Structure activity relationship of N-1 substituted 1,5-naphthyrid-2-one analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-9)

Dose Selection for Phase III Clinical Evaluation of Gepotidacin (GSK2140944) in the Treatment of Uncomplicated Urinary Tract Infections

(2022) Nicole E. Scangarella-Oman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

(2022) Christopher JL Murray et al.   LANCET

Optimization of TopoIV Potency, ADMET Properties, and hERG Inhibition of 5-Amino-1,3-dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Identification of a Lead with In Vivo Efficacy against MRSA

(2021) Yanran Lu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Two Decades of Successful SAR-Grounded Stories of the Novel Bacterial Topoisomerase Inhibitors (NBTIs)

(2020) Anja Kolarič et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phase 2a Pharmacokinetic, Safety, and Exploratory Efficacy Evaluation of Oral Gepotidacin (GSK2140944) in Female Participants With Uncomplicated Urinary Tract Infection (Acute Uncomplicated Cystitis)

(2020) J. Scott Overcash et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Gepotidacin for the Treatment of Uncomplicated Urogenital Gonorrhea: A Phase 2, Randomized, Dose-Ranging, Single-Oral Dose Evaluation

(2018) Stephanie N Taylor et al.   CLINICAL INFECTIOUS DISEASES

Microbiological Analysis From a Phase 2 Randomized Study in Adults Evaluating Single Oral Doses of Gepotidacin in the Treatment of Uncomplicated Urogenital Gonorrhea Caused by Neisseria gonorrhoeae

(2018) Nicole E. Scangarella-Oman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis and Characterization of Tetrahydropyran-Based Bacterial Topoisomerase Inhibitors with Antibacterial Activity against Gram-Negative Bacteria

(2017) Jean-Philippe Surivet et al.   JOURNAL OF MEDICINAL CHEMISTRY

In VitroandIn VivoCharacterization of the Novel Oxabicyclooctane-Linked Bacterial Topoisomerase Inhibitor AM-8722, a Selective, Potent Inhibitor of Bacterial DNA Gyrase

(2016) Christopher M. Tan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structure activity relationship of substituted 1,5-naphthyridine analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-4)

(2015) Sheo B. Singh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure activity relationship of C-2 ether substituted 1,5-naphthyridine analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-5)

(2015) Sheo B. Singh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure activity relationship of pyridoxazinone substituted RHS analogs of oxabicyclooctane-linked 1,5-naphthyridinyl novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-6)

(2015) Sheo B. Singh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Hydroxy tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of RHS moiety (Part-3)

(2015) Sheo B. Singh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Optimization of physicochemical properties and safety profile of novel bacterial topoisomerase type II inhibitors (NBTIs) with activity against Pseudomonas aeruginosa

(2014) Folkert Reck et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Confronting the challenges of discovery of novel antibacterial agents

(2014) Sheo B. Singh   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Determination of Disk Diffusion and MIC Quality Control Guidelines for GSK2140944, a Novel Bacterial Type II Topoisomerase Inhibitor Antimicrobial Agent

(2014) J. E. Ross et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Oxabicyclooctane-Linked Novel Bacterial Topoisomerase Inhibitors as Broad Spectrum Antibacterial Agents

(2014) Sheo B. Singh et al.   ACS Medicinal Chemistry Letters

Novel N-Linked Aminopiperidine Inhibitors of Bacterial Topoisomerase Type II: Broad-Spectrum Antibacterial Agents with Reduced hERG Activity

(2011) Folkert Reck et al.   JOURNAL OF MEDICINAL CHEMISTRY

Type IIA topoisomerase inhibition by a new class of antibacterial agents

(2010) Benjamin D. Bax et al.   NATURE