Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 82-83, Issue -, Pages 86-92Publisher
ELSEVIER
DOI: 10.1016/j.addr.2014.11.008
Keywords
Mesenchymal stem cells; Hematopoietic stem/progenitor cells; Augmentation enterocystoplasty; Ureter; Angiogenesis; Wnt genes; Urethra; Bioscaffold; Elastomer
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Regenerative medicine strategies combine various attributes from multiple disciplines including stem cell biology, chemistry, materials science and medicine. The junction at which these disciplines intersect provides a means to address unmet medical needs in an assortment of pathologies with the goal of creating sustainable, functional replacement tissues. Tissue damage caused by trauma for example, requires rapid responses in order to mitigate further tissue deterioration. Cell/scaffold composites have been utilized to initiate and stabilize regenerative responses in vivo with the hope that functional tissue can be attained. Along with the gross reconfiguration of regenerating tissues, small molecules and growth factors also play a pivotal role in tissue regeneration. Several regenerative studies targeting a variety of urological tissues demonstrate the utility of these small molecules or growth factors in an in vivo setting. (C) 2014 Elsevier B.V. All rights reserved.
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