Article
Chemistry, Multidisciplinary
Jan Steinkuehler, Piermarco Fonda, Tripta Bhatia, Ziliang Zhao, Fernanda S. C. Leomil, Reinhard Lipowsky, Rumiana Dimova
Summary: By preserving the structure and composition of the plasma membrane during isolation, vesicles with cell-like elasticity can be obtained, storing significant area in the form of nanotubes and lipid reservoirs. The interplay of lipid domains and membrane curvature leads to a superelastic response that allows for engineering synthetic biomaterials with enhanced deformability.
Article
Chemistry, Physical
Alessandra Marega Motta, Maressa Donato, Giovanna Mobbili, Paolo Mariani, Rosangela Itri, Francesco Spinozzi
Summary: This study investigates the mechanisms of interaction between Rhamnolipids (RLs) and simulated plasma membrane models. The results show that mono-RL primarily interacts with the outer leaflet of the membrane through insertion without pore formation, but induces lipid mixing. On the other hand, di-RLs initially interact through insertion and later undergo pore formation.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Review
Cell Biology
Yuichi Wakana, Felix Campelo
Summary: Membrane trafficking plays a crucial role in processing and transporting proteins and lipids, as well as in establishing cell compartmentation and tissue organization. The focus of this review is on a specific membrane trafficking route from the trans-Golgi network to the cell surface, highlighting the role of PKD-dependent pathway and membrane contact sites in this process. Additionally, the discussion includes various signaling pathways involved in regulating membrane trafficking, such as those mediated by PKD, GPCRs, growth factors, metabolites, and mechanosensors.
Article
Biochemistry & Molecular Biology
Mussie K. Araya, Yong Zhou, Alemayehu A. Gorfe
Summary: The plasma membrane is a dynamic structure that undergoes constant changes in morphology and composition. Membrane proteins interact with membrane lipids to carry out their functions, and can also remodel the membrane's composition and curvature. This review focuses on the role of membrane proteins containing intrinsically disordered regions (IDRs) in remodeling the plasma membrane.
JOURNAL OF MEMBRANE BIOLOGY
(2022)
Article
Biology
Manuela Ecker, Richard Schregle, Natasha Kapoor-Kaushik, Pascal Rossatti, Verena M. Betzler, Daryan Kempe, Mate Biro, Nicholas Ariotti, Gregory M. Redpath, Jeremie Rossy
Summary: This study investigates the recruitment of SNX9 to CD28 clusters upon CD28 triggering, which promotes membrane tubulation and regulates the stability of CD28 as well as signaling events. CD28 clusters are shown to be dynamic structures, and SNX9-mediated tubulation generates a membrane environment that facilitates CD28 triggering and downstream signaling events.
Review
Engineering, Multidisciplinary
Alessandra Luchini, Giuseppe Vitiello
Summary: Cell membranes are complex biological systems consisting of various lipids and proteins. Biomimetic lipid membranes have been used to study the physical and chemical properties of cell membranes. Future developments in this field include the use of more biologically relevant lipid mixtures and the incorporation of membrane proteins into biomimetic lipid membranes.
Article
Multidisciplinary Sciences
Kang-Cheng Liu, Hudson Pace, Elin Larsson, Shakhawath Hossain, Aleksei Kabedev, Ankita Shukla, Vanessa Jerschabek, Jagan Mohan, Christel A. S. Bergstrom, Marta Bally, Christian Schwieger, Madlen Hubert, Richard Lundmark
Summary: Caveolae, important plasma membrane invaginations, are shaped by the coat protein Cavin1. This study reveals the mechanism of Cavin1 assembly at the membrane interface, involving initial PI(4,5)P-2-dependent membrane adsorption, subsequent partial separation and membrane insertion. This intricate mechanism facilitates membrane curvature generation and dynamic assembly-disassembly of Cavin1 at the membrane.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Julia Bahja, Marcus K. Dymond
Summary: Oxidative stress affects lipid membranes by reducing stored curvature elastic energy, which can potentially be mitigated by compounds that increase stored curvature elastic energy; Age-related changes in lipid composition may represent a homeostatic response of cells to compensate for the accumulation of in vivo lipid oxidation products.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Marina N. Iriondo, Asier Etxaniz, Zurine Anton, L. Ruth Montes, Alicia Alonso
Summary: Autophagy is a crucial process for cell self-repair and survival, involving the formation of autophagosomes that deliver cargo for degradation and re-use. The complex event of autophagosome formation requires specific proteins and membrane biogenesis, with curvature playing a key role in the process.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2021)
Article
Biochemistry & Molecular Biology
Misuzu Ueki, Masayuki Iwamoto
Summary: This study established an experimental procedure to evaluate membrane curvature-induced structural changes in the potassium channel KcsA, showing that a large membrane curvature significantly affects the activation gate conformation of the channel.
Article
Biochemistry & Molecular Biology
Yueqi Niu, Si Jia Chen, Jeffery B. Klauda
Summary: Macrophage membranes in the activated state are more tightly packed, exhibit increased chain order across lipid species, and form specific lipid clusters. These findings provide physiologically accurate models for future computational studies of macrophage membranes and their proteins.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Review
Chemistry, Physical
Stephanie Andrade, Maria J. Ramalho, Joana A. Loureiro, Maria Carmo Pereira
Summary: Understanding how drugs interact with biological membranes is crucial for the pharmaceutical industry. In vitro lipid-based membrane models provide a simple alternative to study these interactions. Different lipid models and biophysical methodologies using liposomes are discussed for investigating drug-membrane interactions.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Review
Medicine, Research & Experimental
Weidong Fei, Jingjing Yan, Xiaodong Wu, Shan Yang, Xiao Zhang, Rong Wang, Yue Chen, Junjun Xu, Caihong Zheng
Summary: Cancer is caused by genetic mutations that result in epigenetic changes. Understanding the lipid alterations in tumor cells and utilizing nanotechnology can offer new approaches for cancer therapy.
Article
Cell Biology
Ilenia Agliarulo, Seetharaman Parashuraman
Summary: This article discusses the central role of the Golgi apparatus in the mammalian secretory pathway and its regulation of plasma membrane biosynthesis through three distinct processes. It also explores the importance of the molecules involved in these processes in physiology and development, as well as how mutations in these molecules can lead to genetic diseases and cancer.
Article
Biochemistry & Molecular Biology
Rose Whiting, Pangaea W. Finn, Andrew Bogard, Fulton McKinney, Dallin Pankratz, Aviana R. Smith, Elen A. Gardner, Daniel Fologea
Summary: Studies have shown that the curvature of lipid membranes influences permeability, with most experiments using flat membranes ignoring this physiological relevance. By adapting an experimental system with differential hydrostatic pressure on a lipid membrane and measuring capacitance and conductance, a strong correlation between membrane geometry changes and conductance was observed. This system may help understand the intricate relationship between membrane mechanics, cellular functionalities, and mechanical stimulation effects.