GLUT5-KHK axis-mediated fructose metabolism drives proliferation and chemotherapy resistance of colorectal cancer

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The colorectal cancer lipidome – identification of a robust tumor-specific lipid species signature

(2021) Josef Ecker et al.   GASTROENTEROLOGY

Sugar-sweetened beverage intake in adulthood and adolescence and risk of early-onset colorectal cancer among women

(2021) Jinhee Hur et al.   GUT

A systematic review of animal models of NAFLD finds high fat, high fructose diets most closely resemble human NAFLD

(2021) Yu Ri Im et al.   HEPATOLOGY

The ZMYND8-regulated mevalonate pathway endows YAP-high intestinal cancer with metabolic vulnerability

(2021) Qiang Pan et al.   MOLECULAR CELL

MicroRNA-146a limits tumorigenic inflammation in colorectal cancer

(2021) Lucien P. Garo et al.   Nature Communications

S100P contributes to promoter demethylation and transcriptional activation of SLC2A5 to promote metastasis in colorectal cancer

(2021) Mingdao Lin et al.   BRITISH JOURNAL OF CANCER

Are sugar-sweetened beverages contributing to the rising occurrence of colorectal cancer in young adults?

(2021) Neil Murphy et al.   GUT

Cell-Type–Specific, Ketohexokinase-Dependent Induction by Fructose of Lipogenic Gene Expression in Mouse Small Intestine

(2020) Arwa Al-Jawadi et al.   JOURNAL OF NUTRITION

m6A-dependent glycolysis enhances colorectal cancer progression

(2020) Chaoqin Shen et al.   Molecular Cancer

High Fructose Drives the Serine Synthesis Pathway in Acute Myeloid Leukemic Cells

(2020) Sangmoo Jeong et al.   Cell Metabolism

High-fructose corn syrup enhances intestinal tumor growth in mice

(2019) Marcus D. Goncalves et al.   SCIENCE

Increased Serine Synthesis Provides an Advantage for Tumors Arising in Tissues Where Serine Levels Are Limiting

(2019) Mark R. Sullivan et al.   Cell Metabolism

Dietary Fructose Consumption and Triple-Negative Breast Cancer Incidence

(2019) Jordan W. Strober et al.   Frontiers in Endocrinology

POTEE drives colorectal cancer development via regulating SPHK1/p65 signaling

(2019) Zhiyong Shen et al.   Cell Death & Disease

CD36 inhibits β-catenin/c-myc-mediated glycolysis through ubiquitination of GPC4 to repress colorectal tumorigenesis

(2019) Yuan Fang et al.   Nature Communications

SNX16 activates c‐Myc signaling by inhibiting ubiquitin‐mediated proteasomal degradation of eEF1A2 in colorectal cancer development

(2019) Zhiyong Shen et al.   Molecular Oncology

Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis

(2018) Pengcheng Bu et al.   Cell Metabolism

LncRNA-FEZF1-AS1 promotes tumor proliferation and metastasis in colorectal cancer by regulating PKM2 signaling

(2018) Zehua Bian et al.   CLINICAL CANCER RESEARCH

Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation

(2017) Yapeng Ji et al.   Nature Communications

Fructose and NAFLD: The Multifaceted Aspects of  Fructose Metabolism

(2017) Prasanthi Jegatheesan et al.   Nutrients

Enhanced Fructose Utilization Mediated by SLC2A5 Is a Unique Metabolic Feature of Acute Myeloid Leukemia with Therapeutic Potential

(2016) Wen-Lian Chen et al.   CANCER CELL

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation

(2016) Xinjian Li et al.   NATURE CELL BIOLOGY

Validation of Metabolic Alterations in Microscale Cell Culture Lysates Using Hydrophilic Interaction Liquid Chromatography (HILIC)-Tandem Mass Spectrometry-Based Metabolomics

(2016) Venugopal Gunda et al.   PLoS One

Fructose in perspective

(2013) Richard D Feinman et al.   Nutrition & Metabolism

Fructose Induces Transketolase Flux to Promote Pancreatic Cancer Growth

(2010) H. Liu et al.   CANCER RESEARCH

Quantitative Metabolome Profiling of Colon and Stomach Cancer Microenvironment by Capillary Electrophoresis Time-of-Flight Mass Spectrometry

(2009) A. Hirayama et al.   CANCER RESEARCH