Article
Cardiac & Cardiovascular Systems
Shaan Khurshid, Lu-Chen Weng, Mostafa A. Al-Alusi, Jennifer L. Halford, Julian S. Haimovich, Emelia J. Benjamin, Ludovic Trinquart, Patrick T. Ellinor, David D. McManus, Steven A. Lubitz
Summary: The study indicated that adherence to guideline-adherent physical activity was associated with lower risks of AF and stroke, while there was weak correlation between accelerometer-derived and self-reported activity.
EUROPEAN HEART JOURNAL
(2021)
Article
Clinical Neurology
Elena Herber, Stefanie Aeschbacher, Michael Coslovsky, Fabian Schwendinger, Elisa Hennings, Andreas Gasser, Marcello Di Valentino, Elia Rigamonti, Tobias Reichlin, Nicolas Rodondi, Seraina Netzer, Juerg H. Beer, Annina Stauber, Andreas Mueller, Peter Ammann, Tim Sinnecker, Marco Duering, Jens Wuerfel, David Conen, Michael Kuhne, Stefan Osswald, Leo H. Bonati
Summary: This study found that regular exercise in patients with atrial fibrillation can reduce the prevalence of ischemic infarcts and white matter lesions, increase brain volume, and improve cognitive performance. Therefore, it is recommended that patients with atrial fibrillation actively participate in physical exercise.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Mathias Pinto Bonnesen, Diana My Frodi, Ketil Jorgen Haugan, Christian Kronborg, Claus Graff, Soren Hojberg, Lars Kober, Derk Krieger, Axel Brandes, Jesper Hastrup Svendsen, Soren Zoga Diederichsen
Summary: This study found that within-individual changes in physical activity are associated with the onset of atrial fibrillation (AF) episodes in individuals at high risk. A 1-hour decrease in daily physical activity was associated with a 25% increase in the odds of AF onset the next day, with the strongest association seen in individuals with the lowest overall activity level.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Adrian D. Elliott, Christian V. Verdicchio, Rajiv Mahajan, Melissa E. Middeldorp, Celine Gallagher, Ricardo S. Mishima, Jeroen M. L. Hendriks, Rajeev K. Pathak, Gijo Thomas, Dennis H. Lau, Prashanthan Sanders
Summary: This study aimed to determine the efficacy of exercise interventions on atrial fibrillation (AF) recurrence and symptoms among patients with symptomatic AF. The results showed that patients who participated in an exercise intervention had a higher rate of freedom from AF and lower symptom severity at 12 months. Exercise intervention for 6 months reduced arrhythmia recurrence and improved symptom severity.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Ruoting Wang, Ivan Olier, Sandra Ortega-Martorell, Yingxin Liu, Zebing Ye, Gregory Y. H. Lip, Guowei Li
Summary: The impact of metabolic status and physical activity on the risk of atrial fibrillation in the obese population was investigated. The study found that metabolically healthy obesity was associated with a reduced risk of atrial fibrillation, while physical activity could modify the relationship between metabolic status and atrial fibrillation risk in metabolically unhealthy obesity participants.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ioannis Anagnostopoulos, Maria Kousta, Charalampos Kossyvakis, Eleni Lakka, Dimitrios Vrachatis, Spyridon Deftereos, Vassilios P. Vassilikos, Georgios Giannopoulos
Summary: This study found a nonlinear inverse relationship between weekly physical activity (PA) and the risk for atrial fibrillation (AF) in females. The risk of AF decreases as PA levels increase up to 50 metabolic equivalents of task-hours per week (METs-h/w). This study provides recommendations for PA dose to reduce the risk of AF in females.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Gregory F. Michaud, William G. Stevenson
Summary: A 63-year-old healthy male with atrial fibrillation presents with symptoms of dyspnea and irregular heartbeat. Physical examination reveals high blood pressure, irregular pulse, and ECG confirms atrial fibrillation. Further evaluation and treatment plan are needed.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Engineering, Biomedical
Sen Liu, Jiacheng He, Aiguo Wang, Cuiwei Yang
Summary: In this study, an adaptive system for atrial fibrillation (AF) detection based on electrocardiogram (ECG) was proposed. The system achieved improved accuracy and performance through the use of transfer learning and data augmentation techniques. After model adaptation and post-processing, the detection accuracy was significantly improved. The results demonstrate that this method can promote research on AF detection based on atrial activity.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2024)
Article
Health Care Sciences & Services
Ayelet Shapira-Daniels, Jelena Kornej, Nicole L. Spartano, Xuzhi Wang, Yuankai Zhang, Chathurangi H. Pathiravasan, Chunyu Liu, Ludovic Trinquart, Belinda Borrelli, David McManus, Joanne M. Murabito, Emelia J. Benjamin, Honghuang Lin
Summary: This study investigated the association between daily step count and the predicted 5-year risk of atrial fibrillation (AF). It found that every 1000 steps were associated with a 0.08% lower AF risk. The association was stronger in men and individuals with obesity. The use of a wearable daily step counter for reducing AF risk deserves further investigation.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Matthias D. Zink, Karl G. Mischke, Andras P. Keszei, Christian Rummey, Ben Freedman, Gabriele Neumann, Alina Tolksdorf, Friederike Frank, Jan Wienstroeer, Nicole Kuth, Joerg B. Schulz, Nikolaus Marx
Summary: Pharmacy-based, automated AF screening in elderly citizens identified subjects with unknown AF and an excess mortality risk over the next year. Participants with newly diagnosed or known AF had a significantly higher mortality risk compared with subjects without a history of AF at baseline and a normal ECG.
Article
Cardiac & Cardiovascular Systems
Xuerong Sun, Shuang Zhao, Keping Chen, Wei Hua, Yangang Su, Wei Xu, Fang Wang, Xiaohan Fan, Yan Dai, Zhimin Liu, Shu Zhang
Summary: Decreased physical activity after ICD/CRT-D implantation is associated with a higher incidence of new-onset atrial fibrillation, resulting in worsened outcomes in cardiac death and all-cause mortality.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Signe Westh Christensen, Selina Kikkenborg Berg, Naja Hulvej Rod, Ann-Dorthe Olsen Zwisler, Lau Caspar Thygesen, Signe Stelling Risom
Summary: A moderate-high level of physical activity was found to be associated with a lower risk of serious adverse events in patients undergoing AF and/or AFL ablation, compared to those with low physical activity levels.
Article
Computer Science, Artificial Intelligence
Gerald Hirsch, Soren H. Jensen, Erik S. Poulsen, Sadasivan Puthusserypady
Summary: The study developed a real-time hybrid scheme for automatic detection of atrial fibrillation based on RR interval time series and atrial activity derived from ECG signals. Testing on the MIT-BIH AF database showed that the random forest classifier provided the best performance in AF prediction.
EXPERT SYSTEMS WITH APPLICATIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Xueyuan Guo, Mengmeng Li, Xin Du, Chenxi Jiang, Songnan Li, Ribo Tang, Caihua Sang, Ronghui Yu, Deyong Long, Jianzeng Dong, Changsheng Ma
Summary: Multimorbidity and polypharmacy are highly prevalent among elderly patients with atrial fibrillation in China, leading to a high rate of inappropriate prescribing. Greater attention should be given to addressing these serious health issues in the elderly population.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Ange Maguy, Yuvaraj Mahendran, Jean-Claude Tardif, David Busseuil, Jin Li
Summary: This study explores the association between autoantibodies targeting cardiac ion channels and unexplained AF. They found a common autoantibody response against K(ir)3.4 protein in patients with AF, even before the development of clinically apparent AF. Functional studies and a mouse model of K(ir)3.4 autoimmunity support the causal relationship between K(ir)3.4 autoantibodies and AF.
Article
Medicine, General & Internal
Ankit Maheshwari, Faye L. Norby, Riccardo M. Inciardi, Wendy Wang, Michael J. Zhang, Elsayed Z. Soliman, Alvaro Alonso, Michelle C. Johansen, Rebecca F. Gottesman, Scott D. Solomon, Amil M. Shah, Lin Yee Chen
Summary: This study evaluated the association between left atrial function and size and ischemic stroke, and determined whether these measures could improve the accuracy of stroke prediction using CHA(2)DS(2)-VASc score variables. The results showed that left atrial size and function were associated with ischemic stroke, and the cumulative incidence rates of severe left atrial enlargement were 2.99%, 3.18%, and 1.99% for left atrial reservoir, conduit, and contractile strain, respectively. Adding left atrial function measures to CHA(2)DS(2)-VASc score variables improved stroke prediction accuracy.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Hematology
Brian T. Steffen, James S. Pankow, Faye L. Norby, Pamela L. Lutsey, Ryan T. Demmer, Weihua Guan, Nathan Pankratz, Aixin Li, Guning Liu, Kunihiro Matsushita, Adrienne Tin, Weihong Tang
Summary: This study identified proteomic signatures and pathways related to 23 gene loci associated with abdominal aortic aneurysm (AAA). The results suggest that low levels of neogenin and kit ligand may be novel risk factors for AAA development.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Faye L. Norby, Kotoka Nakamura, Qin Fu, Vidya Venkatraman, Niveda Sundararaman, Mitra Mastali, Kyndaron Reinier, Angelo Salvucci, Jonathan Jui, Jennifer E. Van Eyk, Sumeet S. Chugh
Summary: The study aimed to identify circulating biomarkers specific for sudden cardiac arrest (SCA), independent of coronary artery disease (CAD). By comparing SCA survivors with controls, the researchers found 26 protein biomarkers associated with SCA, of which 20 differentiated SCA from CAD. The findings have important implications for improving clinical prediction of SCA.
Article
Biochemical Research Methods
Bruno Bohn, Pamela L. Lutsey, Weihong Tang, James S. Pankow, Faye L. Norby, Bing Yu, Christie M. Ballantyne, Eric A. Whitsel, Kunihiro Matsushita, Ryan T. Demmer
Summary: This study compared the proteome of statin users and nonusers and found differences in proteins unrelated to lipid metabolism. Further investigation into these differences may help elucidate the pleiotropic effects of statins.
JOURNAL OF PROTEOMICS
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Rob F. Walker, Neil A. Zakai, Richard F. Maclehose, Faye L. Norby, Wendy Wang, Alvaro Alonso, Pamela L. Lutsey
Meeting Abstract
Cardiac & Cardiovascular Systems
Wendy Wang, Lin Y. Chen, Rob F. Walker, Alvaro Alonso, Faye L. Norby, Kamakshi Lakshminarayan, Pamela L. Lutsey
Article
Cardiac & Cardiovascular Systems
Harpriya S. Chugh, Arayik Sargsyan, Kotoka Nakamura, Audrey Uy-Evanado, Bernadine Dizon, Faye L. Norby, Christopher Young, Katy Hadduck, Jonathan Jui, Daniel Shepherd, Angelo Salvucci, Sumeet S. Chugh, Kyndaron Reinier
Summary: This study assessed the impact of COVID-19 on sudden cardiac arrest (SCA) and found that during the pandemic, SCA incidence increased significantly and survival rates decreased. Hispanics faced more difficulties in bystander CPR and resuscitation compared to non-Hispanics. Therefore, it is necessary to urgently evaluate and intervene in the acute care of SCA, especially among specific ethnic groups.
Article
Cardiac & Cardiovascular Systems
Jorge L. Reyes, Faye L. Norby, Yuekai Ji, Wendy Wang, Romil Parikh, Michael J. Zhang, Niki C. Oldenburg, Pamela L. Lutsey, Clifford R. Jack, Michelle Johansen, Rebecca F. Gottesman, Josef Coresh, Thomas Mosley, Elsayed Z. Soliman, Alvaro Alonso, Lin Yee Chen
Summary: Recent evidence suggests that abnormal P-wave parameters, which are electrocardiogram markers of atrial myopathy, are associated with incident dementia, independent of atrial fibrillation and clinical ischemic stroke. This study found that these abnormal P-wave parameters were associated with a higher prevalence of brain infarcts and microhemorrhage, indicating subclinical vascular brain injury as a possible mechanism underlying the association of atrial myopathy with dementia.
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2023)
Article
Nutrition & Dietetics
Linzi Li, Pamela L. Lutsey, Lin Yee Chen, Elsayed Z. Soliman, Mary R. Rooney, Alvaro Alonso
Summary: Higher serum magnesium is associated with a lower risk of cardiovascular events, especially myocardial infarction, in patients with atrial fibrillation.
Article
Public, Environmental & Occupational Health
Emily A. Groene, Faye L. Norby, Anne A. Eaton, Susan M. Mason, Eva A. Enns, Shalini Kulasingam, David M. Vock
Summary: Gonorrhea diagnosis is associated with pelvic inflammatory disease, ectopic pregnancy, and tubal factor infertility in women, and this association has not changed in recent years.
JOURNAL OF WOMENS HEALTH
(2023)
Article
Medicine, General & Internal
Wendy Wang, Lin Yee Chen, Rob F. Walker, Lisa S. Chow, Faye L. Norby, Alvaro Alonso, James S. Pankow, Pamela L. Lutsey
Summary: The objective of this study was to assess the association between SGLT2 inhibitors and other second-line diabetes therapies with the risk of cardiovascular disease (CVD) and conduct head-to-head comparisons between SGLT2 inhibitors. Using data from the MarketScan databases, SGLT2 inhibitor users were matched with other second-line therapy users. The results showed that SGLT2 inhibitors were associated with a lower risk of CVD compared to other second-line therapies. No significant differences were found when comparing individual SGLT2 inhibitors.
MAYO CLINIC PROCEEDINGS
(2023)
Article
Cardiac & Cardiovascular Systems
Kyndaron Reinier, Jee-Young Moon, Harpriya S. Chugh, Arayik Sargsyan, Kotoka Nakamura, Faye L. Norby, Audrey Uy-Evanado, Gregory A. Talavera, Linda C. Gallo, Martha L. Daviglus, Katy Hadduck, Daniel Shepherd, Angelo Salvucci, Robert C. Kaplan, Sumeet S. Chugh
Summary: This study provides population-based evidence on risk factors for sudden cardiac arrest (SCA) among Hispanic or Latino adults. It shows that chronic kidney disease is the strongest risk factor for SCA in this population, followed by established cardiovascular disease.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Medicine, General & Internal
Ines Gonzalez Casanova, Angel M. Alonso-Gomez, Dora Romaguera, Estefania Toledo, Linzi Li, Elena Fortuny, Luis Lopez, Raul Ramallal, Jordi Salas-Salvado, Lucas Tojal-Sierra, Olga Castaner, Alvaro Alonso
Summary: This study investigated the associations between lifestyle, weight, heart structure, and cognitive functioning, as well as the potential mediating role of heart structure in these associations. The results showed no significant associations between lifestyle, weight, and cognition, and no mediating effects of heart structure were observed. Due to the limited sample size, larger studies should be conducted to examine potential cardiovascular factors mediating the association between lifestyle and cognition.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Lauri Holmstrom, Harpriya S. Chugh, Audrey Uy-Evanado, Arayik Sargsyan, Chad Sorenson, Shiva Salmasi, Faye L. Norby, Sean Hurst, Christopher Young, Angelo Salvucci, Jonathan Jui, Kyndaron Reinier, Sumeet S. Chugh
Summary: Based on the investigation of a large U.S. population of older adults, the study found a low incidence of Sports-related sudden cardiac arrest (SrSCA) in individuals aged 65 and older, with a higher occurrence in men. SrSCA cases had a lower burden of cardiovascular risk factors and comorbidities compared to non-SrSCA cases.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2023)
Article
Respiratory System
David M. MacDonald, Yuekai Ji, Selcuk Adabag, Alvaro Alonso, Lin Yee Chen, Benjamin E. Henkle, Stephen P. Juraschek, Faye L. Norby, Pamela L. Lutsey, Ken M. Kunisaki
Summary: This study found that better cardiovascular autonomic function was associated with a lower risk of COPD hospitalization, while worse autonomic function was associated with a higher risk of COPD hospitalization. This relationship was more significant in participants without airflow obstruction.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)