectiveness of cancer treatment therapies.
Review
Biochemistry & Molecular Biology
Zhifa Cao, Liwei An, Yi Han, Shi Jiao, Zhaocai Zhou
Summary: Gastric cancer is a highly aggressive disease without effective early diagnosis markers and targeted therapies, leading to high mortality rates worldwide. The Hippo signaling pathway, which is involved in organ size control and tissue homeostasis, has been found to play a crucial role in cancer development. This review provides a comprehensive overview of studies on the Hippo pathway in gastric cancer, including its role in tumor initiation, progression, metastasis, acquired drug resistance, and potential therapeutic strategies. The review aims to inspire further research and understanding of the Hippo signaling pathway in gastric cancer, as well as its translational implications for treatment.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Review
Cell Biology
Linda Shyue Huey Chuang, Yoshiaki Ito
Summary: The Hippo-YAP signaling pathway plays critical roles in cell functions, interacts with the RUNX transcription factors in proliferation, differentiation, and cell fate determination, and contributes to development and tumorigenesis.
Article
Cell Biology
Egor Sedov, Elle Koren, Sucheta Chopra, Roi Ankawa, Yahav Yosefzon, Marianna Yusupova, Lucien E. Weiss, Adnan Mahlys, Arad Soifer, Alona Feldman, Chen Luxenburg, Yoav Shechtman, Yaron Fuchs
Summary: In this study, we discovered that the GPI-anchored protein THY1 inhibits the activity of YAP in the skin through multiple molecular mechanisms. Loss of THY1 leads to increased adhesion, resulting in the dissociation of adherens junction complex and the release and translocation of YAP. Increased YAP-dependent proliferation in Thy1(-/-) mice enhances wound repair and hair follicle regeneration.
NATURE CELL BIOLOGY
(2022)
Review
Oncology
Yibo Guo, Juan Luo, Hailin Zou, Chenxin Liu, Liang Deng, Peng Li
Summary: This article provides an overview of the core components and upstream regulators of Hippo-YAP/TAZ signaling in mammals, and systematically summarizes the identified transcription factors or partners responsible for the downstream transcriptional output of YAP/TAZ in various cancers.
Article
Cell Biology
Tadashi Shin, Yuichi Hiraoka, Tokiwa Yamasaki, Jamey D. Marth, Josef M. Penninger, Masami Kanai-Azuma, Kohichi Tanaka, Satoshi Kofuji, Hiroshi Nishina
Summary: Deletion of Mkk7 specifically in mature neurons in female mice leads to a defect in pup retrieval despite normal birth rates, indicating an important role of MKK7 in regulating gene expression patterns for normal social behavior and depression prevention. The mutant mice also exhibit depression-like behavior and alterations in gene expression related to neural signaling pathways and a calcium channel. Loss of neural MKK7 unexpectedly affects gene expression patterns in oligodendrocytes.
Article
Oncology
Caleb Kwame Sinclear, Junichi Maruyama, Shunta Nagashima, Kyoko Arimoto-Matsuzaki, Joshua Agbemefa Kuleape, Hiroaki Iwasa, Hiroshi Nishina, Yutaka Hata
Summary: YAP1 interacts with TEAD transcription factor to upregulate TEAD-target genes in the nucleus, playing a crucial role in cancer. PKC activation induces YAP1 degradation and promotes its binding with p73, leading to apoptosis in cancer cells. Bryostatin can reverse malignant transformation caused by the depletion of LATS kinases.