Review
Cardiac & Cardiovascular Systems
Nazli Okumus, Sonu Abraham, Rishi Puri, W. H. Wilson Tang
Summary: This review comprehensively examines the phenotypes of AS in the context of HF progression and explores the evolving role of TAVR in specific populations.
JACC-HEART FAILURE
(2023)
Article
Medicine, General & Internal
You Mi Hwang, Jun Kim, Gi Byoung Nam, Kee Joon Choi, Duk-Woo Park, Do-Yoon Kang, Seung-Jung Park, Seo Young Park
Summary: The study found a higher incidence of pacemaker dependency after TAVR compared to SAVR, with 58.6% of post-TAVR PPI patients no longer being pacemaker-dependent after 1 year.
Article
Pharmacology & Pharmacy
Zhenyan Zhao, Zhen Meng, Guangyuan Song, Chunrong Wang, Sheng Shi, Jie Zhao, Hongliang Zhang, Moyang Wang, Guannan Niu, Zheng Zhou, Jianhui Wang, Yongjian Wu
Summary: This study found that prophylactic administration of levosimendan immediately after valve implantation in patients undergoing TAVR can reduce stroke or HF-related hospitalization but does not lower all-cause mortality.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Flavien Vincent, Julien Ternacle, Tom Denimal, Mylene Shen, Bjorn Redfors, Cedric Delhaye, Matheus Simonato, Nicolas Debry, Basile Verdier, Bahira Shahim, Thibault Pamart, Hugues Spillemaeker, Guillaume Schurtz, Francois Pontana, Vinod H. Thourani, Philippe Pibarot, Eric Van Belle
Summary: TAVR is rapidly expanding its indications, but faces technical challenges and knowledge gaps when dealing with patients with bicuspid aortic valve (BAV). Physicians need to understand the BAV anatomy and TAVR procedure planning comprehensively to guide treatment decisions.
Article
Medicine, General & Internal
Yi-Ming Li, Tian-Yuan Xiong, Kai Xu, Zhen-Fei Fang, Lei Jiang, Jun Jin, Sheng-Hu He, Yi-Ning Yang, Jing-Jing He, Yu-Heng Jia, Yi Zhang, Yong Peng, Yuan Feng, Mao Chen
Summary: This study delineated the clinical characteristics and outcomes of Chinese TAVR patients, finding that TAVR candidates in China had lower rates of complications and mortality compared to other international registries, and patients with BAV had lower mortality rates. These results suggest that the application of TAVR in low-risk patients will be further propelled.
CHINESE MEDICAL JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Jules Mesnier, Julien Ternacle, Asim N. Cheema, Francisco Campelo-Parada, Marina Urena, Gabriela Veiga-Fernandez, Luis Nombela-Franco, Antonio J. Munoz-Garcia, Victoria Vilalta, Ander Regueiro, David del Val, Lluis Asmarats, Maria del Trigo, Vicenc Serra, Guillaume Bonnet, Melchior Jonveaux, Effat Rezaei, Anthony Matta, Dominique Himbert, Jose Maria de la Torre Hernandez, Gabriela Tirado-Conte, Eduard Fernandez-Nofrerias, Pablo Vidal, Fernando Alfonso, Lola Gutierrez-Alonso, Juan Francisco Oteo, Yassin Belahnech, Siamak Mohammadi, Francois Philippon, Thomas Modine, Josep Rodes-Cabau
Summary: This study evaluated the incidence and predictors of heart failure-related death and sudden cardiac death in patients undergoing TAVR. The results showed that heart failure and sudden cardiac death accounted for a significant portion of deaths after TAVR. Several factors, including atrial fibrillation and prior pacemaker, were associated with heart failure-related death, while valve-in-valve TAVR and transarterial nontransfemoral approach were associated with sudden cardiac death.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Alberto Alperi, Josep Rodes-Cabau, Matheus Simonato, Didier Tchetche, Gaetan Charbonnier, Henrique B. Ribeiro, Azeem Latib, Matteo Montorfano, Marco Barbanti, Sabine Bleiziffer, Bjorn Redfors, Mohamed Abdel-Wahab, Abdelhakim Allali, Giuseppe Bruschi, Massimo Napodano, Marco Agrifoglio, Anna Sonia Petronio, Cristina Giannini, Albert Chan, Ran Kornowski, Nili Schamroth Pravda, Matti Adam, Alessandro Iadanza, Stephane Noble, Andrew Chatfield, Magdalena Erlebach, Joerg Kempfert, Timm Ubben, Harindra Wijeysundera, Moritz Seiffert, Thomas Pilgrim, Won-Keun Kim, Luca Testa, David Hildick-Smith, Roberto Nerla, Claudia Fiorina, Christina Brinkmann, Lars Conzelmann, Didier Champagnac, Francesco Saia, Henrik Nissen, Hafid Amrane, Brian Whisenant, Jasmin Shamekhi, Lars Sondergaard, John G. Webb, Danny Dvir
Summary: In a large series of ViV-TAVR procedures, the incidence of periprocedural PPI was relatively low and decreased with the use of new-generation THV systems. Older age, larger THV size, and previous right bundle branch block were associated with an increased risk of PPI. Although there were no significant differences in 30-day mortality between the PPI and no-PPI groups, PPI patients exhibited a trend toward higher mortality risk at follow-up.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Nicolas Clementy, Arnaud Bisson, Alexandre Bodin, Julien Herbert, Thibaud Lacour, Christophe Saint Etienne, Bertrand Pierre, Pierre Deharo, Dominique Babuty, Laurent Fauchier
Summary: This study evaluated outcomes associated with permanent pacemaker implantation (PPM) after transcatheter aortic valve replacement (TAVR) in a large, nationwide-level population in France from 2010 to 2019. Results showed that both baseline PPM and PPM within 30 days post-TAVR were independently associated with higher mortality and heart failure (HF) hospitalization during follow-up.
Article
Cardiac & Cardiovascular Systems
Takahiro Tsushima, Sadeer Al-Kindi, Luis Augusto Palma Dallan, Anas Fares, Sung-Han Yoon, Heather L. Wheat, Guilherme F. Attizzani, Cristian R. Baeza, Marc P. Pelletier, Mauricio S. Arruda, Judith A. Mackall, Sergio G. Thal
Summary: This study aimed to identify risk factors for worse outcomes in patients with post-TAVR PPM implantation. The results showed that a right ventricular pacing burden (RVPB) >= 30% at 1 year was associated with a higher likelihood of heart failure readmission and a composite endpoint of overall death and/or heart failure. Predicting factors for RVPB >= 30% at 1 year included RVPB >= 40% at 1 month and valve implantation depth measured from the non-coronary cusp >= 4.0 mm.
Article
Cardiac & Cardiovascular Systems
Sam Sharobeem, Dominique Boulmier, Guillaume Leurent, Marc Bedossa, Christophe Leclercq, Philippe Mabo, Raphael P. Martins, Jacques Tomasi, Jean-Philippe Verhoye, Erwan Donal, Gwenaelle Sost, Marielle Le Guellec, Herve Le Breton, Vincent Auffret
Summary: Conduction disturbances requiring PPI after TAVR are a common complication, and this study found that PPI implantation after TAVR increases the risk of hospitalization for heart failure.
Article
Cardiac & Cardiovascular Systems
Riyad Y. Kherallah, Darren Harrison, Ourania Preventza, Guilherme Silva, Kathryn G. Dougherty, Stephanie A. Coulter, Leo Simpson, Neil E. Strickman, Ali Mortazavi, Nicolas Palaskas, Richard D. Fish, Zvonimir Krajcer, Raymond F. Stainback, Juan Carlos Plana Gomez, James J. Livesay, Joseph S. Coselli, Srikanth Koneru
Summary: This retrospective study examined 1341 patients who underwent TAVR, with 50 having a history of CRT. The study found that TAVR is safe and effective for patients with aortic valve stenosis and previous CRT, with outcomes similar to the general aortic stenosis population. However, patients with a history of CRT are more likely to experience postprocedural respiratory failure and require permanent pacemaker implantation.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Joshua D. Aymond, Francis Benn, Cody M. Williams, Michael L. Bernard, A. Elise Hiltbold, Sammy Khatib, Glenn M. Polin, Paul A. Rogers, Jose D. Tafur Soto, Stephen R. Ramee, P. Eugene Parrino, Jason B. Falterman, Sana M. Al-Khatib, Daniel P. Morin
Summary: Aortic stenosis is a common valvular disease requiring replacement, with transcatheter aortic valve replacement becoming a preferred treatment option. However, there is a risk of new conduction disorders necessitating permanent pacemaker implantation post-procedure, and current management strategies for these disturbances lack clarity.
PROGRESS IN CARDIOVASCULAR DISEASES
(2021)
Article
Medicine, General & Internal
Raj R. Makkar, Samir Kapadia, Tarun Chakravarty, Robert J. Cubeddu, Tsuyoshi Kaneko, Paul Mahoney, Dhairya Patel, Aakriti Gupta, Wen Cheng, Susheel Kodali, Deepak L. Bhatt, Michael J. Mack, Martin B. Leon, Vinod H. Thourani
Summary: This study aimed to evaluate the safety and efficacy of redo-TAVR in a national registry. The study found that redo-TAVR had low procedural complication rates, and the rates of death and stroke were similar to those in patients who underwent native-TAVR. Redo-TAVR with balloon-expandable valves might be a suitable treatment for selected patients with failed TAVR.
Article
Cardiac & Cardiovascular Systems
Arthur M. Albuquerque, James M. Brophy
Summary: This study conducted a Bayesian reanalysis and found a moderate to high probability of increased total mortality in patients receiving a cardiac pacemaker following transcatheter aortic valve replacement (TAVR).
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Jialu Wang, Shidong Liu, Xiangxiang Han, Yang Chen, Hao Chen, Zunhui Wan, Bing Song
Summary: Patients with new-onset LBBB after TAVR have worse prognosis compared to those without new-onset LBBB, with higher risks of all-cause mortality, cardiovascular mortality, hospitalization for heart failure, and pacemaker implantation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)